EKS-EQC-00325
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00325
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20281.47.9E-84359569211
StatusUnreviewed
Ensembl ProteinENSECAP00000014993
UniProt AccessionF6ZWD5;
Protein Name
Protein Synonyms/Alias
Gene NamePAK4
Gene Synonyms/Alias PAK4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000017421ENSECAP00000014993ENSECAT00000018379
OrganismEquus caballus
Functional Description
Protein Length588
Protein Sequence
(FASTA)
MFGKKKKRVE ISAPSNFEHR VHTGFDQHEQ KFTGLPRQWQ SLIEESARRP KPLVDPGCIT 60
SIQPGAPKTI VRGSKGAKDG ALTLLLDEFE NMSVTRSNSL RRDSPPPPTR ARQQNGMPVE 120
QATTAGGGPE RAGHGRVAGR SEGGGGSGDR RRAGPEKRPK SSREGSGAPQ ESSRDKRPLS 180
GPDVSAPQPA GLASGAKVAA GRPFNTYPRA DTDHPSRGTQ VTHPPAPGAP IPLSVSILTP 240
SGSGPRPILS LASSPSPGLF PNCPPKPAPS GPFSERPQPA SPEQPHPRLP SWAPPIPHTQ 300
ACPAPSLTLG PGPCPLSCPA SGLALGGLSG GPCSGLVRSQ DERCVHRGGG TQHASLRPQV 360
ASEVVIMRDY QHENVVEMYN SYLVGDELWV VMEFLEGGAL TDIVTHTRMN EEQIAAVCLA 420
VLQALSVLHA QGVIHRDIKS DSILLTHDGR VKLSDFGFCA QVSKEVPRRK SLVGTPYWMA 480
PELISRLPYG PEVDIWSLGV MVIEMVDGEP PYFNEPPLKA MKMIRDNLPP RLKNLHKVSP 540
SLKGFLDRLL VRDPAQRATA AELLKHPFLA KAGPPASIVP LMRQNRTR 588
Nucleotide Sequence
(FASTA)
ATGTTTGGGA AGAAGAAGAA GCGGGTGGAG ATCTCGGCGC CGTCCAACTT CGAGCACCGC 60
GTGCACACGG GCTTCGACCA GCACGAGCAG AAGTTCACGG GGCTGCCCCG CCAGTGGCAG 120
AGCCTCATCG AGGAGTCGGC CCGCCGGCCC AAGCCCCTCG TCGACCCTGG CTGCATCACC 180
TCCATCCAGC CCGGGGCCCC CAAGACCATC GTGCGGGGCA GCAAAGGCGC CAAGGATGGG 240
GCCCTCACCC TGCTGCTTGA TGAGTTCGAG AACATGTCGG TGACCCGCTC CAACTCCCTG 300
CGGAGAGACA GCCCGCCGCC GCCCACCCGG GCCCGCCAGC AGAACGGGAT GCCCGTGGAG 360
CAGGCCACCA CAGCCGGAGG GGGCCCGGAG AGAGCGGGCC ACGGCCGGGT GGCTGGGCGC 420
AGCGAGGGGG GTGGCGGCAG TGGCGACAGG CGGCGGGCGG GGCCGGAGAA GAGGCCCAAG 480
TCTTCCAGGG AGGGCTCAGG GGCGCCCCAG GAGTCTTCCC GGGACAAACG CCCCCTCTCC 540
GGGCCCGACG TCAGCGCCCC CCAGCCTGCC GGTCTGGCCA GTGGGGCGAA AGTGGCAGCT 600
GGCCGGCCCT TTAACACGTA CCCGAGGGCT GACACGGACC ACCCATCCCG GGGCACCCAG 660
GTAACCCATC CCCCTGCCCC AGGAGCCCCC ATCCCACTGT CTGTCTCCAT CCTGACACCA 720
AGCGGGTCTG GTCCCCGCCC CATCCTATCT CTCGCCTCCT CCCCCTCCCC CGGGCTGTTC 780
CCGAACTGTC CCCCTAAACC TGCTCCGTCT GGTCCCTTCT CAGAGAGGCC CCAGCCTGCC 840
AGCCCCGAGC AGCCCCACCC TCGCCTCCCC TCCTGGGCGC CCCCCATTCC CCACACGCAG 900
GCCTGCCCTG CCCCCTCATT GACCCTGGGG CCTGGGCCCT GCCCCTTGTC CTGTCCTGCC 960
TCGGGCTTGG CGCTTGGTGG CCTCTCTGGG GGGCCCTGCT CAGGACTGGT CAGAAGTCAG 1020
GATGAGAGAT GTGTGCACAG GGGTGGGGGC ACCCAGCATG CCAGCCTCAG GCCTCAGGTT 1080
GCCTCTGAGG TGGTGATCAT GCGGGACTAC CAGCACGAGA ACGTGGTGGA GATGTACAAC 1140
AGCTACCTGG TGGGCGACGA GCTCTGGGTG GTGATGGAGT TCCTGGAGGG AGGCGCCCTC 1200
ACCGACATCG TCACCCACAC CAGGATGAAC GAGGAGCAGA TCGCCGCCGT GTGCCTGGCC 1260
GTGCTGCAGG CCTTGTCTGT GCTCCACGCC CAGGGCGTCA TCCACCGGGA CATCAAGAGC 1320
GACTCCATTC TGCTGACCCA CGACGGCCGG GTGAAGCTGT CAGACTTCGG GTTCTGTGCC 1380
CAGGTGAGCA AGGAGGTGCC ACGGAGAAAG TCACTGGTCG GCACGCCCTA CTGGATGGCC 1440
CCGGAGCTCA TCTCCCGCCT TCCCTACGGG CCAGAGGTGG ACATCTGGTC TCTGGGGGTG 1500
ATGGTGATTG AGATGGTGGA CGGGGAGCCC CCCTACTTCA ACGAGCCACC CCTCAAAGCC 1560
ATGAAGATGA TTCGGGACAA CCTGCCGCCC CGACTGAAGA ACCTGCACAA GGTGTCGCCA 1620
TCTCTGAAGG GCTTCCTGGA CCGCCTGCTG GTGCGCGACC CCGCGCAGCG GGCCACGGCA 1680
GCCGAGCTGC TGAAGCACCC GTTCCTGGCC AAAGCGGGCC CGCCCGCCAG CATCGTGCCA 1740
CTCATGCGCC AGAACCGCAC CAGATGA 1767
Domain Profile
S: 42    elqkeisvlkklkhpniveylesflkeeelwlvmeylagGslsdlvkeelkselkEeqia  101
         ++++e+ ++++++h+n+ve+++s+l+ +elw+vme+l+gG+l+d+v+   +++++Eeqia
Q: 359   QVASEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQIA  415
         6789*******************************************...9*********
S: 102   yilrevlkaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgt  161
         +++  vl+aL+ lH+++viHrdik+++iLlt++g+VkLsdfg++aq++k++ +rk++vgt
Q: 416   AVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGT  475
         ************************************************************
S: 162   pywmAPEviaqeekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklk  221
         pywmAPE+i+  +  Y  ++DiwslG+++ie+++gepP+++++plka+ +i +n pp+lk
Q: 476   PYWMAPELIS--RLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLK  533
         **********..9***********************************************
S: 222   skkkfskefkefvekclqknpekRpsasellkhkFl  257
         + +k+s+++k f++++l ++p++R++a+ellkh+Fl
Q: 534   NLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL  569
         ***********************************7
Domain Sequence
(FASTA)
QVASEVVIMR DYQHENVVEM YNSYLVGDEL WVVMEFLEGG ALTDIVTHTR MNEEQIAAVC 60
LAVLQALSVL HAQGVIHRDI KSDSILLTHD GRVKLSDFGF CAQVSKEVPR RKSLVGTPYW 120
MAPELISRLP YGPEVDIWSL GVMVIEMVDG EPPYFNEPPL KAMKMIRDNL PPRLKNLHKV 180
SPSLKGFLDR LLVRDPAQRA TAAELLKHPF L 211
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Gorilla gorilla"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Procavia capensis"; ?>Sus scrofa"; ?>
EKS-AIM-00303
EKS-BOT-00328
EKS-CAF-00331
EKS-GOG-00333
EKS-LOA-00333
EKS-MAE-00035
EKS-MOD-00319
EKS-MYL-00324
EKS-OCP-00055
EKS-ORC-00304
EKS-OTG-00331
EKS-PRC-00049
EKS-SUS-00284
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000095; PAK_box_Rho-bd.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00786; PBD; 1.
PF00069; Pkinase; 1.
SMARTs
SM00285; PBD; 1.
SM00220; S_TKc; 1.
Prosites
PS50108; CRIB; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013