EKS-EQC-00260
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00260
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK453.83.6E-136190518329
StatusUnreviewed
Ensembl ProteinENSECAP00000013135
UniProt AccessionF6TMD3;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK1
Gene Synonyms/Alias HIPK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000015193ENSECAP00000013135ENSECAT00000016269
OrganismEquus caballus
Functional Description
Protein Length1211
Protein Sequence
(FASTA)
MASQLQVFSP PSVSSSAFCS AKKLKIEPSG WDVSGQSSND KYYTHSKTLP TTQGQANSSH 60
QVANFNIPAY DQGLLLPAPA VEHIVVTAAD SSASAATSTF QSSQTLTHRS NVSLLEPYQK 120
CGLKRKSEEV DSNGSVQIIE EHPPLMLQNR TVVGAAATTT TVTTKSSSSS GEGDYQLVQH 180
EILCSMTNSY EVLEFLGRGT FGQVAKCWKR STKEIVAIKI LKNHPSYARQ GQIEVSILSR 240
LSSENADEYN FVRSYECFQH KNHTCLVFEM LEQNLYDFLK QNKFSPLPLK YIRPILQQVA 300
TALMKLKSLG LIHADLKPEN IMLVDPVRQP YRVKVIDFGS ASHVSKAVCS TYLQSRYYRA 360
PEIILGLPFC EAIDMWSLGC VIAELFLGWP LYPGASEYDQ IRYISQTQGL PAEYLLSAGT 420
KTTRFFNRDP NLGYPLWRLK TPEEHELETG IKSKEARKYI FNCLDDMAQV NMSTDLEGTD 480
MLAEKADRRE YIDLLKKMLT IDADKRITPL KTLNHQFVTM THLLDFPHSN HVKSCFQNME 540
ICKRRVHMYD TVSQIKSPFT THVPNTSTNL TMSFSNQLNT VHNQASVLAS SSTAAAATLS 600
LANSDVSLLN YQSALYPSSA APVPGVAQQG VSLQPGTTQI CTQTDPFQQT FIVCPPAFQT 660
GLQATTKHSG FPVRMDNAVP IVPQAPAAQP LQIQPGVLTQ GSCTPLMVAT LHPQVATITP 720
QYAVPFTLSC AAGRPALVEQ TAAVLQAWPG GTQQILLPST WQQLPGVALH NSVQPTAVIP 780
EAMGSGQQLA DWRQEHAHSH GNQYSTIMQQ PSLLTNHVTL ATAQPLNVGV AHVVRQQQSS 840
SLPSKKNKQA APVSSKSSLD VLPSQVYSLV GSSPLRTTSS YNSLVPVQDQ HQPIIIPDTP 900
SPPVSVITIR SDTDEEEDNK YKPSSSGLKA RSNVISYVTV NDSPDSDSSL SSPYSTDTLS 960
ALRGNSGPLL EGPGRVVGDG TGTRTIIVPP LKTQLGDCTV ATQASGLLSS KTKPVASVSG 1020
QSSGCCITPT GYRAQRGGTS AAQPLNLSQN QQSSSAPTSQ ERSSNPAPRR QQAFVAPLSQ 1080
APYAFQHGSP LHSTGHPHLA PAPAHLPSQP HLYTYAAPTS AAALGSTSSI AHLFSPQGSS 1140
RHAAAYTTHP STLVHQVPVS VGPSLLTSAS VAPAQYQHQF ATQSYIGSSR GSAIYTGYPL 1200
SPTKISQYSY L 1211
Nucleotide Sequence
(FASTA)
ATGGCATCAC AGCTGCAGGT GTTTTCCCCC CCATCAGTGT CGTCGAGTGC CTTCTGCAGT 60
GCAAAGAAAC TGAAAATAGA GCCCTCTGGC TGGGATGTTT CTGGACAGAG CAGCAACGAC 120
AAATATTATA CCCACAGCAA AACCCTCCCA ACCACACAAG GGCAAGCCAA CTCCTCTCAC 180
CAGGTAGCAA ATTTCAACAT CCCTGCTTAC GACCAGGGCC TCCTCCTCCC AGCCCCTGCA 240
GTGGAGCATA TTGTTGTAAC AGCCGCTGAT AGCTCAGCCA GCGCTGCTAC ATCAACCTTC 300
CAAAGCAGCC AGACCCTGAC TCACAGAAGC AACGTTTCTT TGCTTGAGCC ATATCAAAAA 360
TGTGGATTGA AAAGGAAAAG TGAAGAAGTT GACAGCAACG GTAGTGTGCA AATCATAGAA 420
GAACATCCCC CTCTCATGCT GCAAAACAGG ACTGTGGTGG GTGCTGCTGC CACAACCACC 480
ACTGTGACCA CAAAGAGTAG CAGTTCCAGC GGAGAAGGGG ATTACCAGCT GGTCCAGCAT 540
GAGATCCTTT GCTCTATGAC CAACAGCTAT GAAGTCTTGG AGTTCCTAGG CAGGGGAACA 600
TTTGGACAGG TGGCTAAGTG CTGGAAGCGA AGCACCAAGG AAATTGTGGC TATTAAAATC 660
TTGAAGAACC ATCCCTCGTA TGCCAGACAA GGACAGATTG AAGTGAGCAT CCTTTCCCGC 720
CTAAGCAGTG AAAATGCTGA TGAGTATAAT TTTGTCCGTT CTTATGAATG TTTTCAGCAT 780
AAGAATCACA CCTGCCTTGT GTTCGAGATG CTGGAGCAGA ACTTATATGA TTTTCTAAAG 840
CAGAACAAGT TTAGCCCACT GCCACTCAAG TACATCAGAC CAATCTTGCA GCAGGTGGCC 900
ACAGCCCTGA TGAAGCTCAA GAGCCTTGGT TTGATTCACG CTGACCTTAA GCCTGAAAAC 960
ATAATGCTGG TTGATCCAGT GCGCCAACCC TACCGAGTGA AGGTCATTGA CTTTGGTTCT 1020
GCTAGTCATG TTTCCAAAGC TGTGTGCTCA ACCTACTTAC AGTCACGTTA CTACAGAGCC 1080
CCTGAAATTA TTCTTGGATT ACCATTTTGT GAAGCTATTG ATATGTGGTC ACTGGGGTGT 1140
GTGATAGCTG AGCTGTTCCT GGGATGGCCT CTTTATCCTG GTGCTTCAGA ATATGATCAG 1200
ATTCGTTACA TTTCACAAAC ACAAGGCCTG CCAGCTGAAT ATCTTCTCAG TGCCGGGACA 1260
AAAACAACCA GGTTTTTCAA CAGAGATCCT AATTTGGGGT ACCCACTGTG GAGGCTTAAG 1320
ACACCTGAAG AACATGAATT GGAGACTGGA ATCAAATCAA AAGAAGCCCG AAAGTACATT 1380
TTTAATTGTT TAGATGACAT GGCTCAGGTG AATATGTCCA CAGACTTAGA GGGAACAGAC 1440
ATGTTGGCAG AGAAGGCAGA TCGAAGAGAA TACATTGATC TGTTAAAAAA AATGCTAACA 1500
ATTGATGCAG ATAAGAGAAT TACTCCTCTG AAAACTCTAA ACCATCAATT TGTGACAATG 1560
ACTCACCTCT TGGATTTTCC ACATAGCAAT CATGTTAAGT CTTGTTTTCA GAACATGGAG 1620
ATCTGCAAGC GGAGGGTTCA CATGTATGAT ACAGTGAGTC AGATCAAGAG TCCCTTCACT 1680
ACTCATGTTC CAAATACAAG CACAAATCTA ACCATGAGCT TCAGCAACCA GCTCAATACA 1740
GTGCACAATC AGGCCAGTGT TCTAGCTTCC AGTTCTACTG CTGCAGCTGC TACCCTTTCT 1800
CTGGCTAATT CAGATGTCTC ACTGCTAAAC TACCAGTCGG CTTTGTACCC ATCATCTGCA 1860
GCACCAGTTC CTGGAGTTGC CCAGCAGGGT GTTTCATTGC AGCCTGGAAC CACTCAGATT 1920
TGCACTCAGA CAGATCCATT CCAACAAACA TTTATAGTAT GTCCACCTGC TTTTCAGACT 1980
GGACTACAAG CAACAACAAA GCATTCTGGA TTCCCTGTGA GGATGGATAA TGCTGTGCCA 2040
ATTGTACCCC AGGCGCCAGC TGCTCAGCCA CTACAGATAC AGCCGGGAGT TCTTACACAG 2100
GGAAGCTGTA CACCACTAAT GGTAGCAACT CTCCACCCTC AAGTAGCCAC CATCACACCG 2160
CAGTATGCGG TGCCCTTTAC TCTGAGCTGC GCAGCCGGCC GGCCGGCGCT GGTTGAACAG 2220
ACTGCCGCTG TACTGCAGGC TTGGCCTGGA GGAACCCAGC AAATTCTCCT GCCTTCAACT 2280
TGGCAACAGT TGCCTGGGGT AGCTCTCCAC AACTCTGTCC AGCCCACAGC AGTGATTCCA 2340
GAGGCCATGG GCAGTGGCCA GCAGCTCGCG GACTGGAGGC AAGAGCATGC CCACTCTCAT 2400
GGTAACCAGT ACAGCACTAT CATGCAGCAG CCATCCCTGC TGACTAACCA TGTGACATTG 2460
GCCACTGCTC AGCCCCTGAA TGTTGGTGTT GCCCATGTTG TCAGACAACA ACAATCCAGT 2520
TCCCTCCCTT CAAAGAAGAA TAAGCAGGCT GCTCCAGTTT CTTCCAAGTC CTCTCTGGAT 2580
GTTCTGCCTT CTCAAGTCTA TTCTCTGGTT GGGAGCAGTC CCCTCCGTAC TACATCTTCT 2640
TATAATTCTC TAGTCCCCGT CCAAGATCAG CATCAGCCAA TCATCATTCC AGATACTCCC 2700
AGCCCTCCTG TGAGTGTCAT CACTATCCGC AGTGACACTG ATGAGGAAGA GGACAACAAA 2760
TATAAGCCCA GTAGCTCTGG CCTGAAGGCA AGGTCTAATG TCATCAGTTA TGTCACTGTC 2820
AATGATTCTC CGGACTCTGA CTCTTCCTTG AGCAGCCCGT ATTCCACTGA TACCCTGAGT 2880
GCACTCCGGG GGAACAGTGG ACCCCTTCTG GAGGGGCCCG GCAGAGTCGT GGGAGATGGC 2940
ACTGGCACCC GCACCATCAT TGTGCCTCCA CTGAAAACTC AGCTTGGTGA CTGCACTGTA 3000
GCAACCCAGG CCTCAGGTCT CCTGAGCAGT AAGACCAAGC CAGTGGCCTC AGTGAGTGGG 3060
CAGTCATCTG GATGTTGTAT CACCCCCACA GGGTATCGAG CTCAACGTGG GGGGACCAGC 3120
GCAGCACAGC CGCTCAACCT TAGCCAGAAC CAGCAATCTT CGTCAGCTCC AACCTCGCAG 3180
GAGAGAAGCA GCAACCCTGC CCCCCGCAGG CAGCAGGCGT TTGTGGCCCC ACTCTCCCAA 3240
GCCCCCTACG CCTTCCAGCA TGGCAGCCCA CTGCACTCGA CGGGGCACCC ACACCTGGCC 3300
CCAGCCCCTG CTCACCTGCC AAGCCAGCCT CACCTGTATA CGTATGCTGC CCCCACCTCT 3360
GCTGCTGCAT TGGGCTCTAC CAGCTCCATT GCTCATCTCT TCTCCCCCCA GGGCTCCTCA 3420
AGGCATGCTG CAGCCTATAC CACCCACCCT AGCACTCTGG TGCACCAGGT CCCTGTCAGT 3480
GTCGGGCCCA GCCTTCTCAC TTCTGCCAGT GTGGCCCCTG CTCAGTACCA ACACCAGTTT 3540
GCCACCCAGT CCTACATTGG GTCTTCCCGA GGCTCAGCAA TTTACACTGG ATACCCACTT 3600
AGTCCTACCA AGATCAGCCA GTATTCCTAC TTGTAG 3636
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevle++g+G+fgqV+k+++++tkeivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 190   YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSS-ENADE  248
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr +e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+
Q: 249   YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS  308
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 309   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  368
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff  
Q: 369   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFnr  428
         **********************************************************66
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
           + ++p ++lkt          ks++++k+++n+ +++++++++++ e +++l+ek+d+
Q: 429   dPNLGYPLWRLKTPeeheletgiKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADR  488
         556778889998889********************************************9
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + ++dllk+ml++d++kRitp ++l+h+fv
Q: 489   ReYIDLLKKMLTIDADKRITPLKTLNHQFV  518
         99***************************7
Domain Sequence
(FASTA)
YEVLEFLGRG TFGQVAKCWK RSTKEIVAIK ILKNHPSYAR QGQIEVSILS RLSSENADEY 60
NFVRSYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPILQQV ATALMKLKSL 120
GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTTRFFNRD 240
PNLGYPLWRL KTPEEHELET GIKSKEARKY IFNCLDDMAQ VNMSTDLEGT DMLAEKADRR 300
EYIDLLKKML TIDADKRITP LKTLNHQFV 329
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00250
EKS-ANC-00257
EKS-BOT-00268
EKS-CAE-00238
EKS-CAJ-00274
EKS-CAF-00275
EKS-CAP-00303
EKS-ECT-00028
EKS-FEC-00254
EKS-GAM-00168
EKS-GAG-00225
EKS-GOG-00268
EKS-HOS-00274
EKS-LAC-00279
EKS-LOA-00278
EKS-MAM-00270
EKS-MEG-00213
EKS-MOD-00265
EKS-MUP-00265
EKS-MYL-00270
EKS-NOL-00245
EKS-ORC-00253
EKS-ORL-00328
EKS-OTG-00274
EKS-PES-00238
EKS-POA-00259
EKS-PTV-00035
EKS-RAN-00283
EKS-SAH-00252
EKS-SUS-00239
EKS-TAG-00284
EKS-TUT-00033
EKS-VIP-00011
EKS-XET-00343
EKS-XIM-00339
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016607; C:nuclear speck
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0009952; P:anterior/posterior pattern specification
GO:0048596; P:embryonic camera-type eye morphogenesis
GO:0060059; P:embryonic retina morphogenesis in camera-type eye
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0061072; P:iris morphogenesis
GO:0060235; P:lens induction in camera-type eye
GO:0030182; P:neuron differentiation
GO:0008284; P:positive regulation of cell proliferation
GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0010842; P:retina layer formation
GO:0007224; P:smoothened signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013