EKS-EQC-00295
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00295
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/Alpha318.52.3E-9516421860219
StatusUnreviewed
Ensembl ProteinENSECAP00000014000
UniProt AccessionF7DZA7;
Protein Name
Protein Synonyms/Alias
Gene NameTRPM6
Gene Synonyms/Alias TRPM6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000015942ENSECAP00000014000ENSECAT00000017252
ENSECAG00000015942ENSECAP00000014083ENSECAT00000017340
OrganismEquus caballus
Functional Description
Protein Length1910
Protein Sequence
(FASTA)
MLKEWKMELP KLVISVHGGI QNFKMPSKLK EIFSQGLVKA AETTGAWIIT EGINTGVSKH 60
VGDALKAHSS HSLRKIWTVG IPPWGVIENQ RDLIGKDVVC LYQTLGNPLS KLTTLNSMHS 120
HFILSDDGTV GKYGNEMKLR RNLEKYLSLQ KIHSCSRQGV PVVGLVVEGG PNVILAVWET 180
VKDKDPVVVC EGTGRAADLL AFTHKHLADE GTLRPQVKEE IICMIQNTFN FSLKQSKHLF 240
QILMECMVHR DSITIFDPDS EESQDLDLAI LTALLKGTNL SASEQLNLAM AWDRVDIAKK 300
HILIYGQHWK PGSLEQAMLD ALVMDRVDFV KLLIEYGVNL HRFLTIPRLE ELYNTKQGPT 360
NMLLHHLVQD VKQHALLSDY KITLVDIGLV IEYLIGGAYR SSYTRKHFRT LYNNLYRKRK 420
RVTSIAQSLS QPPLHWRRPS GIRNETAEST LHSQFIRTAQ PYKFKEKSIV LPKSRKKSKG 480
PNILDDPEIE SFVYPYNDLL VWAVLMKRQK MAMFFWQHGE EATVKAVIAC ILYRAMAHEA 540
KESNMVDDAS EELKNYSKQF GQLALDVLEK AFKQNERMAM KLLTYELKNW SNSTCLKLAV 600
SGGLRPFVSH TCTQMLLTDM WVGCLKMRKN SWLKIIVSIL LPPTILTLEF KSKAEMSHVP 660
QSQDFQFTWY NGDQNPSSAK ESAVMKDCDL ERGPDEKLDE NQHFDLKSGP QSLPWTRKIY 720
EFYSAPIVKF WFYTMAYVAF LMLFTYTVLV EMQPQPSVQE WLVIIYIFTN AVEKVREVCI 780
SEPGKFTQKV KVWISEYWNL METVAIGLFS VGFGLRWGNP PFHTAGRLIY CIDIIFWFSR 840
LLDFFAVNQH AGPYVTMIAK MTANMFYIVI MMAIVLLSFG VARKAILSPQ EPPSWSLARD 900
IVFEPYWMIY GEVYASEIDV CSSDPSCPPG SFLTPFLQAV YLFVQYIIMV NLLIAFFNNV 960
YLDMKSISNK LWKYNRYRYI MTYHEKPWLP PPFILLSHVG LLLRRLCCHQ APNDQEEGDV 1020
GLKLYLSKED LKKLYDFEEQ CVEKYFHEKM EGLNCSCEEQ IRVTSERVTE MYFQLKEMNE 1080
KVSFIKDSLL SLDSQVGHLQ DLSALTVDTL KVLSAVDTLQ EDEALLTNRK HSTCRKLSHS 1140
WNNVICADVL GNMEMCGEKK CQYYSMPTSL LQSRARGWHS PRVRSRPLLE STDRQRETSN 1200
VRDDQEEQET ENKIVASGVN RQRRRKYGQF LLVPSYLKQV PFSAETDLPL SRQSGKAGTD 1260
ALATEQVTQS EVPVHLTWQT PVVSAQDSVA EPKEPYEPVA QIPARQDRGE QVIPTLVCTP 1320
APMKVTSLPS QAESMRTGGG YVNLAFSEGD ETGVLSIEKK WQTCLASTSN SDCNQRGQGQ 1380
RQVRGRSLSD DSTRSAQSSD CSEVGPWLQP DTSFWINPLH RDRPFNRSHS LRSHKEEKLK 1440
LYKIKSKKSS EIGQSAWIKA KMLTKDRRLS KKKKKTKGLQ VPVITVNTCS PSDQLNSEPG 1500
ENNISEEEER SKNWLTVSKF SQTSLKPYVY QKMKTKKIER HAILVSDYLK QSEEVKTKNS 1560
LWNSRRTNLD RNSLLRSSNG ADKISASLKS PEEPHHHYSA IERNNLMRLS QTIPFTPIQM 1620
FAGEEVTVYR LEESSPLNLD KSMSSWSQQG RAAMIQVLSR EEMGGGLRRA MRVISTWSED 1680
DVLKPGQVFI VKSFLPEVVQ TWHNIFQEST VLHLCLREIQ QQRAAQKLIY TFNQVKPQTI 1740
PYAPRFLEVF LIYCHSANQW LTIEKYMTGE FRKYNNNNGD EIAPSNTLEE LMLAFSHWTY 1800
EYTRGELLVL DLQGVGENLT DPSVIKPEDK QSRGMVFGPA NLGEDAIRNF IAKHRCNSCC 1860
RKLKLPDLTR NDYSPGRINS TFGLEIKIEP AEGPPARKKD SNSSEDLTRL 1910
Nucleotide Sequence
(FASTA)
ATGTTGAAAG AATGGAAGAT GGAACTACCA AAGCTCGTGA TCTCTGTTCA TGGGGGCATC 60
CAGAACTTCA AAATGCCCTC CAAACTTAAA GAGATCTTCA GCCAAGGTTT GGTCAAAGCT 120
GCGGAGACAA CGGGAGCGTG GATAATAACC GAAGGCATTA ATACTGGAGT GTCCAAACAT 180
GTTGGGGATG CCCTGAAAGC CCATTCTTCC CACTCCTTGA GAAAAATCTG GACAGTTGGA 240
ATCCCTCCTT GGGGGGTCAT TGAGAATCAA AGAGATCTCA TTGGAAAAGA TGTGGTGTGC 300
CTGTACCAGA CTCTGGGCAA CCCCCTCAGC AAGCTCACCA CACTCAACAG CATGCACTCC 360
CACTTCATCC TGTCCGATGA CGGGACCGTG GGCAAGTATG GAAATGAGAT GAAGCTCAGG 420
AGGAACCTGG AAAAGTACCT CTCTCTGCAG AAAATACATA GCTGCTCAAG ACAAGGTGTA 480
CCTGTGGTTG GGCTGGTGGT AGAAGGTGGC CCCAATGTCA TCCTTGCGGT GTGGGAGACT 540
GTGAAAGACA AAGATCCCGT GGTGGTGTGT GAAGGCACAG GCAGAGCTGC TGACCTCCTG 600
GCCTTCACCC ACAAACACTT AGCAGATGAA GGGACCCTAC GTCCTCAGGT GAAGGAGGAG 660
ATCATCTGCA TGATTCAGAA CACTTTCAAC TTTAGTCTTA AACAGTCCAA ACACCTTTTC 720
CAAATTCTAA TGGAGTGTAT GGTGCACAGA GATTCTATTA CCATATTTGA TCCTGATTCT 780
GAGGAGTCGC AAGACCTTGA TTTAGCAATC CTAACAGCTC TACTAAAGGG CACAAATTTA 840
TCAGCATCAG AACAATTAAA TCTGGCAATG GCTTGGGACA GAGTGGACAT TGCCAAGAAA 900
CATATCCTAA TTTATGGACA ACATTGGAAG CCTGGCTCCC TGGAACAAGC AATGTTAGAT 960
GCTTTAGTGA TGGATCGGGT AGATTTTGTG AAGCTCTTAA TAGAATATGG AGTGAACCTC 1020
CATCGCTTTC TTACCATCCC CCGACTGGAA GAGCTCTATA ATACAAAACA AGGACCTACT 1080
AATATGCTCT TGCATCATCT TGTTCAAGAT GTAAAGCAGC ATGCCCTTCT CTCAGACTAT 1140
AAGATAACAC TGGTTGACAT TGGATTGGTA ATAGAGTACC TCATTGGTGG AGCGTATCGC 1200
AGCAGCTACA CTAGGAAACA TTTCAGAACC CTCTACAACA ACCTCTACAG GAAACGTAAG 1260
AGAGTGACCA GCATTGCTCA AAGCCTATCC CAGCCCCCTC TTCACTGGAG ACGCCCCTCA 1320
GGAATCAGAA ATGAAACTGC AGAAAGCACA CTACATTCTC AGTTCATTAG AACTGCCCAG 1380
CCTTACAAAT TCAAGGAAAA GTCTATAGTC CTTCCTAAAT CAAGGAAGAA GTCAAAAGGA 1440
CCAAATATAT TAGATGACCC TGAAATTGAA AGCTTTGTTT ACCCTTACAA TGACCTGCTG 1500
GTTTGGGCTG TGCTAATGAA AAGGCAGAAG ATGGCCATGT TCTTCTGGCA GCACGGAGAG 1560
GAAGCCACGG TTAAGGCAGT GATTGCTTGT ATTCTCTACC GAGCCATGGC CCATGAAGCT 1620
AAGGAGAGCA ACATGGTGGA TGATGCCTCA GAAGAGTTGA AAAATTACTC AAAACAGTTT 1680
GGCCAGCTTG CCCTGGATGT GTTGGAGAAG GCCTTTAAGC AGAATGAGAG AATGGCCATG 1740
AAACTATTGA CCTATGAACT CAAGAACTGG AGCAATTCAA CCTGTTTGAA ACTGGCCGTG 1800
TCTGGAGGAT TGCGGCCCTT TGTTTCGCAT ACTTGTACCC AAATGCTACT GACTGACATG 1860
TGGGTGGGGT GCCTGAAAAT GAGGAAAAAC TCTTGGTTAA AGATCATCGT AAGTATTCTT 1920
TTACCACCCA CAATTTTGAC ATTGGAATTT AAAAGCAAAG CAGAGATGTC ACATGTTCCC 1980
CAGTCCCAGG ACTTCCAGTT TACGTGGTAT AATGGTGACC AGAACCCCAG CAGTGCCAAA 2040
GAAAGTGCTG TTATGAAAGA TTGTGATTTA GAAAGGGGCC CTGATGAGAA ACTGGATGAA 2100
AATCAGCACT TTGATTTAAA GAGTGGTCCC CAGAGCCTTC CATGGACCAG GAAAATCTAT 2160
GAGTTCTACA GTGCTCCAAT TGTCAAGTTT TGGTTTTATA CGATGGCGTA TGTCGCGTTC 2220
CTCATGCTGT TCACTTACAC AGTGTTGGTG GAGATGCAGC CCCAGCCCAG CGTGCAGGAG 2280
TGGCTTGTCA TCATTTACAT CTTCACCAAC GCCGTTGAGA AAGTCAGGGA GGTCTGTATT 2340
TCAGAACCTG GGAAGTTTAC TCAAAAGGTG AAGGTATGGA TTAGTGAGTA CTGGAACCTA 2400
ATGGAGACTG TGGCTATTGG CCTGTTTTCA GTTGGTTTTG GCCTTCGGTG GGGTAACCCT 2460
CCTTTCCACA CGGCGGGAAG ACTAATCTAC TGCATAGACA TCATATTCTG GTTCTCACGG 2520
CTCTTGGACT TCTTTGCTGT GAATCAACAT GCAGGTCCAT ATGTGACCAT GATTGCAAAA 2580
ATGACAGCAA ACATGTTCTA CATTGTGATC ATGATGGCCA TAGTCCTGCT GAGCTTTGGA 2640
GTGGCACGCA AGGCCATCCT TTCGCCACAG GAGCCCCCAT CTTGGAGCCT TGCTCGAGAT 2700
ATTGTGTTTG AGCCATACTG GATGATATAT GGAGAAGTCT ACGCTTCAGA GATAGACGTT 2760
TGTTCAAGTG ACCCGTCTTG CCCTCCTGGA TCTTTTCTTA CTCCGTTCCT CCAAGCTGTC 2820
TACCTCTTTG TGCAATATAT CATCATGGTG AACCTGTTGA TTGCTTTCTT CAATAATGTT 2880
TACCTAGATA TGAAATCCAT TTCAAATAAA CTGTGGAAAT ACAATCGCTA TCGCTACATC 2940
ATGACCTACC ATGAGAAGCC TTGGCTGCCC CCGCCTTTCA TCCTGCTGAG TCACGTGGGT 3000
CTCCTCCTTC GCCGTCTTTG CTGTCATCAA GCTCCAAACG ACCAAGAAGA GGGAGATGTT 3060
GGATTAAAAC TCTACCTGAG TAAGGAGGAT CTAAAAAAAC TTTACGATTT TGAAGAACAG 3120
TGTGTGGAAA AATACTTCCA TGAGAAGATG GAAGGCCTGA ATTGTAGTTG TGAAGAACAA 3180
ATCCGAGTGA CATCAGAGAG GGTTACAGAG ATGTACTTCC AGCTGAAAGA AATGAATGAA 3240
AAGGTGTCTT TTATAAAGGA CTCCTTACTA TCTTTGGACA GCCAGGTGGG ACACCTGCAG 3300
GACCTCTCTG CCCTGACAGT GGACACCCTA AAAGTCCTTT CTGCTGTTGA CACCTTACAA 3360
GAGGATGAGG CTCTCCTGAC CAACAGAAAG CATTCTACTT GCAGAAAACT TTCCCACAGC 3420
TGGAACAATG TCATCTGTGC AGACGTTCTA GGCAACATGG AAATGTGTGG GGAGAAGAAA 3480
TGCCAGTATT ATAGCATGCC CACTTCTTTG CTGCAGAGCC GGGCCAGAGG CTGGCATTCC 3540
CCAAGAGTGC GGAGCAGGCC CCTTCTTGAG AGTACAGACA GGCAGAGAGA GACTTCAAAC 3600
GTAAGAGATG ACCAGGAGGA GCAAGAAACA GAAAATAAAA TAGTTGCTTC TGGGGTTAAC 3660
AGGCAACGAC GTCGAAAGTA TGGCCAGTTT CTCCTGGTCC CTTCTTATCT AAAGCAAGTT 3720
CCTTTTTCAG CAGAAACTGA CTTGCCCCTG TCCAGACAAT CTGGGAAAGC AGGTACAGAT 3780
GCACTGGCAA CTGAACAGGT TACCCAGAGT GAGGTCCCTG TTCATCTGAC TTGGCAGACT 3840
CCAGTTGTCT CAGCCCAGGA CTCGGTGGCT GAACCCAAGG AGCCATACGA GCCAGTTGCT 3900
CAGATACCAG CCAGACAAGA CAGGGGAGAA CAAGTTATAC CCACTTTGGT TTGCACACCT 3960
GCACCCATGA AAGTGACCTC CCTCCCTTCT CAAGCTGAGA GCATGCGAAC TGGAGGTGGA 4020
TATGTGAACC TGGCATTTTC GGAAGGTGAT GAAACTGGTG TGCTTAGCAT TGAGAAAAAA 4080
TGGCAAACCT GCTTGGCCTC CACTTCTAAC AGTGACTGCA ATCAGAGGGG ACAAGGCCAG 4140
AGGCAGGTCC GGGGCAGATC CCTCTCTGAT GACTCAACAA GATCGGCCCA GAGTAGTGAT 4200
TGCTCAGAGG TGGGACCATG GCTTCAGCCA GACACGTCCT TTTGGATCAA TCCTCTCCAC 4260
AGAGACAGGC CCTTCAATAG AAGTCATAGT CTGAGATCCC ACAAGGAGGA GAAATTGAAG 4320
CTCTATAAGA TTAAAAGTAA GAAATCCTCA GAGATAGGGC AGTCGGCATG GATCAAAGCA 4380
AAAATGCTAA CCAAGGATAG GAGATTGTCG AAGAAAAAGA AGAAAACAAA AGGACTACAG 4440
GTGCCAGTCA TCACAGTCAA TACCTGCTCT CCAAGTGACC AACTGAATTC AGAGCCAGGA 4500
GAAAATAACA TCTCAGAAGA AGAGGAGAGG AGCAAGAACT GGCTCACAGT GTCCAAATTT 4560
AGTCAGACAA GTCTAAAGCC TTACGTATAT CAGAAAATGA AAACTAAAAA AATTGAACGG 4620
CATGCTATAC TAGTCAGTGA TTATCTAAAG CAATCTGAAG AGGTAAAAAC CAAAAACTCT 4680
TTGTGGAATT CCAGGCGCAC CAACCTCGAT AGGAACTCCC TGTTGAGAAG TTCCAATGGA 4740
GCTGACAAAA TCTCAGCCTC CTTAAAAAGC CCTGAAGAGC CTCACCATCA TTATTCAGCC 4800
ATTGAAAGGA ACAATTTAAT GAGGCTTTCT CAGACCATAC CATTTACACC AATCCAAATG 4860
TTTGCAGGAG AAGAAGTAAC TGTCTACAGG CTGGAGGAGA GTTCCCCTTT GAATCTCGAT 4920
AAAAGCATGT CTTCTTGGTC CCAGCAAGGG AGAGCTGCAA TGATCCAAGT GTTGTCCAGA 4980
GAGGAGATGG GTGGTGGCCT CCGCAGAGCC ATGAGAGTCA TAAGTACCTG GTCTGAGGAT 5040
GATGTTCTCA AGCCAGGGCA GGTTTTCATT GTGAAGTCCT TTCTTCCTGA GGTTGTGCAG 5100
ACTTGGCACA ACATCTTCCA GGAGAGTACT GTGCTTCATC TTTGCCTCAG GGAAATTCAA 5160
CAACAAAGAG CTGCTCAAAA ACTGATCTAT ACCTTCAACC AAGTGAAACC ACAAACCATT 5220
CCCTATGCAC CAAGGTTCCT GGAAGTTTTC TTAATCTACT GCCATTCAGC CAACCAATGG 5280
TTGACCATTG AGAAGTATAT GACAGGGGAG TTCCGGAAGT ATAACAACAA CAACGGGGAT 5340
GAAATTGCCC CCAGCAACAC CTTGGAGGAA CTGATGTTGG CTTTCTCTCA CTGGACCTAT 5400
GAGTATACTC GGGGAGAGCT CCTCGTTTTA GATTTGCAAG GTGTTGGAGA AAATTTGACA 5460
GATCCATCTG TTATAAAACC TGAAGACAAA CAATCAAGAG GAATGGTGTT TGGACCAGCC 5520
AATTTAGGGG AAGATGCAAT TAGAAACTTC ATTGCAAAAC ATCGTTGCAA CTCTTGCTGC 5580
CGGAAGCTCA AACTGCCGGA TTTAACAAGG AATGACTATT CCCCCGGAAG GATAAATTCC 5640
ACCTTTGGAC TTGAAATCAA AATAGAACCA GCTGAGGGGC CTCCAGCAAG GAAAAAGGAT 5700
AGTAATTCTT CAGAAGACCT CACACGATTG TAA 5733
Domain Profile
S: 1     ssesWsqqetivlikvlskeekkGalRkalrv..........kkgslflvkeelkevvry  50
         s++sWsqq+++++i+vls+ee+ G+lR+a+rv          k+g++f+vk++l+evv++
Q: 1642  SMSSWSQQGRAAMIQVLSREEMGGGLRRAMRVistwseddvlKPGQVFIVKSFLPEVVQT  1701
         699*********************************************************
S: 51    vakiykeqkvlhlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknqll  110
         +++i++e++vlhl+lr++++qraaqkl+++fnqvkP++i+y pr++evfL++++s+nq+l
Q: 1702  WHNIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYAPRFLEVFLIYCHSANQWL  1761
         ************************************************************
S: 111   tvEeyllGefvKynnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklTD  170
         t+E+y++Gef+Kynnnngdei + n+leelmlafsH+tyeyt+gellV+DlqGvge+lTD
Q: 1762  TIEKYMTGEFRKYNNNNGDEIAPSNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTD  1821
         ************************************************************
S: 171   pqiat....ksrgtkfgkanlgeraiknFfakhhCNeiC  205
         p++++    +srg++fg+anlge+ai+nF+akh+CN++C
Q: 1822  PSVIKpedkQSRGMVFGPANLGEDAIRNFIAKHRCNSCC  1860
         ********9******************************
Domain Sequence
(FASTA)
SMSSWSQQGR AAMIQVLSRE EMGGGLRRAM RVISTWSEDD VLKPGQVFIV KSFLPEVVQT 60
WHNIFQESTV LHLCLREIQQ QRAAQKLIYT FNQVKPQTIP YAPRFLEVFL IYCHSANQWL 120
TIEKYMTGEF RKYNNNNGDE IAPSNTLEEL MLAFSHWTYE YTRGELLVLD LQGVGENLTD 180
PSVIKPEDKQ SRGMVFGPAN LGEDAIRNFI AKHRCNSCC 219
KeywordComplete proteome; Ion transport; Ionic channel; Membrane; Reference proteome; Transmembrane; Transport.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00283
EKS-ANC-00295
EKS-BOT-00302
EKS-CAJ-00307
EKS-CAF-00308
EKS-FEC-00290
EKS-GOG-00297
EKS-ICT-00286
EKS-LAC-00318
EKS-MOD-00298
EKS-MUM-00333
EKS-MUP-00300
EKS-MYL-00302
EKS-NOL-00279
EKS-ORA-00266
EKS-OTG-00310
EKS-POA-00294
EKS-PTV-00068
EKS-RAN-00319
EKS-SAH-00283
EKS-SUS-00267
EKS-TAG-00319
EKS-XET-00377
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0031526; C:brush border membrane
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005261; F:cation channel activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0030001; P:metal ion transport
GO:0009636; P:response to toxin
KEGG
InterPros
IPR005821; Ion_trans_dom.
IPR011009; Kinase-like_dom.
IPR004166; MHCK_EF2_kinase.
Pfam
PF02816; Alpha_kinase; 1.
PF00520; Ion_trans; 1.
SMARTs
SM00811; Alpha_kinase; 1.
Prosites
PS51158; ALPHA_KINASE; 1.
Prints
Created Date20-Feb-2013