EKS-EQC-00363
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00363
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src426.33.9E-128236485250
StatusUnreviewed
Ensembl ProteinENSECAP00000015935
UniProt AccessionF7CU65;
Protein Name
Protein Synonyms/Alias
Gene NameBLK
Gene Synonyms/Alias BLK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000017938ENSECAP00000015935ENSECAT00000019467
OrganismEquus caballus
Functional Description
Protein Length500
Protein Sequence
(FASTA)
MGVVSSKKQV KEKEKGEWSP VKASTQSKDP PPLPPLVVFN HLPPAPPDTH PGQEEHFVVA 60
LYDYTAGNDR DLQMLKGEKL QILKEAGDWW LAKSLVTGRE GYVPSNFVAR VETVEVEKWF 120
FRSISRKDAE RQLLAPVNKV GSFLIRESET SKGTLSLSVK DVTAQGEVIK HYKIRSLDEG 180
GYYITPRITF PTLQALVQHY SKKGDGLCQR LTQPSVSLAP QNPWAQDEWE IPRQSLKLVR 240
KLGSGQFGEV WMGYYKNNVK VAIKTLKEGT MSPEAFLGEA NLMKTLQHER LVRLYAVVTK 300
EPIYIVTEYM ARGCLLDFLK TDEGSKLSLP RLIDMSAQIA EGMAYIEQMN SIHRDLRAAN 360
ILVSETLCCK IADFGLARII DNEYTAQEGA KFPIKWTAPE AIHFGVFTIK ADVWSFGILL 420
MEIVTYGRVP YPGMSNPEVV RSLERGYRMP RPDSCPPELY RGVIAECWRS RPEERPTFDF 480
LQSVLGDFYT ATERQYEPQP 500
Nucleotide Sequence
(FASTA)
ATGGGAGTGG TGAGCAGCAA AAAGCAGGTG AAAGAGAAGG AGAAGGGCGA GTGGAGCCCT 60
GTGAAGGCCA GCACCCAGAG CAAAGATCCC CCACCGCTGC CGCCCCTGGT CGTGTTTAAC 120
CACCTGCCTC CTGCACCTCC TGACACACAC CCAGGCCAAG AGGAGCATTT CGTGGTGGCC 180
CTGTATGACT ACACGGCAGG GAACGACCGG GACCTGCAGA TGCTGAAGGG GGAGAAGCTG 240
CAGATCCTGA AGGAAGCTGG AGACTGGTGG CTGGCCAAGT CTCTCGTCAC AGGAAGAGAA 300
GGCTACGTGC CCAGCAACTT CGTGGCCCGA GTAGAGACTG TGGAAGTGGA AAAGTGGTTC 360
TTTAGATCAA TTAGCCGGAA AGATGCCGAG AGGCAGCTGC TGGCCCCAGT CAATAAGGTG 420
GGCTCCTTTC TGATTAGAGA GAGCGAAACC AGCAAAGGTA CCCTCTCCCT GTCTGTGAAG 480
GATGTGACCG CCCAAGGGGA GGTGATCAAA CACTATAAGA TCCGTTCCCT GGACGAAGGA 540
GGCTACTATA TCACCCCCCG CATCACCTTC CCCACTCTCC AGGCGCTGGT GCAGCACTAT 600
TCTAAGAAAG GGGATGGTTT ATGCCAGAGG CTGACCCAAC CCTCTGTGAG CCTGGCTCCT 660
CAGAACCCCT GGGCCCAGGA TGAATGGGAA ATCCCCCGGC AGTCTCTCAA GTTGGTCAGG 720
AAACTCGGGT CTGGACAGTT TGGCGAAGTC TGGATGGGTT ATTACAAAAA CAACGTGAAA 780
GTGGCCATCA AGACCTTGAA GGAGGGAACC ATGTCTCCGG AGGCCTTCCT GGGCGAGGCC 840
AACCTGATGA AAACTCTGCA GCATGAGAGG CTGGTCCGTC TCTACGCCGT GGTCACCAAG 900
GAGCCCATCT ACATTGTGAC GGAGTACATG GCCAGAGGAT GCTTGCTGGA TTTCTTGAAG 960
ACAGACGAAG GTAGCAAATT GTCCCTCCCA CGACTGATCG ACATGTCGGC CCAGATTGCC 1020
GAAGGAATGG CGTATATCGA GCAAATGAAT TCCATCCACC GCGACCTGAG GGCGGCCAAC 1080
ATCCTGGTTT CTGAGACCTT GTGCTGCAAA ATCGCTGACT TCGGCTTGGC CCGGATCATC 1140
GACAATGAAT ACACTGCCCA GGAGGGGGCC AAGTTCCCCA TCAAGTGGAC TGCCCCCGAG 1200
GCCATCCATT TTGGAGTGTT CACTATCAAA GCAGATGTGT GGTCATTTGG AATCCTGCTG 1260
ATGGAAATCG TCACTTATGG GCGTGTCCCC TACCCAGGAA TGAGCAACCC CGAGGTCGTG 1320
CGCAGCCTGG AGCGCGGCTA CCGCATGCCG CGGCCCGACT CGTGCCCGCC GGAGCTGTAC 1380
CGCGGCGTCA TCGCCGAGTG CTGGCGCAGT CGGCCCGAGG AGCGGCCCAC CTTCGACTTC 1440
CTGCAGTCGG TGCTGGGGGA CTTCTACACG GCCACCGAGC GGCAGTACGA GCCGCAGCCC 1500
TAG 1503
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv+klG+GqfGevw+g++k++vkva+ktlkegt+speafl ea+++k+l+he+lv+ly
Q: 236   LKLVRKLGSGQFGEVWMGYYKNNVKVAIKTLKEGTMSPEAFLGEANLMKTLQHERLVRLY  295
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyivte+ma+G+lldflk++eg+kl+lp+l+d++aq+aeGmay+e++n ihr
Q: 296   AVVTK-EPIYIVTEYMARGCLLDFLKTDEGSKLSLPRLIDMSAQIAEGMAYIEQMNSIHR  354
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+e+l++k+adfGlar+i d+eyta+egak+PikWtaPeai++g+ftik+dv
Q: 355   DLRAANILVSETLCCKIADFGLARII-DNEYTAQEGAKFPIKWTAPEAIHFGVFTIKADV  413
         *************************9.89*******************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239
         WsfGill+eivt+G+vPypGm+n ev++++ergyr+prp++cp ely+ +++ecw+++pe
Q: 414   WSFGILLMEIVTYGRVPYPGMSNPEVVRSLERGYRMPRPDSCPPELYRgVIAECWRSRPE  473
         ************************************************9***********
S: 240   erPtfetlqevl  251
         erPtf++lq+vl
Q: 474   ERPTFDFLQSVL  485
         ********9986
Domain Sequence
(FASTA)
LKLVRKLGSG QFGEVWMGYY KNNVKVAIKT LKEGTMSPEA FLGEANLMKT LQHERLVRLY 60
AVVTKEPIYI VTEYMARGCL LDFLKTDEGS KLSLPRLIDM SAQIAEGMAY IEQMNSIHRD 120
LRAANILVSE TLCCKIADFG LARIIDNEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 180
FGILLMEIVT YGRVPYPGMS NPEVVRSLER GYRMPRPDSC PPELYRGVIA ECWRSRPEER 240
PTFDFLQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00345
EKS-ANC-00360
EKS-BOT-00372
EKS-CAJ-00377
EKS-CAF-00372
EKS-CAP-00405
EKS-DAR-00751
EKS-FEC-00359
EKS-GAM-00225
EKS-GAG-00314
EKS-GOG-00363
EKS-HOS-00379
EKS-ICT-00353
EKS-LAC-00386
EKS-LOA-00381
EKS-MAM-00373
EKS-MEG-00304
EKS-MOD-00360
EKS-MUM-00404
EKS-MUP-00366
EKS-NOL-00339
EKS-ORN-00479
EKS-ORC-00351
EKS-ORL-00443
EKS-OTG-00375
EKS-PES-00329
EKS-POA-00361
EKS-PTV-00095
EKS-RAN-00386
EKS-SAH-00342
EKS-SUS-00325
EKS-TAG-00443
EKS-TAR-00476
EKS-TUT-00099
EKS-XIM-00469
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0032024; P:positive regulation of insulin secretion
KEGG
ecb:100065099;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013