EKS-EQC-00360
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00360
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src439.73.2E-132259508250
StatusUnreviewed
Ensembl ProteinENSECAP00000016020
UniProt AccessionF7AT17;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000017707ENSECAP00000016020ENSECAT00000019564
OrganismEquus caballus
Functional Description
Protein Length523
Protein Sequence
(FASTA)
LGGRSSCEDP GCPQEEERAP RMGCVKSRFL RDRGKVSKSE PGANPHNPVY VPDPTSAGKR 60
WPDSSNNNPP GHTEGAEDTI VIALYDYEAI HHEDLRFQKG DEMVVLEESG EWWRARSLAT 120
GKEGYIPSNY VARVDSLETE EWFFKGISRK DAERQLLAPG NVLGSFMIRD SETTKGSYSL 180
SVRDYDPQYR DTVKHYIRTL DSGGLLHLPA EHFGTLQELV AHYKKASDGL CQKLTVPCMS 240
SKPQKPWEKD AWEIPRESLK MEKKLGAGQF GEVWMATYNK HTKVAVKTMK PGSMSVEAFL 300
AEANLMKTLQ HDKLVKLYAV VTKEPIYIIT EFMAKGSLLD FLKSEEGSKQ PLPKLIDFSA 360
QIAEGMAFIE QRNYIHRDLR AANILVSASL VCKIADFGLA RVIEDNEYTA REGAKFPIKW 420
TAPEAINFGS FTIKSDVWSF GVLLMEIVTY GRIPYPGMSN PEVIRALEHG YRMPRPEHCP 480
EELYNIMTRC WKNSPEERPT FEYIQSVLED FYTATESQYQ QQP 523
Nucleotide Sequence
(FASTA)
CTGGGGGGGC GCTCGAGCTG CGAGGATCCG GGCTGCCCGC AGGAGGAGGA GCGGGCACCC 60
AGGATGGGGT GCGTGAAGTC CAGGTTCCTC CGCGACAGAG GCAAGGTCTC AAAGTCGGAG 120
CCCGGCGCCA ACCCGCACAA CCCAGTGTAC GTGCCGGATC CCACGTCCGC GGGCAAGCGG 180
TGGCCTGACA GCAGCAACAA CAACCCCCCC GGACACACAG AGGGTGCTGA GGACACTATC 240
GTGATTGCCC TGTATGATTA CGAGGCCATT CACCACGAAG ACCTCAGATT CCAGAAGGGG 300
GATGAGATGG TGGTCCTGGA GGAGTCTGGG GAGTGGTGGA GGGCTCGATC CCTGGCCACG 360
GGGAAAGAGG GCTATATCCC GAGCAACTAC GTCGCCCGCG TGGACTCTCT GGAGACGGAG 420
GAGTGGTTCT TCAAGGGCAT CAGCCGGAAG GATGCAGAGC GCCAACTCCT GGCCCCTGGC 480
AACGTGCTGG GCTCCTTCAT GATCCGGGAC AGTGAGACCA CCAAAGGAAG CTACTCTTTG 540
TCTGTGCGAG ACTACGACCC CCAGTACAGG GACACGGTGA AGCATTACAT CCGGACCCTG 600
GACAGCGGAG GGCTTCTACA TCTCCCCGCA GAGCACTTCG GCACCCTGCA GGAGCTGGTG 660
GCCCACTACA AGAAGGCGAG CGATGGACTC TGCCAGAAGC TGACAGTGCC CTGCATGTCC 720
TCCAAGCCCC AGAAGCCGTG GGAGAAAGAT GCCTGGGAGA TCCCCCGGGA ATCGCTCAAG 780
ATGGAGAAGA AGCTTGGAGC TGGGCAGTTT GGGGAAGTCT GGATGGCCAC CTACAACAAG 840
CACACCAAGG TGGCCGTGAA GACGATGAAG CCGGGCAGCA TGTCCGTGGA AGCCTTCCTG 900
GCGGAGGCCA ACCTGATGAA AACTCTGCAG CATGACAAGC TGGTGAAGCT GTACGCGGTG 960
GTCACGAAGG AGCCCATCTA CATCATCACG GAGTTCATGG CCAAAGGAAG CCTGCTGGAT 1020
TTCCTGAAGA GTGAAGAAGG TAGCAAGCAG CCCCTGCCGA AGCTCATTGA CTTTTCGGCC 1080
CAGATTGCAG AAGGCATGGC CTTCATCGAG CAGAGGAACT ATATTCACCG AGACCTGCGA 1140
GCCGCTAACA TCTTGGTCTC CGCGTCCCTG GTTTGCAAGA TAGCCGACTT CGGCCTGGCG 1200
CGGGTCATCG AGGACAACGA GTACACTGCT CGGGAAGGGG CCAAGTTCCC CATCAAGTGG 1260
ACAGCTCCTG AGGCCATCAA CTTTGGCTCC TTCACCATCA AGTCGGATGT CTGGTCCTTT 1320
GGTGTCCTGC TGATGGAGAT TGTCACCTAT GGCAGGATCC CTTACCCAGG GATGTCGAAC 1380
CCCGAGGTGA TCCGAGCCCT GGAGCACGGA TACAGGATGC CTCGACCAGA GCACTGCCCC 1440
GAGGAGCTTT ACAACATCAT GACCCGCTGC TGGAAGAACA GCCCCGAGGA GCGGCCCACC 1500
TTCGAGTACA TCCAGAGTGT GCTGGAGGAC TTCTACACCG CCACCGAGAG CCAGTACCAA 1560
CAGCAGCCGT GA 1572
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lk++kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkly
Q: 259   LKMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLY  318
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyi+te+makGslldflk+eeg+k++lpkl+d++aq+aeGma++e++n+ihr
Q: 319   AVVTK-EPIYIITEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR  377
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 378   DLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  437
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfG+ll+eivt+G++PypGm+n ev++++e+gyr+prpe+cpeely+++++cwk++pee
Q: 438   WSFGVLLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPEHCPEELYNIMTRCWKNSPEE  497
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q+vl
Q: 498   RPTFEYIQSVL  508
         *******9976
Domain Sequence
(FASTA)
LKMEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKT LQHDKLVKLY 60
AVVTKEPIYI ITEFMAKGSL LDFLKSEEGS KQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 120
LRAANILVSA SLVCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180
SFGVLLMEIV TYGRIPYPGM SNPEVIRALE HGYRMPRPEH CPEELYNIMT RCWKNSPEER 240
PTFEYIQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PEM-00194
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XIM-00467
Gene Ontology
GO:0005884; C:actin filament
GO:0005901; C:caveola
GO:0031234; C:extrinsic to internal side of plasma membrane
GO:0005925; C:focal adhesion
GO:0005764; C:lysosome
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0043066; P:negative regulation of apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0006909; P:phagocytosis
GO:2000251; P:positive regulation of actin cytoskeleton reorganization
GO:0008284; P:positive regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0050764; P:regulation of phagocytosis
GO:0071801; P:regulation of podosome assembly
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013