EKS-EQC-00382

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00382

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	350.5	7.7E-105	536	792	257

Status

Unreviewed

Ensembl Protein

ENSECAP00000013190

UniProt Accession

F6T7C9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K6

Gene Synonyms/Alias

MAP3K6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000015410	ENSECAP00000013190	ENSECAT00000016330

Organism

Equus caballus

Functional Description

Protein Length

1183

Protein Sequence
(FASTA)

DVVVLEVSSS LAQPSLFYHL GVRESFSMTN NVLLCSQADL PDLQALREDV FQKNSDCVGS 60

YTLIPYVVTA TGRVLCGDAG LLRGLADGLV QAGVGTEALL TPLVGRFARL LEATPTDSCG 120

YFRETIRQDI RQARRFSGQQ LRQELARLQR RLDSVELLSP DIIMNLLLSY RDVQDYSAII 180

ELVETLQALP TCDVAEQHNI CFHYTFALNR RNRPGDREKA LAVLLPLVQF EGSVAPDLYC 240

MCGRVYKDMF ISSGFQDAEH REQAYHWYRK AFDVEPSLHS GINAAVFLIA AGQRFEDSEE 300

LQLIGMKLGC LLARKGCVEK MQYYWDVGFY LGAQILANDL TQVVLAAEQL YKLNAPIWYL 360

LSVMETFLLY QHFRPTPEPP GGPPRRAHFW LHFLLQSCQP LKTACPQGDQ CLVLVLEMNK 420

VLLPAKLEVQ GTDPVSAVAV SLLEPETQDG PSSWTFPVTS ICGVSASKRD ERCCFLYVLP 480

PAQDVQLCFP SVGHCQWFCG LIQTLVTNPD STAPAEEAEG VGEVLEFDYE YTETGERLVL 540

GKGTYGVVYA GRDRHTRVRI AIKEIPERDS RFSQPLHEEI ALHKRLRHKN IVRYLGSASQ 600

GGYLKIFMEE VPGGSLSSLL RSVWGPLQDN ESTISFYTRQ ILQGLSYLHD NHIVHRDIKG 660

DNVLINTFSG LLKISDFGTS KRLAGITPCT ETFTGTLQYM APEIIDQGPR GYGKAADIWS 720

LGCTVIEMAT GRPPFHELGS PQAAMFQVGM YKVHPPMPSS LSAEAQAFLL RTFEPDPRLR 780

ASAQALLGDP FLQPGKRSRS PGSPRHAPRP SDNPSASPAP SADSTTQSQT FPRPQAPSQH 840

LPSPPKRCLS YGDTSQLRVP EEPGAEEPAS PEESSESSGL SLLHQESERR AMLAAVLEQE 900

LPALAENLRL EQEQSPRLSR SHVEQLLRCL RAHIHTPNRR QLSQELRALQ GQLRAQGLGP 960

AVLHGPLFAF PDAVKQILRR RQIRPHWMFV LDSLLSRAVR AALAALGPEG EKEAVPPRSE 1020

ESSKEEESLQ RQQETLVQPN GLPREPEQDP PPLMVQLGLL RAETDRLRDV LAEKEQECQA 1080

LVRQALQRVE GEARTYVPAS EPSAALTVDQ GLVQWLQELS VDSGTIQTLL NHSFTLHALL 1140

TCATRDDLIY TRIRGGMICR IWRAILAQRA GSTPVTLGPQ EAE 1183

Nucleotide Sequence
(FASTA)

GATGTGGTGG TGCTAGAGGT GAGCAGCTCC TTGGCGCAGC CTTCCCTGTT CTACCACCTT 60

GGTGTGCGTG AGAGCTTCAG TATGACCAAC AACGTGCTCC TCTGCTCCCA GGCAGACCTC 120

CCTGATCTGC AGGCTCTGCG GGAGGATGTT TTCCAGAAGA ACTCGGACTG CGTTGGCAGC 180

TACACACTGA TCCCCTATGT GGTGACAGCC ACTGGTCGGG TGCTGTGTGG AGATGCAGGC 240

CTCCTGAGGG GCCTGGCTGA TGGGCTAGTA CAGGCCGGGG TGGGCACTGA GGCCCTACTC 300

ACACCCCTGG TGGGCCGGTT TGCCCGCCTG CTGGAGGCCA CACCCACGGA CTCTTGTGGC 360

TATTTCCGGG AGACCATTCG GCAGGACATC CGCCAGGCCC GGCGGTTCAG CGGGCAGCAG 420

CTGCGGCAGG AGCTGGCTCG CCTGCAGCGG AGACTGGACA GCGTGGAGCT GCTGAGCCCC 480

GACATCATCA TGAATCTGCT GCTCTCCTAC CGTGACGTGC AGGACTACTC AGCCATCATT 540

GAGCTGGTGG AGACGCTGCA GGCTTTGCCC ACCTGTGACG TGGCTGAGCA GCACAACATC 600

TGCTTCCACT ACACGTTTGC CCTCAACCGG AGGAACAGGC CTGGGGATCG GGAGAAGGCA 660

CTGGCTGTGC TGCTGCCGCT GGTACAGTTT GAGGGCTCTG TGGCACCTGA CCTATACTGC 720

ATGTGTGGCC GTGTCTACAA GGACATGTTC ATCAGCTCTG GCTTCCAGGA TGCTGAGCAC 780

CGGGAGCAGG CCTATCACTG GTATCGCAAG GCTTTTGACG TCGAGCCCAG CCTCCATTCA 840

GGCATCAATG CAGCCGTGTT CCTCATCGCC GCCGGGCAGC GCTTTGAGGA CTCTGAGGAG 900

CTCCAGCTTA TTGGCATGAA GCTGGGCTGC CTGCTGGCCC GAAAAGGCTG TGTGGAGAAG 960

ATGCAGTATT ACTGGGATGT AGGCTTCTAC CTGGGAGCTC AGATCCTCGC CAATGACCTC 1020

ACCCAGGTGG TGCTGGCTGC AGAGCAGCTG TACAAGCTCA ATGCCCCCAT ATGGTATCTG 1080

CTGTCCGTGA TGGAAACCTT CCTGCTGTAC CAGCATTTCA GACCGACACC AGAGCCCCCT 1140

GGAGGACCCC CACGCCGTGC CCACTTCTGG CTCCACTTCT TGCTACAGTC CTGCCAGCCG 1200

CTCAAAACGG CCTGTCCCCA AGGGGACCAG TGCTTGGTGC TGGTCCTGGA GATGAACAAG 1260

GTGCTGCTGC CTGCAAAGCT GGAGGTTCAG GGTACGGACC CGGTGAGTGC AGTGGCTGTG 1320

AGCCTGCTGG AGCCTGAGAC TCAGGACGGT CCCTCCAGCT GGACCTTCCC GGTCACCTCC 1380

ATCTGCGGGG TCAGCGCCTC CAAGCGAGAC GAGCGCTGCT GCTTCCTCTA CGTGCTTCCC 1440

CCGGCCCAGG ATGTCCAGCT GTGCTTCCCC AGCGTAGGGC ACTGCCAGTG GTTCTGCGGC 1500

CTGATCCAGA CCTTGGTGAC GAATCCGGAT TCCACGGCGC CTGCGGAGGA GGCAGAGGGC 1560

GTGGGGGAGG TGCTGGAGTT TGATTATGAG TACACGGAGA CAGGCGAGCG GTTGGTGCTG 1620

GGCAAGGGCA CGTACGGGGT AGTGTACGCC GGCCGCGATC GGCACACGCG GGTACGCATC 1680

GCCATCAAGG AGATCCCGGA GCGGGACAGC AGGTTCTCTC AGCCCCTGCA CGAAGAGATC 1740

GCTCTGCACA AACGTCTGCG CCACAAGAAC ATTGTGCGCT ATCTGGGCTC AGCCAGCCAA 1800

GGCGGATACC TCAAGATCTT CATGGAGGAA GTGCCTGGAG GCAGCTTGTC CTCCTTGCTG 1860

CGCTCAGTGT GGGGACCTCT GCAGGACAAT GAGAGTACCA TCAGTTTCTA CACCCGCCAG 1920

ATCCTGCAGG GACTCAGCTA CCTGCATGAC AACCACATTG TGCATCGAGA CATCAAGGGG 1980

GACAATGTTC TGATCAACAC CTTCAGTGGG CTGCTCAAGA TTTCTGACTT TGGCACCTCC 2040

AAGAGGTTGG CAGGCATCAC ACCGTGCACT GAGACCTTCA CAGGGACCCT TCAGTATATG 2100

GCCCCAGAAA TCATTGATCA GGGCCCACGA GGGTATGGGA AGGCGGCTGA CATCTGGTCA 2160

CTGGGCTGCA CTGTAATTGA GATGGCCACA GGTCGTCCAC CCTTCCACGA GCTAGGGAGC 2220

CCACAGGCTG CCATGTTTCA GGTGGGCATG TACAAGGTGC ATCCGCCAAT GCCCAGTTCT 2280

CTGTCAGCCG AGGCCCAAGC CTTCCTCCTC CGAACTTTTG AGCCAGACCC CCGCCTCCGA 2340

GCCAGTGCTC AGGCACTGCT GGGGGACCCC TTCCTGCAGC CGGGGAAGAG GAGCCGCAGC 2400

CCTGGCTCCC CACGACATGC TCCACGGCCC TCAGATAACC CTTCAGCCAG CCCTGCTCCT 2460

TCAGCTGACT CCACCACCCA GTCCCAGACA TTCCCGCGCC CTCAGGCACC TTCTCAGCAC 2520

CTGCCCAGTC CCCCCAAGCG CTGCCTCAGT TATGGGGACA CCAGCCAGCT CCGGGTGCCT 2580

GAGGAGCCCG GGGCCGAGGA GCCCGCGTCC CCCGAGGAGA GTTCGGAGAG TTCGGGGCTG 2640

AGCCTGCTGC ACCAAGAGAG CGAGCGCCGG GCCATGCTGG CCGCGGTGCT GGAGCAGGAG 2700

CTGCCCGCGC TGGCGGAGAA TCTGCGCCTG GAGCAGGAAC AGAGTCCCCG TCTGAGCAGG 2760

AGTCATGTGG AACAGCTACT GCGCTGCCTC AGGGCGCACA TCCACACTCC CAACCGCCGG 2820

CAGTTGTCTC AGGAGCTGCG GGCGCTACAA GGGCAGCTGC GGGCCCAGGG CCTTGGGCCT 2880

GCTGTTTTGC ATGGACCTCT CTTCGCCTTC CCGGATGCGG TGAAACAGAT CCTCCGTAGG 2940

CGCCAGATCC GCCCACACTG GATGTTCGTG CTGGACTCGC TGCTCAGCCG CGCTGTACGG 3000

GCAGCCCTGG CTGCGCTGGG CCCAGAGGGT GAGAAGGAGG CAGTCCCACC GAGATCAGAG 3060

GAGTCCAGTA AAGAAGAGGA GTCCCTGCAG AGACAGCAGG AGACCCTGGT CCAGCCAAAC 3120

GGGCTTCCCA GGGAGCCCGA GCAGGATCCC CCACCTCTGA TGGTGCAGCT GGGCCTCCTG 3180

CGAGCAGAGA CTGATAGGCT TCGAGATGTC CTGGCTGAGA AGGAACAGGA GTGCCAGGCC 3240

CTGGTGCGAC AAGCTCTACA GCGGGTGGAG GGGGAGGCCA GGACCTATGT CCCAGCCTCA 3300

GAGCCCTCAG CTGCTCTCAC AGTGGACCAG GGCCTGGTGC AGTGGCTACA GGAACTGAGC 3360

GTGGACTCAG GCACCATCCA GACGCTGCTG AACCACAGCT TCACCCTCCA TGCCCTGCTG 3420

ACCTGTGCCA CTAGAGATGA CCTCATCTAT ACCCGCATCA GGGGAGGGAT GATATGCCGC 3480

ATCTGGAGAG CTATCTTGGC ACAGCGAGCA GGATCCACGC CAGTGACCCT TGGACCCCAG 3540

GAGGCTGAAT GA 3552

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d +t+ ++a+Ke+   pe++s+   +++l+eEi+l+k+l+H+n

Q: 536   ERLVLGKGTYGVVYAGRDRHTRVRIAIKEI---PERDSR--FSQPLHEEIALHKRLRHKN  590

         5779**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G++++ ++lkif+E v+gGslssll+  +g+l+  es+i++yt+qil+gl+yLH+

Q: 591   IVRYLGSASQGGYLKIFMEEVPGGSLSSLLRsVWGPLQdnESTISFYTRQILQGLSYLHD  650

         *******************************99****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivHRDiKg+N+l+++ sg++k+sDFG+skrla ++++   +e++tGtl+ymaPE+i++

Q: 651   NHIVHRDIKGDNVLINTfSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ  707

         *****************9*********************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc+viem+tg++Pf+el++++a+mf+vg+ k++P++p++ls+e+++

Q: 708   GPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQA  767

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl +++e dp+ r+sa+ LL ++fl

Q: 768   FLLRTFEPDPRLRASAQALLGDPFL  792

         **********************996

Domain Sequence
(FASTA)

ERLVLGKGTY GVVYAGRDRH TRVRIAIKEI PERDSRFSQP LHEEIALHKR LRHKNIVRYL 60

GSASQGGYLK IFMEEVPGGS LSSLLRSVWG PLQDNESTIS FYTRQILQGL SYLHDNHIVH 120

RDIKGDNVLI NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA 180

ADIWSLGCTV IEMATGRPPF HELGSPQAAM FQVGMYKVHP PMPSSLSAEA QAFLLRTFEP 240

DPRLRASAQA LLGDPFL 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013