EKS-EQC-00067

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00067

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	353.9	6.4E-106	13	300	288

Status

Unreviewed

Ensembl Protein

ENSECAP00000014071

UniProt Accession

F6XCT7;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK6

Gene Synonyms/Alias

CDK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000016512	ENSECAP00000014071	ENSECAT00000017328

Organism

Equus caballus

Functional Description

Protein Length

326

Protein Sequence
(FASTA)

MEKDGLSRAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTG EEGMPLSTIR 60

EVAVLRHLET FEHPNVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE 120

TIKDMMFQLL RGLDFLHSHR VVHRDLKPQN ILVTSSGQIK LADFGLARIY SFQMALTSVV 180

VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GSSDVDQLGK ILDVIGLPGE 240

EDWPRDVALP RQAFHSKSPQ PIEKFVTDID EQGKDLLLKC LTFNPAKRIS AYSALSHPYF 300

HDLERCKENL DSHLPPSQNS SEMNTA 326

Nucleotide Sequence
(FASTA)

ATGGAGAAGG ACGGCCTGAG CCGCGCCGAC CAGCAGTACG AGTGCGTGGC GGAGATCGGG 60

GAGGGCGCCT ATGGGAAGGT GTTCAAGGCC CGGGATCTGA AGAACGGAGG CCGTTTCGTG 120

GCACTGAAGC GCGTGCGGGT GCAGACGGGC GAGGAGGGCA TGCCGCTTTC CACCATCCGC 180

GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTCGAGCACC CCAACGTGGT CAGGTTGTTT 240

GATGTGTGCA CAGTGTCACG AACAGACAGA GAAACCAAAC TAACATTAGT GTTTGAACAT 300

GTTGATCAAG ACTTGACCAC TTATTTGGAT AAAGTTCCAG AGCCTGGAGT GCCCACTGAA 360

ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGTCTGG ACTTTCTTCA TTCTCACCGA 420

GTAGTGCATC GTGATCTAAA ACCACAGAAC ATCCTGGTGA CCAGCAGTGG ACAAATAAAA 480

CTGGCTGACT TCGGCCTTGC CCGCATCTAT AGTTTTCAGA TGGCTCTTAC CTCAGTGGTC 540

GTCACGCTGT GGTACAGAGC TCCAGAAGTC TTGCTTCAGT CCAGCTACGC CACCCCTGTG 600

GATCTCTGGA GTGTTGGCTG CATATTTGCA GAAATGTTTC GTAGAAAGCC TCTTTTTCGT 660

GGAAGTTCAG ATGTCGATCA ACTAGGAAAA ATCTTGGACG TAATTGGACT CCCAGGAGAA 720

GAAGACTGGC CTAGAGATGT TGCCCTTCCC CGGCAGGCGT TTCACTCAAA ATCTCCTCAA 780

CCGATTGAGA AGTTTGTAAC AGATATTGAT GAACAAGGCA AAGACCTACT TCTGAAGTGC 840

TTGACATTTA ATCCAGCCAA AAGAATATCT GCCTACAGTG CCCTGTCTCA CCCATACTTC 900

CACGACCTGG AGAGGTGCAA GGAGAACCTG GATTCCCATC TGCCGCCCAG CCAGAACAGC 960

TCGGAGATGA ATACAGCCTG A 981

Domain Profile

S: 1     yeklekigeGtygkvykakd.ketgevvAlKkirlekekegvpitalrEisllkel...k  56

         ye++++igeG+ygkv+ka+d k+ g++vAlK++r+++ +eg+p +++rE+++l++l   +

Q: 13    YECVAEIGEGAYGKVFKARDlKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLetfE  72

         899*****************888999*****************************98889

S: 57    hknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleg  112

         h+n+v+L +v++     +++kl+Lvfe+++qdL+++l+k ++ ++++e++k +++qll+g

Q: 73    HPNVVRLFDVCTvsrtDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG  132

         ************99855569****************************************

S: 113   laylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelL  172

         l++lHs++++HRDlKpqN+L++++g++klaDfGlar +s ++  +t++vvTlwYraPe+L

Q: 133   LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVL  191

         *****************************************99.****************

S: 173   lgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklp  232

         l++ +Y t vD+Wsvgci+ae+++rkplf+g+s++dql +i++++g p e++wp+   lp

Q: 192   LQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP  250

         *88.5*******************************************************

S: 233   eykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +   +f++k+++ +++ v++++e++ dll k+l+++p+kRisa +al+h+yf

Q: 251   RQ--AFHSKSPQPIEKFVTDIDEQGKDLLLKCLTFNPAKRISAYSALSHPYF  300

         95..599999*****************************************9

Domain Sequence
(FASTA)

YECVAEIGEG AYGKVFKARD LKNGGRFVAL KRVRVQTGEE GMPLSTIREV AVLRHLETFE 60

HPNVVRLFDV CTVSRTDRET KLTLVFEHVD QDLTTYLDKV PEPGVPTETI KDMMFQLLRG 120

LDFLHSHRVV HRDLKPQNIL VTSSGQIKLA DFGLARIYSF QMALTSVVVT LWYRAPEVLL 180

QSSYATPVDL WSVGCIFAEM FRRKPLFRGS SDVDQLGKIL DVIGLPGEED WPRDVALPRQ 240

AFHSKSPQPI EKFVTDIDEQ GKDLLLKCLT FNPAKRISAY SALSHPYF 288

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0000307	; C:cyclin-dependent protein kinase holoenzyme complex
GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0001726	; C:ruffle
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0043697	; P:cell dedifferentiation
GO:0000080	; P:G1 phase of mitotic cell cycle
GO:0042063	; P:gliogenesis
GO:0002244	; P:hematopoietic progenitor cell differentiation
GO:0060218	; P:hematopoietic stem cell differentiation
GO:0045786	; P:negative regulation of cell cycle
GO:2000773	; P:negative regulation of cellular senescence
GO:0050680	; P:negative regulation of epithelial cell proliferation
GO:0045638	; P:negative regulation of myeloid cell differentiation
GO:0045668	; P:negative regulation of osteoblast differentiation
GO:0007219	; P:Notch signaling pathway
GO:0001954	; P:positive regulation of cell-matrix adhesion
GO:0048146	; P:positive regulation of fibroblast proliferation
GO:0010628	; P:positive regulation of gene expression
GO:0045646	; P:regulation of erythrocyte differentiation
GO:0009615	; P:response to virus
GO:0033077	; P:T cell differentiation in thymus
GO:0003323	; P:type B pancreatic cell development

KEGG

ecb:100061625

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013