EKS-EQC-00364

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00364

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	421.4	1.3E-126	119	372	254

Status

Unreviewed

Ensembl Protein

ENSECAP00000015668

UniProt Accession

F6RRJ4;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000018039	ENSECAP00000015668	ENSECAT00000019154

Organism

Equus caballus

Functional Description

Protein Length

391

Protein Sequence
(FASTA)

WFFGAIKRAD AEKQLLYSEN QTGAFLIRES ESQKGEFSLS VLHGRVVKHY RIRRLDEGGF 60

FLTRRQTFST LNEFVSHYMK TSDGLCVKLG KPCLKVEVPA PFDLSYKTVD QWEIDRNSVQ 120

LLKRLGSGQF GEVWEGLWNN TTPVAVKTLK PGSMDPNDFL REAQIMKNLR HPKLIQLYAV 180

CTLEDPIYII TELMRHGSLQ EYLQNDAGSK IHLPQQVDMA AQVASGMAYL ESQNYIHRDL 240

AARNVLVGEH NIYKVADFGL ARVFKVDNED IYESKHEIKL PVKWTAPEAI RSNKFSIKSD 300

VWSFGILLYE IITYGKMPYS GMTGAQVIQM LGQNYRLPQP SNCPLQFYNI MLECWNAEPK 360

ERPTFETLHW KLEDYFETDS SSYSDTENFV R 391

Nucleotide Sequence
(FASTA)

TGGTTCTTTG GAGCAATCAA GAGAGCAGAT GCAGAAAAAC AGCTATTATA TTCAGAAAAT 60

CAGACGGGTG CTTTTCTAAT CAGAGAAAGC GAAAGCCAGA AAGGAGAATT CTCCCTCTCA 120

GTTTTACATG GCAGGGTTGT GAAACACTAC AGAATCAGAA GGCTGGATGA AGGGGGCTTT 180

TTCCTTACCC GAAGACAGAC CTTCTCAACA CTGAATGAAT TCGTGAGTCA TTACATGAAA 240

ACAAGCGATG GCCTATGCGT GAAACTGGGA AAACCATGCT TAAAGGTAGA AGTCCCAGCT 300

CCCTTTGATT TGTCATATAA AACTGTGGAC CAGTGGGAGA TAGACCGCAA CTCTGTACAG 360

CTTCTGAAGC GATTAGGATC CGGTCAGTTT GGCGAAGTGT GGGAAGGCCT GTGGAACAAT 420

ACCACTCCAG TAGCAGTAAA AACATTGAAA CCAGGTTCAA TGGATCCAAA TGACTTCCTG 480

AGGGAGGCAC AGATAATGAA GAACCTGAGA CATCCAAAGC TTATCCAGCT TTATGCCGTT 540

TGCACTTTAG AAGATCCAAT TTATATTATT ACAGAGTTGA TGAGACATGG AAGTCTGCAA 600

GAATATCTCC AAAATGATGC TGGATCAAAA ATCCATCTGC CTCAGCAGGT AGACATGGCG 660

GCACAGGTTG CCTCTGGAAT GGCCTATCTG GAGTCCCAGA ACTACATCCA TAGAGATCTG 720

GCTGCCAGAA ATGTCCTTGT TGGTGAACAT AATATCTACA AAGTGGCAGA TTTTGGACTT 780

GCAAGAGTTT TTAAGGTTGA TAATGAAGAC ATCTATGAAT CTAAACACGA AATAAAGCTG 840

CCGGTGAAGT GGACCGCGCC TGAAGCCATT CGTTCTAATA AATTCAGCAT TAAGTCCGAT 900

GTGTGGTCGT TCGGAATCCT TCTTTATGAA ATCATTACTT ATGGCAAAAT GCCTTATAGT 960

GGTATGACAG GTGCTCAGGT CATCCAGATG TTGGGTCAAA ACTACAGACT CCCTCAACCA 1020

TCTAACTGCC CACTGCAATT CTACAACATC ATGTTGGAGT GTTGGAATGC AGAGCCCAAG 1080

GAGCGGCCAA CATTTGAGAC ACTGCATTGG AAACTTGAGG ATTATTTTGA AACAGACTCT 1140

TCTTCATATT CAGATACGGA AAACTTCGTA AGATGA 1176

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 119   VQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLY  178

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+++l+++ g+k++lp++vd+aaqva+Gmayle++n+ihr

Q: 179   AVCTLEDPIYIITELMRHGSLQEYLQNDAGSKIHLPQQVDMAAQVASGMAYLESQNYIHR  238

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar+++   +d+y++k++ klP+kWtaPeai+ +kf+ik

Q: 239   DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYESKHEIKLPVKWTAPEAIRSNKFSIK  298

         ************************998878999***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+Gk+Py+Gmt ++v++++ ++yrlp+p++cp ++y+++lecw+++

Q: 299   SDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLGQNYRLPQPSNCPLQFYNIMLECWNAE  358

         ************************************************************

S: 238   peerPtfetlqevl  251

         p+erPtfetl+++l

Q: 359   PKERPTFETLHWKL  372

         **********9986

Domain Sequence
(FASTA)

VQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LQEYLQNDAG SKIHLPQQVD MAAQVASGMA YLESQNYIHR 120

DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI KLPVKWTAPE AIRSNKFSIK 180

SDVWSFGILL YEIITYGKMP YSGMTGAQVI QMLGQNYRLP QPSNCPLQFY NIMLECWNAE 240

PKERPTFETL HWKL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013