EKS-EQC-00173
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00173
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC428.89.4E-129213471259
StatusUnreviewed
Ensembl ProteinENSECAP00000016037
UniProt AccessionF7AMF7;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCB
Gene Synonyms/Alias PRKCB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000017393ENSECAP00000016037ENSECAT00000019586
ENSECAG00000017393ENSECAP00000016080ENSECAT00000019634
OrganismEquus caballus
Functional Description
Protein Length542
Protein Sequence
(FASTA)
MKCDTCMMNV HKRCVMNVPS LCGTDHTERR ARIYIQAHIE REVLIVVVRD AKNLVPMDPN 60
GLSDPYVKLK LIPDPKSESK QKTKTIKCSL NPEWNETFRF QLKESDKDRR LSVEIWDWDL 120
TSRNDFMGSL SFGISELQKA GVDGWFKLLS QEEGEYFNVP VPPEGGEGSE ELRQKFERAK 180
ISQGTKTPEE KTTNTISKFD NNGNRDRMKL TDFNFLMVLG KGSFGKVMLS ERKGTDELYA 240
VKILKKDVVI QDDDVECTMV EKRVLALPGK PPFLTQLHSC FQTMDRSYFL PKFATLSDLQ 300
LSLTQVAVSK ESHALFYAAE IAIGLFFLQS KGIIYRDLKL DNVMLDSEGH IKIADFGMCK 360
ENIWDGVTTK TFCGTPDYIA PEIIAYQPYG KSVDWWAFGV LLYEMLAGQA PFEGEDEDEL 420
FQSIMEHNVA YPKSMSKEAV AICKGLMTKH PGKRLGCGPE GERDIKEHAF FRYIDWEKLE 480
RKEIQPPYKP KARDRRDTSN FDKEFTRQPV ELTPTDKLFI MNLDQNEFAG FSYTNPEFVI 540
NV 542
Nucleotide Sequence
(FASTA)
ATGAAATGTG ACACCTGCAT GATGAACGTC CACAAGCGCT GCGTGATGAA CGTCCCCAGC 60
CTCTGCGGCA CGGACCACAC GGAGCGCCGC GCCCGCATCT ACATCCAGGC CCACATCGAG 120
AGGGAAGTCC TCATCGTTGT CGTAAGAGAT GCTAAAAACC TTGTACCTAT GGATCCCAAT 180
GGCTTGTCAG ATCCTTACGT GAAACTGAAA CTGATTCCTG ACCCCAAAAG TGAGAGCAAG 240
CAGAAGACCA AAACCATCAA GTGCTCCCTC AACCCTGAGT GGAATGAGAC GTTTAGATTC 300
CAGCTGAAAG AATCGGACAA AGACAGGAGA CTGTCTGTAG AGATTTGGGA TTGGGATCTG 360
ACCAGCAGGA ATGACTTCAT GGGATCTTTG TCGTTTGGGA TTTCTGAATT GCAGAAAGCT 420
GGTGTTGATG GCTGGTTTAA GTTACTGAGC CAGGAGGAAG GCGAGTACTT CAACGTGCCT 480
GTGCCGCCGG AAGGAGGCGA GGGCAGTGAA GAGCTGCGGC AGAAGTTCGA GAGGGCCAAG 540
ATCAGTCAGG GGACTAAGAC TCCAGAAGAA AAGACGACCA ACACCATATC CAAATTTGAC 600
AACAATGGGA ACAGGGACCG GATGAAGCTG ACCGATTTTA ACTTCCTGAT GGTGCTGGGG 660
AAAGGCAGCT TTGGCAAGGT CATGCTCTCA GAGCGAAAGG GCACAGATGA GCTCTATGCT 720
GTGAAGATCC TCAAGAAGGA TGTGGTGATC CAAGATGACG ATGTGGAATG CACGATGGTG 780
GAGAAGCGGG TGCTGGCCCT GCCCGGGAAG CCGCCGTTCC TGACCCAGCT GCACTCCTGC 840
TTTCAGACCA TGGACAGAAG TTACTTCCTC CCCAAATTTG CTACCCTTTC TGATCTTCAA 900
CTGTCCTTGA CCCAAGTGGC AGTCTCTAAG GAGAGTCACG CACTATTTTA CGCTGCAGAA 960
ATTGCCATCG GTCTGTTCTT CTTACAGAGC AAGGGCATCA TTTACCGTGA CCTAAAACTT 1020
GATAACGTGA TGCTAGATTC GGAGGGCCAC ATCAAGATCG CTGATTTTGG CATGTGTAAG 1080
GAAAACATCT GGGACGGAGT GACGACCAAG ACATTCTGTG GCACTCCAGA CTATATCGCC 1140
CCTGAGATAA TTGCTTATCA GCCCTATGGG AAGTCCGTGG ATTGGTGGGC ATTCGGAGTC 1200
TTGCTGTATG AAATGTTGGC TGGGCAGGCT CCCTTTGAAG GGGAGGATGA GGATGAACTC 1260
TTCCAGTCCA TCATGGAACA CAATGTGGCT TATCCGAAGT CCATGTCCAA GGAGGCTGTG 1320
GCCATCTGCA AAGGGCTGAT GACCAAACAC CCAGGCAAGC GTCTGGGTTG TGGACCTGAA 1380
GGCGAACGTG ACATCAAAGA GCATGCATTC TTCCGGTATA TTGACTGGGA GAAACTTGAA 1440
CGCAAAGAGA TTCAGCCCCC GTATAAGCCA AAAGCCAGAG ACAGGCGAGA CACCTCCAAC 1500
TTCGACAAAG AGTTCACCAG ACAGCCTGTG GAACTCACGC CTACGGATAA GCTCTTCATC 1560
ATGAACTTGG ACCAAAACGA ATTTGCTGGC TTCTCCTATA CTAACCCAGA GTTTGTCATT 1620
AATGTGTAG 1629
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+l+e+k+tdelya+k+lkkdvv+qdddve+t+vekrvlal  k+p
Q: 213   FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP  272
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt+dr +f  ++ +  dl   + ++   ke++a fyaaei+++l+fl++kg
Q: 273   FLTQLHSCFQTMDRSYFLPKFATLSDLQLSLTQVAVSKESHALFYAAEIAIGLFFLQSKG  332
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke+i++g tt+tfcGtPdyiaPei+++++ygks
Q: 333   IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS  392
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pfegededelf+si+e++v+yPks+skeav+i+kgl+tk+p 
Q: 393   VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG  452
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+dikehaff
Q: 453   KRLGCGPEGERDIKEHAFF  471
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLSER KGTDELYAVK ILKKDVVIQD DDVECTMVEK RVLALPGKPP 60
FLTQLHSCFQ TMDRSYFLPK FATLSDLQLS LTQVAVSKES HALFYAAEIA IGLFFLQSKG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEN IWDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAFGVLL YEMLAGQAPF EGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPG 240
KRLGCGPEGE RDIKEHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>
EKS-BOT-00168
EKS-CAJ-00172
EKS-CAF-00175
EKS-CAP-00168
EKS-FEC-00158
EKS-GAG-00144
EKS-GOG-00171
EKS-HOS-00174
EKS-ICT-00163
EKS-LOA-00167
EKS-MAM-00166
EKS-MUM-00173
EKS-MUP-00172
EKS-NOL-00161
EKS-OCP-00107
EKS-ORC-00156
EKS-OTG-00174
EKS-PAT-00159
EKS-POA-00165
EKS-RAN-00164
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005246; F:calcium channel regulator activity
GO:0003682; F:chromatin binding
GO:0035403; F:histone kinase activity (H3-T6 specific)
GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0046872; F:metal ion binding
GO:0004697; F:protein kinase C activity
GO:0042113; P:B cell activation
GO:0050853; P:B cell receptor signaling pathway
GO:0006816; P:calcium ion transport
GO:0006874; P:cellular calcium ion homeostasis
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0035556; P:intracellular signal transduction
GO:0010829; P:negative regulation of glucose transport
GO:0045766; P:positive regulation of angiogenesis
GO:0050861; P:positive regulation of B cell receptor signaling pathway
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00360; C2DOMAIN.
Created Date20-Feb-2013