EKS-EQC-00178
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00178
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKA482.72.5E-14536290255
StatusUnreviewed
Ensembl ProteinENSECAP00000014954
UniProt AccessionF7AI06;
Protein Name
Protein Synonyms/Alias
Gene NamePRKACA
Gene Synonyms/Alias PRKACA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000016874ENSECAP00000014954ENSECAT00000018339
OrganismEquus caballus
Functional Description
Protein Length343
Protein Sequence
(FASTA)
MASNPNDVKE FLAKAKEDFL KKWENPAQNT AHLDQFERIK TLGTGSFGRV MLVKHKETGN 60
HFAMKILDKQ KVVKLKQIEH TLNEKRILQA VNFPFLVKLE FSFKDNSNLY MIMEYVPGGE 120
MFSHLRRIGR FSEPHARFYA AQIVLTFEYL HSLDLIYRDL KPENLLIDQH GYIQVTDFGF 180
AKRVKGRTWT LCGTPEYLAP EIILSKGYNK AVDWWALGVL IYEMAAGYPP FFADQPIQIY 240
EKIVSGKVRF PSHFSSDLKD LLRNLLQVDL TKRFGNLKNG VNDIKNHKWF ATTDWIAIYQ 300
RKVEAPFIPK FKGPGDTSNF DDYEEEEIRV SINEKCGKEF SEF 343
Nucleotide Sequence
(FASTA)
ATGGCTTCCA ACCCCAACGA TGTGAAAGAG TTCTTAGCTA AAGCCAAAGA AGATTTTCTT 60
AAAAAATGGG AAAATCCTGC TCAGAATACA GCCCATTTGG ATCAGTTTGA ACGAATCAAG 120
ACCCTTGGAA CGGGCTCCTT CGGGCGGGTG ATGCTCGTGA AGCACAAGGA GACGGGGAAC 180
CACTTCGCCA TGAAGATCCT CGACAAACAG AAGGTGGTGA AGCTGAAACA GATCGAGCAC 240
ACCCTGAACG AAAAGCGCAT CTTGCAAGCC GTCAACTTCC CGTTCCTCGT CAAACTCGAG 300
TTCTCCTTCA AGGACAACTC GAATCTGTAC ATGATCATGG AGTACGTGCC TGGCGGGGAG 360
ATGTTCTCAC ACCTGCGGCG GATCGGAAGG TTCAGTGAGC CCCATGCCCG CTTCTATGCG 420
GCCCAGATCG TGCTGACCTT CGAGTACCTG CACTCGCTCG ACCTCATCTA CCGGGACCTG 480
AAGCCGGAGA ACCTGCTCAT CGACCAGCAC GGCTACATCC AGGTGACAGA CTTCGGTTTC 540
GCCAAGCGCG TGAAAGGCCG CACCTGGACC TTGTGTGGGA CCCCCGAGTA CCTGGCCCCG 600
GAAATCATCC TGAGCAAAGG CTACAACAAG GCTGTGGACT GGTGGGCCCT GGGGGTTCTC 660
ATCTACGAGA TGGCCGCTGG CTACCCACCC TTCTTTGCCG ACCAGCCCAT CCAGATCTAC 720
GAGAAGATTG TCTCCGGGAA GGTGCGGTTC CCGTCCCACT TCAGCTCTGA CCTGAAGGAC 780
CTGCTGCGGA ACCTCCTGCA GGTGGACCTC ACCAAGCGCT TCGGGAACCT CAAGAATGGG 840
GTTAATGACA TCAAGAACCA CAAGTGGTTT GCCACGACTG ACTGGATCGC CATCTACCAG 900
AGGAAGGTGG AAGCTCCCTT CATACCAAAG TTTAAAGGCC CTGGGGACAC GAGTAACTTT 960
GACGACTATG AGGAGGAAGA GATCCGAGTC TCCATCAATG AGAAGTGTGG CAAGGAGTTC 1020
TCTGAGTTTT AG 1032
Domain Profile
S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60
         fer+ktlGtGsfGrv+lv++ke+++++a+k+l+k+kvvklkq+eh+ nekr+l+av+fpf
Q: 36    FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF  95
         799*********************************************************
S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120
         lvkl++sfkd+snly+++eyv+GGe+fs+lr+++rfse++arfyaa+ivl++eylhsldl
Q: 96    LVKLEFSFKDNSNLYMIMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL  155
         ************************************************************
S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180
         iyrdlkpenll+d++Gyi+vtdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww
Q: 156   IYRDLKPENLLIDQHGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW  215
         ************************************************************
S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240
         alGvliye++aGyppff+dqpi+iyekivsgk++fps++ssdlkdll++llqvdltkr+g
Q: 216   ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFG  275
         ************************************************************
S: 241   nlkngvedikehkwf  255
         nlkngv+dik+hkwf
Q: 276   NLKNGVNDIKNHKWF  290
         **************9
Domain Sequence
(FASTA)
FERIKTLGTG SFGRVMLVKH KETGNHFAMK ILDKQKVVKL KQIEHTLNEK RILQAVNFPF 60
LVKLEFSFKD NSNLYMIMEY VPGGEMFSHL RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL 120
IYRDLKPENL LIDQHGYIQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180
ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVRFPSHFS SDLKDLLRNL LQVDLTKRFG 240
NLKNGVNDIK NHKWF 255
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00171
EKS-BOT-00180
EKS-CAE-00173
EKS-CAF-00187
EKS-CAP-00207
EKS-CII-00117
EKS-DAR-00478
EKS-DIO-00090
EKS-FEC-00169
EKS-GAM-00098
EKS-GAA-00222
EKS-GOG-00178
EKS-HOS-00186
EKS-ICT-00176
EKS-LOA-00180
EKS-MAE-00062
EKS-MOD-00179
EKS-MUM-00185
EKS-MUP-00183
EKS-ORN-00231
EKS-ORA-00159
EKS-ORL-00217
EKS-OTG-00187
EKS-PAT-00170
EKS-PEM-00096
EKS-PRC-00056
EKS-PTV-00152
EKS-RAN-00176
EKS-SAH-00173
EKS-SUS-00157
EKS-TAR-00237
EKS-TEN-00233
EKS-TUT-00156
EKS-XIM-00225
Gene Ontology
GO:0005813; C:centrosome
GO:0005739; C:mitochondrion
GO:0031594; C:neuromuscular junction
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004691; F:cAMP-dependent protein kinase activity
GO:0071333; P:cellular response to glucose stimulus
GO:0071374; P:cellular response to parathyroid hormone stimulus
GO:0001707; P:mesoderm formation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0071158; P:positive regulation of cell cycle arrest
GO:0046827; P:positive regulation of protein export from nucleus
GO:0046777; P:protein autophosphorylation
GO:0045667; P:regulation of osteoblast differentiation
GO:0061136; P:regulation of proteasomal protein catabolic process
GO:0050804; P:regulation of synaptic transmission
GO:2000810; P:regulation of tight junction assembly
GO:0048240; P:sperm capacitation
KEGG
ecb:100064302;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013