EKS-EQC-00449

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00449

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	431.2	1.8E-129	31	319	289

Status

Unreviewed

Ensembl Protein

ENSECAP00000012473

UniProt Accession

F7C0M6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK3

Gene Synonyms/Alias

MAPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000014460	ENSECAP00000012473	ENSECAT00000015512

Organism

Equus caballus

Functional Description

Protein Length

368

Protein Sequence
(FASTA)

GEPRGADGVG PGVPGEVEVV KGQPFDVGPR YTQLQYIGEG AYGMVSSAYD HVRKTRVAIK 60

KISPFEHQTY CQRTLREIQI LLRFHHENVI GIRDILRAPT LEAMRDVYIV QDLMETDLYK 120

LLKSQQLSND HICYFLYQIL RGLKYIHSAN VLHRDLKPSN LLINTTCDLK ICDFGLARIA 180

DPEHDHTGFL TEYVATRWYR APEIMLNSKG YTKSIDIWSV GCILAEMLSN RPIFPGKHYL 240

DQLNHILGIL GSPSQEDLNC IINMKARNYL QSLPSKTKVA WAKLFPKSDS KALDLLDRML 300

TFNPNKRITV EEALAHPYLE QYYDPTDEPV AEEPFTFDME LDDLPKERLK ELIFQETARF 360

QPGVLEAP 368

Nucleotide Sequence
(FASTA)

GGGGAGCCCC GGGGAGCTGA TGGGGTTGGC CCGGGGGTCC CAGGGGAAGT GGAAGTAGTG 60

AAGGGGCAGC CGTTCGACGT GGGCCCGCGG TACACGCAGC TGCAGTACAT CGGCGAGGGC 120

GCGTACGGCA TGGTCAGCTC AGCTTACGAC CATGTGCGCA AGACTCGAGT GGCCATCAAG 180

AAAATCAGCC CCTTCGAGCA TCAGACCTAC TGCCAGCGCA CGCTGCGGGA GATCCAGATC 240

TTGCTGCGCT TCCACCATGA GAATGTCATT GGCATCCGAG ACATTCTGCG GGCACCCACC 300

CTGGAAGCCA TGAGGGATGT CTACATTGTG CAGGACCTGA TGGAGACAGA CCTGTACAAG 360

TTGCTCAAAA GCCAGCAGCT GAGCAACGAC CACATCTGCT ATTTCCTTTA CCAGATCCTT 420

CGGGGCCTCA AGTATATCCA CTCAGCCAAC GTGCTCCACC GGGATTTAAA ACCCTCCAAC 480

CTGCTCATCA ACACCACCTG TGACCTTAAG ATCTGCGATT TTGGCCTTGC CCGGATCGCC 540

GATCCTGAGC ACGACCACAC CGGCTTCCTG ACAGAATACG TGGCCACTCG CTGGTACCGG 600

GCCCCAGAAA TCATGCTTAA CTCCAAGGGC TATACCAAGT CCATCGACAT CTGGTCTGTG 660

GGTTGCATTT TGGCTGAGAT GCTTTCCAAC CGGCCCATAT TCCCTGGCAA GCACTACCTG 720

GACCAGCTCA ACCACATTCT GGGTATCCTT GGTTCCCCAT CCCAGGAGGA CCTGAATTGT 780

ATCATCAACA TGAAGGCTCG AAACTACCTA CAGTCTCTGC CCTCCAAGAC CAAGGTGGCC 840

TGGGCCAAGC TTTTCCCCAA GTCAGACTCC AAAGCCCTTG ACCTACTGGA CCGGATGTTG 900

ACCTTTAACC CCAACAAACG GATCACAGTG GAGGAAGCGC TGGCTCACCC CTACCTGGAG 960

CAGTACTATG ACCCAACGGA TGAGCCAGTG GCGGAAGAAC CTTTCACCTT TGACATGGAG 1020

CTGGATGATC TACCAAAGGA GCGGCTGAAG GAGCTCATCT TCCAGGAAAC AGCCCGCTTC 1080

CAGCCTGGGG TGCTGGAGGC CCCCTAA 1107

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+++geGayg+v sa+d+ +++rvaikk+s pf+++t ++rtlRE+++l +++heN+

Q: 31    YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFHHENV  89

         7899****************************9.**************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i + d++++ + le+++dvY+v++lmetdL+k++ksq+ls++hi ++lyqilrglky+Hs

Q: 90    IGIRDILRAPT-LEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS  148

         *********99.************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178

         anv+HrDlKPsNll+n++c+lki+dFGlar+ad+e++++  lteyvatrwYraPei+l++

Q: 149   ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTgfLTEYVATRWYRAPEIMLNS  208

         ***********************************99999********************

S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238

         k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il +lg+ps+e+l++i + +arn

Q: 209   KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN  268

         ************************************************************

S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         y++slp+k+k  +++lfpk++++aldLl+++L+++p+kRi+veeaL+hpYl

Q: 269   YLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL  319

         **************************************************7

Domain Sequence
(FASTA)

YTQLQYIGEG AYGMVSSAYD HVRKTRVAIK KISPFEHQTY CQRTLREIQI LLRFHHENVI 60

GIRDILRAPT LEAMRDVYIV QDLMETDLYK LLKSQQLSND HICYFLYQIL RGLKYIHSAN 120

VLHRDLKPSN LLINTTCDLK ICDFGLARIA DPEHDHTGFL TEYVATRWYR APEIMLNSKG 180

YTKSIDIWSV GCILAEMLSN RPIFPGKHYL DQLNHILGIL GSPSQEDLNC IINMKARNYL 240

QSLPSKTKVA WAKLFPKSDS KALDLLDRML TFNPNKRITV EEALAHPYL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0031143	; C:pseudopodium
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0051216	; P:cartilage development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0070498	; P:interleukin-1-mediated signaling pathway
GO:0031663	; P:lipopolysaccharide-mediated signaling pathway
GO:0000165	; P:MAPK cascade
GO:2000657	; P:negative regulation of apolipoprotein binding
GO:0009887	; P:organ morphogenesis
GO:0035066	; P:positive regulation of histone acetylation
GO:0033129	; P:positive regulation of histone phosphorylation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0051090	; P:regulation of sequence-specific DNA binding transcription factor activity
GO:0006974	; P:response to DNA damage stimulus
GO:0043330	; P:response to exogenous dsRNA
GO:0019233	; P:sensory perception of pain
GO:0006351	; P:transcription, DNA-dependent

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013