EKS-EQC-00176

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00176

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/SRPK	856.8	5.6E-258	56	629	574

Status

Unreviewed

Ensembl Protein

ENSECAP00000012199

UniProt Accession

F7C1S0;

Protein Name

Protein Synonyms/Alias

Gene Name

SRPK1

Gene Synonyms/Alias

SRPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000014213	ENSECAP00000012199	ENSECAT00000015200

Organism

Equus caballus

Functional Description

Protein Length

631

Protein Sequence
(FASTA)

RSETQHRGSA PHSESDLPEQ EEEILGSDDD EQEDPNDYCK GGYHLVKIGD LFNGRYHVIR 60

KLGWGHFSTV WLSWDIQGKK FVAMKVVKSA EHYTETALDE IRLLKSVRNS DPNDPNREMV 120

VQLLDDFKIS GVNGTHICMV FEVLGHHLLK WIIKSNYQGL PLPCVKKIIQ QVLQGLDYLH 180

TKCRIIHTDI KPENILLSVN EQYIRRLAAE ATEWQRSGAP PPSGSAVSTA PQPKPADKMS 240

KNKKKKLKKK QKRQAELLEK RMQEIEEMEK ESGPGQKRPN KQEESESPVE RPLKENPPSN 300

MTQEKLEESS TVDQDQTLME RGVEGGAAEI NCNGVIEIVN YTENSNKETL RLKEDLHNAN 360

DCDVQNLKQE PSFLSSPNGD SSTSQETDSC TPVTSEVSDS MMCQSPSNVD QSFSEQHISQ 420

LQESIRAEIP CEDEQEREHN GPLDNKGKST AGHFLVNPLE PKNAEKLQVK IADLGNACWV 480

HKHFTEDIQT RQYRSLEVLI GSGYNTPADI WSTACMAFEL ATGDYLFEPH SGEEYTRDED 540

HIALIIELLG KVPRKLIVAG KYSKEFFTKK GDLKHITKLK PWGLFEVLVE KYEWSQEEAA 600

GFTDFLLPML ELIPEKRATA ADCLRHPWLN S 631

Nucleotide Sequence
(FASTA)

AGATCTGAAA CTCAGCACCG AGGTTCTGCA CCCCACTCTG AGAGTGATCT ACCAGAGCAG 60

GAAGAGGAGA TTCTGGGATC TGATGATGAT GAGCAGGAAG ATCCCAATGA TTATTGTAAA 120

GGTGGTTATC ATCTTGTGAA AATTGGAGAT CTGTTCAATG GGAGATATCA TGTTATCCGA 180

AAGTTGGGCT GGGGACACTT TTCAACAGTG TGGTTATCAT GGGACATCCA GGGGAAGAAA 240

TTTGTGGCAA TGAAAGTAGT TAAAAGTGCT GAACATTATA CAGAAACAGC ACTAGATGAA 300

ATCCGGTTGC TGAAATCAGT TCGCAATTCT GACCCTAATG ATCCAAATAG AGAAATGGTT 360

GTTCAACTAC TAGATGACTT TAAAATATCA GGAGTTAATG GAACACATAT CTGCATGGTG 420

TTTGAAGTTT TGGGGCATCA TCTGCTCAAG TGGATCATCA AGTCCAATTA TCAAGGGCTC 480

CCGCTGCCTT GTGTCAAAAA AATCATTCAG CAAGTGTTAC AGGGTCTGGA TTATTTACAC 540

ACCAAGTGCC GTATCATCCA CACCGACATT AAACCAGAAA ACATCTTGTT GTCAGTGAAC 600

GAGCAGTACA TCCGAAGGCT GGCTGCAGAA GCCACAGAAT GGCAGCGATC TGGAGCTCCT 660

CCACCTTCCG GATCTGCAGT CAGTACTGCA CCCCAGCCTA AACCAGCTGA CAAAATGTCA 720

AAGAATAAGA AGAAGAAATT GAAGAAGAAG CAGAAGCGCC AGGCAGAATT ACTAGAGAAG 780

CGAATGCAGG AAATTGAGGA AATGGAGAAA GAGTCGGGCC CTGGGCAAAA AAGACCAAAC 840

AAGCAAGAAG AATCAGAGAG TCCTGTTGAA AGACCCTTGA AAGAGAACCC ACCTAGTAAC 900

ATGACCCAAG AAAAACTTGA AGAGTCGAGT ACAGTTGACC AGGATCAGAC ACTTATGGAA 960

CGTGGTGTAG AGGGTGGTGC AGCAGAAATT AATTGCAATG GAGTAATTGA AATCGTTAAT 1020

TATACTGAGA ACAGTAATAA AGAAACATTG AGGCTTAAAG AGGATCTACA TAATGCTAAT 1080

GACTGTGATG TCCAAAATTT GAAGCAGGAA CCTAGTTTCC TAAGCTCCCC AAATGGAGAC 1140

AGCAGCACAT CTCAAGAAAC AGACTCTTGT ACACCTGTAA CGTCTGAGGT GTCAGATAGC 1200

ATGATGTGCC AGTCTCCATC AAATGTAGAC CAGTCATTCA GTGAACAGCA CATCAGCCAA 1260

CTTCAAGAAA GCATTCGGGC AGAGATACCC TGTGAAGATG AGCAAGAGCG AGAACATAAC 1320

GGACCACTGG ATAACAAAGG AAAATCCACT GCTGGACATT TTCTTGTTAA TCCCCTTGAG 1380

CCAAAAAATG CAGAAAAGCT CCAAGTGAAG ATTGCTGATC TTGGAAATGC CTGTTGGGTG 1440

CACAAACATT TCACTGAAGA TATTCAAACA AGGCAGTATC GCTCCTTGGA AGTTCTGATA 1500

GGATCTGGCT ATAACACCCC TGCTGACATT TGGAGCACGG CATGCATGGC CTTTGAACTG 1560

GCCACAGGCG ACTATTTGTT TGAACCTCAT TCAGGGGAAG AGTACACTCG AGATGAAGAT 1620

CACATTGCAC TGATCATAGA ACTCCTGGGG AAGGTGCCTC GCAAGCTCAT TGTGGCAGGA 1680

AAATATTCCA AGGAATTTTT CACCAAAAAA GGTGACCTGA AACACATCAC GAAGCTGAAA 1740

CCCTGGGGCC TCTTTGAGGT TCTGGTGGAG AAGTACGAGT GGTCTCAGGA AGAAGCAGCT 1800

GGCTTCACGG ATTTCTTACT GCCCATGTTG GAGCTGATTC CCGAGAAGAG AGCCACTGCC 1860

GCCGATTGTC TCCGGCACCC TTGGCTCAAC TCCTAA 1896

Domain Profile

S: 1     yhvirkLGWGhfstvWLawdlqekrfvalkvvksaehytetaldeikllksvresdpsdp  60

         yhvirkLGWGhfstvWL+wd+q+k+fva+kvvksaehytetaldei+llksvr+sdp+dp

Q: 56    YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDP  115

         9***********************************************************

S: 61    krekvvqllddfkisGvnGvhvclvfevLGenLlkliiksnyrGlpleqvkkiirqvLeg  120

         +re+vvqllddfkisGvnG+h+c+vfevLG++Llk+iiksny+Glpl++vkkii+qvL+g

Q: 116   NREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQG  175

         ************************************************************

S: 121   LdylhekCkiihtdikPenvLlavddeyirrlaaeatewqkagakppsgsavstapqkka  180

         Ldylh+kC+iihtdikPen+Ll+v+++yirrlaaeatewq++ga+ppsgsavstapq+k+

Q: 176   LDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKP  235

         ************************************************************

S: 181   ieklsknkkkklkkkqkrqaellekrlqeleele..........................  214

         ++k+sknkkkklkkkqkrqaellekr+qe+ee+e

Q: 236   ADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEkesgpgqkrpnkqeesespverplke  295

         ************************************************************

S: 215   ..........aaeanseaedqelkedaekgeleeieadveeevanedeaseeee......  258

                   ++e+++  +dq+l+e+  +g+++ei+++ ++e++n++e+s++e+

Q: 296   nppsnmtqekLEESSTVDQDQTLMERGVEGGAAEINCNGVIEIVNYTENSNKETlrlked  355

         *********99999999********************************99999999999

S: 259   ..............essltsssdaesksgelseastellsesleqlacgsvls.......  297

                       e s++ss + +s+++++++++t+++se++++++c+s ++

Q: 356   lhnandcdvqnlkqEPSFLSSPNGDSSTSQETDSCTPVTSEVSDSMMCQSPSNvdqsfse  415

         99999999**9999************************************99999*****

S: 298   ........................................vnplepknadkikvkiadLG  317

                                                 vnplepkna+k++vkiadLG

Q: 416   qhisqlqesiraeipcedeqerehngpldnkgkstaghflVNPLEPKNAEKLQVKIADLG  475

         ************************************************************

S: 318   naCwvhkhftediqtrqyrslevliGagygtpadiWstaClafeLatGdyLfephsgedy  377

         naCwvhkhftediqtrqyrslevliG+gy+tpadiWstaC+afeLatGdyLfephsge+y

Q: 476   NACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEY  535

         ************************************************************

S: 378   srdedhiakiiellGkiPrklilkGkysreffnkkgeLrhitkLkpwsLlevLvekyews  437

         +rdedhia iiellGk+Prkli++Gkys+eff+kkg+L+hitkLkpw+L+evLvekyews

Q: 536   TRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWS  595

         ************************************************************

S: 438   keeaaefsdfLlPmleldpekrasaaeclkhpwL  471

         +eeaa f+dfLlPmlel+pekra+aa+cl+hpwL

Q: 596   QEEAAGFTDFLLPMLELIPEKRATAADCLRHPWL  629

         *********************************8

Domain Sequence
(FASTA)

YHVIRKLGWG HFSTVWLSWD IQGKKFVAMK VVKSAEHYTE TALDEIRLLK SVRNSDPNDP 60

NREMVVQLLD DFKISGVNGT HICMVFEVLG HHLLKWIIKS NYQGLPLPCV KKIIQQVLQG 120

LDYLHTKCRI IHTDIKPENI LLSVNEQYIR RLAAEATEWQ RSGAPPPSGS AVSTAPQPKP 180

ADKMSKNKKK KLKKKQKRQA ELLEKRMQEI EEMEKESGPG QKRPNKQEES ESPVERPLKE 240

NPPSNMTQEK LEESSTVDQD QTLMERGVEG GAAEINCNGV IEIVNYTENS NKETLRLKED 300

LHNANDCDVQ NLKQEPSFLS SPNGDSSTSQ ETDSCTPVTS EVSDSMMCQS PSNVDQSFSE 360

QHISQLQESI RAEIPCEDEQ EREHNGPLDN KGKSTAGHFL VNPLEPKNAE KLQVKIADLG 420

NACWVHKHFT EDIQTRQYRS LEVLIGSGYN TPADIWSTAC MAFELATGDY LFEPHSGEEY 480

TRDEDHIALI IELLGKVPRK LIVAGKYSKE FFTKKGDLKH ITKLKPWGLF EVLVEKYEWS 540

QEEAAGFTDF LLPMLELIPE KRATAADCLR HPWL 574

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007059	; P:chromosome segregation
GO:0045071	; P:negative regulation of viral genome replication
GO:0045070	; P:positive regulation of viral genome replication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013