EKS-EQC-00455

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00455

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	389.7	7.9E-117	1	274	274

Status

Unreviewed

Ensembl Protein

ENSECAP00000015310

UniProt Accession

F6QEZ0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK12

Gene Synonyms/Alias

MAPK12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000017373	ENSECAP00000015284	ENSECAT00000018721
ENSECAG00000017373	ENSECAP00000015310	ENSECAT00000018750

Organism

Equus caballus

Functional Description

Protein Length

330

Protein Sequence
(FASTA)

GAYGAVCSAV DSRTGAKVAI KKLYRPFQSE LFAKRAYREL RLLKHMRHEN VIGLLDVFTP 60

DETLDDFTDF YVMPFMGTDL GKLMKHEKLS EDRIQFVYQM LKGLEYPMPA GVIHRDLKPG 120

NLAVNEDCEL KILDFGLARQ ADSEMTGYVV TRWYRAPEVI LNWMHYTQTV DIWSVGCIMA 180

EMITGKTLFK GNDHLDQLKE IMKVTGTPPA DFVQRLQSVE AKNYMKGLPE LEKKDFASIL 240

TNASPLAVSL LERMLVLDAE RRVTAAEALA HPYFESLQDA EDEPRAQKYD ESFDDVDRTL 300

DEWKRVTYKE VLSFKPPRQL GAKVSKETAL 330

Nucleotide Sequence
(FASTA)

GGGGCCTACG GCGCCGTGTG CTCGGCCGTG GACAGCCGCA CAGGCGCCAA GGTGGCCATC 60

AAGAAGCTGT ACCGGCCCTT CCAGTCCGAG TTGTTCGCCA AGCGCGCCTA CCGCGAGCTG 120

CGCCTCCTTA AGCACATGCG CCACGAGAAC GTGATTGGGC TGCTGGATGT GTTCACTCCT 180

GACGAGACCC TGGATGACTT CACAGATTTC TATGTGATGC CGTTCATGGG CACTGACCTG 240

GGCAAGCTCA TGAAGCATGA GAAGCTGAGT GAGGACCGGA TCCAGTTTGT CTACCAGATG 300

TTGAAGGGAC TGGAATATCC AATGCCTGCT GGTGTCATCC ACAGGGACCT GAAGCCTGGC 360

AACCTGGCGG TGAACGAGGA CTGTGAGCTG AAGATCCTGG ACTTCGGCCT GGCCAGGCAG 420

GCAGATAGTG AGATGACCGG ATACGTGGTG ACCCGGTGGT ACCGGGCGCC TGAGGTCATA 480

TTGAATTGGA TGCACTACAC ACAGACGGTG GACATCTGGT CAGTGGGCTG CATCATGGCA 540

GAGATGATCA CGGGGAAGAC GTTATTCAAG GGCAACGACC ACCTGGACCA GCTGAAGGAG 600

ATCATGAAGG TGACAGGGAC GCCTCCCGCA GACTTTGTGC AGAGGCTGCA GAGCGTAGAA 660

GCGAAGAACT ACATGAAGGG CCTCCCCGAG CTGGAGAAGA AGGATTTTGC CTCAATCTTG 720

ACCAATGCAA GCCCTCTGGC CGTGAGCCTG CTGGAGAGAA TGCTGGTGCT CGATGCAGAG 780

CGGCGGGTGA CAGCGGCCGA GGCACTGGCC CACCCCTACT TCGAGTCACT GCAGGACGCG 840

GAGGATGAAC CCAGGGCCCA GAAGTACGAC GAGTCCTTTG ATGACGTGGA CCGCACGCTG 900

GATGAGTGGA AGCGTGTCAC GTATAAAGAG GTGCTCAGCT TCAAGCCTCC CCGGCAGCTG 960

GGAGCCAAGG TCTCCAAGGA GACAGCCCTG TGA 993

Domain Profile

S: 10    GaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiiklldvftp  69

         Gayg v+savd+rt+ +vaikkl rpfq+e  akr++REl+llk+++heN+i lldvftp

Q: 1     GAYGAVCSAVDSRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTP  60

         8***********************************************************

S: 70    eeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHsanviHrDlK  129

         +e+l++++d+Y v+ +m+tdL k++k++kls+++i+ ++yq+l+gl+y   a+viHrDlK

Q: 61    DETLDDFTDFY-VMPFMGTDLGKLMKHEKLSEDRIQ-FVYQMLKGLEYPMPAGVIHRDLK  118

         **********9.689********************9.68*********************

S: 130   PsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeytkavDiWs  189

         P+Nl+vnedcelkildFGlar+ad+e    +t+yv+trwYraPe++l++++yt++vDiWs

Q: 119   PGNLAVNEDCELKILDFGLARQADSE----MTGYVVTRWYRAPEVILNWMHYTQTVDIWS  174

         *************************9....******************************

S: 190   vGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyikslpkkkkk  249

         vGCI+aE++tgk+lf+g+d++dql++i++v+gtp ++f+++++s ea+ny+k lp+ +kk

Q: 175   VGCIMAEMITGKTLFKGNDHLDQLKEIMKVTGTPPADFVQRLQSVEAKNYMKGLPELEKK  234

         ************************************************************

S: 250   dfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         df++++++as+ a+ Lle++Lvld+++R++++eaL+hpY+

Q: 235   DFASILTNASPLAVSLLERMLVLDAERRVTAAEALAHPYF  274

         ***************************************6

Domain Sequence
(FASTA)

GAYGAVCSAV DSRTGAKVAI KKLYRPFQSE LFAKRAYREL RLLKHMRHEN VIGLLDVFTP 60

DETLDDFTDF YVMPFMGTDL GKLMKHEKLS EDRIQFVYQM LKGLEYPMPA GVIHRDLKPG 120

NLAVNEDCEL KILDFGLARQ ADSEMTGYVV TRWYRAPEVI LNWMHYTQTV DIWSVGCIMA 180

EMITGKTLFK GNDHLDQLKE IMKVTGTPPA DFVQRLQSVE AKNYMKGLPE LEKKDFASIL 240

TNASPLAVSL LERMLVLDAE RRVTAAEALA HPYF 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade
GO:0045445	; P:myoblast differentiation
GO:0018105	; P:peptidyl-serine phosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013