EKS-EQC-00063

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00063

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	375.3	2.0E-112	91	383	293

Status

Unreviewed

Ensembl Protein

ENSECAP00000014957

UniProt Accession

F7AHY3;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK13

Gene Synonyms/Alias

CDK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000017341	ENSECAP00000014957	ENSECAT00000018342

Organism

Equus caballus

Functional Description

Protein Length

838

Protein Sequence
(FASTA)

MLPEDKDTDS LRGNISVKAV KKEVEKKLRC LLADLPLPPE LPGGDDLSKS PEEKKTATQL 60

HSKRRPKICG PRYGEIKEKD IDWGKRCVDK FDIIGIIGEG TYGQVYKARD KDTGEMVALK 120

KVRLDNEKEG FPITAIREIK ILRQLTHQSI INMKEIVTDK EDALDFKKDK GAFYLVFEYM 180

DHDLMGLLES GLVHFNENHI KSFMRQLMEG LDYCHKKNFL HRDIKCSNIL LNNRGQIKLA 240

DFGLARLYSS EESRPYTNKV ITLWYRPPEL LLGEERYTPA IDVWSCGCIL GELFTKKPIF 300

QANQELAQLE LISRICGSPC PAVWPDVIKL PYFNTMKPKK QYRRKLREEF VFIPAAALDL 360

FDYMLALDPS KRCTAEQALQ CEFLRDVEPS KMPPPDLPLW QDCHELWSKK RRRQKQMGMT 420

DDVSTIKAPR KDLSLGLDDS RTSTPQGVLP SSQLKSQGNS NVAPGEKQTD PSTPQQESSK 480

PLGGIQPSSQ SIQPKVETDA TQAAVQSAFA VLLTQLIKAQ QSKQKDVLLE ERENGSGHEA 540

SLQLRPPPEP STPVSGQDDL IQHQDMRILE LTPEPDRPRI LPPDQRPPEP PEPPPVTEED 600

LDYRTENQHV PTTGSSLTDP HAGVKAALLQ LLAQHQPQDD PKREGGIDYQ VGDTYVPTSD 660

YKDNFGSSSF SSAPYVSSDG LGGSSAPPLE RRSFIGNSDI QSLDNYSTTS SHSGGPPQPS 720

AFSESFPSSV AGYGDIYLNT GPMLFSGDKD HRFEYSHGPI AVLANSSDPS TGPESTHPLP 780

AKMHNYNYGG NLQENPGGPG LMHGQTWTSP AQGPGYSQGY RGHISTSTGR GRGRGLPY 838

Nucleotide Sequence
(FASTA)

ATGCTGCCTG AAGATAAAGA TACTGATAGC TTACGAGGAA ATATTTCAGT AAAAGCGGTT 60

AAAAAAGAAG TAGAAAAGAA ACTACGATGT CTACTTGCTG ATTTACCACT GCCCCCTGAG 120

CTACCAGGAG GGGATGATCT CTCCAAGAGT CCAGAGGAAA AGAAAACAGC AACACAGTTA 180

CATAGTAAAA GGAGACCTAA AATATGTGGG CCTCGCTATG GTGAAATCAA AGAAAAAGAT 240

ATTGACTGGG GAAAACGCTG CGTGGATAAA TTTGATATCA TCGGAATTAT CGGAGAAGGT 300

ACCTATGGAC AAGTTTACAA AGCCAGGGAT AAAGACACTG GAGAGATGGT AGCCTTAAAA 360

AAAGTACGTC TAGATAATGA AAAGGAAGGC TTTCCGATTA CAGCAATTCG AGAAATTAAA 420

ATTCTCCGGC AGCTTACCCA TCAGAGTATT ATCAATATGA AGGAAATAGT GACCGATAAA 480

GAAGATGCTC TGGATTTTAA GAAGGATAAA GGTGCATTTT ATCTGGTGTT TGAATACATG 540

GACCATGATC TGATGGGACT ACTGGAATCA GGCTTGGTTC ATTTTAATGA AAATCACATA 600

AAGTCATTTA TGAGACAGCT CATGGAAGGT CTAGATTATT GTCATAAGAA GAACTTTTTG 660

CATAGAGATA TTAAATGTTC AAATATTCTT CTAAATAATA GAGGGCAGAT AAAACTCGCT 720

GATTTTGGAC TTGCTCGATT ATATAGCTCA GAAGAAAGTC GGCCATATAC TAACAAGGTC 780

ATCACTTTAT GGTACCGTCC ACCTGAACTG CTGTTGGGAG AAGAACGATA TACGCCAGCT 840

ATTGACGTAT GGAGCTGTGG ATGTATCCTT GGTGAACTCT TCACTAAAAA ACCGATATTT 900

CAAGCAAATC AGGAACTTGC ACAACTAGAA TTAATAAGCC GTATATGTGG GAGTCCATGT 960

CCTGCAGTCT GGCCCGATGT AATCAAACTA CCCTATTTCA ACACCATGAA ACCAAAGAAG 1020

CAATACCGTC GAAAGTTAAG AGAAGAATTT GTTTTTATCC CTGCAGCCGC ACTAGACTTG 1080

TTTGATTACA TGCTCGCCTT GGATCCTAGT AAGCGCTGCA CTGCAGAACA GGCTCTTCAA 1140

TGTGAGTTCC TACGAGACGT GGAACCTTCA AAAATGCCTC CGCCAGACCT TCCTTTATGG 1200

CAAGATTGTC ATGAGTTATG GAGTAAAAAA CGAAGAAGAC AGAAGCAGAT GGGCATGACT 1260

GATGATGTTT CCACAATTAA AGCCCCCAGA AAGGACTTGT CTCTGGGCTT GGATGACAGC 1320

AGAACCAGTA CCCCTCAGGG TGTGCTGCCG TCTTCACAAC TGAAATCTCA GGGCAACTCG 1380

AATGTAGCAC CTGGTGAAAA ACAGACAGAT CCATCAACAC CACAGCAGGA GTCTTCGAAA 1440

CCATTGGGAG GAATTCAGCC TTCTTCTCAG AGCATCCAGC CTAAAGTGGA GACTGATGCT 1500

ACCCAGGCTG CTGTGCAGAG CGCATTTGCG GTTCTGTTGA CTCAGTTAAT AAAGGCTCAG 1560

CAGTCGAAGC AGAAAGACGT GCTACTAGAA GAGAGGGAGA ATGGATCGGG ACATGAAGCG 1620

TCGTTACAAC TCAGGCCACC TCCAGAACCT AGCACTCCGG TCTCGGGGCA AGATGACCTC 1680

ATCCAACACC AAGATATGAG GATATTGGAG CTCACACCAG AACCAGACCG GCCTCGCATT 1740

CTGCCTCCTG ATCAGCGACC TCCTGAACCA CCTGAACCAC CACCAGTCAC TGAGGAAGAT 1800

CTGGATTATC GGACAGAAAA CCAGCACGTC CCCACCACTG GTTCTTCCTT AACTGACCCT 1860

CATGCCGGAG TGAAAGCAGC GCTGTTACAG CTTCTTGCTC AGCATCAGCC CCAGGATGAT 1920

CCCAAAAGAG AAGGTGGTAT TGACTACCAA GTAGGAGACA CTTACGTACC CACTTCAGAC 1980

TACAAGGACA ACTTTGGATC TTCTTCCTTC TCCTCTGCTC CTTATGTTAG CAGTGATGGT 2040

CTAGGGGGTA GCTCTGCTCC ACCACTGGAA CGACGTAGCT TCATCGGGAA CTCTGATATT 2100

CAGTCTTTGG ACAACTACAG TACTACTTCA TCTCATTCTG GTGGGCCACC TCAGCCTTCT 2160

GCCTTTTCGG AGTCATTTCC TAGTTCAGTA GCTGGATATG GAGACATTTA CCTCAATACT 2220

GGTCCCATGT TGTTTAGTGG AGACAAGGAC CATAGATTTG AATATAGCCA TGGCCCCATT 2280

GCAGTCCTGG CAAACAGCAG TGACCCTTCC ACAGGGCCCG AGAGTACTCA TCCTTTGCCA 2340

GCAAAGATGC ACAACTATAA CTATGGTGGT AACTTACAGG AAAACCCAGG CGGCCCTGGC 2400

CTCATGCATG GACAGACCTG GACTTCTCCT GCTCAAGGAC CTGGATATTC ACAAGGATAC 2460

AGGGGACACA TTAGCACATC AACTGGCAGA GGTCGAGGCA GAGGGTTACC ATACTGA 2517

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vyka+dk+tge+vAlKk+rl++ekeg+pita+rEi++l++l+h+ i

Q: 91    FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSI  150

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         ++++e+v+         kdk  +yLvfe++++dL+ ll++    +++++++ks+++ql+e

Q: 151   INMKEIVTdkedaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFNENHIKSFMRQLME  209

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar +ss+++  yt++v+TlwYr+Pe

Q: 210   GLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESrPYTNKVITLWYRPPE  269

         ***************************************7665527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq+++e  qle i++++g+p  +vwp+v k

Q: 270   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIK  329

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhky  283

         lp +++  pkk+++ kl+e++  +  +aldl++ +laldp+kR++a++alq ++

Q: 330   LPYFNTMKPKKQYRrKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEF  383

         *****7777777777******999999************************988

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKARD KDTGEMVALK KVRLDNEKEG FPITAIREIK ILRQLTHQSI 60

INMKEIVTDK EDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFNENHI KSFMRQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNRGQIKLA DFGLARLYSS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANQELAQLE LISRICGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRKLREEF VFIPAAALDL FDYMLALDPS KRCTAEQALQ CEF 293

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0019908	; C:nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0016607	; C:nuclear speck
GO:0005524	; F:ATP binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0000380	; P:alternative mRNA splicing, via spliceosome
GO:0030097	; P:hemopoiesis
GO:0070816	; P:phosphorylation of RNA polymerase II C-terminal domain

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013