EKS-EQC-00276

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00276

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	396.7	6.5E-119	213	506	294

Status

Unreviewed

Ensembl Protein

ENSECAP00000013026

UniProt Accession

F6UZ08;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000015269	ENSECAP00000013026	ENSECAT00000016147

Organism

Equus caballus

Functional Description

Protein Length

536

Protein Sequence
(FASTA)

VNNDIMITDN NGAVKLPQLC KFCDVTSSTC DNQKSCMSNC SITSICEDPH EVCVAVWRKN 60

DKNITLETVC HDPKLTYHGF VLEDAASPKC IMKEKKVSGE TFFMCSCSSD ECNDHIIFSE 120

EYATNNPDLL LVIFQVTGVS LLPPLGIAIA VIITFYCYRV HRQQKLSPSW ETSKPRKLME 180

FSEHLAIILE DDRSDISSTC ANNINHNTEL LPIELDTLVG KGRFAEVYKA KLKQNTSEQF 240

ETVAVKIFPY EEYASWKTEK DIFSDINLKH ENILQFLTAE ERKTELGKQY WLITAFHAKG 300

NLQEYLTRHV ISWEDLRKLG SSLARGIAHL HSDHTLCGRP KMPIVHRDLK SSNILVKNDL 360

TCCLCDFGLS LRLDPTLSVD DLANSGQVGT ARYMAPEVLE SRMNLENVES FKQTDVYSMA 420

LVLWEMTSRC NAVGEVKDYE PPFGSKVREH PCVESMKDNV LRDRGRPEIP SSWLNHQGIQ 480

MVCETLTECW DHDPEARLTA QCVAERFSEL EHMDRLSGRS CSEEKIPEDG SLNTTK 536

Nucleotide Sequence
(FASTA)

GTTAATAACG ACATCATGAT CACTGACAAC AATGGTGCAG TCAAGCTTCC ACAACTGTGT 60

AAATTTTGTG ACGTGACGTC TTCCACCTGT GACAATCAGA AATCCTGCAT GAGCAACTGC 120

AGCATCACAT CCATCTGTGA GGATCCACAC GAAGTCTGTG TGGCTGTCTG GAGAAAGAAT 180

GATAAGAACA TAACACTAGA GACGGTTTGC CATGACCCCA AGCTCACCTA CCATGGATTT 240

GTTCTTGAAG ATGCTGCTTC TCCAAAGTGT ATTATGAAGG AAAAAAAAGT GTCTGGCGAG 300

ACTTTCTTTA TGTGTTCCTG TAGCTCTGAT GAGTGCAACG ACCACATCAT CTTCTCAGAA 360

GAATATGCCA CCAACAACCC TGACTTGTTG TTAGTCATAT TCCAAGTGAC AGGCGTCAGC 420

CTCCTGCCAC CGCTGGGAAT TGCCATTGCG GTCATCATCA CCTTCTACTG CTACCGCGTT 480

CACCGGCAGC AGAAGCTGAG CCCGTCCTGG GAGACCAGCA AGCCACGGAA GCTCATGGAG 540

TTCAGCGAGC ACCTTGCCAT CATTCTGGAA GACGACCGCT CCGACATCAG CTCTACGTGT 600

GCCAACAATA TCAACCACAA CACAGAGCTG CTGCCCATTG AGCTGGACAC CCTGGTGGGG 660

AAAGGTCGCT TTGCTGAGGT CTACAAGGCC AAGCTGAAGC AGAACACTTC AGAGCAGTTT 720

GAGACCGTGG CAGTCAAGAT CTTTCCTTAT GAGGAGTACG CCTCCTGGAA GACAGAGAAG 780

GACATTTTTT CAGACATCAA CCTGAAGCAT GAGAACATAC TCCAGTTCCT GACAGCTGAG 840

GAGCGAAAGA CAGAACTGGG AAAGCAATAT TGGCTGATCA CCGCTTTCCA TGCCAAGGGC 900

AACCTACAGG AATACCTTAC ACGGCATGTC ATCAGCTGGG AGGACCTGCG CAAGCTAGGC 960

AGCTCCCTAG CCCGGGGCAT TGCTCACCTG CACAGTGACC ACACCCTGTG CGGGAGGCCC 1020

AAGATGCCCA TTGTGCACAG GGACCTCAAG AGCTCCAACA TCCTCGTGAA GAATGACCTG 1080

ACCTGCTGCC TGTGTGACTT TGGGCTTTCC CTGCGTTTGG ACCCGACCCT GTCTGTGGAT 1140

GACCTGGCCA ACAGTGGGCA GGTGGGAACT GCAAGATACA TGGCCCCAGA AGTCCTGGAG 1200

TCCAGGATGA ATTTGGAGAA TGTTGAGTCC TTCAAGCAGA CAGATGTCTA CTCCATGGCT 1260

CTGGTGCTCT GGGAAATGAC ATCTCGCTGT AACGCAGTGG GAGAAGTGAA AGATTATGAG 1320

CCTCCATTTG GTTCCAAGGT GCGGGAGCAT CCCTGTGTCG AAAGCATGAA GGACAATGTC 1380

TTGAGAGATC GAGGACGACC AGAAATTCCC AGCTCCTGGC TCAACCACCA GGGCATCCAG 1440

ATGGTGTGTG AGACTCTGAC CGAGTGCTGG GACCACGACC CGGAGGCCCG TCTCACGGCC 1500

CAGTGCGTGG CGGAACGCTT CAGCGAGCTG GAGCACATGG ACAGACTCTC GGGGAGGAGC 1560

TGCTCCGAGG AGAAGATTCC CGAAGACGGC TCGCTGAACA CTACCAAATA G 1611

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ ++l+hen

Q: 213   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKDIFSDINLKHEN  272

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l +l +sla+G+ahLH+

Q: 273   ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS  332

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K+ i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 333   D-HTLCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  391

         *.7888******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++

Q: 392   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  450

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip++w +++ +++++++l+ecWd+dpeaRlta++v++r

Q: 451   PCVESMKDNVLRDRGRPEIPSSWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER  506

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDINLKHEN 60

ILQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLRKLGSS LARGIAHLHS 120

DHTLCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSS WLNHQGIQMV CETLTECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009897	; C:external side of plasma membrane
GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0005539	; F:glycosaminoglycan binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0032147	; P:activation of protein kinase activity
GO:0006915	; P:apoptotic process
GO:0007420	; P:brain development
GO:0060434	; P:bronchus morphogenesis
GO:0051216	; P:cartilage development
GO:0048701	; P:embryonic cranial skeleton morphogenesis
GO:0035162	; P:embryonic hemopoiesis
GO:0007369	; P:gastrulation
GO:0007507	; P:heart development
GO:0001701	; P:in utero embryonic development
GO:0002088	; P:lens development in camera-type eye
GO:0060463	; P:lung lobe morphogenesis
GO:0060443	; P:mammary gland morphogenesis
GO:0043011	; P:myeloid dendritic cell differentiation
GO:0060021	; P:palate development
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0001569	; P:patterning of blood vessels
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0002663	; P:positive regulation of B cell tolerance induction
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0051138	; P:positive regulation of NK T cell differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0002666	; P:positive regulation of T cell tolerance induction
GO:0002651	; P:positive regulation of tolerance induction to self antigen
GO:0070723	; P:response to cholesterol
GO:0042493	; P:response to drug
GO:0023014	; P:signal transduction by phosphorylation
GO:0007224	; P:smoothened signaling pathway
GO:0060440	; P:trachea formation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0001570	; P:vasculogenesis

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013