EKS-EQC-00172
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00172
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC429.94.2E-129227496270
StatusUnreviewed
Ensembl ProteinENSECAP00000012512
UniProt AccessionF7DT34;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCZ
Gene Synonyms/Alias PRKCZ;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000014312ENSECAP00000012512ENSECAT00000015556
OrganismEquus caballus
Functional Description
Protein Length570
Protein Sequence
(FASTA)
DILITSLDPA MTFEELCEEV REMCSLHQGH PLTLKWVDSE GDPCTVSSQM ELEEAFRLAC 60
QRRDEGLIIH VFPSIPEQPG MPCPGEDKSI YRRGARRWRK LYRANGHLFQ AKRFNRRAYC 120
GQCSERIWGL ARQGYRCINC KLLVHKRCHV LVPLTCNRHM DPVMPSQEPA VDDKDDVDLP 180
SEETHGIAYI SSTRKHDSIK DDSEDLKPVI DGMDGIKISQ GLGLQDFDLI RVIGRGSYAK 240
VLLVRLKKND QIYAMKVVKK ELVHDDEDID WVQTEKHVFE QASSNPFLVG LHSCFQTTSR 300
LFLVIEYVNG GDLMFHMQRQ RKLPEEHARF YAAEICIALN FLHERGIIYR DLKLDNVLLD 360
ADGHIKLTDY GMCKASSPGL GPGDTTSTFC GTPNYIAPEI LRGEEYGFSV DWWALGVLMF 420
EMMAGRSPFD IITDNPDMNT EDYLFQVILE KPIRIPRFLS VKASHVLKGF LNKDPKERLG 480
CRPQTGFSDI KSHAFFRSID WDLLEKKQAL PPFQPQITDD YGLDNFDTQF TSEPVQLTPD 540
DEDVIKRIDQ SEFEGFEYIN PLLLSTEESV 570
Nucleotide Sequence
(FASTA)
GACATCCTGA TCACCAGCTT GGACCCCGCG ATGACCTTCG AGGAGCTCTG TGAGGAAGTG 60
CGAGAGATGT GCAGTCTGCA CCAGGGGCAC CCCCTCACCC TCAAGTGGGT GGACAGTGAA 120
GGTGACCCCT GCACCGTGTC CTCCCAGATG GAGCTGGAGG AGGCCTTCCG CCTGGCCTGT 180
CAGCGCAGGG ACGAGGGGCT CATCATTCAC GTTTTCCCGA GCATCCCCGA GCAGCCAGGC 240
ATGCCTTGTC CCGGAGAAGA CAAATCCATC TACCGCCGTG GAGCCAGAAG ATGGAGGAAG 300
CTGTACCGCG CCAACGGCCA TCTCTTCCAA GCCAAGCGCT TTAACAGGAG AGCTTACTGT 360
GGCCAGTGCA GCGAAAGGAT ATGGGGTCTC GCGAGGCAGG GCTACAGGTG CATCAACTGC 420
AAACTGCTGG TCCATAAACG CTGCCACGTC CTCGTCCCGC TGACCTGCAA CAGGCATATG 480
GATCCTGTCA TGCCTTCCCA GGAACCTGCA GTAGATGACA AGGACGACGT GGACCTTCCC 540
TCGGAGGAGA CCCATGGAAT TGCTTATATT TCTTCAACCC GGAAACATGA CAGCATTAAA 600
GATGATTCTG AGGACCTCAA GCCGGTCATC GATGGGATGG ATGGAATCAA AATCTCTCAG 660
GGGCTCGGGC TGCAGGACTT CGACCTCATC AGGGTCATCG GGCGCGGGAG CTACGCCAAG 720
GTCCTGCTGG TGCGGCTGAA GAAGAATGAT CAGATTTACG CCATGAAAGT GGTGAAGAAG 780
GAGCTGGTCC ATGACGATGA GGACATCGAC TGGGTGCAGA CAGAGAAGCA CGTGTTTGAG 840
CAAGCATCCA GCAACCCCTT CCTGGTTGGC TTACACTCCT GCTTCCAGAC GACGAGTCGG 900
TTGTTCCTGG TCATAGAGTA CGTCAACGGC GGGGACCTTA TGTTCCACAT GCAGAGACAG 960
AGGAAGCTTC CGGAGGAGCA CGCCAGATTC TATGCTGCTG AGATTTGTAT CGCTCTCAAC 1020
TTCTTACATG AGAGAGGGAT TATCTACCGG GACCTGAAAC TGGACAATGT CCTCCTGGAT 1080
GCCGACGGCC ACATCAAGTT GACGGACTAC GGCATGTGCA AGGCGAGCAG CCCCGGCCTG 1140
GGCCCTGGTG ACACGACAAG CACTTTCTGC GGAACCCCAA ACTACATCGC ACCAGAAATC 1200
CTGCGGGGAG AGGAGTACGG GTTCAGCGTG GACTGGTGGG CGCTGGGCGT CCTCATGTTT 1260
GAGATGATGG CCGGCCGCTC CCCCTTCGAC ATCATCACCG ACAACCCCGA CATGAACACC 1320
GAGGACTACC TTTTCCAAGT GATCCTGGAG AAGCCCATCC GGATCCCCCG ATTCCTCTCC 1380
GTCAAAGCCT CCCACGTCTT GAAAGGATTT TTAAACAAGG ACCCCAAAGA GAGGCTCGGC 1440
TGCCGGCCAC AGACTGGATT TTCTGACATC AAGTCGCACG CGTTCTTCCG CAGCATAGAC 1500
TGGGACCTGC TGGAGAAGAA GCAGGCCCTC CCGCCATTCC AGCCGCAGAT CACCGACGAC 1560
TACGGCCTGG ACAACTTCGA CACACAGTTC ACCAGCGAGC CCGTGCAGCT GACCCCGGAC 1620
GACGAGGACG TCATAAAGAG GATCGACCAG TCTGAGTTTG AAGGTTTCGA GTACATCAAC 1680
CCGTTACTGC TCTCCACCGA GGAGTCCGTG TGA 1713
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+l++v+G+Gs++kvll++lkk+d++ya+kv+kk++v++d+d++++++ek+v+++as++p
Q: 227   FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP  286
         89**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         flv l+scfqt++rlf+v+eyvnGGdlmfh+q++rkl+ee+arfyaaei++al+flhe+g
Q: 287   FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERG  346
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlcke...eilegkttstfcGtPdyiaPeilkeeey  177
         iiyrdlkldnvllda+Ghikl+d+G+ck    ++  g+ttstfcGtP+yiaPeil++eey
Q: 347   IIYRDLKLDNVLLDADGHIKLTDYGMCKAsspGLGPGDTTSTFCGTPNYIAPEILRGEEY  406
         ****************************83346899************************
S: 178   gksvdwwalGvllyemlagqsPfe.......gededelfesilekevlyPkslskeavei  230
         g+svdwwalGvl++em+ag+sPf+       +++ed+lf++ilek +++P+ ls++a+++
Q: 407   GFSVDWWALGVLMFEMMAGRSPFDiitdnpdMNTEDYLFQVILEKPIRIPRFLSVKASHV  466
         *****************************999****************************
S: 231   lkglltkdpekrlGvk.eegeedikehaff  259
         lkg+l+kdp++rlG++ ++g +dik+haff
Q: 467   LKGFLNKDPKERLGCRpQTGFSDIKSHAFF  496
         ***************889***********9
Domain Sequence
(FASTA)
FDLIRVIGRG SYAKVLLVRL KKNDQIYAMK VVKKELVHDD EDIDWVQTEK HVFEQASSNP 60
FLVGLHSCFQ TTSRLFLVIE YVNGGDLMFH MQRQRKLPEE HARFYAAEIC IALNFLHERG 120
IIYRDLKLDN VLLDADGHIK LTDYGMCKAS SPGLGPGDTT STFCGTPNYI APEILRGEEY 180
GFSVDWWALG VLMFEMMAGR SPFDIITDNP DMNTEDYLFQ VILEKPIRIP RFLSVKASHV 240
LKGFLNKDPK ERLGCRPQTG FSDIKSHAFF 270
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00165
EKS-BOT-00174
EKS-CAF-00181
EKS-DAR-00466
EKS-DIO-00088
EKS-FEC-00166
EKS-GAG-00149
EKS-GAA-00210
EKS-GOG-00173
EKS-ICT-00168
EKS-LAC-00182
EKS-LOA-00172
EKS-MAM-00174
EKS-MEG-00138
EKS-MOD-00171
EKS-MUP-00178
EKS-OCP-00108
EKS-ORL-00205
EKS-OTG-00179
EKS-PES-00153
EKS-POA-00172
EKS-RAN-00170
EKS-SAH-00165
EKS-TEN-00219
EKS-XET-00161
EKS-XIM-00213
Gene Ontology
GO:0045179; C:apical cortex
GO:0016324; C:apical plasma membrane
GO:0035748; C:myelin sheath abaxonal region
GO:0005635; C:nuclear envelope
GO:0016363; C:nuclear matrix
GO:0043234; C:protein complex
GO:0005923; C:tight junction
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
GO:0000226; P:microtubule cytoskeleton organization
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0031333; P:negative regulation of protein complex assembly
GO:0018105; P:peptidyl-serine phosphorylation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:2001181; P:positive regulation of interleukin-10 secretion
GO:2000667; P:positive regulation of interleukin-13 secretion
GO:0032753; P:positive regulation of interleukin-4 production
GO:2000664; P:positive regulation of interleukin-5 secretion
GO:2000553; P:positive regulation of T-helper 2 cell cytokine production
GO:0045630; P:positive regulation of T-helper 2 cell differentiation
GO:0072659; P:protein localization to plasma membrane
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR000270; OPR_PB1.
IPR012233; PKC_zeta.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00564; PB1; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00666; PB1; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013