EKS-EQC-00431

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00431

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	495.7	3.4E-149	77	343	267

Status

Unreviewed

Ensembl Protein

ENSECAP00000016133

UniProt Accession

F7A5X7;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPA

Gene Synonyms/Alias

CDC42BPA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000017881	ENSECAP00000016133	ENSECAT00000019694

Organism

Equus caballus

Functional Description

Protein Length

1719

Protein Sequence
(FASTA)

MSGEVRLRQL EQFILDGPAQ TNGQCFSVET LLDILICLYD ECNNSPLRRE KNILEYLEWA 60

KPFTSKVKQM RLHREDFEIL KVIGRGAFGE VAVVKLKNAD KVFAMKILNK WEMLKRAETA 120

CFREERDVLV NGDNKWITTL HYAFQDDNNL YLVMDYYVGG DLLTLLSKFE DRLPEDMARF 180

YLAEMVIAID SVHQLHYVHR DIKPDNILMD MNGHIRLADF GSCLKLMEDG TVQSSVAVGT 240

PDYISPEILQ AMEDGKGRYG PECDWWSLGV CMYEMLYGET PFYAESLVET YGKIMNHKER 300

FQFPAQVTDV SENAKDLIRR LICSREHRLG QNGIEDFKKH PFFNGIDWDN IRNCEAPYIP 360

EVSSPTDTSN FDVDDDCLKN SETMPPPTHT AFSGHHLPFV GFTYTSSCVL SDRSCLRVTA 420

GPTSLDLDVN VQRTLDNTLA TEAYERRIKR LEQEKLELSR KLQESTQTVQ ALQYSTADGP 480

LTASKDLEIK NLKEEIEKLR KQVRESSHLE QQLEEANSVR RELDDAFRQI KAYEKQIKAL 540

QQEREDLNKE LVQASERLKN QSKELKDAHC QRKLAMQEFM EINERLTELH AQKQKLARHV 600

RDKEEEVDLV MQKVESLRQE LRRTERAKKE LEVHTEAVAA EASKDRKLRE QSEHYSKQLE 660

NELEGLKQKQ ISYSPGVCSI EHQQEITKLK TDLEKKSIFY EEELSKREGI HANEIKNLKK 720

ELHDSEGQQL ALNKEIMILK DKLEKNRRES QSEREEFENE FKQQYEREKV LLTEENKKLT 780

SELDKLTTLY ENLSVHNQQL EEEVKDLADK RESVAHWEAQ ITEIIQWVSD EKDARGYLQA 840

LASKMTEELE ALRNSSLGTR ATDMPWKMRR FAKLDMSARL ELQSALDAEI RAKQAIQEEL 900

NKVKASNIVT ECKLKDSEKK NLELLSEIEQ LIKDTEELRS EKGVEPRDSQ HSFLAFLNAP 960

PDALDQLETV DSAPLPVHTP TLRKKGCPGS AGFPAKRKTH QFFVKSFATP TKCHQCTSLM 1020

VGLIRQGCSC EVCGFSCHIT CVNKAPTTCP VPPEQTKGPL GIDPQKGTGT AYEGHVRIPK 1080

PAGVKKGWQR ALAVVCDFKL FLYDIAEGKA SQPSVVVSQV IDMRDEEFSV SSVLASDVIH 1140

ASRKDIPCIF RVTASQLSAS NNTCSILMLA DSENEKSKWV GVLSELHKIL KKNKFRDRSV 1200

YVPKEAYDST LPLIKTTQAA AIIDHERIAL GNEEGLFVVH VTKDEIIRVG DNKKIHQIEL 1260

IPNDQLVAVI SGRNRHVRLF PMSALDGRET EFYKLAETKG CQTITSGRVR HGALTCLCVA 1320

MKRQVLCYEL FQSKTRHRKF KEIQVPYNVQ WMAIFSEQLC VGFQSGFLRY PLNGEGSPYS 1380

MLHSNDHTLS FIAHQPMDAI CAVEISSKEY LLCFNSIGIY TDCQGRRSRQ QELMWPANPS 1440

SCCYNAPYLS VYSENAVDIF DVNSMEWIQT LPLKKVRPLN SEGSLNLLGL ETIRLIYFKN 1500

KMAEGDELVV PETSDNSRKQ MVRNINNKRR YSFRVPEEER MQQRREMLRD PEMRNKLISN 1560

PTNFNHIAHM GPGDGIQILK DLPMNPRPQE SRTVFSGSVS IPSITKSRPE PGRSMSASSG 1620

LSARSSAQNG SALKREFSGG SYSAKRQPMP SPSEGSLSSG GMDQGSDAPA RDFDGEDSDS 1680

PRHSTASNSS NLSSPPSPVS PRKTKSLSLE STDRGGWEP 1719

Nucleotide Sequence
(FASTA)

ATGTCTGGAG AAGTGCGTTT GAGGCAGTTG GAGCAGTTTA TTTTGGATGG GCCCGCTCAG 60

ACCAATGGGC AGTGCTTCAG TGTGGAAACG CTGCTGGATA TCCTCATCTG CCTTTATGAT 120

GAATGCAATA ATTCTCCATT GAGAAGAGAG AAGAACATTC TTGAATACCT GGAATGGGCT 180

AAACCATTTA CTTCTAAAGT GAAACAGATG CGATTACACA GAGAAGACTT TGAAATATTA 240

AAGGTGATTG GTCGAGGAGC TTTTGGAGAG GTTGCTGTGG TGAAACTAAA AAATGCAGAT 300

AAGGTATTTG CCATGAAAAT ATTGAATAAA TGGGAAATGC TGAAAAGAGC TGAGACAGCA 360

TGTTTTCGTG AAGAAAGGGA TGTTTTAGTG AATGGAGACA ATAAATGGAT TACAACTTTG 420

CATTATGCTT TCCAGGATGA CAATAACTTA TACCTGGTTA TGGATTATTA TGTTGGTGGG 480

GATTTGCTTA CTCTGCTCAG CAAATTTGAA GATAGATTGC CTGAAGATAT GGCTCGATTC 540

TACTTGGCTG AGATGGTGAT AGCAATTGAT TCAGTGCATC AGCTGCATTA TGTACACAGG 600

GATATCAAAC CTGACAATAT ATTGATGGAT ATGAATGGAC ATATTCGGTT AGCAGATTTT 660

GGGTCTTGTC TGAAGCTGAT GGAAGATGGA ACGGTGCAGT CCTCAGTGGC TGTTGGAACT 720

CCGGATTATA TCTCTCCTGA AATCCTTCAA GCCATGGAAG ATGGAAAAGG CAGATATGGA 780

CCTGAGTGTG ACTGGTGGTC TTTGGGAGTC TGTATGTATG AAATGCTTTA TGGAGAAACG 840

CCGTTTTATG CAGAATCTCT GGTGGAGACA TATGGAAAAA TCATGAATCA TAAAGAAAGG 900

TTTCAGTTTC CAGCTCAAGT GACTGATGTG TCTGAAAATG CTAAGGATCT TATTCGAAGG 960

CTCATCTGTA GCAGAGAGCA TCGACTTGGT CAGAATGGAA TAGAAGACTT TAAGAAACAC 1020

CCATTTTTCA ATGGAATTGA CTGGGATAAT ATTCGAAACT GTGAAGCACC GTATATTCCA 1080

GAAGTTAGCA GTCCAACAGA TACATCAAAT TTTGATGTGG ATGATGACTG TTTAAAGAAT 1140

TCTGAAACAA TGCCCCCACC AACACATACT GCATTTTCTG GCCACCATCT GCCATTTGTT 1200

GGTTTTACGT ATACTAGTAG CTGCGTTCTT TCTGATCGGA GCTGTTTGAG AGTTACTGCT 1260

GGTCCCACTT CACTGGATCT TGACGTTAAC GTTCAAAGGA CTCTAGATAA CACCTTAGCA 1320

ACTGAAGCTT ATGAAAGAAG AATTAAGCGC CTTGAACAGG AAAAACTTGA ACTTAGTAGA 1380

AAGCTTCAAG AGTCAACGCA GACTGTCCAA GCTCTGCAGT ATTCAACTGC TGATGGTCCA 1440

CTCACAGCAA GCAAAGATTT AGAAATCAAA AACTTAAAAG AAGAAATCGA AAAACTAAGG 1500

AAACAAGTAA GAGAATCAAG TCACTTGGAA CAGCAACTTG AAGAAGCTAA TTCTGTGAGG 1560

CGAGAACTAG ATGATGCTTT TAGACAAATC AAGGCTTATG AAAAGCAAAT CAAAGCATTA 1620

CAGCAAGAAA GGGAGGACTT AAATAAGGAA CTAGTCCAGG CTAGTGAGCG ATTAAAAAAC 1680

CAGTCCAAAG AGCTGAAAGA CGCACACTGT CAGAGGAAAC TGGCCATGCA GGAGTTCATG 1740

GAGATCAATG AGCGGCTAAC AGAATTGCAC GCCCAAAAAC AGAAACTTGC TCGCCACGTC 1800

CGAGATAAGG AAGAAGAGGT GGACCTGGTG ATGCAAAAAG TTGAAAGCTT AAGGCAAGAA 1860

CTGCGCAGAA CAGAAAGAGC CAAAAAAGAG CTGGAAGTTC ACACAGAAGC TGTAGCTGCT 1920

GAAGCATCTA AAGACAGGAA ATTGCGTGAA CAGAGCGAGC ACTACTCTAA GCAACTGGAA 1980

AATGAATTGG AGGGACTGAA GCAAAAACAG ATTAGTTACT CACCAGGAGT ATGCAGCATA 2040

GAGCATCAGC AAGAGATAAC CAAACTAAAG ACTGATTTGG AAAAGAAAAG TATCTTTTAT 2100

GAAGAAGAAT TGTCTAAAAG AGAAGGAATA CATGCAAATG AAATCAAAAA TCTGAAGAAA 2160

GAACTGCACG ATTCAGAAGG CCAGCAACTT GCTCTCAACA AAGAAATTAT GATTTTGAAA 2220

GACAAGTTGG AAAAAAACAG GAGAGAGAGT CAAAGTGAAA GGGAAGAATT TGAAAATGAG 2280

TTCAAACAAC AGTATGAACG AGAAAAAGTG TTATTAACTG AAGAAAATAA AAAACTGACA 2340

AGTGAACTTG ATAAGCTTAC CACGTTGTAT GAGAACTTAA GTGTACACAA CCAGCAGTTA 2400

GAGGAAGAGG TGAAAGATCT AGCAGACAAG AGAGAATCCG TTGCACACTG GGAAGCCCAG 2460

ATCACAGAAA TCATTCAGTG GGTCAGTGAT GAAAAGGATG CACGAGGATA TCTTCAGGCC 2520

TTAGCTTCTA AAATGACTGA AGAACTGGAA GCATTAAGAA ATTCCAGCCT GGGTACACGA 2580

GCAACAGATA TGCCCTGGAA AATGCGTCGT TTTGCAAAAC TGGATATGTC TGCTAGACTG 2640

GAGTTGCAGT CAGCTCTGGA TGCAGAAATA AGAGCCAAAC AGGCCATCCA AGAAGAGCTG 2700

AACAAAGTTA AAGCATCTAA CATCGTCACA GAATGTAAAC TAAAAGATTC AGAGAAGAAG 2760

AACTTGGAAC TGCTATCAGA AATTGAACAG CTGATAAAGG ACACTGAAGA GCTTAGATCT 2820

GAAAAGGGTG TAGAGCCCCG AGACTCACAG CATTCTTTCT TGGCATTTTT GAATGCGCCT 2880

CCCGATGCTC TGGATCAACT GGAAACTGTA GACTCCGCTC CACTTCCAGT TCACACACCA 2940

ACCTTAAGGA AAAAGGGGTG CCCTGGTTCA GCCGGCTTTC CAGCTAAGCG CAAGACTCAT 3000

CAGTTTTTTG TCAAATCTTT TGCTACTCCT ACCAAATGTC ATCAGTGTAC CTCTTTGATG 3060

GTGGGTTTGA TAAGACAAGG CTGTTCCTGT GAAGTGTGTG GATTCTCATG TCATATAACC 3120

TGTGTAAACA AAGCTCCGAC CACTTGCCCA GTTCCTCCTG AACAGACCAA AGGTCCCCTA 3180

GGTATAGATC CACAGAAAGG GACAGGAACA GCGTACGAAG GTCATGTCAG GATTCCTAAG 3240

CCAGCTGGAG TGAAGAAAGG ATGGCAAAGA GCATTAGCTG TAGTTTGTGA CTTCAAACTC 3300

TTTCTGTACG ACATTGCTGA AGGAAAAGCA TCGCAGCCCA GTGTTGTAGT CAGTCAAGTG 3360

ATTGACATGA GGGATGAAGA ATTTTCTGTG AGTTCAGTCT TGGCTTCTGA TGTTATTCAT 3420

GCAAGTCGAA AAGATATACC GTGTATATTT AGAGTCACAG CTTCCCAGCT CTCAGCATCT 3480

AATAACACAT GTTCGATCCT GATGCTGGCA GATAGTGAGA ATGAGAAGAG TAAGTGGGTG 3540

GGAGTGCTGA GTGAATTGCA CAAGATTTTG AAGAAAAACA AATTCAGAGA CCGCTCAGTC 3600

TATGTTCCCA AAGAGGCTTA TGACAGCACT CTACCCCTCA TTAAAACAAC CCAGGCAGCT 3660

GCAATCATAG ATCACGAGAG GATAGCTTTG GGAAATGAAG AAGGGTTATT TGTTGTGCAT 3720

GTCACTAAAG ATGAAATTAT TAGAGTTGGT GACAATAAGA AGATTCATCA GATTGAACTC 3780

ATTCCAAATG ATCAGCTTGT TGCTGTGATC TCAGGACGAA ATCGTCATGT CCGACTTTTT 3840

CCTATGTCAG CTTTGGACGG GCGAGAGACT GAGTTTTATA AGCTGGCAGA AACTAAAGGG 3900

TGTCAAACCA TAACTTCTGG AAGAGTGCGC CACGGAGCTC TTACATGCCT GTGTGTGGCT 3960

ATGAAAAGGC AGGTCCTCTG TTATGAACTA TTTCAGAGCA AGACCCGTCA CAGAAAATTT 4020

AAGGAAATTC AAGTCCCATA TAATGTCCAG TGGATGGCCA TCTTCAGTGA ACAACTCTGT 4080

GTGGGATTCC AGTCAGGATT TCTGAGATAC CCCTTGAATG GAGAAGGAAG TCCGTACAGT 4140

ATGCTCCATT CAAACGACCA CACACTGTCA TTTATTGCAC ATCAACCAAT GGATGCCATC 4200

TGCGCGGTTG AGATCTCCAG TAAAGAGTAC CTGCTGTGTT TTAACAGCAT TGGGATATAT 4260

ACCGACTGCC AGGGCCGAAG ATCTAGACAG CAGGAGTTGA TGTGGCCAGC AAATCCTTCC 4320

TCTTGTTGTT ACAATGCACC CTATCTCTCA GTGTATAGTG AGAACGCGGT CGATATCTTT 4380

GATGTGAACT CCATGGAATG GATTCAGACT CTCCCCCTCA AAAAGGTCCG ACCCTTAAAC 4440

AGTGAAGGAT CATTAAATCT TTTAGGGTTG GAGACAATTA GATTAATATA TTTCAAAAAT 4500

AAGATGGCAG AAGGGGATGA GCTAGTAGTT CCTGAAACAT CCGATAATAG TCGGAAACAA 4560

ATGGTGAGAA ACATTAACAA CAAGCGGCGT TACTCCTTCC GAGTCCCAGA AGAGGAGAGG 4620

ATGCAGCAGA GGAGAGAGAT GCTACGAGAT CCAGAAATGA GAAATAAGTT AATTTCTAAC 4680

CCAACTAATT TTAACCACAT AGCACACATG GGTCCGGGAG ATGGAATACA GATCCTAAAA 4740

GACCTGCCCA TGAACCCTCG GCCTCAGGAA AGTCGGACAG TATTCAGTGG CTCAGTCAGT 4800

ATTCCATCTA TCACCAAATC CCGCCCTGAA CCAGGTCGCT CCATGAGCGC CAGCAGTGGC 4860

CTGTCAGCAA GGTCATCTGC ACAGAATGGC AGTGCGTTAA AGAGAGAATT CTCTGGAGGA 4920

AGCTACAGTG CGAAGCGGCA GCCCATGCCC TCCCCATCAG AGGGCTCGCT GTCTTCCGGA 4980

GGCATGGACC AAGGAAGTGA TGCCCCAGCG AGGGACTTTG ATGGAGAGGA CTCTGATTCT 5040

CCCAGGCATT CCACAGCTTC CAACAGTTCC AACCTGAGCA GCCCACCCAG CCCCGTGTCG 5100

CCCCGGAAGA CCAAGAGCCT GTCTCTGGAG AGCACTGACC GCGGGGGCTG GGAGCCCTGA 5160

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         feilkviGrGafgevavv+ k+++kv+amkil+k+e+lkrae+a+freerdvlv++d++w

Q: 77    FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKW  136

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqd+++lylvm+y+vGGdlltllsk+ed+lpe++arfylae+v+a+dsvh+l+

Q: 137   ITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLH  196

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdnil+d++Ghi+ladfGsclkl+edgtv+ssvavGtpdyispe+l+a+e+gk

Q: 197   YVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGK  256

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nhke+++fp+++ +vse+akd

Q: 257   GRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVtDVSENAKD  316

         **************************************************99********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg++gied+kkhpff

Q: 317   LIRRLICSREHRLGQNGIEDFKKHPFF  343

         **************************9

Domain Sequence
(FASTA)

FEILKVIGRG AFGEVAVVKL KNADKVFAMK ILNKWEMLKR AETACFREER DVLVNGDNKW 60

ITTLHYAFQD DNNLYLVMDY YVGGDLLTLL SKFEDRLPED MARFYLAEMV IAIDSVHQLH 120

YVHRDIKPDN ILMDMNGHIR LADFGSCLKL MEDGTVQSSV AVGTPDYISP EILQAMEDGK 180

GRYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HKERFQFPAQ VTDVSENAKD 240

LIRRLICSRE HRLGQNGIED FKKHPFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

ecb:100054548

;

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013