EPS-EQC-00020
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-EQC-00020
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
PPM/PP2C207.53.3E-61663908246
StatusUnreviewed
Ensembl ProteinENSECAP00000014734
UniProt AccessionF6WXS3;
Protein Name
Protein Synonyms/Alias
Gene NamePHLPP1
Gene Synonyms/Alias PHLPP1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000016885ENSECAP00000014734ENSECAT00000018084
OrganismEquus caballus
Functional Description
Protein Length1196
Protein Sequence
(FASTA)
MDSEIGCLIR FYAGKPHSTS NSERIQLSGM YNVRKGKMQL PVNRWTRRQV ILCGTCLIVS 60
SVKDSLTGKM HVLPLIGGKV EEVKKHQHCL AFSSSGPQSQ TYYICFDTFT EYLRWLRQVS 120
KVASQRISSV DLSCCSLEHL PANLFYSQDL THLNLKQNFL RQNPSLPTAR GLNELQRFTK 180
LKSLNLSNNH LGDFPLAVCN IPTLTELNVS CNALRAVPAA VGVMHNLQTF LLDGNFLQAL 240
PAELENMHQL SYLGLSFNEF TDIPEVLEKL TAVDKLCMSG NCMETLRLQA LRKMPHIKHV 300
DLRLNILRKL IADEVDFLQH VTQLDLRDNK LGDLDAMIFN NIEVLHCERN QLVTLNICGY 360
FLKALYASSN ELVQLDVYPV PNYLSYMDVS RNRLENVPEW ICESRKLEVL DIGHNQICEL 420
PARLFCNSSL RKLLAGHNQL TRLPERLERT SVEVLDVQHN QLLELPPNLL MKADSLRFLN 480
ASANKLETLP PATLSEETNS ILQELYLTNN NLTDKCVPLL TGHPHLKILH MAYNRLQSFP 540
ASKMAKLEEL EEIDISGNKL KAIPTTIMNC RRMHTVIAHS NCIEVFPEVM QLPEIKCVDL 600
SCNELSEVTL PENLPSKLQE LDLTGNPRLT LDHKTLELLN NIRCFKIDQP SAGDASGAPA 660
VWSHGYTEAS GVKNKLCVAA LSVNNFCDNR EALYGVFDGD RNVEVPYLLQ CTMSDILAEE 720
LQKTKNEEEY MVNTFIVMQR KLGTAGQKLG GAAVLCHIRH DPVDPGGSFT LTSANVGKCQ 780
TVLCRNGQPL PLSRSYVMSC EEELKRIKRH KAIITEDGKV NGVTESTRIL GYTFLHPSVV 840
PRPHVQSVPL TPQDEFFILG SKGLWDSLSI EEAVGAVRNV PDALAAAKKL CTLAQSYGCH 900
DSISAVVVQL SVTEDSFCCC ELSAGGAVPP PSPGIFPPSV SMVIKDRPTD GLGVPSSSSG 960
MASEISSELS TSEMSSEVGS TASDEPPSGA LNENSPAYPS EQRCMLHPVC LSNSFQRQLS 1020
SATFSSAFSD NGLDSDDEEP IEGVFTNGSR VEVEVDIHCS RAKEKEKQQH LLQVPAEASD 1080
EGIVISANED EPGLPRKVDF ATVGTIGRRR ANGSVAPQER SHNMIEVATD APLRKPGGYF 1140
AAPAQPDPDD QFIIPPELEE EVKEIMKHHQ QQQQPPAQLP LQQPQRQCPA DPLPDY 1196
Nucleotide Sequence
(FASTA)
ATGGACTCGG AGATCGGCTG CCTCATCCGC TTCTATGCAG GAAAACCTCA CAGCACCAGT 60
AACTCTGAAC GGATTCAGCT CTCAGGAATG TATAATGTCC GTAAAGGCAA AATGCAGTTG 120
CCAGTGAACC GATGGACCAG ACGCCAAGTC ATCCTGTGTG GGACCTGCCT AATAGTATCA 180
TCTGTGAAAG ACAGCTTGAC CGGAAAGATG CATGTTCTGC CGCTAATTGG TGGAAAAGTA 240
GAAGAAGTGA AAAAGCACCA GCACTGTTTA GCATTTAGCT CCTCTGGACC CCAAAGCCAG 300
ACTTACTACA TTTGTTTTGA TACATTCACG GAGTATTTAA GGTGGCTTCG ACAAGTCTCC 360
AAGGTTGCAT CACAGCGTAT TAGCTCAGTG GACCTCTCGT GTTGTAGCCT GGAGCATCTG 420
CCTGCCAACC TCTTCTACAG CCAAGACCTC ACTCATCTCA ATTTAAAACA AAACTTCCTA 480
AGGCAAAATC CTAGCCTACC AACTGCCAGG GGCCTCAATG AGCTACAAAG GTTCACCAAA 540
TTGAAGAGTC TTAACCTTTC CAATAATCAT TTAGGGGACT TCCCATTAGC AGTCTGCAAT 600
ATTCCGACCC TGACTGAGCT GAATGTGTCC TGCAACGCCC TTCGTGCAGT CCCGGCGGCC 660
GTCGGAGTCA TGCACAACTT GCAGACATTT TTGTTGGATG GAAACTTTCT CCAGGCCCTT 720
CCTGCTGAGT TGGAGAACAT GCATCAGCTT AGTTATCTCG GTCTTTCTTT CAATGAATTC 780
ACTGACATTC CAGAGGTATT GGAGAAATTA ACTGCTGTGG ATAAACTTTG TATGTCTGGA 840
AACTGTATGG AGACCCTTAG GCTACAGGCT TTGCGAAAAA TGCCTCACAT TAAACACGTG 900
GATCTAAGAC TGAACATACT TAGGAAGCTA ATAGCAGATG AAGTGGACTT TCTCCAGCAT 960
GTCACTCAGC TTGATCTGCG CGACAATAAG CTTGGTGATC TAGATGCTAT GATTTTCAAC 1020
AACATTGAAG TTTTACACTG TGAAAGGAAT CAACTGGTGA CGTTAAACAT CTGTGGCTAC 1080
TTCCTGAAAG CGCTCTATGC CTCTTCTAAC GAACTTGTTC AACTTGATGT TTACCCAGTT 1140
CCGAATTATC TGTCCTACAT GGACGTTTCA AGGAACCGCT TAGAAAACGT GCCTGAGTGG 1200
ATATGTGAAA GTCGAAAGCT GGAAGTTTTG GATATTGGCC ATAATCAAAT ATGTGAACTT 1260
CCTGCACGCT TATTTTGTAA TAGTAGTCTC CGGAAACTAC TGGCAGGACA CAACCAGCTG 1320
ACGAGGCTTC CTGAAAGGCT AGAAAGAACC TCAGTGGAGG TCTTGGATGT GCAACACAAC 1380
CAGCTCCTGG AGCTACCACC GAACCTTCTG ATGAAGGCGG ACAGCCTGAG ATTTCTGAAT 1440
GCATCTGCGA ACAAACTGGA AACCCTTCCT CCAGCCACAC TTTCTGAAGA GACGAACAGC 1500
ATCTTACAGG AGTTGTATTT GACAAATAAC AACCTCACGG ATAAATGTGT GCCCTTGTTA 1560
ACAGGACACC CCCATCTGAA GATCCTTCAC ATGGCCTATA ACCGACTTCA AAGCTTTCCA 1620
GCAAGTAAAA TGGCAAAACT GGAGGAACTG GAAGAAATTG ATATCAGTGG GAATAAACTG 1680
AAAGCCATCC CAACAACTAT CATGAATTGC AGGCGCATGC ACACCGTGAT CGCTCACTCC 1740
AACTGCATTG AGGTCTTTCC TGAAGTTATG CAGCTCCCGG AGATCAAGTG CGTGGACCTG 1800
AGCTGTAATG AACTAAGCGA AGTCACTTTA CCAGAAAACT TGCCCTCAAA ACTGCAAGAA 1860
CTAGACCTCA CTGGAAACCC CCGACTTACC CTCGATCACA AAACCCTGGA ACTGCTGAAT 1920
AATATCCGCT GTTTCAAGAT TGATCAGCCT TCAGCAGGAG ATGCATCTGG AGCCCCAGCT 1980
GTATGGAGCC ATGGTTACAC TGAAGCTTCA GGAGTGAAAA ACAAGTTGTG TGTTGCAGCC 2040
CTGTCGGTGA ATAACTTCTG TGACAACCGG GAGGCCCTGT ATGGTGTATT TGACGGAGAC 2100
CGTAACGTGG AGGTACCCTA CCTTCTCCAG TGTACTATGA GTGACATTTT GGCAGAAGAG 2160
CTGCAGAAAA CAAAAAATGA AGAAGAATAC ATGGTCAATA CGTTCATCGT TATGCAAAGG 2220
AAACTCGGAA CTGCTGGGCA GAAACTTGGA GGTGCTGCTG TCCTCTGTCA TATCAGGCAT 2280
GACCCTGTGG ACCCAGGAGG ATCCTTCACC TTGACCTCTG CTAATGTGGG CAAGTGCCAA 2340
ACGGTTCTCT GTCGGAATGG GCAGCCGTTG CCTCTGTCCA GATCGTATGT CATGAGCTGT 2400
GAAGAAGAAC TGAAGAGAAT TAAACGGCAC AAGGCCATTA TCACTGAGGA CGGCAAGGTG 2460
AATGGAGTGA CGGAGTCCAC GCGCATCCTG GGCTACACCT TCCTCCACCC CAGCGTGGTG 2520
CCTCGCCCCC ACGTACAGTC TGTGCCCCTG ACCCCTCAGG ACGAGTTCTT CATCCTAGGA 2580
AGTAAGGGCT TGTGGGACAG CCTGTCCATC GAGGAGGCTG TGGGGGCTGT GCGGAATGTG 2640
CCTGATGCCC TGGCTGCTGC CAAGAAGCTG TGCACGCTGG CCCAGAGCTA TGGCTGCCAC 2700
GACAGCATCA GCGCCGTGGT GGTGCAGCTC AGCGTCACTG AGGACAGCTT CTGCTGCTGC 2760
GAGCTCAGCG CAGGTGGGGC TGTCCCGCCA CCCAGCCCAG GCATCTTCCC TCCCTCCGTC 2820
AGCATGGTCA TCAAGGACCG GCCCACCGAC GGGCTGGGCG TGCCATCCTC CAGCAGCGGC 2880
ATGGCCTCTG AGATCAGCAG TGAGCTGTCC ACCTCCGAGA TGAGCAGTGA GGTGGGGTCT 2940
ACAGCTTCTG ATGAGCCCCC ATCTGGAGCC CTGAATGAGA ACAGCCCTGC CTACCCCAGC 3000
GAGCAGCGCT GCATGCTCCA CCCGGTCTGC CTGTCCAACT CCTTCCAGCG CCAGCTGTCC 3060
AGCGCCACTT TCTCCAGCGC GTTCTCTGAC AATGGCCTTG ACAGCGATGA TGAAGAGCCA 3120
ATTGAGGGTG TCTTTACCAA TGGCAGCCGA GTAGAGGTAG AAGTCGACAT CCACTGCAGC 3180
AGGGCCAAGG AGAAGGAGAA ACAGCAGCAC CTGCTCCAGG TGCCAGCGGA GGCCAGCGAT 3240
GAGGGGATTG TCATCAGCGC CAACGAGGAT GAGCCAGGTC TGCCCAGGAA AGTAGACTTT 3300
GCCACTGTGG GGACCATTGG CCGCCGGAGG GCCAACGGCT CTGTGGCGCC CCAGGAAAGG 3360
AGCCACAACA TGATAGAGGT AGCTACAGAC GCGCCTCTCC GAAAGCCTGG AGGCTATTTT 3420
GCGGCCCCGG CTCAGCCAGA CCCTGATGAT CAGTTTATCA TACCCCCAGA GCTGGAGGAG 3480
GAGGTCAAGG AGATCATGAA ACACCACCAG CAGCAGCAGC AGCCTCCAGC ACAGCTCCCC 3540
CTGCAGCAGC CACAGCGGCA GTGCCCGGCA GACCCGCTGC CAGACTAC 3588
Domain Profile
S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61
         ++g+++ +g +n+++ a+ s++nf++++e+     ++gv+DG+++ ev + +++++++il
Q: 663   SHGYTEASGVKNKLCVAALSVNNFCDNREA-----LYGVFDGDRNVEVPYLLQCTMSDIL  717
         689***********************9885.....9************************
S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115
         aeel+    ++++ ++++ ++F+ ++++l       ++ +k G +av+++i+++      
Q: 718   AEELQ----KTKNEEEYMVNTFIVMQRKL------GTAGQKLGGAAVLCHIRHDpvdpgg  767
         ***99....999*****************......99***********************
S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173
           +l+ anvG++++vLcrng++++ls+ + +s+e+El+Ri+++++ ++++   +v+Gv++
Q: 768   sfTLTSANVGKCQTVLCRNGQPLPLSRSYVMSCEEELKRIKRHKAIITEDG--KVNGVTE  825
         *99*****************************************9999998..*******
S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233
          +R lG ++l+p v+p+P+v+s++lt++def+iL+s+Glwd +s eeav +vr+v +   
Q: 826   STRILGYTFLHPSVVPRPHVQSVPLTPQDEFFILGSKGLWDSLSIEEAVGAVRNVPD---  882
         *********************************************************...
S: 234   aeqeaakkLvklalargskdnvsaivv  260
          + +aakkL++la+++g++d++sa+vv
Q: 883   -ALAAAKKLCTLAQSYGCHDSISAVVV  908
         .************************97
Domain Sequence
(FASTA)
SHGYTEASGV KNKLCVAALS VNNFCDNREA LYGVFDGDRN VEVPYLLQCT MSDILAEELQ 60
KTKNEEEYMV NTFIVMQRKL GTAGQKLGGA AVLCHIRHDP VDPGGSFTLT SANVGKCQTV 120
LCRNGQPLPL SRSYVMSCEE ELKRIKRHKA IITEDGKVNG VTESTRILGY TFLHPSVVPR 180
PHVQSVPLTP QDEFFILGSK GLWDSLSIEE AVGAVRNVPD ALAAAKKLCT LAQSYGCHDS 240
ISAVVV 246
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EPS-AIM-00028
EPS-ANC-00033
EPS-BOT-00025
EPS-CAJ-00024
EPS-CAF-00032
EPS-CAP-00023
EPS-DAR-00059
EPS-FEC-00030
EPS-GAM-00030
EPS-GAG-00028
EPS-GAA-00045
EPS-GOG-00027
EPS-HOS-00024
EPS-LOA-00022
EPS-MEG-00031
EPS-MOD-00025
EPS-MUM-00025
EPS-MYL-00028
EPS-NOL-00026
EPS-OCP-00015
EPS-ORN-00039
EPS-ORC-00024
EPS-ORL-00040
EPS-OTG-00026
EPS-PAT-00024
EPS-PES-00032
EPS-PEM-00022
EPS-POA-00031
EPS-RAN-00027
EPS-SAH-00023
EPS-SUS-00019
EPS-TAG-00026
EPS-TAR-00046
EPS-TEN-00037
EPS-TUT-00019
EPS-XET-00030
EPS-XIM-00053
EPS-SAC-00009
EPS-SCP-00007
Gene Ontology
GO:0003824; F:catalytic activity
GO:0005543; F:phospholipid binding
GO:0009649; P:entrainment of circadian clock
GO:0008152; P:metabolic process
KEGG
InterPros
IPR001611; Leu-rich_rpt.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR001932; PP2C-like.
Pfam
PF00560; LRR_1; 1.
PF00481; PP2C; 1.
SMARTs
SM00233; PH; 1.
SM00332; PP2Cc; 1.
Prosites
PS51450; LRR; 17.
PS50003; PH_DOMAIN; 1.
Prints
Created Date20-Feb-2013