EKS-EQC-00106
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00106
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec482.42.8E-145271521251
StatusUnreviewed
Ensembl ProteinENSECAP00000014619
UniProt AccessionF6Y4C4;
Protein Name
Protein Synonyms/Alias
Gene NameTXK
Gene Synonyms/Alias TXK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000016892ENSECAP00000014619ENSECAT00000017957
OrganismEquus caballus
Functional Description
Protein Length527
Protein Sequence
(FASTA)
MICFSDNTIQ SIFCCCCCCS VQKRQVRTQI SLSKDEELSE KCPQRRRPWF SELSSKKQSD 60
RGRVQPSKRK PLPPLPLSEV AEEKIQVKAL YDFLPREPCD LALKRAEEYL ILEKYNPHWW 120
KARDRLGNEG LIPSNYVTEN KLTNLEIYEW YHRNITRNQA EHLLRQEAKE GAFIVRDSRH 180
LGSYTISVFI RARRSMEATI KHYQIKRNDS GQWYVAERHL FESIPDLIWY HQHNAAGLMT 240
RLRYPVGLMG NCLPATAGFS YEKWEIDPSE LAFVEEIGSG QFGVVHLGKW RSHIQVAIKA 300
INEGSMSEED FIEEAKVMTK LSHSRLVQLY GVCTQQKPLY IVTEFMENGC LLNYLRERKG 360
KLRKEMLLSV CQDICEGMEY LERNCFIHRD LAARNCLVSS TSVVKISDFG MTRYVLDDEY 420
ICSSGAKFPV KWSPPEVFHF NKYSSKSDVW SFGVLMWEVF TEGKMPFENK SNLQVVEAIS 480
NGFRLYRPRL APMSVYEVMY SCWHEKPKGR PTFTELLQVL TEIAETW 527
Nucleotide Sequence
(FASTA)
ATGATCTGCT TTTCAGATAA TACCATCCAG TCGATTTTCT GTTGCTGCTG TTGCTGTTCC 60
GTGCAGAAGC GGCAAGTGAG AACACAAATA AGCCTAAGTA AAGATGAAGA ACTTTCAGAA 120
AAATGTCCTC AGCGTCGCAG GCCATGGTTC AGCGAATTGT CAAGTAAGAA GCAATCCGAC 180
AGGGGCCGCG TGCAACCGTC AAAACGCAAG CCGCTGCCTC CCCTCCCACT CTCTGAGGTT 240
GCTGAAGAGA AGATCCAAGT GAAAGCTCTG TATGATTTTC TGCCCAGAGA GCCCTGTGAT 300
TTAGCATTAA AGAGAGCAGA GGAATACCTG ATATTGGAGA AGTACAATCC TCACTGGTGG 360
AAGGCAAGAG ACCGTTTGGG GAATGAAGGC TTAATCCCAA GCAACTACGT GACTGAAAAC 420
AAATTAACCA ATTTAGAAAT ATATGAGTGG TACCATAGAA ACATTACCAG AAATCAGGCA 480
GAACATCTTT TGAGACAAGA GGCTAAAGAA GGAGCATTCA TTGTCAGAGA TTCAAGGCAT 540
TTGGGATCCT ACACAATTTC TGTGTTTATA AGAGCTAGAA GAAGTATGGA GGCTACCATC 600
AAACATTATC AGATTAAAAG GAATGACTCT GGACAGTGGT ACGTGGCTGA AAGGCACCTC 660
TTTGAATCAA TCCCTGATTT GATCTGGTAT CACCAGCACA ATGCAGCCGG TCTCATGACG 720
CGTCTCCGCT ACCCAGTTGG GCTGATGGGC AATTGTTTGC CAGCCACGGC TGGTTTCAGC 780
TATGAAAAGT GGGAGATCGA TCCATCTGAG TTGGCTTTTG TAGAGGAGAT TGGAAGTGGT 840
CAGTTTGGGG TGGTGCATTT AGGCAAGTGG CGATCACACA TCCAGGTAGC CATCAAGGCC 900
ATCAATGAAG GCTCCATGTC TGAAGAGGAT TTCATCGAAG AGGCCAAAGT GATGACGAAA 960
TTATCTCATT CAAGGCTAGT TCAGCTTTAT GGCGTATGTA CACAGCAGAA GCCTCTTTAC 1020
ATTGTGACAG AATTTATGGA AAATGGCTGC CTGCTTAACT ACCTCAGAGA GAGAAAAGGC 1080
AAGCTTAGGA AGGAAATGCT ACTGAGTGTG TGCCAGGATA TATGTGAAGG AATGGAGTAT 1140
CTGGAGAGAA ACTGCTTTAT TCACAGGGAT TTAGCAGCAA GGAATTGTTT GGTCAGTTCT 1200
ACAAGTGTAG TAAAAATTTC GGACTTTGGA ATGACAAGGT ATGTTTTGGA TGATGAATAT 1260
ATCTGTTCTT CTGGAGCCAA GTTCCCAGTC AAGTGGTCCC CTCCTGAAGT TTTCCATTTC 1320
AACAAGTACA GCAGCAAATC TGATGTCTGG TCATTCGGAG TCTTAATGTG GGAAGTTTTT 1380
ACAGAAGGAA AAATGCCTTT TGAAAATAAG TCAAATTTGC AAGTTGTGGA AGCCATTTCT 1440
AATGGCTTCA GACTATACCG CCCTCGCCTG GCACCAATGT CCGTATACGA AGTCATGTAC 1500
AGCTGCTGGC ATGAGAAACC CAAAGGCCGC CCTACGTTCA CTGAGCTGCT GCAGGTTCTC 1560
ACAGAGATTG CAGAAACCTG GTGA 1584
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         l++++e+gsgqfgvv+lgkwr++i+vaikai+eg+mseedfieeakvm+klsh++lvqly
Q: 271   LAFVEEIGSGQFGVVHLGKWRSHIQVAIKAINEGSMSEEDFIEEAKVMTKLSHSRLVQLY  330
         68**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc++qkp+yivte++engcllnylre+k+kl+ke+ll++c+d+cegmeyler++fihrd
Q: 331   GVCTQQKPLYIVTEFMENGCLLNYLRERKGKLRKEMLLSVCQDICEGMEYLERNCFIHRD  390
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv++++vvk+sdfg++ryvldd+y+ s+gakfpvkwsppev++++kyssksdvw
Q: 391   LAARNCLVSSTSVVKISDFGMTRYVLDDEYICSSGAKFPVKWSPPEVFHFNKYSSKSDVW  450
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevf+egk+p+e+ksn +vve++s+g+rlyrp+la+++vyevm+scw+ekp++r
Q: 451   SFGVLMWEVFTEGKMPFENKSNLQVVEAISNGFRLYRPRLAPMSVYEVMYSCWHEKPKGR  510
         ************************************************************
S: 241   ptfkellsale  251
         ptf+ell+ l+
Q: 511   PTFTELLQVLT  521
         *******9986
Domain Sequence
(FASTA)
LAFVEEIGSG QFGVVHLGKW RSHIQVAIKA INEGSMSEED FIEEAKVMTK LSHSRLVQLY 60
GVCTQQKPLY IVTEFMENGC LLNYLRERKG KLRKEMLLSV CQDICEGMEY LERNCFIHRD 120
LAARNCLVSS TSVVKISDFG MTRYVLDDEY ICSSGAKFPV KWSPPEVFHF NKYSSKSDVW 180
SFGVLMWEVF TEGKMPFENK SNLQVVEAIS NGFRLYRPRL APMSVYEVMY SCWHEKPKGR 240
PTFTELLQVL T 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00100
EKS-BOT-00109
EKS-CAJ-00110
EKS-CAF-00110
EKS-CAP-00106
EKS-ERE-00053
EKS-FEC-00104
EKS-GAG-00089
EKS-GOG-00109
EKS-HOS-00111
EKS-LAC-00111
EKS-LOA-00104
EKS-MAM-00104
EKS-MEG-00084
EKS-MIM-00047
EKS-MOD-00108
EKS-MUM-00110
EKS-MUP-00112
EKS-MYL-00122
EKS-NOL-00101
EKS-ORC-00100
EKS-OTG-00110
EKS-PAT-00099
EKS-PES-00091
EKS-POA-00101
EKS-RAN-00106
EKS-SAH-00103
EKS-SUS-00096
EKS-TUT-00096
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001012; F:RNA polymerase II regulatory region DNA binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0032609; P:interferon-gamma production
GO:0032633; P:interleukin-4 production
GO:0001865; P:NK T cell differentiation
GO:0032729; P:positive regulation of interferon-gamma production
GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
GO:0050852; P:T cell receptor signaling pathway
KEGG
ecb:100054343;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013