EPS-EQC-00058
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-EQC-00058
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/PTEN66.06.4E-1815252
StatusUnreviewed
Ensembl ProteinENSECAP00000014788
UniProt AccessionF6WQ37;
Protein Name
Protein Synonyms/Alias
Gene NamePTEN
Gene Synonyms/Alias PTEN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000017012ENSECAP00000014788ENSECAT00000018144
OrganismEquus caballus
Functional Description
Protein Length270
Protein Sequence
(FASTA)
MICAYLLHRG KFLKAQEALD FYGEVRTRDK KGVTIPSQRR YVYYYSYLLK NHLDYRPVAL 60
LFHKMMFETI PMFSGGTCNP QFVVCQLKVK IYSSNSGPTR REDKFMYFEF PQPLPVCGDI 120
KVEFFHKQNK MLKKDKMFHF WVNTFFIPGP EETSEKVENG SLCDQEIDSI CSIERADNDK 180
EYLVLTLTKN DLDKANKDKA NRYFSPNFKV KLYFTKTVEE PSNPEASSST SVTPDVSDNE 240
PDHYRYSDTT DSDPENEPFD EDQHTQITKV 270
Nucleotide Sequence
(FASTA)
ATGATTTGTG CATATTTGTT ACATCGGGGC AAGTTTTTAA AGGCACAGGA GGCCCTAGAT 60
TTCTATGGAG AAGTAAGGAC CAGAGATAAA AAGGGAGTAA CTATTCCCAG TCAGAGGCGC 120
TATGTGTATT ATTATAGCTA CCTGTTAAAG AATCATCTGG ATTATAGACC AGTGGCACTG 180
TTGTTTCACA AGATGATGTT TGAAACTATT CCAATGTTCA GTGGCGGAAC TTGCAATCCT 240
CAGTTTGTGG TCTGCCAGCT AAAGGTGAAG ATATATTCCT CCAATTCAGG ACCCACACGA 300
CGGGAAGACA AGTTCATGTA CTTTGAGTTC CCTCAGCCGT TGCCTGTGTG TGGTGACATC 360
AAAGTAGAGT TCTTCCACAA ACAGAACAAG ATGCTAAAAA AGGACAAAAT GTTTCACTTT 420
TGGGTAAATA CATTCTTTAT ACCAGGACCA GAGGAAACCT CAGAAAAAGT AGAAAATGGA 480
AGTCTATGTG ATCAAGAAAT TGATAGTATT TGCAGTATAG AGCGTGCAGA TAATGACAAA 540
GAATATCTAG TACTCACTTT AACAAAAAAT GATCTCGACA AAGCAAATAA AGACAAGGCC 600
AACCGATACT TTTCTCCAAA TTTTAAGGTG AAGCTGTACT TCACAAAAAC AGTAGAGGAG 660
CCATCAAATC CAGAGGCTAG CAGTTCAACT TCTGTAACAC CAGATGTTAG TGACAATGAA 720
CCTGATCATT ATAGATATTC TGACACCACT GACTCTGATC CAGAGAATGA ACCTTTTGAT 780
GAAGATCAGC ATACACAAAT TACAAAAGTC TGA 813
Domain Profile
S: 121   ivcayllaseisakadealdtfgerrtredkvagvkqPsqrryvsyfsqllkgs  174
         ++cayll++++++ka+eald++ge+rtr++k  gv++Psqrryv+y+s+llk++
Q: 1     MICAYLLHRGKFLKAQEALDFYGEVRTRDKK--GVTIPSQRRYVYYYSYLLKNH  52
         8******************************..******************986
Domain Sequence
(FASTA)
MICAYLLHRG KFLKAQEALD FYGEVRTRDK KGVTIPSQRR YVYYYSYLLK NH 52
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EPS-AIM-00070
EPS-ANC-00070
EPS-BOT-00060
EPS-CAJ-00060
EPS-CAF-00075
EPS-CAP-00056
EPS-CHH-00018
EPS-CII-00031
EPS-DAR-00103
EPS-DIO-00023
EPS-ERE-00015
EPS-FEC-00070
EPS-GAM-00057
EPS-GAG-00064
EPS-GAA-00095
EPS-GOG-00071
EPS-HOS-00056
EPS-ICT-00059
EPS-LAC-00074
EPS-LOA-00054
EPS-MAM-00059
EPS-MEG-00066
EPS-MOD-00058
EPS-MUM-00056
EPS-MYL-00058
EPS-NOL-00066
EPS-ORN-00073
EPS-ORA-00063
EPS-ORC-00054
EPS-ORL-00083
EPS-OTG-00058
EPS-PAT-00053
EPS-PES-00071
EPS-POA-00072
EPS-RAN-00059
EPS-SAH-00057
EPS-SUS-00058
EPS-TAG-00068
EPS-TAR-00092
EPS-TAS-00020
EPS-TEN-00069
EPS-VIP-00021
EPS-XET-00068
EPS-XIM-00102
Gene Ontology
GO:0042995; C:cell projection
GO:0005737; C:cytoplasm
GO:0009898; C:internal side of plasma membrane
GO:0035749; C:myelin sheath adaxonal region
GO:0005634; C:nucleus
GO:0043220; C:Schmidt-Lanterman incisure
GO:0051717; F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438; F:phosphatidylinositol-3-phosphatase activity
GO:0004722; F:protein serine/threonine phosphatase activity
GO:0004725; F:protein tyrosine phosphatase activity
GO:0007092; P:activation of mitotic anaphase-promoting complex activity
GO:0001525; P:angiogenesis
GO:0060070; P:canonical Wnt receptor signaling pathway
GO:0048738; P:cardiac muscle tissue development
GO:0032286; P:central nervous system myelin maintenance
GO:0021955; P:central nervous system neuron axonogenesis
GO:0060997; P:dendritic spine morphogenesis
GO:0021542; P:dentate gyrus development
GO:0043542; P:endothelial cell migration
GO:0048853; P:forebrain morphogenesis
GO:0006917; P:induction of apoptosis
GO:0046855; P:inositol phosphate dephosphorylation
GO:0007611; P:learning or memory
GO:0045475; P:locomotor rhythm
GO:0060291; P:long-term synaptic potentiation
GO:0060179; P:male mating behavior
GO:0042711; P:maternal behavior
GO:0033555; P:multicellular organismal response to stress
GO:0043066; P:negative regulation of apoptotic process
GO:0050771; P:negative regulation of axonogenesis
GO:0090344; P:negative regulation of cell aging
GO:0030336; P:negative regulation of cell migration
GO:0045792; P:negative regulation of cell size
GO:0031658; P:negative regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0061002; P:negative regulation of dendritic spine morphogenesis
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0090394; P:negative regulation of excitatory postsynaptic membrane potential
GO:0051895; P:negative regulation of focal adhesion assembly
GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle
GO:0031642; P:negative regulation of myelination
GO:0046621; P:negative regulation of organ growth
GO:0051898; P:negative regulation of protein kinase B signaling cascade
GO:0090071; P:negative regulation of ribosome biogenesis
GO:2000808; P:negative regulation of synaptic vesicle clustering
GO:0007270; P:neuron-neuron synaptic transmission
GO:0046856; P:phosphatidylinositol dephosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential
GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0097107; P:postsynaptic density assembly
GO:0060134; P:prepulse inhibition
GO:0097105; P:presynaptic membrane assembly
GO:0060736; P:prostate gland growth
GO:0043491; P:protein kinase B signaling cascade
GO:0050821; P:protein stabilization
GO:0002902; P:regulation of B cell apoptotic process
GO:0033032; P:regulation of myeloid cell apoptotic process
GO:0060024; P:rhythmic synaptic transmission
GO:0035176; P:social behavior
GO:0060074; P:synapse maturation
KEGG
InterPros
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR014020; Tensin_phosphatase_C2-dom.
Pfam
PF10409; PTEN_C2; 1.
SMARTs
Prosites
PS51182; C2_TENSIN; 1.
Prints
Created Date20-Feb-2013