EKS-EQC-00256
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00256
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK292.14.2E-87135305171
StatusUnreviewed
Ensembl ProteinENSECAP00000015669
UniProt AccessionF6RRI6;
Protein Name
Protein Synonyms/Alias
Gene NamePLK1
Gene Synonyms/Alias PLK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000017777ENSECAP00000015669ENSECAT00000019156
OrganismEquus caballus
Functional Description
Protein Length604
Protein Sequence
(FASTA)
MSAAATAGKL ARAPADPGKA GAPGVAAPGA PAAPPAKEIP EVLVDPRSRR RYLRGRFLGK 60
GGFAKEGGSW TRGDARRESG GVAGPGRTVV MDPLTGGKVQ IAVVLEKELG GGPWLPLPND 120
TSSPPWASSL LLSFPRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN RVIHRDLKLG 180
NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI 240
MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP TARPTIHELL 300
NDEFFTSGYI PARLPITCLT IPPRFSIAPS SLDPSNRKPL TVLNKGVENP MPERPREKEE 360
PVVRETSEAV DCHLGDMLQQ LHSVNASRPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK 420
YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGTE SYLTVSSHPN SLMKKITLLK 480
YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGCV QINFFQDHTK 540
LILCPLMAAV TYIDEKRDFR TYRLSLLEEY GCSKELASRL RYARTMVDKL LSSRSATNRL 600
KASS 604
Nucleotide Sequence
(FASTA)
ATGAGTGCGG CGGCAACTGC AGGGAAGCTG GCGCGGGCAC CAGCCGACCC AGGGAAAGCC 60
GGGGCACCTG GAGTTGCAGC TCCCGGGGCC CCGGCGGCTC CGCCGGCGAA AGAGATCCCG 120
GAGGTCCTAG TGGACCCGCG CAGCCGCCGG CGCTATCTGC GGGGCCGCTT TCTGGGGAAG 180
GGCGGCTTTG CCAAAGAAGG CGGCTCCTGG ACGCGAGGTG ATGCGCGGAG GGAGAGCGGG 240
GGAGTCGCGG GGCCGGGGAG AACCGTGGTA ATGGACCCAC TTACCGGAGG GAAAGTCCAG 300
ATCGCAGTTG TCCTGGAGAA GGAGTTGGGG GGAGGGCCCT GGCTGCCTTT ACCTAATGAC 360
ACCTCCTCAC CCCCTTGGGC CTCCTCACTT CTCCTCTCCT TCCCCCGCTC TCTCCTGGAG 420
CTGCACAAAC GGAGGAAAGC ACTCACCGAG CCCGAGGCCC GCTACTACCT GCGGCAGATC 480
GTCCTCGGCT GCCAGTACCT GCACCGAAAC CGGGTTATTC ACCGGGACCT CAAGCTGGGC 540
AACCTCTTCC TGAACGAGGA TCTGGAGGTG AAAATAGGGG ATTTTGGACT GGCAACCAAA 600
GTCGAATATG ATGGGGAGCG GAAGAAGACC CTGTGCGGGA CTCCTAACTA CATAGCTCCT 660
GAGGTGCTGA GCAAGAAAGG GCACAGCTTC GAGGTGGACG TGTGGTCCAT TGGGTGCATC 720
ATGTATACCT TGTTAGTGGG CAAGCCGCCT TTTGAGACCT CTTGCCTAAA AGAGACCTAC 780
CTCCGGATCA AGAAGAATGA ATACAGCATT CCCAAGCACA TCAACCCGGT GGCCGCCTCC 840
CTCATCCAGA AGATGCTGCA GACAGATCCC ACTGCCCGCC CGACCATTCA CGAGCTGCTC 900
AATGACGAGT TTTTCACTTC TGGCTATATC CCTGCCCGTC TCCCCATCAC CTGCCTCACC 960
ATTCCACCGA GGTTCTCAAT CGCTCCCAGC AGCCTGGACC CCAGCAACCG GAAGCCTCTC 1020
ACAGTCCTCA ATAAAGGTGT AGAGAACCCC ATGCCCGAGC GGCCCCGGGA AAAAGAGGAA 1080
CCAGTGGTCC GGGAGACCAG CGAGGCAGTC GACTGCCACC TTGGTGACAT GCTGCAGCAG 1140
CTGCACAGCG TCAATGCCTC CAGGCCCTCC GAGCGGGGGC TGGTGAGGCA AGAGGAGGCT 1200
GAGGATCCCG CCTGCATCCC CATCTTCTGG GTCAGCAAGT GGGTGGACTA TTCGGACAAG 1260
TACGGCCTCG GGTATCAGCT GTGTGACAAC AGCGTAGGGG TGCTCTTCAA TGACTCTACG 1320
CGCCTCATCC TGTACAATGA TGGCGACAGC CTGCAGTACA TAGAGCGTGA TGGCACCGAG 1380
TCCTACCTCA CCGTGAGTTC CCATCCCAAC TCCTTGATGA AGAAGATCAC TCTTCTTAAG 1440
TATTTCCGAA ACTACATGAG TGAACACTTG TTGAAGGCGG GCGCCAATAT CACGCCCCGG 1500
GAAGGTGACG AGCTAGCCCG GCTACCCTAC CTGCGGACCT GGTTTCGCAC CCGTAGCGCC 1560
ATCATCCTGC ACCTCAGTAA TGGCTGTGTG CAGATCAACT TCTTCCAGGA CCATACCAAA 1620
CTCATCCTGT GCCCGCTGAT GGCAGCCGTG ACCTACATCG ACGAGAAGCG GGACTTCCGC 1680
ACGTACCGCC TGAGCCTCCT GGAGGAGTAC GGCTGCTCCA AGGAGCTGGC CAGCCGGCTC 1740
CGCTACGCCC GCACCATGGT GGACAAGCTG CTGAGCTCAC GCTCGGCCAC CAATCGCCTC 1800
AAGGCCTCCT CGTAG 1815
Domain Profile
S: 83    rrslaellkrrkaltepevryylrqivsglkylhekrilhrdlklgnlflneelevkigd  142
          rsl el+krrkaltepe+ryylrqiv g++ylh++r++hrdlklgnlflne+levkigd
Q: 135   PRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGD  194
         689*********************************************************
S: 143   fGlatrlekeeerkktlcGtPnyiaPevlskkghslevdiWslGcilytllvGkPPfetk  202
         fGlat++e+++erkktlcGtPnyiaPevlskkghs+evd+Ws+Gci+ytllvGkPPfet+
Q: 195   FGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETS  254
         ************************************************************
S: 203   elketyekikkaeyslPsslskeaksliakllkkePeerpsleevlkdefl  253
         +lkety +ikk+eys+P+++++ a+sli+k+l+++P++rp+++e+l+def+
Q: 255   CLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIHELLNDEFF  305
         **************************************************8
Domain Sequence
(FASTA)
PRSLLELHKR RKALTEPEAR YYLRQIVLGC QYLHRNRVIH RDLKLGNLFL NEDLEVKIGD 60
FGLATKVEYD GERKKTLCGT PNYIAPEVLS KKGHSFEVDV WSIGCIMYTL LVGKPPFETS 120
CLKETYLRIK KNEYSIPKHI NPVAASLIQK MLQTDPTARP TIHELLNDEF F 171
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00244
EKS-ANC-00253
EKS-BOT-00261
EKS-CAE-00235
EKS-CAJ-00267
EKS-CAF-00268
EKS-CAP-00296
EKS-CII-00158
EKS-CIS-00035
EKS-DAR-00596
EKS-DRM-00134
EKS-ECT-00012
EKS-FEC-00247
EKS-GAM-00161
EKS-GAG-00220
EKS-GAA-00322
EKS-GOG-00259
EKS-HOS-00268
EKS-ICT-00246
EKS-LAC-00273
EKS-LOA-00271
EKS-MAM-00263
EKS-MAE-00014
EKS-MEG-00209
EKS-MIM-00017
EKS-MOD-00258
EKS-MUM-00291
EKS-MUP-00258
EKS-MYL-00262
EKS-ORN-00340
EKS-ORA-00231
EKS-ORC-00247
EKS-ORL-00317
EKS-OTG-00267
EKS-PES-00234
EKS-POA-00254
EKS-RAN-00276
EKS-SAH-00247
EKS-TAG-00279
EKS-TAR-00335
EKS-TEN-00331
EKS-TUB-00014
EKS-TUT-00029
EKS-XET-00336
EKS-XIM-00332
Gene Ontology
GO:0005813; C:centrosome
GO:0000942; C:condensed nuclear chromosome outer kinetochore
GO:0030496; C:midbody
GO:0005876; C:spindle microtubule
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007092; P:activation of mitotic anaphase-promoting complex activity
GO:0051297; P:centrosome organization
GO:0000910; P:cytokinesis
GO:0031572; P:G2/M transition DNA damage checkpoint
GO:0000086; P:G2/M transition of mitotic cell cycle
GO:0001578; P:microtubule bundle formation
GO:0043066; P:negative regulation of apoptotic process
GO:0045736; P:negative regulation of cyclin-dependent protein kinase activity
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018105; P:peptidyl-serine phosphorylation
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation
GO:0031648; P:protein destabilization
GO:0071168; P:protein localization to chromatin
GO:0016567; P:protein ubiquitination
GO:0090007; P:regulation of mitotic anaphase
GO:0043393; P:regulation of protein binding
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 2.
SMARTs
Prosites
PS50078; POLO_BOX; 2.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013