EKS-EQC-00451

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00451

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	416.2	6.8E-125	64	359	296

Status

Unreviewed

Ensembl Protein

ENSECAP00000015489

UniProt Accession

F6R294;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000017280	ENSECAP00000015489	ENSECAT00000018953

Organism

Equus caballus

Functional Description

Protein Length

464

Protein Sequence
(FASTA)

MSLHLLYYCS EPTFDVKIAF CQGFHKQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV 60

LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH 120

KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL 180

HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY 240

KENVDIWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN 300

RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN 360

VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA 420

VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCR 464

Nucleotide Sequence
(FASTA)

ATGAGCCTCC ATTTATTGTA CTACTGCAGT GAACCAACCT TCGATGTGAA AATTGCCTTT 60

TGTCAGGGAT TCCATAAACA AGTGGATGTG TCATATATTG CCAAACATTA CAACATGAGC 120

AAAAGCAAAG TTGACAACCA GTTCTACAGC GTGGAAGTGG GAGACTCAAC CTTCACCGTT 180

CTCAAGCGCT ACCAGAATCT AAAGCCTATT GGCTCTGGCG CTCAGGGAAT AGTTTGTGCT 240

GCGTATGATG CTGTTCTGGA CAGAAATGTG GCCATTAAGA AGCTCAGCAG ACCCTTTCAG 300

AACCAAACAC ATGCCAAGAG AGCTTACCGG GAGCTGGTCC TCATGAAGTG TGTGAATCAT 360

AAAAATATTA TTAGTTTATT AAATGTCTTC ACACCCCAGA AAACACTGGA GGAGTTCCAG 420

GATGTTTACT TAGTAATGGA ACTGATGGAC GCTAACTTGT GTCAGGTGAT TCAGATGGAA 480

TTAGACCATG AGCGAATGTC TTACCTGCTA TACCAAATGT TGTGTGGCAT CAAGCACCTC 540

CACTCTGCTG GCATTATTCA CAGGGATTTA AAACCAAGTA ACATTGTAGT GAAGTCTGAT 600

TGTACATTGA AAATCCTCGA CTTTGGACTG GCCAGGACGG CAGGCACCAG CTTCATGATG 660

ACTCCTTATG TGGTGACCCG TTATTACAGA GCCCCCGAGG TCATCCTGGG GATGGGTTAC 720

AAGGAGAATG TGGATATATG GTCTGTGGGA TGCATTATGG GAGAAATGGT TCGCCACAAA 780

ATCCTCTTTC CAGGAAGGGA CTATATTGAC CAGTGGAACA AGGTAATTGA ACAACTAGGA 840

ACACCCTGTC CGGAATTCAT GAAGAAATTG CAACCCACAG TACGAAACTA TGTGGAGAAT 900

CGGCCCAAGT ATGCAGGACT CACCTTCCCC AAGCTCTTTC CAGATTCCCT CTTCCCAGCG 960

GACTCCGAGC ACAATAAACT CAAAGCCAGC CAAGCCAGGG ACTTGTTGTC AAAGATGCTA 1020

GTGATTGACC CAGCAAAAAG GATATCTGTG GACGACGCCT TACAGCATCC ATACATCAAT 1080

GTGTGGTACG ACCCTGCCGA AGTGGAGGCG CCTCCACCTC AGATATATGA CAAACAGTTG 1140

GATGAAAGAG AACACACCAT TGAAGAATGG AAAGAACTTA TCTACAAGGA AGTAATGAAT 1200

TCAGAAGAGA AGACTAAAAA TGGTGTTGTA AAAGGACAAC CTTCTCCTTC AGGTGCAGCA 1260

GTGAACAGCA GTGAGAGTCT CCCTCCGTCC TCATCCGTCA ATGACATCTC CTCCATGTCC 1320

ACCGACCAGA CCCTGGCATC TGACACTGAC AGCAGCCTGG AAGCCTCAGC GGGACCCCTG 1380

GGTTGTTGCA GGTGA 1395

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 64    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  123

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 124   ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  182

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 183   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  239

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 240   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  298

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv++aL+hpY

Q: 299   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDDALQHPY  358

         *****************************99*****************************

S: 289   l  289

Q: 359   I  359

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KTLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDDA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

ecb:100052608

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013