EKS-EQC-00387
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00387
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl545.42.4E-164486751266
StatusUnreviewed
Ensembl ProteinENSECAP00000015977
UniProt AccessionF7DKP9;
Protein Name
Protein Synonyms/Alias
Gene NameTYRO3
Gene Synonyms/Alias TYRO3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000017862ENSECAP00000015977ENSECAT00000019516
OrganismEquus caballus
Functional Description
Protein Length858
Protein Sequence
(FASTA)
LLLPEAAAAG LKLMGAPVKL TVSQGQPVKL NCSVEGMEDP EIQWVKDGAV VQSVDQVYIP 60
VSEQHWIGFL SLKSVERSDA GRYWCQVEDG GETEISQPVW LTVEGVPFFT VEPKDLAVPP 120
NAPFQLSCEA VGPPEPVTIV WWRGGTKVGE PAPSPSVLNV TGVTQSTVFS CEAHNLKGLA 180
SSRPATVRLQ APPAAPFNIT VTKLSSSNAS VAWTPGADGR ALLQSCTVQV TQAPGGWEVL 240
AVVVPVPPFT CLLRDLAPAT NYSLRVRCAN ALGPSPYADW VPFRTKGLAP ASAPQNLHAI 300
RTDSGLILQW EEVIPEGPWE GPLGPYKLSW VQDNGTQGEL TVEGTRANLT GWDPQKDLTV 360
RVCISNAVGC GPWSQPLVVS SHDHAGQQGP PHSRTSWVPV VLGVLTALVT AAALALILLR 420
KRRKETRFGQ AFDSVMARGE PAVHFRAARS FNRERPERIE ATLDSLGISD ELKDKLEDVL 480
IPEQQFTLGR MLGKGEFGSV REAQLKQEDG SFVKVAVKML KADIIASSDI EEFLREAACM 540
KEFDHPHVAK LVGVSLRSRA KGRLPIPMVI LPFLKHGDLH AFLLASRMGE NPFNLPLQTL 600
IRFMVDIACG MEYLSSRNFI HRDLAARNCM LAEDMTVCVA DFGLSRKIYS GDYYRQGCAS 660
KLPVKWLALE SLADNLYTVH SDVWAFGVTM WEIMTRGQTP YAGIENAEIY NYLIGGNRLK 720
QPPDCLEDVY ELMYQCWSAD PKQRPSFTCL RMELENILGH LSVLSISQDP LYINLERAEE 780
PAEGGGLDLP GGDQASSGAG DGSGIGAVGG IPSDCRYILS PGGLAEQPGQ EEQQPESPLN 840
EAQRLLLLQQ GLLPHSSC 858
Nucleotide Sequence
(FASTA)
CTGCTGCTCC CGGAGGCCGC GGCCGCAGGC CTGAAGCTCA TGGGAGCCCC AGTGAAGCTG 60
ACAGTGTCTC AGGGGCAGCC AGTGAAACTC AACTGCAGCG TGGAGGGGAT GGAAGATCCT 120
GAGATACAGT GGGTGAAGGA TGGGGCCGTG GTCCAGAGTG TGGATCAGGT GTACATCCCA 180
GTCAGTGAGC AGCACTGGAT TGGCTTCCTC AGCTTGAAGT CAGTGGAGCG CTCTGATGCG 240
GGCCGGTACT GGTGCCAGGT GGAGGATGGG GGCGAAACTG AGATCTCCCA GCCAGTGTGG 300
CTCACGGTAG AAGGTGTACC ATTTTTCACT GTGGAGCCAA AAGATCTGGC AGTGCCACCC 360
AATGCGCCTT TCCAACTGTC TTGTGAGGCT GTGGGTCCCC CCGAACCTGT TACCATTGTC 420
TGGTGGCGAG GAGGCACGAA GGTTGGGGAA CCTGCTCCCT CTCCCTCTGT TTTAAATGTT 480
ACAGGGGTGA CCCAGAGCAC TGTGTTCTCC TGTGAAGCTC ACAACCTAAA AGGCCTGGCC 540
TCTTCTCGCC CAGCCACTGT TCGTCTTCAA GCACCACCTG CAGCCCCGTT CAACATCACA 600
GTGACGAAGC TTTCCAGCAG CAATGCCAGC GTGGCCTGGA CACCAGGGGC CGACGGCCGA 660
GCCCTGCTGC AATCATGCAC GGTCCAGGTG ACACAGGCCC CAGGGGGCTG GGAGGTCCTT 720
GCTGTTGTGG TCCCCGTGCC ACCTTTTACC TGCCTGCTCC GGGACCTGGC ACCTGCCACC 780
AACTATAGCC TCAGGGTGCG CTGTGCCAAC GCCTTGGGGC CTTCTCCATA TGCTGACTGG 840
GTGCCCTTTC GGACAAAGGG TCTAGCCCCA GCCAGTGCGC CCCAGAACCT CCATGCCATC 900
CGCACAGACT CAGGCCTCAT CCTGCAGTGG GAAGAAGTGA TCCCTGAGGG CCCTTGGGAA 960
GGCCCCCTGG GACCCTATAA ACTGTCCTGG GTTCAAGACA ACGGAACCCA GGGTGAGCTG 1020
ACAGTAGAGG GGACCAGGGC CAACTTGACA GGCTGGGATC CCCAGAAGGA CCTGACTGTG 1080
CGTGTGTGCA TCTCCAATGC AGTTGGCTGC GGGCCCTGGA GTCAGCCACT GGTGGTCTCT 1140
TCTCATGACC ATGCAGGCCA GCAGGGCCCT CCCCACAGCC GCACATCCTG GGTGCCTGTG 1200
GTCCTAGGTG TGCTGACAGC CCTGGTGACA GCTGCTGCCC TGGCCCTCAT CCTGCTTCGA 1260
AAGAGGCGGA AGGAGACACG GTTTGGGCAA GCCTTTGACA GTGTCATGGC CCGGGGGGAG 1320
CCAGCCGTTC ACTTCCGGGC AGCCCGGTCC TTCAATCGGG AAAGGCCTGA GCGCATCGAA 1380
GCCACATTGG ACAGCTTGGG CATCAGCGAT GAACTGAAGG ACAAACTGGA GGATGTGCTC 1440
ATTCCAGAGC AGCAGTTCAC TCTGGGCCGG ATGTTGGGCA AAGGAGAGTT TGGTTCAGTG 1500
CGGGAGGCCC AGTTGAAGCA GGAGGATGGC TCCTTTGTAA AAGTGGCTGT AAAGATGCTG 1560
AAAGCTGACA TCATTGCCTC AAGCGACATT GAAGAGTTCC TCAGGGAAGC GGCTTGCATG 1620
AAGGAGTTTG ACCACCCACA CGTGGCCAAG CTTGTTGGGG TGAGCCTCCG GAGCAGGGCC 1680
AAAGGCCGTC TCCCTATCCC CATGGTCATC CTGCCCTTCC TGAAGCACGG GGACCTGCAC 1740
GCCTTCCTGC TCGCCTCCCG GATGGGGGAG AACCCCTTTA ACCTGCCCCT GCAGACCCTG 1800
ATCCGGTTCA TGGTGGACAT TGCCTGTGGC ATGGAGTACC TGAGCTCCCG GAACTTTATC 1860
CACCGAGATC TGGCCGCTCG GAATTGCATG CTGGCAGAAG ACATGACAGT GTGCGTGGCT 1920
GACTTTGGAC TGTCCCGGAA AATCTACAGC GGGGACTACT ATCGTCAGGG CTGTGCCTCC 1980
AAATTGCCTG TCAAGTGGTT GGCCCTGGAG AGCCTGGCTG ACAACCTGTA TACTGTGCAC 2040
AGTGACGTGT GGGCCTTTGG GGTGACCATG TGGGAGATCA TGACTCGTGG GCAGACGCCA 2100
TATGCTGGCA TCGAGAACGC TGAGATTTAC AACTACCTCA TCGGCGGGAA CCGCCTGAAA 2160
CAGCCTCCGG ACTGTTTGGA GGACGTGTAT GAGCTCATGT ACCAGTGCTG GAGTGCCGAC 2220
CCCAAGCAGC GCCCGAGCTT CACATGCCTG CGAATGGAGC TGGAGAACAT CCTGGGCCAC 2280
CTGTCTGTGC TGTCCATCAG CCAGGACCCC TTGTACATCA ACCTTGAGAG AGCCGAGGAG 2340
CCTGCTGAGG GAGGCGGCCT GGACCTGCCT GGCGGGGACC AGGCCAGCAG CGGGGCTGGG 2400
GATGGCAGCG GCATAGGGGC AGTTGGGGGC ATCCCCAGTG ACTGTCGGTA CATCCTCAGC 2460
CCTGGGGGGC TAGCTGAGCA GCCGGGGCAG GAGGAGCAGC AGCCAGAAAG CCCCCTCAAT 2520
GAGGCCCAGA GGCTGCTGCT GCTGCAGCAA GGGCTACTGC CGCACAGTAG CTGTTAG 2577
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lg++lg+gefgsv+e+qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdh
Q: 486   FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDH  545
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         p+v++lvgvsl+s++kgrlp+p+vilpf+k+gdlhafll+sr+genp++lplqtl++fmv
Q: 546   PHVAKLVGVSLRSRAKGRLPIPMVILPFLKHGDLHAFLLASRMGENPFNLPLQTLIRFMV  605
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         dia+gmeylssrnfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk
Q: 606   DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  665
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl++gnrlkqp+dc
Q: 666   WLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPDC  725
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         l+++y+lmy+cw+adpk+rpsf+ lr
Q: 726   LEDVYELMYQCWSADPKQRPSFTCLR  751
         ***********************998
Domain Sequence
(FASTA)
FTLGRMLGKG EFGSVREAQL KQEDGSFVKV AVKMLKADII ASSDIEEFLR EAACMKEFDH 60
PHVAKLVGVS LRSRAKGRLP IPMVILPFLK HGDLHAFLLA SRMGENPFNL PLQTLIRFMV 120
DIACGMEYLS SRNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180
WLALESLADN LYTVHSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIG GNRLKQPPDC 240
LEDVYELMYQ CWSADPKQRP SFTCLR 266
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00372
EKS-ANC-00384
EKS-BOT-00399
EKS-CAJ-00404
EKS-CAF-00400
EKS-CAP-00424
EKS-CIS-00152
EKS-DAR-00777
EKS-FEC-00382
EKS-GAG-00338
EKS-GAA-00488
EKS-GOG-00387
EKS-HOS-00403
EKS-ICT-00375
EKS-LOA-00403
EKS-MAM-00399
EKS-MEG-00329
EKS-MOD-00385
EKS-MUM-00432
EKS-MUP-00390
EKS-MYL-00393
EKS-NOL-00364
EKS-ORN-00511
EKS-ORA-00344
EKS-ORC-00374
EKS-ORL-00465
EKS-OTG-00402
EKS-PES-00355
EKS-POA-00391
EKS-PTV-00110
EKS-RAN-00411
EKS-SAH-00365
EKS-SUS-00346
EKS-TAG-00471
EKS-TAR-00502
EKS-TAS-00046
EKS-XET-00511
EKS-XIM-00503
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0016021; C:integral to membrane
GO:0005635; C:nuclear envelope
GO:0005524; F:ATP binding
GO:0043548; F:phosphatidylinositol 3-kinase binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0021885; P:forebrain cell migration
GO:0001779; P:natural killer cell differentiation
GO:0050728; P:negative regulation of inflammatory response
GO:0045824; P:negative regulation of innate immune response
GO:0051250; P:negative regulation of lymphocyte activation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0070050; P:neuron homeostasis
GO:0042698; P:ovulation cycle
GO:0070527; P:platelet aggregation
GO:0046777; P:protein autophosphorylation
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013