EKS-EQC-00232

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00232

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	388.3	1.4E-116	39	290	252

Status

Unreviewed

Ensembl Protein

ENSECAP00000014818

UniProt Accession

F6WVC3;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK3

Gene Synonyms/Alias

MARK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000016955	ENSECAP00000014818	ENSECAT00000018176

Organism

Equus caballus

Functional Description

Protein Length

736

Protein Sequence
(FASTA)

HTSHGDGRQE VTSRTGRSGA RCRNSIASCA DEQPHIGNYR LLKTIGKGNF AKVKLARHIL 60

TGREVAIKII DKTQLNPTSL QKLFREVRIM KILNHPNIVK LFEVIETDKT LYLIMEYASG 120

GEVFDYLVAH GRMKEKEARA KFRQIVSAVQ YCHQKRIVHR DLKAENLLLD ADMNIKIADF 180

GFSNEFTVGS KLDTFCGSPP YAAPELFQGK KYDGPEVDVW SLGVILYTLV SGSLPFDGQN 240

LKELRERVLR GKYRIPFYMS TDCENLLKRF LVLNPIKRGT LEQIMKDRWI NAGHEEDELK 300

PFVEPELDIS DQKRIDIMVG MGYSQEEIQE SLSKMKYDEI TATYLLLGRK SSELDASDSS 360

SSSNLSLAKV RPSSDLNNST GQSPHHKVQR SVSSSQKQRR YSDHAGPAIP SVVAYPKRSQ 420

TSTADSDLKE DGIPSRKSSS SAVGGKGIAP ASPMLGNASN PNKADIPERK KSSTVPSSNT 480

TSGGMTRRNT YVCSERTTAD RHSVIQNGKE NSTIPDQRTP VASTHSISSA TTPDRIRFPR 540

GTASRSTFHG QPRERRTATY NGPPASPSLS HEATPLSQTR SRGSTNLFSK LTSKLTRRNM 600

SFRFIKRLPT EYERNGRYEG SSRNVSAEQK DENKEAKPRS LRFTWSMKTT SSMDPNDMMR 660

EIRKVLDANN CDYEQRERFL LFCVHGDGHA ENLVQWEMEV CKLPRLSLNG VRFKRISGTS 720

IAFKNIASKI ANELKL 736

Nucleotide Sequence
(FASTA)

CACACGTCAC ATGGAGATGG GCGGCAAGAA GTTACCTCTC GCACTGGACG CTCTGGAGCT 60

CGGTGTAGAA ACTCTATAGC TTCCTGTGCA GATGAACAAC CTCACATCGG AAACTACAGA 120

CTGTTGAAAA CAATCGGCAA GGGGAATTTT GCAAAAGTGA AATTGGCAAG ACACATCCTT 180

ACAGGCAGAG AGGTTGCCAT AAAAATAATT GACAAAACTC AGTTGAATCC AACAAGTCTA 240

CAAAAGCTCT TCAGAGAAGT AAGAATAATG AAGATTTTAA ATCATCCAAA CATAGTGAAG 300

TTATTCGAAG TCATTGAAAC TGACAAAACA CTCTACCTAA TCATGGAGTA TGCAAGTGGA 360

GGTGAAGTGT TTGACTATTT GGTTGCACAT GGAAGAATGA AGGAAAAAGA AGCAAGAGCT 420

AAATTTAGAC AGATAGTGTC TGCAGTCCAG TACTGCCACC AGAAGCGGAT CGTTCACAGA 480

GACCTCAAGG CTGAAAATCT ATTGTTAGAT GCTGATATGA ACATTAAAAT AGCTGACTTT 540

GGTTTTAGCA ATGAATTTAC TGTTGGCAGT AAACTGGATA CGTTTTGTGG CAGTCCTCCA 600

TATGCAGCCC CAGAGCTCTT CCAGGGCAAG AAATACGATG GGCCAGAAGT GGACGTTTGG 660

AGCCTTGGTG TCATTCTTTA CACTCTAGTC AGTGGGTCGC TCCCCTTTGA TGGACAGAAC 720

CTAAAGGAAC TGAGAGAGAG AGTATTAAGA GGGAAATACA GAATCCCTTT CTACATGTCC 780

ACAGACTGTG AAAACCTTCT CAAACGTTTC CTGGTGCTAA ATCCAATAAA GCGAGGCACT 840

CTAGAGCAAA TCATGAAGGA CAGGTGGATC AATGCAGGGC ATGAGGAAGA TGAACTTAAA 900

CCATTTGTTG AACCAGAACT AGACATCTCA GACCAGAAAA GAATAGATAT TATGGTGGGA 960

ATGGGATATT CACAAGAAGA AATTCAAGAA TCTCTTAGTA AAATGAAATA TGATGAAATC 1020

ACAGCTACGT ATTTGTTGTT GGGGAGAAAG TCTTCAGAGC TGGATGCTAG TGATTCCAGT 1080

TCTAGCAGCA ATCTTTCACT TGCTAAGGTT AGGCCAAGCA GTGACCTCAA CAACAGTACT 1140

GGCCAGTCTC CTCACCACAA AGTACAGAGA AGTGTTTCTT CAAGCCAGAA GCAGAGGCGG 1200

TACAGTGACC ATGCTGGACC AGCTATTCCT TCAGTTGTGG CGTATCCGAA AAGGAGTCAG 1260

ACCAGCACTG CGGATAGTGA CCTCAAAGAA GATGGAATTC CCTCCCGGAA ATCAAGCAGT 1320

AGTGCTGTTG GAGGAAAGGG AATTGCTCCA GCCAGTCCCA TGCTTGGAAA TGCCAGTAAT 1380

CCCAATAAGG CAGATATTCC TGAACGCAAG AAAAGCTCCA CTGTCCCTAG TAGTAATACA 1440

ACATCTGGCG GAATGACACG GCGAAATACT TACGTTTGCA GTGAAAGAAC CACAGCTGAT 1500

AGACATTCAG TAATTCAGAA TGGCAAAGAA AACAGCACTA TTCCTGATCA GAGAACTCCA 1560

GTTGCTTCAA CACACAGTAT TAGCAGTGCC ACCACCCCAG ATCGAATCCG CTTCCCAAGA 1620

GGCACTGCAA GTCGTAGCAC TTTCCACGGC CAGCCCCGGG AGCGGCGAAC TGCAACATAT 1680

AATGGCCCGC CAGCCTCGCC CAGCCTGTCC CATGAAGCCA CACCATTGTC ACAGACTCGA 1740

AGCCGAGGCT CCACTAATCT TTTTAGTAAA TTAACTTCAA AACTCACAAG GAGAAACATG 1800

TCATTCAGGT TTATCAAAAG GCTTCCAACT GAATATGAGA GGAACGGGAG ATATGAGGGC 1860

TCAAGTCGCA ACGTATCTGC TGAGCAAAAG GACGAAAACA AAGAAGCAAA ACCTCGTTCC 1920

CTGCGCTTTA CCTGGAGCAT GAAAACCACT AGTTCCATGG ATCCCAATGA CATGATGCGG 1980

GAAATCCGCA AAGTGCTGGA CGCCAATAAC TGCGACTATG AGCAGAGAGA GCGCTTCTTG 2040

CTCTTCTGTG TCCATGGCGA TGGGCACGCA GAGAACCTCG TGCAGTGGGA GATGGAGGTG 2100

TGCAAGCTGC CAAGACTGTC TCTGAATGGG GTCCGGTTTA AGCGGATATC AGGGACATCC 2160

ATAGCTTTCA AAAATATTGC TTCCAAAATT GCCAATGAGC TAAAGCTGTA A 2211

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 39    YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  98

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lyl++eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+iv

Q: 99    VKLFEVIETDKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIV  158

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 159   HRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVD  218

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+++Lv +p kR

Q: 219   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR  278

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 279   GTLEQIMKDRWI  290

         ***********7

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETD KTLYLIMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKRIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GSKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK RFLVLNPIKR 240

GTLEQIMKDR WI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013