EKS-EQC-00257
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00257
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK470.43.3E-141155468314
StatusUnreviewed
Ensembl ProteinENSECAP00000013514
UniProt AccessionF6UT97;
Protein Name
Protein Synonyms/Alias
Gene NameDYRK2
Gene Synonyms/Alias DYRK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000015977ENSECAP00000013514ENSECAT00000016717
OrganismEquus caballus
Functional Description
Protein Length534
Protein Sequence
(FASTA)
GGSKHTMNDH LHVGSHGHGQ VQVQQLFEDN SNKRTVLTTQ PNGLTTVGKT GLPGVPERQL 60
ESIHRRQGSS TSLKSMEGVG KAKATPMTPE QAMKQYMQKL TAFEHHEIFS YPEIYFLGPN 120
AKKRQGMTGG PNNGGYDDDQ GSYVQVPHDH VAYRYEVLKV IGKGSFGQVV KAYDHKVHQH 180
VALKMVRNEK RFHRQAAEEI RILEHLRKQD KDNTMNVIHM LENFTFRNHI CMTFELLSMN 240
LYELIKKNKF QGFSLPLVRK FAHSILQCLD ALHKNRIIHC DLKPENILLK QQGRSGIKVI 300
DFGSSCYEHQ RVYTYIQSRF YRAPEVILGA RYGMPIDMWS LGCILAELLT GYPLLPGEDE 360
GDQLACMIEL LGMPSQKLLD TSKRAKNFVS SKGYPRYCTV TTLSDGSVVL NGGRSRRGKL 420
RGPPESREWG NALKGCDDPL FLDFLKQCLE WDPGVRLTPG QALRHPWLRR RLPKPPTGEK 480
TSVKRVTEAT GAITSISKLP PPSSSASKLR TNLAQMTDAN GNIQQRTVLP KLVS 534
Nucleotide Sequence
(FASTA)
GGCGGCAGCA AGCACACAAT GAACGATCAC CTGCATGTCG GCAGCCACGG CCACGGGCAG 60
GTCCAGGTTC AGCAGCTGTT CGAGGATAAC AGTAACAAGC GGACAGTGCT CACGACACAA 120
CCAAATGGGC TTACAACAGT GGGCAAAACG GGATTGCCGG GCGTGCCGGA GCGGCAGCTG 180
GAGAGCATCC ACCGAAGGCA GGGGAGCTCC ACCTCCCTGA AGTCTATGGA GGGTGTGGGG 240
AAGGCAAAAG CCACCCCCAT GACTCCCGAG CAAGCAATGA AGCAATACAT GCAAAAACTA 300
ACCGCCTTTG AACACCACGA GATTTTCAGC TACCCCGAAA TATACTTCTT GGGTCCAAAC 360
GCAAAGAAGC GCCAGGGCAT GACAGGTGGG CCCAACAACG GTGGCTATGA CGATGACCAG 420
GGGTCGTACG TGCAGGTGCC CCACGACCAT GTGGCTTACA GGTACGAGGT CCTCAAGGTC 480
ATTGGAAAGG GCAGCTTTGG GCAGGTGGTC AAGGCCTACG ACCACAAGGT CCACCAGCAC 540
GTGGCCCTGA AGATGGTGCG AAACGAGAAG CGCTTCCACC GGCAGGCGGC GGAGGAGATC 600
CGGATTCTGG AGCACCTGCG CAAGCAGGAC AAGGACAACA CCATGAACGT CATCCACATG 660
CTGGAGAATT TCACCTTCCG CAACCACATC TGCATGACGT TTGAGCTGCT GAGCATGAAC 720
CTCTACGAGC TCATCAAGAA GAATAAATTC CAGGGCTTCA GCCTGCCTTT GGTCCGCAAG 780
TTTGCCCACT CGATTCTGCA GTGCTTGGAT GCTTTGCACA AAAACAGGAT AATCCACTGT 840
GACCTTAAGC CCGAGAACAT TCTGTTAAAG CAGCAGGGGA GAAGCGGCAT TAAAGTGATC 900
GATTTTGGCT CCAGTTGTTA CGAGCATCAG CGTGTCTACA CGTACATTCA GTCCCGTTTT 960
TACCGGGCCC CGGAAGTGAT CCTTGGCGCC AGGTACGGCA TGCCCATCGA CATGTGGAGC 1020
CTGGGCTGCA TCTTGGCAGA GCTCCTGACC GGTTACCCCC TCTTGCCTGG GGAAGATGAA 1080
GGGGACCAGC TGGCCTGCAT GATTGAACTC TTGGGCATGC CGTCCCAGAA ACTGCTGGAT 1140
ACATCCAAAC GAGCCAAAAA TTTTGTGAGC TCCAAGGGTT ACCCCCGCTA CTGCACTGTC 1200
ACCACTCTCT CTGACGGCTC TGTGGTCCTC AACGGGGGCC GTTCCCGGAG GGGGAAGCTG 1260
AGGGGCCCGC CCGAGAGCAG AGAGTGGGGG AATGCACTGA AGGGCTGCGA TGACCCCCTT 1320
TTCCTCGACT TCTTAAAACA GTGTTTAGAG TGGGATCCTG GGGTTCGCCT GACCCCCGGC 1380
CAGGCTTTAC GGCACCCCTG GCTGAGGAGG CGGCTGCCAA AGCCGCCGAC GGGGGAGAAG 1440
ACGTCAGTGA AAAGGGTGAC CGAGGCCACT GGTGCTATCA CCTCCATTTC CAAGTTACCT 1500
CCACCTTCCA GCTCAGCCTC CAAACTGAGG ACGAATTTGG CACAGATGAC GGATGCCAAT 1560
GGGAATATTC AGCAGAGGAC AGTGTTGCCA AAACTTGTTA GCTGA 1605
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevl+vigkGsfgqVvka+d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++
Q: 155   YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT  214
         9***********************************************************
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++
Q: 215   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK  274
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180
         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg++y 
Q: 275   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGARYG  333
         *************************************.**********************
S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240
         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kll+++k+ak+f+++k+
Q: 334   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDTSKRAKNFVSSKG  393
         ************************************************************
S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300
         +p+y+++t+ sd +++l+ ++++++k r +p+s+e+g+alk ++d lf d+lk++le+dp
Q: 394   YPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDP  453
         ************************************************************
S: 301   akRitpkealkhpfv  315
           R+tp +al+hp++
Q: 454   GVRLTPGQALRHPWL  468
         **************6
Domain Sequence
(FASTA)
YEVLKVIGKG SFGQVVKAYD HKVHQHVALK MVRNEKRFHR QAAEEIRILE HLRKQDKDNT 60
MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDALHK 120
NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGARYGM 180
PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP SQKLLDTSKR AKNFVSSKGY 240
PRYCTVTTLS DGSVVLNGGR SRRGKLRGPP ESREWGNALK GCDDPLFLDF LKQCLEWDPG 300
VRLTPGQALR HPWL 314
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00254
EKS-BOT-00265
EKS-CAE-00237
EKS-CAJ-00271
EKS-CAF-00272
EKS-CAP-00300
EKS-CHH-00017
EKS-CII-00159
EKS-CIS-00039
EKS-DAR-00600
EKS-DAN-00013
EKS-DRM-00136
EKS-ECT-00027
EKS-ERE-00019
EKS-FEC-00251
EKS-GAM-00163
EKS-GAG-00222
EKS-GAA-00325
EKS-GOG-00265
EKS-HOS-00271
EKS-ICT-00250
EKS-LAC-00277
EKS-LOA-00275
EKS-MAM-00267
EKS-MEG-00210
EKS-MUM-00296
EKS-MUP-00262
EKS-MYL-00267
EKS-NOL-00243
EKS-OCP-00023
EKS-ORN-00342
EKS-ORA-00232
EKS-ORC-00250
EKS-ORL-00319
EKS-OTG-00271
EKS-PES-00235
EKS-PEM-00140
EKS-POA-00258
EKS-PTV-00034
EKS-RAN-00280
EKS-SAH-00249
EKS-SOA-00021
EKS-SUS-00230
EKS-TAG-00280
EKS-TAR-00338
EKS-TEN-00333
EKS-TUB-00020
EKS-TUT-00030
EKS-XET-00340
EKS-XIM-00334
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0030529; C:ribonucleoprotein complex
GO:0000151; C:ubiquitin ligase complex
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0030145; F:manganese ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0007224; P:smoothened signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013