EKS-EQC-00066

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00066

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	360.7	5.5E-108	12	295	284

Status

Unreviewed

Ensembl Protein

ENSECAP00000012209

UniProt Accession

F7DTX6;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK7

Gene Synonyms/Alias

CDK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000014570	ENSECAP00000012209	ENSECAT00000015210

Organism

Equus caballus

Functional Description

Protein Length

346

Protein Sequence
(FASTA)

MAVDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL 60

REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM 120

TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRAYT HQVVTRWYRA 180

PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM 240

CSLPDFVTFK SFPRIPLQHI FIAAGDDLLD LIQGLFLFNP CTRITATQAL KTKYFSNRPG 300

PTPGCQLPRP NCPVETLKEQ PNPAVATKRK RTEALEQGGL PKKLIF 346

Nucleotide Sequence
(FASTA)

ATGGCTGTGG ACGTGAAGTC GCGAGCAAAG CGTTACGAAA AACTAGACTT CCTCGGGGAA 60

GGACAGTTTG CCACGGTTTA CAAGGCCAGA GACAAGAACA CCAACCAAAT CGTCGCCATT 120

AAGAAAATCA AACTTGGACA TAGATCAGAA GCTAAAGATG GTATAAATAG GACAGCCTTA 180

AGAGAGATCA AATTGTTACA GGAGCTAAGT CATCCAAATA TAATTGGTCT CCTTGATGCT 240

TTTGGGCATA AATCTAATAT TAGCCTTGTC TTTGATTTTA TGGAAACTGA TTTAGAGGTT 300

ATAATAAAGG ATAATAGTCT TGTGCTGACA CCATCACACA TCAAAGCCTA CATGTTGATG 360

ACTCTTCAAG GGTTAGAATA TTTACATCAA CATTGGATTC TACATAGGGA CCTAAAACCA 420

AACAACTTGT TGCTAGATGA AAATGGCGTT CTAAAACTGG CAGATTTTGG CCTGGCCAAA 480

TCATTTGGGA GCCCCAATAG AGCTTATACA CATCAGGTTG TGACCAGGTG GTATCGGGCC 540

CCTGAGTTAT TATTTGGAGC TAGAATGTAT GGTGTAGGTG TGGACATGTG GGCTGTTGGC 600

TGTATATTAG CAGAGTTGCT TCTAAGGGTT CCTTTTTTGC CAGGAGATTC AGACCTTGAT 660

CAACTAACAA GAATATTTGA AACTTTGGGC ACACCAACTG AGGAACAGTG GCCTGACATG 720

TGTAGTCTTC CAGATTTCGT GACATTCAAG AGTTTCCCTA GAATCCCACT GCAGCACATC 780

TTCATTGCAG CAGGAGACGA CTTGCTAGAT CTCATACAAG GCTTATTCTT ATTTAACCCG 840

TGTACTCGAA TTACAGCCAC ACAGGCCTTG AAAACTAAGT ATTTCAGTAA TCGGCCAGGG 900

CCAACACCTG GATGTCAGCT GCCAAGACCA AACTGTCCAG TGGAAACTTT AAAGGAGCAG 960

CCAAATCCAG CTGTGGCAAC AAAACGGAAG AGAACAGAAG CCTTGGAACA AGGAGGATTA 1020

CCCAAGAAAC TAATTTTTTA G 1041

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG++++vyka+dk+t+++vA+Kki+l +++e   g++ talrEi+ll+el+h

Q: 12    YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEakdGINRTALREIKLLQELSH  71

         99********************************88764444******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ Ll+ +  +k+++ Lvf+f+e+dL+ ++k+++   l+++++k ++l+ l+gl+ylH

Q: 72    PNIIGLLDAFG-HKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMTLQGLEYLH  129

         ***********.99**********************9.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         +++ilHRDlKp+NlL++++g+lklaDfGla++f+sp+++yt++vvT+wYraPelL+ga+

Q: 130   QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM  189

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p+++g+s+ dql+rif++lgtp+e++wp++ +lp++  +

Q: 190   YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDFV-T  248

         *********************************************************8.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f++ ++  l++ + ++ ++ ldl++ l+ ++p +Ri+a++al++kyf

Q: 249   FKSFPRIPLQHIFIAAGDDLLDLIQGLFLFNPCTRITATQALKTKYF  295

         9999999******99999****************************9

Domain Sequence
(FASTA)

YEKLDFLGEG QFATVYKARD KNTNQIVAIK KIKLGHRSEA KDGINRTALR EIKLLQELSH 60

PNIIGLLDAF GHKSNISLVF DFMETDLEVI IKDNSLVLTP SHIKAYMLMT LQGLEYLHQH 120

WILHRDLKPN NLLLDENGVL KLADFGLAKS FGSPNRAYTH QVVTRWYRAP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRVP FLPGDSDLDQ LTRIFETLGT PTEEQWPDMC SLPDFVTFKS 240

FPRIPLQHIF IAAGDDLLDL IQGLFLFNPC TRITATQALK TKYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005675	; C:holo TFIIH complex
GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0008094	; F:DNA-dependent ATPase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006366	; P:transcription from RNA polymerase II promoter

KEGG

ecb:100049964

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013