EKS-EQC-00282

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00282

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	366.0	1.0E-109	722	986	265

Status

Unreviewed

Ensembl Protein

ENSECAP00000014839

UniProt Accession

F6WNU4;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000017103	ENSECAP00000014839	ENSECAT00000018203

Organism

Equus caballus

Functional Description

Protein Length

1018

Protein Sequence
(FASTA)

MKEFLDKKRY HNDSRFINYC LKFAECNSDR HQFFEFLYNH GIGTLSSPLY VAWAGHLEGQ 60

GNLQHASAVF RRGIQNQAEP SELLQQQYRL FQTRLTKTHL PAQARTSEPL HNDQVLNQMM 120

TSKSNPGNNS ASVSKNQGSE LYGVNSSACD KDSNTEQRVI MISKSGYSVP PSLAANADVQ 180

QVVMYCKEKL IRGDSEFSFE ELRAQKYNQR RKHEQWVNED RHYMKRKEAS AFEEQLLKQK 240

IDELHKQLGR MAENPAAVQE GPEVHLAPVG PSVGSQKELR APALLASSQQ TSENVGETPR 300

QAPPVVPLVS PAVSQSAAPP GPLTAQPVTD AAFAAAGKDA RCVNKNTHEL KPQSGAEIKE 360

GCETHKAVNT SSFHTTPNTS LGTVQATPSR VQPSPTVHTK EALGFIMNMF QAPTLPDISD 420

DKDEWPSLDQ NEDAFEAQFQ KNARSSGAWG VNKIISSLSS AFPVFDDGNK ENYGLPQPKS 480

KPTGARTFGE RSVSGFPSKP KEAPHTEEFL DDSTVWGVRC SRALAPSPKG PGDFTSAAQL 540

ASTPFHKLAG DLVHALEDKE NVVAKQCTRV TLDACEENMV EPLKDRKFSP IQEKSREPAF 600

PTAVSSASLL HLGQAAASSV LTSEAERGLQ ACKLTDSDLA VAEDRPDASA GLQAEQMQTG 660

SLGDVSAPKV TVENPWDDKL ILKLLSGLSK PVSSYPNTFE WQCKLPAIKP KTEFQLGSLL 720

VYVDHLLGEG AFAQVYEVTH GDVNDTKKKQ KFVLKVQKPA NPWEFYIGTQ LMERLEPSVQ 780

HMFIKFYSAH FFQNGSVLVG DLYSYGTLLN AINLYKNTPE KVMPPALVLS FAITMLHMIE 840

QVHSCEIVHG DIKPDNFILG SRQVDSEDDD LFAGLTLIDL GQSIDMKLFP KGTVFTGKCE 900

TSGFQCTEML SNRPWNYQID YFGVAATVYC MLFGTYMKVK NEGGVWKPEG LFRRLPHLDV 960

WNEFFHIMLN IPDCHHLPSL DLLRQKLKNV FQEHYTNKIK TLRNRLIVLL LECKRSRK 1018

Nucleotide Sequence
(FASTA)

ATGAAGGAAT TTTTAGATAA GAAGAGATAC CACAATGACT CAAGATTCAT CAATTATTGT 60

TTGAAATTTG CTGAATGCAA CAGTGACCGT CATCAGTTTT TTGAGTTTCT GTACAACCAT 120

GGGATCGGGA CCCTGTCCTC TCCGCTGTAC GTAGCCTGGG CTGGGCATCT GGAAGGCCAA 180

GGAAATCTAC AGCATGCCAG CGCTGTTTTT CGGAGAGGAA TTCAAAACCA GGCTGAACCT 240

AGCGAGCTGC TGCAACAGCA GTACAGGTTG TTTCAAACAC GCCTCACCAA AACCCATTTG 300

CCGGCTCAAG CTAGAACCTC AGAACCTCTA CATAATGATC AGGTTTTAAA CCAAATGATG 360

ACATCAAAAT CAAATCCAGG AAATAACTCA GCCAGCGTTT CTAAGAATCA GGGTTCAGAA 420

CTTTATGGAG TGAATTCTTC AGCTTGTGAT AAAGACTCAA ATACGGAACA AAGGGTGATC 480

ATGATTTCTA AATCAGGCTA TTCTGTACCG CCGTCTTTGG CAGCCAACGC TGATGTTCAG 540

CAGGTTGTTA TGTATTGCAA AGAGAAGCTT ATTCGTGGAG ATTCAGAATT TTCCTTTGAA 600

GAACTGAGAG CCCAGAAATA TAATCAACGG AGAAAGCATG AACAGTGGGT AAATGAAGAC 660

AGACATTATA TGAAGAGGAA AGAAGCAAGC GCCTTTGAAG AGCAGCTGTT AAAGCAGAAG 720

ATAGACGAAC TGCATAAGCA GCTGGGTCGA ATGGCAGAGA ACCCGGCCGC CGTCCAGGAG 780

GGGCCTGAGG TTCATCTGGC GCCTGTGGGG CCAAGCGTAG GCTCCCAGAA GGAGCTGAGA 840

GCTCCAGCTC TTCTAGCCAG CAGCCAGCAG ACCTCAGAGA ACGTGGGAGA GACACCCAGA 900

CAGGCACCTC CTGTTGTTCC TTTGGTGTCC CCAGCCGTCA GCCAGAGCGC AGCTCCTCCT 960

GGGCCTCTGA CGGCCCAGCC AGTGACAGAC GCCGCGTTTG CAGCAGCAGG AAAAGATGCC 1020

AGATGTGTGA ATAAAAATAC TCACGAACTT AAGCCACAGA GCGGAGCAGA GATCAAAGAA 1080

GGGTGTGAAA CACATAAGGC TGTTAACACA AGTTCGTTTC ACACAACTCC CAACACATCA 1140

CTGGGAACGG TTCAGGCAAC ACCTTCCAGA GTGCAGCCGT CACCCACCGT GCACACGAAG 1200

GAGGCGTTAG GTTTCATCAT GAATATGTTT CAAGCTCCCA CACTTCCTGA TATTTCCGAT 1260

GACAAAGATG AATGGCCATC TCTTGATCAA AATGAAGATG CGTTTGAAGC CCAGTTTCAA 1320

AAAAATGCAA GGTCTTCTGG GGCTTGGGGA GTCAACAAGA TTATCTCTTC TTTGTCATCT 1380

GCTTTTCCTG TGTTTGATGA TGGAAACAAA GAAAATTACG GGTTACCACA GCCTAAGAGT 1440

AAACCCACGG GAGCCAGGAC CTTTGGGGAA CGCTCTGTAA GCGGATTTCC TTCAAAACCG 1500

AAGGAAGCAC CGCACACCGA GGAGTTCTTG GACGACTCGA CCGTCTGGGG CGTCCGCTGC 1560

AGCAGAGCCC TGGCGCCCAG TCCGAAGGGC CCTGGGGACT TCACGTCTGC GGCACAACTG 1620

GCGTCCACCC CCTTCCACAA GCTTGCGGGG GACTTAGTGC ACGCTCTAGA AGATAAAGAA 1680

AATGTGGTAG CCAAACAATG CACCCGTGTG ACTTTGGACG CTTGTGAAGA AAACATGGTG 1740

GAACCCTTAA AAGACAGAAA GTTCAGCCCA ATTCAGGAGA AAAGCCGAGA ACCAGCGTTC 1800

CCCACAGCCG TATCTTCGGC ATCCTTGCTC CATTTGGGCC AGGCTGCTGC AAGCAGTGTG 1860

CTGACCAGCG AGGCGGAGCG GGGCCTGCAG GCCTGTAAAC TCACCGACTC TGACCTTGCC 1920

GTTGCAGAGG ATCGGCCAGA CGCCAGCGCC GGGCTCCAAG CAGAACAGAT GCAGACTGGT 1980

TCACTTGGGG ATGTCAGTGC TCCAAAAGTC ACTGTTGAGA ACCCGTGGGA TGATAAGCTG 2040

ATTCTCAAGC TCTTATCTGG GCTTTCTAAA CCAGTGAGTT CCTATCCAAA TACATTTGAA 2100

TGGCAGTGTA AACTTCCAGC CATCAAGCCC AAGACTGAGT TTCAATTGGG TTCTTTGCTG 2160

GTCTACGTTG ATCACCTTCT TGGAGAAGGG GCTTTTGCCC AAGTCTATGA AGTTACTCAT 2220

GGAGATGTGA ATGATACCAA AAAGAAACAG AAATTTGTTT TAAAGGTCCA GAAGCCCGCC 2280

AATCCCTGGG AGTTCTACAT CGGGACCCAG CTGATGGAGA GACTAGAGCC GAGTGTGCAA 2340

CATATGTTCA TCAAATTCTA TTCTGCCCAC TTTTTCCAGA ATGGCAGTGT ATTGGTGGGA 2400

GATCTCTACA GCTATGGAAC ATTATTAAAT GCCATTAATC TCTATAAAAA TACCCCTGAG 2460

AAAGTGATGC CTCCAGCGCT CGTCCTCTCT TTTGCCATCA CCATGCTCCA CATGATCGAG 2520

CAAGTCCACA GCTGCGAAAT CGTTCACGGA GACATCAAAC CAGACAACTT CATACTTGGA 2580

AGCAGGCAAG TGGACAGCGA AGATGATGAT TTATTCGCTG GCTTGACACT GATTGACCTG 2640

GGTCAGAGTA TAGATATGAA ACTTTTTCCA AAAGGAACTG TATTTACAGG AAAGTGTGAA 2700

ACATCTGGTT TTCAGTGTAC TGAGATGCTG AGCAACAGAC CGTGGAACTA CCAGATTGAT 2760

TACTTTGGAG TTGCTGCAAC AGTGTACTGC ATGCTTTTCG GCACTTACAT GAAAGTGAAA 2820

AATGAAGGAG GAGTCTGGAA GCCCGAAGGT CTTTTTAGAA GGCTCCCTCA TTTGGATGTG 2880

TGGAATGAAT TTTTTCACAT CATGTTGAAT ATACCAGACT GTCATCATCT TCCGTCTTTG 2940

GATTTGTTAA GGCAAAAGCT GAAGAATGTA TTTCAGGAAC ACTATACGAA CAAGATTAAG 3000

ACTCTACGTA ATAGGCTAAT TGTCCTGCTC TTGGAATGCA AGCGTTCTCG AAAATAA 3057

Domain Profile

S: 2     eiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeell  57

         ++++++geGa+a+vy+ +h    d+k++++++lKv+kpan+WefYI +ql+eRl+ ++++

Q: 722   YVDHLLGEGAFAQVYEVTHgdvnDTKKKQKFVLKVQKPANPWEFYIGTQLMERLE-PSVQ  780

         799*******************99******************************9.78**

S: 58    ksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkive  117

         +++i+++sa+ fq++s+lv +++sygtll++in++k++ +kvm+ +lv+++++ +l+++e

Q: 781   HMFIKFYSAHFFQNGSVLVGDLYSYGTLLNAINLYKNTPEKVMPPALVLSFAITMLHMIE  840

         ************************************************************

S: 118   klHeveIiHgDlkPdnfllgnrimdkadkdkeekglkliDfgrsiDmkllpdgtkfkgka  177

         ++H++eI+HgD+kPdnf+lg r  d  d d+  +gl liD+g+siDmkl+p+gt f+gk+

Q: 841   QVHSCEIVHGDIKPDNFILGSRQVDSED-DDLFAGLTLIDLGQSIDMKLFPKGTVFTGKC  899

         **********************999877.8999***************************

S: 178   ktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkke  237

         +t++f+c+eml++++w+Yq+D+fg+aa+++++lfg+y++v++egg wk++  ++rl++ +

Q: 900   ETSGFQCTEMLSNRPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGVWKPEGLFRRLPHLD  959

         ************************************************************

S: 238   lwekiferlLNisdastlpsleelveek  265

         +w+++f+ +LNi+d+++lpsl+ l++ k

Q: 960   VWNEFFHIMLNIPDCHHLPSLDLLRQ-K  986

         ************************95.4

Domain Sequence
(FASTA)

YVDHLLGEGA FAQVYEVTHG DVNDTKKKQK FVLKVQKPAN PWEFYIGTQL MERLEPSVQH 60

MFIKFYSAHF FQNGSVLVGD LYSYGTLLNA INLYKNTPEK VMPPALVLSF AITMLHMIEQ 120

VHSCEIVHGD IKPDNFILGS RQVDSEDDDL FAGLTLIDLG QSIDMKLFPK GTVFTGKCET 180

SGFQCTEMLS NRPWNYQIDY FGVAATVYCM LFGTYMKVKN EGGVWKPEGL FRRLPHLDVW 240

NEFFHIMLNI PDCHHLPSLD LLRQK 265

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000777	; C:condensed chromosome kinetochore
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007063	; P:regulation of sister chromatid cohesion
GO:0071173	; P:spindle assembly checkpoint

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013