EKS-EQC-00147

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00147

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	555.1	2.4E-167	478	754	277

Status

Unreviewed

Ensembl Protein

ENSECAP00000013783

UniProt Accession

F6V0E6;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000015006	ENSECAP00000013785	ENSECAT00000017020
ENSECAG00000015006	ENSECAP00000013783	ENSECAT00000017018

Organism

Equus caballus

Functional Description

Protein Length

822

Protein Sequence
(FASTA)

MWSWKCLLFW AVLVTATLCT ARPAPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD 60

VQSINWLRDG VQLVESNRTR ITGEEVEVRD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD 120

ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS 180

SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN 240

HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI 300

GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE 360

ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIIYKMK SGTKKSDFHS QMAVHKLAKS 420

IPLRRQWTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL 480

GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK 540

HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL 600

VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG 660

RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD 720

KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF 780

PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR 822

Nucleotide Sequence
(FASTA)

ATGTGGAGCT GGAAGTGCCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC ACTCTGCACC 60

GCCAGGCCGG CCCCAACTTT GCCTGAACAA GCCCAGCCCT GGGGAGCCCC TGTGGAAGTG 120

GAGTCCTTCC TGGTCCACCC TGGTGACCTG CTGCAGCTTC GCTGTCGGCT GCGGGACGAT 180

GTCCAGAGCA TCAACTGGCT GCGGGACGGG GTACAGCTGG TGGAAAGCAA CCGTACCCGC 240

ATCACGGGGG AGGAGGTGGA GGTGCGGGAT TCCGTGCCCG CTGACTCCGG CCTCTACGCT 300

TGCGTGACCA GCAGCCCCTC AGGCAGCGAC ACCACCTACT TCTCCGTCAA TGTCTCAGAT 360

GCTCTCCCTT CCTCGGAGGA CGACGATGAT GATGATGACT CCTCTTCAGA GGAGAAGGAG 420

ACAGATAACA CCAAACCAAA CCGTATGCCC GTGGCTCCAT ATTGGACGTC CCCGGAAAAG 480

ATGGAAAAGA AATTGCATGC AGTGCCAGCT GCTAAGACAG TGAAGTTCAA GTGCCCTTCC 540

AGTGGGACTC CTAACCCTAC ACTGCGCTGG CTGAAAAATG GCAAAGAATT CAAACCTGAC 600

CACAGGATCG GAGGCTACAA GGTCCGTTAT GCCACGTGGA GCATCATAAT GGACTCGGTG 660

GTGCCCTCTG ACAAGGGCAA CTATACCTGC ATCGTGGAGA ACGAGTATGG CAGCATTAAC 720

CACACCTACC AGCTCGACGT CGTGGAGCGG TCTCCTCACC GGCCCATCCT GCAGGCAGGG 780

TTGCCTGCCA ACAAGACAGT GGCCCTGGGC AGTAATGTGG AGTTCATGTG TAAGGTGTAC 840

AGTGACCCAC AGCCCCACAT CCAGTGGCTA AAGCACATCG AGGTGAATGG GAGTAAGATT 900

GGCCCGGACA ACCTTCCGTA TGTCCAGATC TTGAAGACTG CCGGAGTTAA TACCACCGAC 960

AAAGAGATGG AAGTGCTTCA CTTAAGGAAT GTCTCCTTTG AGGACGCGGG GGAGTATACG 1020

TGCTTGGCGG GTAACTCTAT CGGACTCTCC CATCACTCTG CATGGTTGAC CGTTCTGGAA 1080

GCCCTGGAAG AGAGACCCGC GGTGATGACC TCGCCCCTGT ACCTGGAGAT CATCATCTAT 1140

TGCACGGGGG CCTTCCTCAT CTCCTGCATG GTGGGCTCTG TCATCATCTA CAAGATGAAG 1200

AGTGGCACCA AGAAGAGTGA CTTCCACAGC CAGATGGCCG TGCACAAGCT GGCCAAGAGC 1260

ATCCCTCTGC GCAGACAGTG GACTGTGTCA GCCGACTCCA GCGCGTCCAT GAACTCTGGG 1320

GTTCTGCTGG TTCGGCCCTC ACGTCTCTCC TCCAGTGGAA CCCCCATGCT GGCTGGGGTC 1380

TCTGAATATG AGCTTCCTGA AGACCCTCGC TGGGAGCTGC CTCGAGACAG ACTGGTTTTA 1440

GGCAAACCCC TGGGAGAGGG CTGCTTTGGG CAGGTGGTGC TGGCGGAGGC CATTGGGCTG 1500

GACAAGGACA AACCCAACCG TGTGACCAAA GTGGCTGTGA AGATGCTGAA ATCGGATGCA 1560

ACCGAGAAAG ACCTGTCAGA CCTGATCTCA GAAATGGAGA TGATGAAGAT GATCGGGAAG 1620

CACAAGAACA TCATCAACCT GCTGGGGGCC TGCACGCAGG ATGGTCCTTT GTATGTCATC 1680

GTGGAGTATG CCTCCAAGGG CAACCTACGG GAGTACCTGC AGGCCCGGAG GCCTCCTGGG 1740

CTGGAATACT GTTACAACCC CAGCCACAAC CCCGAAGAGC AGCTCTCCTC CAAGGACCTG 1800

GTATCCTGTG CCTATCAGGT GGCCCGAGGC ATGGAATATC TTGCCTCTAA GAAGTGCATA 1860

CACCGAGACC TGGCCGCGAG GAATGTCCTG GTGACAGAGG ACAATGTGAT GAAGATCGCA 1920

GATTTTGGCC TAGCTCGGGA CATTCACCAC ATCGACTACT ATAAAAAGAC AACCAATGGC 1980

CGACTGCCTG TGAAGTGGAT GGCACCCGAG GCATTGTTTG ACCGGATCTA CACCCACCAG 2040

AGTGATGTAT GGTCTTTTGG GGTGCTCCTG TGGGAAATCT TCACTCTGGG TGGCTCCCCA 2100

TATCCTGGCG TGCCTGTGGA GGAGCTTTTC AAGCTGCTGA AGGAAGGTCA TCGAATGGAC 2160

AAGCCCAGTA ACTGCACCAA CGAGCTGTAC ATGATGATGC GGGATTGTTG GCATGCAGTA 2220

CCCTCTCAGA GACCTACCTT CAAGCAGCTG GTGGAAGACC TGGACCGCAT TGTGGCCTTG 2280

ACCTCCAACC AGGAGTATCT GGACCTGTCA ATGCCCCTGG ACCAATACTC TCCCAGCTTT 2340

CCTGACACCC GAAGCTCTAC CTGTTCCTCA GGGGAGGATT CCGTTTTCTC TCATGAGCCG 2400

TTGCCTGAGG AGCCCTGTCT GCCCCGACAC CCAGCCCAGC TTGCCAATGG CGGACTCAAA 2460

CGACGCTGA 2469

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 478   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  537

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 538   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  597

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 598   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  657

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 658   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  717

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 718   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  754

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008201	; F:heparin binding
GO:0001525	; P:angiogenesis
GO:0060117	; P:auditory receptor cell development
GO:0060445	; P:branching involved in salivary gland morphogenesis
GO:0048469	; P:cell maturation
GO:0002062	; P:chondrocyte differentiation
GO:0030326	; P:embryonic limb morphogenesis
GO:0035607	; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0001701	; P:in utero embryonic development
GO:0042472	; P:inner ear morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0048762	; P:mesenchymal cell differentiation
GO:0030901	; P:midbrain development
GO:0042474	; P:middle ear morphogenesis
GO:0043066	; P:negative regulation of apoptotic process
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001759	; P:organ induction
GO:0042473	; P:outer ear morphogenesis
GO:0048339	; P:paraxial mesoderm development
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0045787	; P:positive regulation of cell cycle
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0090080	; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045666	; P:positive regulation of neuron differentiation
GO:0010976	; P:positive regulation of neuron projection development
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0007605	; P:sensory perception of sound
GO:0001657	; P:ureteric bud development
GO:0021847	; P:ventricular zone neuroblast division

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013