EKS-EQC-00294

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00294

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/Alpha	321.6	2.5E-96	1595	1813	219

Status

Unreviewed

Ensembl Protein

ENSECAP00000016257

UniProt Accession

F7BQ57;

Protein Name

Protein Synonyms/Alias

Gene Name

TRPM7

Gene Synonyms/Alias

TRPM7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000017780	ENSECAP00000016257	ENSECAT00000019830

Organism

Equus caballus

Functional Description

Protein Length

1862

Protein Sequence
(FASTA)

SQKSWIESTT KRECVYIIPS SKDPHRCLPG CQICQQLVRC FCGRLVKQHA CFTASLAMKY 60

SDVKLGDHFN QTPEEWSVEK HTEQSPTDAY GVINFQGGSH SYRAKYVRLS YDTKPEIILQ 120

LLLKEWQMEL PKLVISVHGG MQKFELHPRI KQLIGKGLIK AAVTTGAWIL TGGVNTGVAK 180

HVGDALKEHA SRSSRKICTI GIAPWGVIEN RNDLVGRDVV APYQTLLNPL SKLNVLNNLH 240

SHFILVDDGT VGKYGAEVRL RRELEKTINQ QRIHARIGQG VPVVALIFEG GPNVILTVLE 300

YLQESPPVPV VVCEGTGRAA DLLAYIYKQT EEGGNLPDAA EPDIISTIKK TFNFGQSEAV 360

HLFQTLMECM KRKELITVFH IGSDEHQDID VAILTALLKG TNASAFDQLI LTLAWDRVDI 420

AKNHVFVYGQ QWLVGSLEQA MLDALVMDRV AFVKLLIENG VSMHKFLTIP RLEELYNTKQ 480

GPTNPMLFHL VRDVKQGNLP PGYKITLIDI GLVIEYLMGG TYRCTYTRKR FRLIYNSLGG 540

NNRRSGRNTS SSTPQLRKSH ESFSNRADKK ERMRHNHFIK TAQPYRPKID TTVEEGKKKR 600

TKDEIVDIDD PETKRFPYPL NELLIWACLM KRQVMARFLW QHGEESMAKA LVACKIYRSM 660

AYEAKQSDLV DDTSEELKQY SNDFGQLAVE LLEQSFRQDE TMAMKLLTYE LKNWSNSTCL 720

KLAVSSRLRP FVAHTCTQML LSDMWMGRLN MRKNSWYKVI LSILVPPAIL MLEYKTKAEM 780

SHIPQSQDAH QMTMEDSENN FQNMTEEIPM EVFKEIKILD SNEGKNEVEI QIKSKKLPVT 840

RKFYAFYHAP IVKFWFNTLA YLGFLMLYTF VVLVQMERLP SVQEWIVIAY IFTYAIEKVR 900

EIFMSEAGKI SQKIKVWFSD YFNISDTIAI ISFFIGFGLR FGAKWNFENA YDNHVFVAGR 960

LIYCLNIIFW YVRLLDFLAV NQQAGPYVMM IGKMVANMFY IVVIMALVLL SFGVPRKAIL 1020

YPHEAPSWTL AKDIVFHPYW MIFGEVYAYE IDVCANDSSV TQLCGPGTWL TPFLQAVYLF 1080

VQYIIMVNLL IAFFNNVYLQ VKAISNIVWK YQRYHFIMAY HEKPVLPPPL IILSHIVSLF 1140

CCICKRRKKD KTSDGPKLFL TEEDQKKLHD FEEQCVEMYF NEKDDKFHSG SEERIRVTFE 1200

RVEQMCIQVK EVGDRVNYIK RSLQSLDSQI GHLQDLSALT VDTLKTLTAQ KASEASKVHN 1260

EITRELSISK HLAQNLIDDG PARPSVWKKH SVVNTLSSSL PQGGLESNNP FLCNIFMKDE 1320

KDPQCNLFDQ DLPVVSQSKD FNFPEGSSSG ALFPSAISPP ELRQRLHGVE TLKMFSKSQK 1380

LGSTSNSIPH LSSPPKFFVS TPSQPSCKSH LENTKDQETV CSKAAEGDNI EFGAFVGNQD 1440

STWEMSTVIN TQTKIKEILS NDIPAENTLK HVKSHAGFTE YHKTSIPLHS EQVESSSRRP 1500

SAEETHEVDS KAALLPDWLQ DRPSKREMPS EEGTLNGLAS PFKPVMDTNY YYSAVERNNL 1560

MRLSQSIPFT PVPPRGEPVT VYRLEESSPN ILNNSMSSWS QLGLCAKIEF LSKEEMGGGL 1620

RRAVKVQCTW SEHDILKSGH LYIIKSFLPE VVNTWSSIYK EDTVLHLCLR EIQQQRAAQK 1680

LTFAFNQMKP KSIPYSPRFL EVFLLYCHSA GQWFAVEECM TGEFRKYNNN NGDEIIPTNT 1740

LEEIMLAFSH WTYEYTRGEL LVLDLQGVGE NLTDPSVIKA EEKRSCDMVF GPANLGEDAI 1800

KNFRAKHHCN SCCRKLKLPD LKRNDYTPDK ILFPQDEPSD LTLQPGNSTK ESDSTNSIRL 1860

ML 1862

Nucleotide Sequence
(FASTA)

TCCCAGAAAT CCTGGATAGA AAGCACTACC AAGAGGGAAT GTGTATATAT TATACCAAGT 60

TCCAAAGACC CTCACAGATG CCTTCCAGGA TGTCAAATTT GTCAGCAACT CGTCAGGTGT 120

TTTTGTGGTC GCTTAGTCAA GCAACATGCT TGTTTTACTG CAAGTCTTGC CATGAAATAC 180

TCAGATGTGA AATTGGGTGA CCATTTTAAT CAGACACCAG AAGAATGGTC TGTGGAAAAA 240

CATACAGAAC AGAGCCCAAC GGATGCATAT GGAGTCATAA ATTTTCAAGG GGGTTCTCAT 300

TCCTACAGAG CAAAGTATGT GAGACTGTCC TATGACACCA AACCTGAAAT CATTCTGCAA 360

CTTTTGCTTA AAGAATGGCA AATGGAATTA CCCAAACTTG TTATCTCTGT ACATGGGGGC 420

ATGCAGAAAT TTGAGCTTCA CCCACGAATC AAGCAGTTGA TTGGAAAGGG TCTCATTAAA 480

GCTGCAGTTA CGACCGGAGC CTGGATTTTA ACTGGAGGAG TAAACACAGG TGTGGCAAAA 540

CATGTTGGTG ATGCCCTCAA AGAACATGCT TCCAGATCAT CTCGAAAGAT TTGCACTATT 600

GGAATAGCTC CATGGGGAGT GATTGAGAAC AGAAATGATC TTGTTGGGAG AGATGTGGTT 660

GCTCCTTATC AAACCTTATT GAACCCTCTG AGCAAACTGA ATGTTCTAAA TAATCTGCAT 720

TCCCATTTCA TATTGGTGGA TGATGGCACT GTTGGAAAGT ATGGGGCAGA AGTCAGACTG 780

AGACGAGAAC TTGAAAAAAC TATTAATCAG CAAAGAATTC ATGCTAGAAT TGGTCAAGGT 840

GTCCCTGTGG TAGCCCTTAT ATTTGAGGGT GGGCCAAATG TTATCCTCAC AGTTTTAGAA 900

TACCTTCAGG AAAGTCCTCC TGTTCCAGTT GTTGTATGTG AAGGAACAGG CAGAGCTGCA 960

GATCTACTAG CATATATTTA TAAACAAACA GAAGAAGGAG GGAATCTTCC TGATGCAGCA 1020

GAGCCTGATA TTATTTCAAC TATCAAAAAA ACATTTAACT TTGGCCAGAG TGAAGCAGTT 1080

CATTTATTTC AAACACTGAT GGAGTGCATG AAAAGAAAGG AGCTTATCAC TGTTTTCCAC 1140

ATTGGATCAG ATGAACATCA AGATATTGAT GTAGCAATAC TTACTGCACT GCTTAAAGGC 1200

ACTAATGCAT CTGCATTTGA CCAGCTCATT CTTACATTGG CGTGGGATAG AGTTGACATT 1260

GCCAAAAATC ATGTATTTGT TTATGGACAG CAGTGGCTGG TTGGATCCTT GGAACAAGCT 1320

ATGCTTGATG CTCTTGTAAT GGATAGAGTT GCATTTGTAA AACTTCTTAT TGAAAATGGA 1380

GTAAGCATGC ATAAATTCCT TACCATTCCT AGACTGGAAG AACTTTATAA CACGAAACAA 1440

GGTCCAACTA ATCCAATGCT ATTTCATCTT GTTCGAGACG TCAAACAGGG AAATCTTCCT 1500

CCAGGATATA AGATCACTCT AATTGATATA GGACTTGTTA TTGAATATCT TATGGGAGGA 1560

ACCTATAGAT GCACCTACAC TCGGAAACGT TTTCGATTAA TATATAATAG TCTTGGTGGA 1620

AATAATCGGA GATCTGGCCG AAATACCTCC AGCAGCACTC CTCAGTTACG AAAGAGTCAT 1680

GAATCTTTCA GCAATAGGGC AGATAAAAAG GAAAGAATGA GACATAATCA TTTCATTAAA 1740

ACAGCACAGC CCTACCGACC AAAGATTGAT ACAACTGTGG AAGAAGGAAA GAAGAAAAGA 1800

ACCAAAGATG AAATTGTAGA TATTGATGAT CCAGAAACAA AGCGCTTTCC TTATCCACTT 1860

AATGAACTGT TAATTTGGGC TTGCCTTATG AAGAGGCAGG TGATGGCTCG TTTTTTATGG 1920

CAGCATGGTG AAGAATCAAT GGCTAAGGCA TTAGTTGCCT GTAAGATCTA TCGTTCAATG 1980

GCATATGAAG CAAAGCAGAG TGACCTTGTA GATGATACTT CTGAAGAATT GAAACAGTAT 2040

TCCAATGATT TTGGTCAACT GGCGGTTGAA TTACTAGAGC AGTCCTTCAG ACAAGATGAA 2100

ACCATGGCTA TGAAATTGCT CACTTATGAA CTGAAAAACT GGAGTAATTC TACCTGCCTT 2160

AAGTTAGCAG TTTCCTCAAG ACTTAGACCT TTTGTAGCCC ACACCTGTAC ACAAATGTTG 2220

TTATCTGATA TGTGGATGGG AAGGCTGAAT ATGAGGAAGA ATTCCTGGTA CAAGGTCATA 2280

TTAAGCATTT TAGTTCCACC TGCCATATTA ATGCTAGAAT ACAAAACTAA AGCTGAGATG 2340

TCCCATATTC CACAATCTCA AGATGCCCAT CAGATGACGA TGGAAGATAG TGAGAACAAC 2400

TTTCAAAACA TGACAGAAGA GATTCCTATG GAAGTGTTTA AAGAAATAAA AATATTGGAC 2460

AGTAATGAAG GAAAGAATGA AGTGGAGATA CAGATAAAAT CAAAAAAGCT TCCAGTCACA 2520

CGAAAGTTTT ATGCCTTTTA TCATGCACCA ATTGTAAAGT TCTGGTTTAA CACGTTGGCA 2580

TACTTAGGAT TTCTGATGCT TTACACATTT GTGGTTCTTG TGCAAATGGA ACGATTACCT 2640

TCAGTTCAAG AATGGATTGT TATTGCTTAT ATTTTTACCT ATGCTATTGA GAAAGTCCGT 2700

GAGATCTTTA TGTCTGAAGC TGGAAAAATC AGCCAGAAGA TTAAAGTGTG GTTTAGTGAT 2760

TATTTCAATA TCAGTGATAC AATTGCCATA ATTTCTTTCT TCATTGGATT TGGACTAAGA 2820

TTTGGAGCAA AATGGAACTT TGAGAACGCA TATGATAATC ATGTTTTTGT GGCTGGGAGA 2880

TTAATTTATT GTCTTAACAT AATATTTTGG TATGTGCGTT TGCTAGATTT TCTGGCTGTA 2940

AATCAACAGG CAGGACCTTA TGTAATGATG ATTGGAAAAA TGGTGGCCAA TATGTTCTAC 3000

ATTGTAGTGA TTATGGCTCT TGTATTACTT AGTTTTGGTG TTCCCAGAAA GGCAATACTT 3060

TATCCTCATG AAGCACCATC TTGGACTCTT GCTAAAGATA TAGTTTTTCA TCCATACTGG 3120

ATGATTTTTG GTGAAGTTTA TGCATATGAA ATTGATGTGT GTGCAAATGA TTCCAGTGTG 3180

ACTCAACTCT GTGGTCCCGG GACATGGTTG ACTCCATTTC TTCAAGCAGT CTACCTCTTT 3240

GTACAGTATA TCATTATGGT CAATCTTCTT ATTGCATTTT TCAATAATGT GTATTTACAA 3300

GTGAAGGCAA TTTCCAATAT TGTCTGGAAG TACCAACGTT ATCATTTTAT TATGGCTTAT 3360

CATGAGAAAC CAGTTCTGCC TCCACCGCTT ATCATTCTCA GCCATATAGT TTCTCTTTTT 3420

TGCTGCATAT GTAAAAGAAG AAAAAAAGAT AAGACTTCAG ATGGACCAAA ACTTTTTTTA 3480

ACAGAAGAAG ATCAAAAGAA ACTTCATGAT TTTGAAGAGC AGTGTGTTGA GATGTATTTT 3540

AATGAAAAAG ATGACAAATT CCATTCTGGG AGTGAAGAGA GAATTCGTGT CACTTTTGAA 3600

AGAGTGGAGC AGATGTGCAT TCAGGTTAAA GAAGTTGGAG ATCGCGTCAA CTATATAAAA 3660

AGATCATTAC AGTCATTAGA TTCTCAAATT GGCCATTTGC AAGATCTTTC AGCCCTGACA 3720

GTAGACACAT TAAAAACACT CACTGCCCAG AAAGCTTCGG AAGCTAGCAA AGTTCACAAT 3780

GAAATCACAC GAGAATTGAG CATTTCCAAA CATTTGGCTC AAAACCTTAT TGATGATGGT 3840

CCTGCAAGAC CTTCTGTTTG GAAAAAGCAC AGTGTTGTAA ATACACTTAG CTCCTCACTT 3900

CCTCAAGGTG GTCTTGAAAG TAATAATCCT TTTCTTTGTA ATATTTTTAT GAAGGATGAA 3960

AAAGATCCCC AGTGTAACCT ATTTGATCAA GATTTACCTG TAGTATCCCA GAGCAAAGAT 4020

TTCAATTTTC CAGAGGGTTC CTCTTCTGGT GCCTTATTCC CAAGTGCTAT TTCTCCTCCA 4080

GAACTGCGAC AGAGACTACA TGGGGTAGAA ACATTAAAAA TGTTTAGTAA AAGTCAAAAA 4140

TTAGGTAGTA CATCTAATAG TATACCACAT CTATCATCCC CACCAAAATT TTTTGTTAGT 4200

ACACCATCCC AGCCAAGTTG CAAAAGCCAC TTGGAAAACA CCAAAGATCA AGAAACTGTT 4260

TGCTCTAAAG CTGCAGAAGG AGATAATATA GAATTTGGAG CCTTTGTAGG TAACCAGGAT 4320

TCTACTTGGG AAATGAGTAC AGTCATAAAC ACCCAAACCA AAATAAAAGA AATTCTCTCG 4380

AATGATATTC CTGCTGAAAA CACTTTGAAA CACGTGAAGT CCCATGCTGG ATTTACTGAG 4440

TATCACAAAA CTTCTATTCC TCTTCATTCA GAACAAGTGG AAAGTAGCAG TAGAAGGCCA 4500

TCTGCAGAGG AAACTCATGA AGTAGATTCC AAAGCAGCTT TACTACCGGA TTGGTTACAA 4560

GATAGACCAT CAAAGAGAGA AATGCCATCT GAAGAAGGAA CATTAAATGG TCTTGCTTCT 4620

CCATTTAAGC CAGTTATGGA TACAAATTAC TATTACTCAG CTGTGGAAAG AAATAATTTG 4680

ATGAGATTAT CCCAGAGCAT TCCATTTACA CCTGTGCCTC CAAGAGGTGA GCCTGTCACA 4740

GTGTATCGCT TGGAGGAGAG TTCACCCAAC ATACTGAATA ACAGCATGTC TTCTTGGTCA 4800

CAGCTAGGCC TCTGTGCCAA AATAGAGTTT TTAAGTAAAG AGGAGATGGG AGGAGGTTTA 4860

CGGAGAGCTG TCAAGGTACA ATGTACCTGG TCAGAACATG ATATCCTCAA ATCAGGGCAT 4920

CTTTATATTA TCAAATCTTT CCTTCCTGAA GTGGTTAACA CATGGTCAAG TATTTATAAA 4980

GAAGATACGG TTCTGCATCT CTGTCTCAGA GAAATTCAAC AACAAAGAGC AGCACAAAAG 5040

CTCACATTTG CCTTCAACCA AATGAAACCC AAATCCATAC CGTATTCTCC AAGGTTCCTT 5100

GAAGTTTTCC TGCTGTATTG CCATTCAGCA GGACAGTGGT TTGCTGTGGA AGAATGTATG 5160

ACTGGAGAAT TTAGAAAATA CAACAATAAT AATGGTGATG AAATTATTCC AACTAATACA 5220

CTGGAAGAGA TCATGCTAGC CTTTAGCCAC TGGACTTACG AATATACAAG AGGGGAGTTA 5280

CTGGTCCTTG ATTTACAAGG TGTGGGTGAA AATTTGACTG ATCCATCTGT GATAAAAGCA 5340

GAAGAAAAGA GATCCTGTGA TATGGTTTTT GGCCCAGCAA ATCTAGGAGA AGATGCAATA 5400

AAAAACTTCA GAGCAAAGCA TCACTGTAAT TCTTGTTGTA GAAAGCTTAA ACTTCCAGAT 5460

CTGAAGAGGA ATGACTATAC ACCTGATAAA ATTCTGTTTC CTCAGGATGA GCCTTCAGAT 5520

TTGACTCTTC AGCCTGGAAA TTCCACCAAA GAATCAGATT CAACTAATTC TATTCGTCTA 5580

ATGTTATAA 5589

Domain Profile

S: 1     ssesWsqqetivlikvlskeekkGalRkalrv..........kkgslflvkeelkevvry  50

         s++sWsq +++++i++lskee+ G+lR+a++v          k+g+l+++k++l+evv++

Q: 1595  SMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVqctwsehdilKSGHLYIIKSFLPEVVNT  1654

         699*********************************************************

S: 51    vakiykeqkvlhlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknqll  110

         +++iyke++vlhl+lr++++qraaqkl+++fnq+kPk+i+y+pr++evfL +++s++q++

Q: 1655  WSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWF  1714

         ************************************************************

S: 111   tvEeyllGefvKynnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklTD  170

         +vEe+++Gef+Kynnnngdei+++n+lee+mlafsH+tyeyt+gellV+DlqGvge+lTD

Q: 1715  AVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTD  1774

         ************************************************************

S: 171   pqiat....ksrgtkfgkanlgeraiknFfakhhCNeiC  205

         p++++    +s++++fg+anlge+aiknF+akhhCN++C

Q: 1775  PSVIKaeekRSCDMVFGPANLGEDAIKNFRAKHHCNSCC  1813

         *****99999*****************************

Domain Sequence
(FASTA)

SMSSWSQLGL CAKIEFLSKE EMGGGLRRAV KVQCTWSEHD ILKSGHLYII KSFLPEVVNT 60

WSSIYKEDTV LHLCLREIQQ QRAAQKLTFA FNQMKPKSIP YSPRFLEVFL LYCHSAGQWF 120

AVEECMTGEF RKYNNNNGDE IIPTNTLEEI MLAFSHWTYE YTRGELLVLD LQGVGENLTD 180

PSVIKAEEKR SCDMVFGPAN LGEDAIKNFR AKHHCNSCC 219

Keyword

Complete proteome; Ion transport; Ionic channel; Membrane; Reference proteome; Transmembrane; Transport.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0001726	; C:ruffle
GO:0005524	; F:ATP binding
GO:0005262	; F:calcium channel activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0031032	; P:actomyosin structure organization
GO:0016340	; P:calcium-dependent cell-matrix adhesion
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR005821	; Ion_trans_dom.
IPR011009	; Kinase-like_dom.
IPR004166	; MHCK_EF2_kinase.

Pfam

PF02816	; Alpha_kinase; 1.
PF00520	; Ion_trans; 1.

SMARTs

SM00811

; Alpha_kinase; 1.

Prosites

PS51158

; ALPHA_KINASE; 1.

Prints

Created Date

20-Feb-2013