EPS-EQC-00017

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-EQC-00017

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	290.0	2.1E-86	23	293	271

Status

Unreviewed

Ensembl Protein

ENSECAP00000014809

UniProt Accession

F6WVS9;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B

Gene Synonyms/Alias

PPM1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000016986	ENSECAP00000014809	ENSECAT00000018165

Organism

Equus caballus

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL EDWSFFAVYD 60

GHAGSRVANY CSTHLLEHIT NNEDFRAAGK SGSALEPSVE NVKNGIRTGF LKIDEYMRNF 120

SDLRNGMDRS GSTAVGVMIS PKHVYFINCG DSRAVLYRNG QVCFSTQDHK PCNPREKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL 240

ACDGIWDVMS NEELCEFVKS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSI VLVCFSNAPK 300

VSDEAVRKDS ELDKYLESRV EEIMEKSGEE GMPDLAHVMR ILSAENIPNL PPGGGLASKR 360

NVIEAVYSRL NPHRESDGAS DEAEESGSQG KLVEALRQMR INHRGNYRQL LEEMLTSYRL 420

AKVEGEESPA EPAATATTSN SDAGSPVTMQ ESHTESKSDL AELDSSNEDA GTKMSDEKI 479

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTTTGGATAA ACCCAAAACC GAGAAACATA ATGCTCATGG TGCTGGGAAT 60

GGTTTACGTT ATGGCCTGAG CAGCATGCAA GGATGGAGAG TGGAAATGGA AGATGCACAC 120

ACAGCTGTTG TAGGTATTCC TCACGGCTTG GAAGACTGGT CGTTTTTTGC AGTTTATGAT 180

GGTCATGCTG GATCCCGAGT AGCAAATTAT TGCTCAACAC ATTTATTAGA ACACATCACT 240

AATAATGAAG ACTTCAGGGC AGCTGGAAAA TCAGGATCTG CTCTTGAGCC TTCAGTGGAA 300

AATGTCAAGA ATGGTATCAG AACTGGCTTT TTGAAAATTG ATGAATACAT GCGTAACTTT 360

TCAGACCTCA GAAATGGAAT GGACAGGAGC GGTTCAACTG CAGTGGGAGT TATGATTTCA 420

CCTAAGCATG TCTACTTTAT CAACTGTGGT GATTCACGTG CTGTTCTGTA TAGGAATGGA 480

CAAGTCTGCT TTTCTACCCA GGATCACAAA CCTTGCAATC CAAGGGAGAA GGAGCGAATC 540

CAAAATGCAG GAGGCAGCGT AATGATACAA CGTGTTAATG GTTCATTAGC AGTGTCTCGT 600

GCTCTGGGGG ACTATGATTA CAAGTGTGTT GATGGCAAGG GCCCAACAGA ACAACTTGTT 660

TCTCCAGAGC CTGAGGTTTA TGAAATTTTA AGAGCAGAAG AGGATGAATT TATCATCTTG 720

GCTTGTGATG GGATCTGGGA TGTTATGAGT AATGAGGAGC TCTGTGAATT TGTTAAATCT 780

AGGCTTGAGG TATCTGATGA CCTGGAAAAT GTGTGCAATT GGGTAGTGGA CACTTGTTTA 840

CATAAGGGAA GTCGAGATAA CATGAGTATT GTACTAGTTT GCTTTTCAAA TGCCCCTAAG 900

GTCTCAGATG AAGCAGTGAG AAAAGATTCA GAGTTGGATA AGTACTTGGA ATCACGGGTT 960

GAAGAGATTA TGGAGAAGTC TGGTGAGGAA GGAATGCCGG ATCTTGCCCA CGTCATGCGC 1020

ATCTTGTCTG CAGAAAATAT CCCGAATTTG CCTCCTGGGG GAGGGCTTGC TAGCAAGCGC 1080

AATGTTATTG AAGCTGTTTA TAGTAGGCTG AATCCACATA GAGAAAGTGA TGGGGCCTCC 1140

GATGAAGCAG AGGAAAGTGG ATCACAGGGG AAATTGGTGG AAGCTCTCAG GCAAATGAGA 1200

ATTAATCATA GGGGAAACTA CCGACAACTT CTGGAGGAGA TGCTGACTAG TTACAGGCTA 1260

GCTAAAGTAG AGGGAGAAGA AAGCCCTGCT GAACCAGCTG CCACAGCTAC TACTTCGAAC 1320

AGTGATGCTG GAAGCCCAGT GACAATGCAG GAAAGCCATA CTGAATCAAA AAGTGATCTT 1380

GCTGAATTAG ACAGCTCTAA TGAAGATGCA GGGACAAAGA TGAGTGATGA AAAAATATGA 1440

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++    + +d ++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGIPH--GLED-WSFFAVYDGHAGSRVANYCSTHLLEHI  79

         69****************98555444..4434.***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +++ +         + e++ ++vk+ ++++Fl++de ++++++ ++ +d+sGstav ++i

Q: 80    TNNEDfraagksgsALEPSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMI  139

         ***99********999********************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++++y++n+GdSravL rng+++  ++dHkp +++E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPKHVYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev+++ + +edef+iLa+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le +++++++++ +v+++l++gs+dn+s+++v

Q: 257   FVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLV  293

         ********************************98875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGIPHGLED WSFFAVYDGH AGSRVANYCS THLLEHITNN 60

EDFRAAGKSG SALEPSVENV KNGIRTGFLK IDEYMRNFSD LRNGMDRSGS TAVGVMISPK 120

HVYFINCGDS RAVLYRNGQV CFSTQDHKPC NPREKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVYEILRA EEDEFIILAC DGIWDVMSNE ELCEFVKSRL 240

EVSDDLENVC NWVVDTCLHK GSRDNMSIVL V 271

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

ecb:100053585

;

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013