EPS-EQC-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-EQC-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	90.7	1.4E-25	46	322	277

Status

Unreviewed

Ensembl Protein

ENSECAP00000015040

UniProt Accession

F6PKV9;

Protein Name

Protein Synonyms/Alias

Gene Name

TAB1

Gene Synonyms/Alias

TAB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000017245	ENSECAP00000015040	ENSECAT00000018433

Organism

Equus caballus

Functional Description

Protein Length

493

Protein Sequence
(FASTA)

EQQPSWTDDL PLCHLSGVGS ASNRTYSADG KGTESHPPED SWLKFRSENN CFLYGVFNGY 60

DGTRVTNFVA QRLSAELLLG QLNAEHTEAD VRRVLVQAFD VVERSFLESI DDALAEKASL 120

QSQLPEGVPQ HQLPPQYQKI LERLKTLERE ISGGAMAVVA VLLNNKLYVA NVGTNRALLC 180

KSTVDGLQVT QLNVDHTTEN EDELFRLSQL GLDAGKIKQV GIICGQESTR RIGDYKVKYG 240

YTDIDLLSSA KSKPIIAEPE IHGAQPLDGV TGFLVLMSEG LYKALEAAHG PGQANQEIAA 300

MIDTEFAKQT SLDSVAQAVV DRVKRIHGDT FASGGERAKF CPRHEDMTLL VRNFGYPLGE 360

LSQPTPTPAP AAGGRVYPVS VPYSSAQSTS KTSVTLSLVM PSQGQLVNGA HSASTLDEAT 420

PTLTNQSPTL TLQSTSTHTQ SSSSSSDGGL FRSRPAHSLP PGEDGRVEPY VDFAEFYRLW 480

SVDHGEQSVM TAP 493

Nucleotide Sequence
(FASTA)

GAGCAGCAGC CGAGCTGGAC AGACGACCTG CCCCTCTGCC ACCTCTCTGG GGTTGGCTCA 60

GCCTCCAACC GCACCTACTC TGCTGACGGC AAGGGCACCG AGAGCCACCC CCCGGAGGAC 120

AGCTGGCTCA AGTTCAGGAG TGAGAACAAC TGCTTCCTGT ACGGGGTCTT CAATGGCTAC 180

GATGGCACCC GGGTGACCAA CTTCGTGGCC CAGCGGCTGT CCGCGGAGCT TCTGCTGGGC 240

CAGCTCAACG CCGAGCACAC CGAGGCCGAC GTGCGACGCG TTCTGGTGCA GGCCTTCGAT 300

GTGGTGGAGA GGAGCTTCCT GGAGTCCATC GATGACGCAT TGGCTGAGAA GGCGAGCCTC 360

CAGTCCCAGC TGCCGGAGGG TGTCCCCCAG CACCAGCTGC CTCCTCAGTA TCAGAAGATC 420

CTCGAAAGAC TCAAGACGCT GGAGAGGGAG ATTTCAGGAG GGGCCATGGC CGTCGTGGCG 480

GTCCTTCTCA ACAACAAGCT CTACGTCGCC AATGTTGGTA CGAACCGCGC CCTTTTATGC 540

AAATCCACGG TGGACGGGCT GCAGGTGACA CAGCTGAACG TGGATCACAC CACGGAGAAC 600

GAGGATGAGC TCTTCCGCCT CTCGCAGCTG GGTCTGGACG CAGGAAAGAT CAAGCAAGTA 660

GGGATCATCT GCGGGCAGGA GAGCACCAGG CGCATCGGGG ATTACAAGGT CAAGTACGGC 720

TACACCGACA TCGACCTGCT CAGCTCTGCC AAGTCCAAGC CGATCATCGC GGAACCTGAA 780

ATCCACGGTG CGCAGCCCCT GGACGGGGTG ACTGGCTTCC TGGTGCTGAT GTCCGAGGGG 840

CTGTACAAGG CCCTGGAGGC AGCCCACGGG CCTGGACAGG CCAACCAGGA GATCGCTGCC 900

ATGATTGACA CTGAGTTCGC CAAGCAGACT TCCCTGGACT CGGTGGCCCA GGCCGTGGTG 960

GACCGGGTGA AGCGTATCCA CGGTGACACC TTTGCCAGCG GCGGGGAGCG GGCCAAGTTC 1020

TGCCCGAGGC ATGAGGACAT GACCCTGTTG GTGAGGAACT TTGGCTACCC ACTGGGCGAG 1080

CTGAGCCAGC CCACGCCGAC CCCAGCCCCA GCCGCAGGAG GACGCGTGTA CCCTGTGTCC 1140

GTGCCTTACT CCAGCGCCCA GAGCACCAGC AAGACCAGCG TGACCCTGTC CCTCGTCATG 1200

CCCTCCCAGG GCCAGCTGGT CAACGGGGCC CACAGCGCTT CCACCCTGGA CGAAGCCACT 1260

CCCACCCTCA CCAACCAGAG CCCGACCCTG ACCCTGCAGT CCACCAGCAC GCACACCCAG 1320

AGCAGCAGCT CCAGCTCGGA CGGGGGCCTC TTCCGCTCGC GGCCTGCCCA CTCGCTCCCG 1380

CCCGGCGAGG ACGGCCGCGT CGAGCCCTAC GTGGACTTTG CTGAGTTTTA CCGCCTCTGG 1440

AGTGTGGACC ATGGCGAGCA GAGTGTGATG ACGGCACCGT AG 1482

Domain Profile

S: 29    pekkdrlaffgvyDGhggsevakfcseklheilaeelesseseerkvkkalakaFlstde  88

         +++++   ++gv++G  g++v++f++++l+  l     + e +e++v+++l +aF  +++

Q: 46    RSENN-CFLYGVFNGYDGTRVTNFVAQRLSAELLLGQLNAEHTEADVRRVLVQAFDVVER  104

         44444.589********************976665555599*******************

S: 89    el................................kvleeksldidk..sGstavvalikd  114

          +                                k+le+ ++ +++   G+ avva++ +

Q: 105   SFlesiddalaekaslqsqlpegvpqhqlppqyqKILERLKTLEREisGGAMAVVAVLLN  164

         *******************************99966666666666676999*********

S: 115   sklyvanvGdSravLcrng.k...avelssdHkpsredEleRieeag...gsvilkdgaR  167

         +klyvanvG  ra+Lc++  +   + +l +dH++++edEl R+++ g   g++ +

Q: 165   NKLYVANVGTNRALLCKSTvDglqVTQLNVDHTTENEDELFRLSQLGldaGKIKQVG--I  222

         ****************9663366699*********************9777777665..6

S: 168   vlGvLavsRalGdlylk..............pyvtpePevtshrl.tsedefliLasDGl  212

         ++G  + +R +Gd+++k              + +++ePe++  +  +  + fl+L s Gl

Q: 223   ICG-QESTRRIGDYKVKygytdidllssaksKPIIAEPEIHGAQPlDGVTGFLVLMSEGL  281

         677.69***********************9989*******98765155555*********

S: 213   wdvvs........neeavslvrdvlekkeaeqeaakkLvkl  245

         ++ ++        n+e+ +++     k+++++++a+ +v++

Q: 282   YKALEaahgpgqaNQEIAAMIDTEFAKQTSLDSVAQAVVDR  322

         **986333333336666666665555777777777777765

Domain Sequence
(FASTA)

RSENNCFLYG VFNGYDGTRV TNFVAQRLSA ELLLGQLNAE HTEADVRRVL VQAFDVVERS 60

FLESIDDALA EKASLQSQLP EGVPQHQLPP QYQKILERLK TLEREISGGA MAVVAVLLNN 120

KLYVANVGTN RALLCKSTVD GLQVTQLNVD HTTENEDELF RLSQLGLDAG KIKQVGIICG 180

QESTRRIGDY KVKYGYTDID LLSSAKSKPI IAEPEIHGAQ PLDGVTGFLV LMSEGLYKAL 240

EAAHGPGQAN QEIAAMIDTE FAKQTSLDSV AQAVVDR 277

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0003824	; F:catalytic activity
GO:0019209	; F:kinase activator activity
GO:0000185	; P:activation of MAPKKK activity
GO:0003007	; P:heart morphogenesis
GO:0001701	; P:in utero embryonic development
GO:0030324	; P:lung development
GO:0008152	; P:metabolic process
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR001932	; PP2C-like.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

Prints

Created Date

20-Feb-2013