EKS-EQC-00311

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00311

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	326.3	1.5E-97	409	657	249

Status

Unreviewed

Ensembl Protein

ENSECAP00000015101

UniProt Accession

F6SBJ9;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK6

Gene Synonyms/Alias

PAK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000017471	ENSECAP00000015101	ENSECAT00000018508

Organism

Equus caballus

Functional Description

Protein Length

680

Protein Sequence
(FASTA)

MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP KPVVDPSHIT 60

RVQLQPMKTV VRGSSVPSDG YISGLLSDIQ KLSVISSNTL RGRSPTSRRR AQSLGLLGDE 120

HWATDPDMYL QSPQSEHTDP HGLYLSCNGG TPAGRRQTPW PEPQSPRVLP NGLATKAQSL 180

GPAEFQGATQ RCLQLGACLQ SSPPGTSPPT ATGRRGAKAA RHGSEEARPQ SCLVGSAAGR 240

PGGEGSPSPK TQENSLKRRL FRSMFLSTPA TAPLSSKPGP PLQSKPSSSF RPPQKGSPTS 300

LVAKAQSLPS DQPVGIFSPL TTSDTSSPQK SLRTAPATGP PPGRSSPAGS PRTRHAQIST 360

SNLYLPHDPT VAKGALAGED TGVVTHEQFK AALRMVVDQG DPRLLLDSYV KIGEGSTGIV 420

CLAREKHSGR QVAVKMMDLR KQQRRELLFN EVVIMRDYQH VNVVEMYKSY LVGEELWVLM 480

EFLQGGALTD IVSQVRLNEE QIATVCEAVL QALAYLHAQG VIHRDIKSDS ILLTLDGRVK 540

LSDFGFCAQI SKDVPKRKSL VGTPYWMAPE VISRSLYATE VDIWSLGIMV IEMVDGEPPY 600

FSDSPVQAMK RLRDSPPPKL KNSHKVSPVL RDFLERMLVR DPQERATAQE LLDHPFLLQT 660

GLPDCLVPLI QLYRKQTSAC 680

Nucleotide Sequence
(FASTA)

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCGG CCCCACAGAA CTTCCAGCAC 60

CGCGTTCACA CCTCCTTCGA CCCCAAGGAA GGCAAGTTCG TGGGCCTGCC CCCGCAATGG 120

CAGAACATTC TGGACACACT GAGGAGACCG AAGCCCGTGG TGGACCCTTC CCACATCACG 180

CGGGTGCAGC TGCAGCCCAT GAAGACAGTG GTGCGGGGCA GCTCTGTGCC CTCGGACGGC 240

TACATCTCCG GGCTTCTCAG CGATATCCAG AAGTTGTCGG TCATCAGCTC CAACACCCTG 300

CGTGGCCGCA GTCCTACCAG CCGGCGGCGG GCACAATCCC TGGGGCTGCT GGGGGATGAG 360

CACTGGGCCA CCGACCCGGA CATGTACCTG CAGAGCCCCC AGTCTGAGCA CACTGACCCC 420

CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCGCAGGCA GACGCCGTGG 480

CCCGAGCCGC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CCACCAAGGC ACAGTCCCTG 540

GGCCCCGCCG AGTTCCAGGG TGCCACACAG CGCTGCCTGC AGCTTGGCGC CTGTCTGCAG 600

AGTTCCCCGC CTGGCACCTC ACCCCCCACA GCCACCGGTA GGCGTGGGGC CAAGGCTGCC 660

AGGCATGGCT CGGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCCGC TGCAGGCAGG 720

CCGGGCGGGG AGGGCAGCCC CAGCCCTAAG ACCCAGGAGA ACAGCCTCAA GCGCAGGCTG 780

TTCCGAAGCA TGTTCCTGTC CACTCCTGCC ACGGCCCCTC TGAGCAGCAA GCCAGGCCCT 840

CCACTGCAAA GCAAGCCCAG CTCCTCTTTC CGACCGCCAC AGAAAGGCTC CCCCACAAGC 900

CTGGTGGCTA AGGCCCAGTC CTTGCCTTCC GACCAGCCCG TGGGGATCTT CAGCCCTCTG 960

ACCACCTCAG ATACCAGCAG CCCCCAGAAG TCCCTCCGCA CAGCCCCAGC CACTGGGCCA 1020

CCTCCAGGCC GGTCTTCCCC AGCGGGCTCA CCCCGCACCC GGCATGCCCA GATCAGCACC 1080

AGCAACCTGT ACCTGCCCCA TGACCCCACG GTGGCCAAGG GTGCCCTGGC TGGCGAGGAC 1140

ACAGGTGTTG TGACCCACGA GCAGTTCAAG GCTGCGCTCA GGATGGTGGT GGACCAGGGC 1200

GACCCCCGGC TGCTGCTGGA CAGCTACGTG AAGATTGGCG AGGGCTCCAC AGGCATAGTC 1260

TGCCTGGCCC GGGAGAAGCA CTCGGGCCGC CAGGTGGCCG TCAAGATGAT GGACCTCAGG 1320

AAGCAGCAGC GCAGGGAGCT GCTCTTTAAT GAGGTGGTGA TCATGCGGGA CTACCAGCAC 1380

GTCAACGTGG TGGAGATGTA CAAGAGCTAC CTGGTGGGTG AGGAGCTGTG GGTGCTTATG 1440

GAGTTCCTGC AGGGCGGGGC CCTCACCGAC ATCGTCTCCC AAGTCAGGCT GAACGAGGAG 1500

CAGATCGCCA CAGTGTGTGA GGCCGTGCTG CAGGCCCTGG CTTACCTGCA TGCCCAGGGT 1560

GTCATCCACC GGGACATCAA GAGTGACTCC ATCCTGCTGA CCCTCGATGG CAGGGTGAAA 1620

CTCTCCGACT TCGGATTTTG TGCTCAGATC AGCAAAGATG TCCCTAAGAG GAAGTCCCTG 1680

GTGGGAACCC CCTACTGGAT GGCTCCTGAA GTGATCTCCA GGTCTTTGTA TGCGACCGAG 1740

GTGGATATCT GGTCTCTGGG CATCATGGTG ATTGAGATGG TGGACGGGGA GCCACCGTAC 1800

TTCAGCGACT CACCAGTGCA AGCCATGAAG AGGCTCCGGG ACAGCCCTCC ACCCAAGCTG 1860

AAAAACTCTC ACAAGGTGTC CCCCGTGCTG CGAGACTTCC TGGAACGGAT GCTGGTACGC 1920

GACCCCCAGG AAAGGGCCAC CGCCCAGGAG CTCCTGGACC ACCCCTTCCT GCTGCAGACG 1980

GGGCTGCCCG ATTGCCTGGT GCCCCTGATC CAGCTCTACC GCAAGCAGAC CTCTGCCTGC 2040

TGA 2043

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyle  63

         + +ig+G++g v+larek++g++va+k+++l+kq++ e+l++e+ ++++++h n+ve+++

Q: 409   YVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHVNVVEMYK  468

         679*********************************************************

S: 64    sflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrd  123

         s+l+ eelw++me+l+gG+l+d+v+   + +l+Eeqia++++ vl+aL+ylH+++viHrd

Q: 469   SYLVGEELWVLMEFLQGGALTDIVS---QVRLNEEQIATVCEAVLQALAYLHAQGVIHRD  525

         *************************...99******************************

S: 124   ikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDi  183

         ik+++iLlt +g+VkLsdfg++aq++k++ krk++vgtpywmAPEvi+  ++ Y +++Di

Q: 526   IKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS--RSLYATEVDI  583

         ************************************************..9*********

S: 184   wslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpe  243

         wslGI++ie+++gepP+++ +p++a+ +  +++ppklk+++k+s+ +++f+e++l ++p+

Q: 584   WSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQ  643

         ************************************************************

S: 244   kRpsasellkhkFl  257

         +R++a+ell+h+Fl

Q: 644   ERATAQELLDHPFL  657

         *************7

Domain Sequence
(FASTA)

YVKIGEGSTG IVCLAREKHS GRQVAVKMMD LRKQQRRELL FNEVVIMRDY QHVNVVEMYK 60

SYLVGEELWV LMEFLQGGAL TDIVSQVRLN EEQIATVCEA VLQALAYLHA QGVIHRDIKS 120

DSILLTLDGR VKLSDFGFCA QISKDVPKRK SLVGTPYWMA PEVISRSLYA TEVDIWSLGI 180

MVIEMVDGEP PYFSDSPVQA MKRLRDSPPP KLKNSHKVSP VLRDFLERML VRDPQERATA 240

QELLDHPFL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ecb:100071463

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013