EKS-EQC-00188

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00188

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	416.7	3.9E-125	30	278	249

Status

Unreviewed

Ensembl Protein

ENSECAP00000015334

UniProt Accession

F6SQ82;

Protein Name

Protein Synonyms/Alias

Gene Name

TESK2

Gene Synonyms/Alias

TESK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000017621	ENSECAP00000015334	ENSECAT00000018775

Organism

Equus caballus

Functional Description

Protein Length

539

Protein Sequence
(FASTA)

MTQVGRVWPS SYRALISAFS RLTRLDDFTC EKIGSGFFSE VFKVRHRASG QVMALKMNTL 60

NSNRANMLKE VQLMNRLSHP NILRFMGVCV HQGQLHALTE YINSGNLEQL LDSNLHLPWT 120

VRVKLAYDIA VGLRYLHFKG IFHRDLTSKN CLIKRDENGY SAVVADFGLA EKIPDVSKGS 180

EKLAVVGSPF WMAPEVLRDE PYNEKADVFS YGIILCEIIA RIQADPDYLP RTENFGLDYD 240

AFQHMVGDCP PDFLQLTFNC CNMDPKLRPS FVEIEKTLEE ILSRLQEEEV ERDRKLQTPP 300

KGLLEKGPGV KRLSSLDDKI PPKSPRPRRN IWLSRSQSDI FSRKPVNVLD PYYRPQQGDA 360

ARTPKINPFS ARQDLKGGKI KFFDLPSKSV ISLVFDLDAP GPGTMPVADW QEPLAPPARR 420

WRSLPGSPEF LHQEACPFVG REESLSDGPP PRLSSLKYRV REIPPFRASA LPAAPAHEAM 480

DCSSLQEENG FGPRPQGASP CLAGTSEEME VEEERPRSLA PVPFSVSGIG LKTQGEQDG 539

Nucleotide Sequence
(FASTA)

ATGACCCAGG TGGGAAGGGT TTGGCCTTCT TCATATCGAG CTCTTATAAG TGCCTTTTCC 60

AGACTGACGC GTTTAGATGA CTTCACCTGT GAAAAAATAG GGTCTGGCTT CTTCTCTGAA 120

GTGTTCAAGG TGCGCCACCG AGCTTCTGGT CAGGTGATGG CTCTTAAGAT GAACACGTTG 180

AACAGTAACC GGGCGAACAT GCTGAAAGAA GTGCAGCTCA TGAATAGACT CTCCCATCCC 240

AATATCCTTA GGTTCATGGG TGTGTGTGTA CATCAAGGAC AATTGCATGC ACTTACAGAG 300

TATATCAACT CTGGAAACCT GGAACAGTTG CTAGACAGTA ACCTGCATTT GCCCTGGACT 360

GTGAGGGTGA AACTGGCCTA TGATATAGCA GTGGGTCTCC GCTACCTTCA CTTCAAAGGC 420

ATTTTCCATC GGGACCTCAC GTCTAAGAAC TGCCTGATAA AGAGGGATGA GAATGGTTAC 480

TCTGCAGTGG TGGCTGACTT TGGCCTGGCT GAGAAGATCC CTGATGTCAG CAAGGGGAGT 540

GAGAAGCTGG CTGTGGTGGG CTCACCCTTC TGGATGGCAC CTGAGGTTCT CCGAGATGAG 600

CCCTACAATG AGAAGGCGGA CGTGTTCTCT TATGGTATCA TCCTCTGTGA GATCATCGCC 660

CGCATCCAGG CTGATCCGGA CTATCTTCCC CGTACAGAGA ACTTCGGGCT GGACTATGAC 720

GCTTTCCAGC ATATGGTGGG AGACTGTCCT CCCGACTTTC TGCAGCTCAC CTTCAACTGC 780

TGTAACATGG ATCCCAAACT GCGCCCATCC TTTGTGGAGA TTGAGAAGAC TTTGGAGGAA 840

ATTCTGAGCC GCCTACAGGA GGAAGAGGTG GAGAGGGACA GGAAGCTGCA GACCCCCCCC 900

AAGGGACTCT TGGAGAAAGG GCCTGGGGTG AAGCGACTGA GTTCACTGGA TGACAAGATC 960

CCTCCTAAGT CCCCACGCCC AAGACGTAAT ATCTGGCTGT CTCGGAGCCA GTCAGACATC 1020

TTCTCCCGTA AGCCAGTGAA TGTCTTGGAC CCCTACTACC GGCCACAACA AGGTGATGCT 1080

GCCCGCACCC CCAAAATCAA CCCTTTCAGT GCTCGCCAGG ACCTCAAGGG TGGCAAGATC 1140

AAGTTCTTTG ACCTTCCCAG CAAGTCTGTC ATCTCCCTGG TATTTGACCT GGATGCACCA 1200

GGGCCTGGAA CTATGCCTGT GGCTGACTGG CAGGAGCCCC TGGCCCCACC TGCTCGCCGG 1260

TGGCGTTCTT TGCCTGGTTC ACCAGAATTC TTGCATCAAG AAGCCTGTCC ATTTGTGGGC 1320

CGAGAAGAAT CACTATCTGA TGGGCCCCCA CCACGCCTCA GTAGTCTCAA GTACAGAGTA 1380

AGAGAGATCC CGCCATTCCG AGCATCTGCC CTACCAGCTG CTCCAGCCCA TGAGGCCATG 1440

GACTGCTCCA GTCTCCAGGA AGAAAATGGT TTTGGGCCCA GGCCCCAGGG GGCCAGTCCA 1500

TGCCTCGCAG GTACCTCTGA GGAAATGGAG GTAGAAGAAG AAAGACCAAG AAGCTTGGCT 1560

CCAGTTCCCT TCTCTGTCTC AGGCATAGGC CTGAAAACCC AGGGAGAGCA GGATGGGTGA 1620

Domain Profile

S: 4     geklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfiG  63

          ek+G+Gffsevfkv+hrasG+vm+lk  ++++++nr+n+lkev+l+++l+hpn+l+f+G

Q: 30    CEKIGSGFFSEVFKVRHRASGQVMALK--MNTLNSNRANMLKEVQLMNRLSHPNILRFMG  87

         59*************************..*******************************

S: 64    vlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihrdln  123

         v+v++++lh+lteyi++G+l++ll+s+ +lpwt+rv+la+dia+Gl+ylh+kgi+hrdl+

Q: 88    VCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLRYLHFKGIFHRDLT  147

         ************************************************************

S: 124   sknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPe  180

         skncl+++   ++s+vvadfGla          ek+++++k+  +++l+vvGsP+wmaPe

Q: 148   SKNCLIKRdenGYSAVVADFGLA----------EKIPDVSKG--SEKLAVVGSPFWMAPE  195

         *******9887899*********..........9****9998..899*************

S: 181   vlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeaf  240

         vl+++ y+ek+dvfs+Gi+lceiiar++adPdylPrte+fgld++af++ +v+ dcP++f

Q: 196   VLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQH-MVG-DCPPDF  253

         *************************************************.999.******

S: 241   lklavvccdldpesrpsfeelekkl  265

         l+l+++cc++dp+ rpsf+e+ek+l

Q: 254   LQLTFNCCNMDPKLRPSFVEIEKTL  278

         **********************986

Domain Sequence
(FASTA)

CEKIGSGFFS EVFKVRHRAS GQVMALKMNT LNSNRANMLK EVQLMNRLSH PNILRFMGVC 60

VHQGQLHALT EYINSGNLEQ LLDSNLHLPW TVRVKLAYDI AVGLRYLHFK GIFHRDLTSK 120

NCLIKRDENG YSAVVADFGL AEKIPDVSKG SEKLAVVGSP FWMAPEVLRD EPYNEKADVF 180

SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNMDPKLRP 240

SFVEIEKTL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013