EKS-EQC-00159
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00159
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb498.15.4E-150398655258
StatusUnreviewed
Ensembl ProteinENSECAP00000015162
UniProt AccessionF6RWB8;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA1
Gene Synonyms/Alias RPS6KA1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000016238ENSECAP00000015173ENSECAT00000018592
ENSECAG00000016238ENSECAP00000015162ENSECAT00000018581
OrganismEquus caballus
Functional Description
Protein Length715
Protein Sequence
(FASTA)
QNGQASGEDT GLQPSKDEGI LKEISITHHV KAGSEKADPS HFELLKVLGQ GSFGKVFLVR 60
KITRPDSGHL YAMKVLKKAT LKVRDRVRTK MERDILADVN HPFVVKLHYA FQTEGKLYLI 120
LDFLRGGDLF TRLSKEVMFT EEDVKFYLAE LALGLDHLHS LGIIYRDLKP ENILLDEEGH 180
IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHT HSADWWSYGV LMFEMLTGSL 240
PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN PANRLGSGPD GAEEIKRHVF 300
YSTIDWNKLY RREIKPPFKP AVAQPDDTFY FDTEFTSRTP KDSPGIPPSA GAHQLFRGFS 360
FVATGLMEDD GKPRSTQAPL HSVVQQLHGK NLVFSDGYVV KETIGVGSYS VCKRCVHKAT 420
NMEYAVKVID KSKRDPSEEI EILLRYGQHP NIITLKDVYD DGKHVYLVTE LMRGGELLDK 480
ILRQKFFSER EASFVLHTIS KTVEYLHSQG VVHRDLKPSN ILYVDESGNP ECLRICDFGF 540
AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL GILLYTMLAG YTPFANGPSD 600
TPEEILTRIG SGKFTLSGGN WNTVSETAKD LVSKMLHVDP HQRLTAKQVL QHPWITQKDK 660
LPQSQLSHQD LQLVKGAMAA TYSALNSSKP TPQLKPIESS ILAQRRVRKL PSTTL 715
Nucleotide Sequence
(FASTA)
CAGAATGGAC AGGCCTCAGG GGAAGACACT GGACTTCAGC CATCCAAGGA TGAGGGTATC 60
CTCAAGGAGA TCTCCATCAC GCACCATGTC AAGGCTGGCT CTGAGAAGGC TGACCCATCC 120
CATTTTGAGC TGCTCAAGGT TCTGGGCCAG GGATCCTTTG GCAAAGTCTT CCTGGTGCGG 180
AAGATCACCC GGCCTGACAG TGGGCACCTG TATGCCATGA AGGTACTAAA GAAGGCAACG 240
CTGAAAGTGC GTGACCGCGT TCGGACCAAG ATGGAGAGAG ACATCCTGGC CGACGTAAAC 300
CACCCATTTG TGGTGAAGCT GCACTATGCC TTCCAGACTG AGGGCAAGCT CTATCTTATT 360
CTGGACTTCC TGCGTGGTGG GGACCTCTTC ACACGGCTCT CTAAAGAGGT TATGTTCACG 420
GAGGAGGATG TGAAGTTTTA CCTGGCTGAG CTGGCTTTGG GCCTGGACCA CCTGCACAGC 480
CTGGGCATCA TTTACAGAGA CCTCAAGCCT GAGAACATCC TTCTGGATGA GGAGGGCCAC 540
ATCAAACTCA CTGACTTCGG CCTGAGTAAG GAGGCCATTG ACCATGAGAA GAAGGCCTAT 600
TCTTTCTGTG GGACAGTGGA GTACATGGCT CCCGAGGTCG TCAACCGCCA GGGCCACACC 660
CACAGTGCTG ACTGGTGGTC CTATGGGGTG TTGATGTTTG AGATGCTGAC GGGCTCCCTG 720
CCCTTCCAAG GGAAGGACCG GAAGGAGACC ATGACATTGA TCCTAAAGGC GAAGCTAGGC 780
ATGCCCCAGT TTCTGAGCAC AGAAGCCCAG AGCCTCCTGC GGGCCCTGTT CAAGCGGAAT 840
CCTGCCAACC GGCTTGGCTC CGGCCCTGAC GGGGCAGAGG AAATCAAGCG TCATGTCTTC 900
TACTCCACCA TTGACTGGAA TAAGCTGTAC CGTCGTGAGA TCAAGCCACC CTTCAAGCCA 960
GCCGTGGCAC AACCTGATGA CACCTTCTAC TTTGACACTG AGTTCACGTC CCGCACACCC 1020
AAGGACTCCC CAGGCATCCC CCCCAGCGCT GGTGCCCATC AGCTGTTTCG TGGCTTCAGC 1080
TTCGTGGCCA CTGGCCTGAT GGAGGATGAT GGCAAGCCTC GCAGCACACA GGCTCCACTG 1140
CACTCGGTGG TACAGCAACT CCATGGGAAG AACCTGGTTT TTAGCGATGG CTACGTGGTA 1200
AAGGAGACAA TTGGTGTGGG CTCCTACTCC GTGTGCAAGC GCTGTGTCCA CAAGGCCACC 1260
AACATGGAGT ATGCTGTCAA GGTCATTGAC AAGAGCAAGC GGGATCCCTC GGAAGAGATT 1320
GAGATTCTTC TGCGGTACGG GCAGCACCCC AACATCATCA CTCTGAAAGA TGTGTATGAT 1380
GATGGCAAAC ACGTATACCT GGTGACAGAG CTGATGCGGG GTGGGGAGCT GCTGGACAAG 1440
ATCCTACGGC AGAAATTCTT CTCAGAGCGG GAGGCCAGCT TTGTTCTGCA CACCATCAGC 1500
AAGACCGTGG AGTATCTGCA CTCCCAGGGG GTTGTGCATA GGGACCTCAA GCCCAGCAAC 1560
ATCCTGTACG TGGATGAATC TGGGAACCCC GAGTGCCTGC GCATCTGCGA CTTCGGCTTT 1620
GCCAAGCAGC TGCGGGCTGA GAACGGGCTC CTCATGACAC CTTGCTACAC TGCCAACTTC 1680
GTCGCACCTG AGGTGCTGAA GCGCCAGGGC TACGATGAAG GCTGTGACAT CTGGAGCCTG 1740
GGCATTCTGC TGTACACCAT GCTGGCAGGA TACACTCCAT TTGCCAACGG ACCCAGTGAC 1800
ACACCAGAGG AAATCCTGAC CCGGATCGGC AGTGGGAAGT TCACCCTCAG CGGGGGAAAT 1860
TGGAACACAG TTTCAGAGAC AGCCAAAGAC CTGGTGTCCA AGATGCTGCA TGTGGACCCC 1920
CACCAGCGCC TCACAGCTAA GCAGGTCCTG CAGCACCCAT GGATCACCCA GAAAGACAAG 1980
CTTCCCCAGA GCCAGCTGTC CCACCAAGAC CTGCAGCTTG TGAAGGGAGC CATGGCAGCT 2040
ACGTACTCTG CACTCAACAG CTCCAAGCCC ACCCCTCAGC TGAAGCCCAT TGAGTCATCT 2100
ATCCTGGCCC AACGGCGGGT GAGGAAGCTG CCGTCCACCA CCCTGTGA 2148
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         y+vke++GvGsysvckrcvhkatn+e+avk+idkskrd+seeieillry+qhpni+tlkd
Q: 398   YVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKD  457
         689*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgk+vylv+el++GGelld+i+++kffsereas +l+t++k+veylh+qGvvhrdlk
Q: 458   VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLK  517
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nilyvdes+n+e+++i+dfGfak++raengll+tpcyt+nfvapevlkrqGyde+cd+
Q: 518   PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI  577
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG+llytmlaGy+pfangp+dt+eeil++i++Gkf+lsG++w++vse+akdlvsk+l+
Q: 578   WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLH  637
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl+++q+l+h+w+
Q: 638   VDPHQRLTAKQVLQHPWI  655
         *****************8
Domain Sequence
(FASTA)
YVVKETIGVG SYSVCKRCVH KATNMEYAVK VIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKHVYL VTELMRGGEL LDKILRQKFF SEREASFVLH TISKTVEYLH SQGVVHRDLK 120
PSNILYVDES GNPECLRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180
WSLGILLYTM LAGYTPFANG PSDTPEEILT RIGSGKFTLS GGNWNTVSET AKDLVSKMLH 240
VDPHQRLTAK QVLQHPWI 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00153
EKS-BOT-00160
EKS-CAE-00123
EKS-CAJ-00166
EKS-CAF-00167
EKS-CAP-00160
EKS-CIS-00193
EKS-DAR-00450
EKS-DRM-00076
EKS-ERE-00040
EKS-FEC-00151
EKS-GAG-00138
EKS-GAA-00191
EKS-GOG-00161
EKS-HOS-00166
EKS-LAC-00172
EKS-LOA-00161
EKS-MAM-00159
EKS-MAE-00059
EKS-MEG-00129
EKS-MIM-00076
EKS-MOD-00160
EKS-MUM-00165
EKS-MUP-00163
EKS-MYL-00171
EKS-NOL-00154
EKS-ORN-00201
EKS-ORC-00148
EKS-ORL-00188
EKS-OTG-00166
EKS-PAT-00151
EKS-PES-00143
EKS-POA-00157
EKS-PRC-00043
EKS-RAN-00158
EKS-SAH-00155
EKS-SUS-00142
EKS-TAG-00190
EKS-TAR-00208
EKS-TEN-00200
EKS-XET-00151
EKS-XIM-00195
Gene Ontology
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0043066; P:negative regulation of apoptotic process
GO:2000491; P:positive regulation of hepatic stellate cell activation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
ecb:100057166;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013