EKS-EQC-00420

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00420

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/Aur	473.0	1.8E-142	77	327	251

Status

Unreviewed

Ensembl Protein

ENSECAP00000012236

UniProt Accession

F7DPL7;

Protein Name

Protein Synonyms/Alias

Gene Name

AURKB

Gene Synonyms/Alias

AURKB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000014384	ENSECAP00000012236	ENSECAT00000015240

Organism

Equus caballus

Functional Description

Protein Length

344

Protein Sequence
(FASTA)

MTQKENAYPW PYGRQTAQSG LNTLPQRVLR KEPATPSALV LMSRSNAQPT VALGQKVMEN 60

SSGTPNLLMR SFTIDDFEIG RPLGKGKFGN VYLAREKKSH FIVALKVLFK SQIEKEGVEH 120

QLRREIEIQA HLQHPNILRL YNYFYDRRRI YLILEYAPRG ELYKELQKSR TFDEQRTATI 180

MEELADALMY CHGKKVIHRD IKPENLLLGL QGELKIADFG WSVHAPSLRR KTMCGTLDYL 240

PPEMIEGRTH NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPPSVPAGA 300

QDLISKLLRH NPSERLPLAQ VSAHPWVRAH SRRVLPPSAL QSVP 344

Nucleotide Sequence
(FASTA)

ATGACCCAGA AGGAGAACGC CTACCCCTGG CCCTACGGTC GGCAGACGGC TCAATCTGGC 60

CTGAACACCC TGCCCCAGAG AGTCCTCCGG AAGGAGCCTG CCACCCCATC TGCACTTGTC 120

CTCATGAGCC GCTCCAATGC TCAGCCCACA GTTGCCCTTG GCCAGAAGGT GATGGAGAAC 180

AGCAGTGGGA CACCCAACTT GTTAATGCGT TCCTTCACAA TTGATGACTT TGAGATTGGG 240

CGTCCTCTGG GCAAAGGCAA GTTTGGAAAC GTGTACTTGG CTCGGGAGAA GAAGAGCCAT 300

TTCATCGTGG CCCTCAAGGT CCTCTTCAAG TCTCAGATAG AGAAGGAGGG CGTGGAGCAC 360

CAGCTGCGCA GGGAGATCGA AATCCAGGCC CATCTGCAGC ATCCCAACAT CTTGCGTCTC 420

TACAACTATT TCTATGACCG GCGAAGGATC TACTTGATTC TGGAGTATGC CCCCCGGGGG 480

GAGCTCTACA AGGAGCTGCA GAAGAGCCGC ACTTTTGATG AGCAGCGAAC AGCCACGATC 540

ATGGAGGAGC TGGCAGATGC CCTGATGTAC TGCCACGGGA AGAAGGTGAT TCACAGAGAC 600

ATAAAGCCAG AGAATCTGCT CTTGGGGCTC CAGGGAGAGC TGAAGATTGC CGACTTTGGC 660

TGGTCGGTGC ACGCGCCCTC CCTGAGGAGG AAGACGATGT GTGGCACCCT GGACTACCTG 720

CCCCCTGAGA TGATTGAGGG CCGCACGCAC AATGAGAAGG TGGATCTGTG GTGCATTGGA 780

GTACTCTGCT ATGAGCTGCT GGTGGGAAAC CCGCCCTTTG AGAGTGCTTC ACACAACGAG 840

ACATATCGGC GCATCGTCAA GGTAGACCTG AAGTTCCCCC CTTCTGTGCC CGCGGGAGCC 900

CAGGACCTCA TCTCCAAGCT GCTCAGGCAT AACCCCTCAG AACGGCTGCC CCTGGCCCAG 960

GTCTCAGCCC ACCCTTGGGT CCGGGCCCAT TCTCGGAGGG TGCTGCCTCC CTCTGCCCTT 1020

CAGTCTGTCC CCTGA 1035

Domain Profile

S: 1     feiGrklGkGkfGnvylarekkskfivalkvlfkeqlekegvekqlrreieiqshlkhpn  60

         feiGr+lGkGkfGnvylarekks+fivalkvlfk+q+ekegve+qlrreieiq+hl+hpn

Q: 77    FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLQHPN  136

         9***********************************************************

S: 61    ilrlygyfhdekrvylileyaprGelykelqkskkldeqraakyieeladalsylhkkkv  120

         ilrly+yf+d++r+ylileyaprGelykelqks+++deqr+a+++eeladal+y+h kkv

Q: 137   ILRLYNYFYDRRRIYLILEYAPRGELYKELQKSRTFDEQRTATIMEELADALMYCHGKKV  196

         ************************************************************

S: 121   ihrdikpenlllgskgelkladfGwsvhapsskrktlcGtldylppemvegreydekvdl  180

         ihrdikpenlllg++gelk+adfGwsvhaps +rkt+cGtldylppem+egr+++ekvdl

Q: 197   IHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRTHNEKVDL  256

         ************************************************************

S: 181   walGvlcyellvGkppfeseskdetykrikkvdlklpssvskgakdliskllkkepkerl  240

         w++GvlcyellvG+ppfes+s++ety+ri+kvdlk+p sv++ga+dliskll+++p+erl

Q: 257   WCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPPSVPAGAQDLISKLLRHNPSERL  316

         ************************************************************

S: 241   tladvlahpwi  251

         +la+v+ahpw+

Q: 317   PLAQVSAHPWV  327

         **********8

Domain Sequence
(FASTA)

FEIGRPLGKG KFGNVYLARE KKSHFIVALK VLFKSQIEKE GVEHQLRREI EIQAHLQHPN 60

ILRLYNYFYD RRRIYLILEY APRGELYKEL QKSRTFDEQR TATIMEELAD ALMYCHGKKV 120

IHRDIKPENL LLGLQGELKI ADFGWSVHAP SLRRKTMCGT LDYLPPEMIE GRTHNEKVDL 180

WCIGVLCYEL LVGNPPFESA SHNETYRRIV KVDLKFPPSV PAGAQDLISK LLRHNPSERL 240

PLAQVSAHPW V 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0032133	; C:chromosome passenger complex
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0034644	; P:cellular response to UV
GO:0002903	; P:negative regulation of B cell apoptotic process
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0071777	; P:positive regulation of cell cycle cytokinesis
GO:0034501	; P:protein localization to kinetochore
GO:0051256	; P:spindle midzone assembly involved in mitosis

KEGG

ecb:100073050

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013