EKS-EQC-00447

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00447

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	504.5	7.8E-152	26	310	285

Status

Unreviewed

Ensembl Protein

ENSECAP00000016055

UniProt Accession

F7ARP6;

Protein Name

Protein Synonyms/Alias

Gene Name

PIK3R4

Gene Synonyms/Alias

PIK3R4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000018119	ENSECAP00000016055	ENSECAT00000019606

Organism

Equus caballus

Functional Description

Protein Length

1358

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60

TLPLTSYKQE LEELKIRLHS AQNCLPFQKA AEKASEKAAM LFRQYVRDNL YDRISTRPFL 120

NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP 180

ADFNYFFDTS RRRTCYIAPE RFVDGGLFAT ELEYMRDPST PLVDLNSNQR TRGELKRAMD 240

IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG QFFPEQVLNK IEDRSIRELV TQMIHREPDK 300

RLEAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIINNLCGH 360

DLPEKAEGEP KENGLVILVS VITSCLQTLK YCDSKLAALE LILHLAPRLS VEILLDRITP 420

YLLHFSNDSV PRVRAEALRT LTKVLALVKE VPRNDINIYP EYILPGIAHL AQDDATIVRL 480

AYAENIALLA ETALRFLELV QLKNLNMEND PNSEEIDEVT HPNGNYDTEL QALHEMVQQK 540

VVTLLSDPEN IVKQTLMENG ITRLCVFFGR QKANDVLLSH MITFLNDKND WHLRGAFFDS 600

IVGVAAYVGW QSSSILKPLL QQGLSDAEEF VIVKALNALT CMCQLGLLQK PHVYEFASDI 660

APFLCHPNLW IRYGAVGFIT GVADQISTAD VYCKLMPYLH PYITQPIIQI ERKLVLLSVL 720

KEPVSRSIFD YALRSKDITS LFRHLYMRQK KRNGSLPDCP PPEDPAIAQL LKKLLSQGMT 780

EEEEDKLLAL KDFMMKSNKA KANIVDQSHL HDGSQKGVID LAALGITGRQ VDLVKTKQEP 840

DDKRARKHVK QDSNVNEEWK SMFGSLEPPN IPQALPKGSD QEVIQTGKPP RSESSAGICV 900

PLSTSPQIPE VTNVQNRKPT IQVLSSTILP STYQIRITTC KTELQQLIQQ KREQCNAERI 960

AKQMMENAEW ESKPPPPGWR PKGLLVAHLH EHKSAVNRIR VSDEHSLFAT CSNDGTVKIW 1020

NSQKMEGKTT TTRSILTYSR IGGRVKTLTF CQGSHYLAIA SDNGAVQLLG IEASKLPKSP 1080

KIHPLQSRTL DQKEDGCVVD MHHFNSGAQS VLAYATVNGS LVGWDLRSSS NAWTLKHDLK 1140

SGLITSFAVD IHQCWLCIGT SSGTMACWDM RFQLPISSHC HPSRARIRRL SMHPLYQSWV 1200

IAAVQGNNEV SMWDMETGDR RFTLWASSAP PLSELQPSAH SVHGIYCSPA DGNPILLTAG 1260

SDMKIRFWDL AYPERSYIVA GSTSSPSVSY YRKIIEGTEV VQEIQNKQKV GPSDDTPRRG 1320

PESLPVGHHD IITDVATFQT SQGFIVTASR DGIVKVWK 1358

Nucleotide Sequence
(FASTA)

ATGGGAAATC AGCTCGCTGG CATTGCTCCT TCCCAGATCC TTTCTGTGGA GAGTTATTTC 60

TCAGACATCC ATGACTTTGA ATATGATAAG AGCCTGGGGA GTACTCGGTT TTTTAAAGTT 120

GCTCGAGCGA AGCATCGAGA AGGCCTGGTG GTTGTCAAGG TCTTTGCAAT TCAGGATCCC 180

ACATTGCCTT TAACCAGCTA CAAACAAGAA CTGGAGGAAC TGAAAATCAG GCTTCATTCT 240

GCGCAAAACT GCCTGCCTTT CCAGAAAGCC GCAGAAAAAG CATCTGAGAA AGCAGCCATG 300

CTCTTTAGGC AATATGTACG AGACAATCTC TATGATCGCA TCAGTACCCG TCCATTCTTA 360

AATAACATTG AGAAGCGTTG GATTGCTTTC CAGATCCTGA CAGCTGTGGA CCAAGCACAC 420

AAATCTGGAG TCCGTCATGG GGACATCAAG ACTGAGAATG TAATGGTCAC CAGTTGGAAC 480

TGGGTCCTTC TAACTGATTT TGCCAGTTTT AAACCCACTT ATCTTCCAGA GGACAACCCA 540

GCAGATTTCA ACTATTTCTT TGACACTTCA CGGAGGAGAA CTTGCTATAT TGCTCCTGAA 600

CGTTTTGTTG ATGGTGGATT GTTTGCCACT GAGTTAGAAT ATATGAGAGA TCCTTCGACT 660

CCACTTGTAG ACTTAAATAG CAATCAGAGA ACAAGAGGAG AGTTGAAGCG AGCAATGGAC 720

ATCTTTTCAG CAGGTTGTGT GATAGCGGAG CTTTTTACAG AAGGTGTACC ACTATTTGAT 780

CTCTCTCAAC TTTTGGCTTA TAGAAATGGA CAATTTTTCC CCGAACAAGT GCTAAATAAA 840

ATTGAAGATC GCAGTATCAG AGAACTGGTA ACTCAGATGA TTCACCGTGA GCCAGATAAA 900

CGTTTAGAGG CAGAAGATTA CTTAAAGCAG CAGCGTGGCA ATGCCTTTCC TGAAATATTT 960

TACACTTTCC TTCAGCCCTA CATGGCCCAG TTTGCCAAGG AAACATTTCT TTCTGCAGAT 1020

GAGCGTATTC TGGTTATACG AAAGGATTTG GGCAACATTA TTAACAATCT CTGTGGACAC 1080

GATCTGCCGG AAAAAGCAGA AGGAGAGCCT AAGGAAAACG GGCTGGTTAT CTTAGTGTCT 1140

GTTATAACGT CCTGCCTGCA GACCCTTAAA TACTGTGATT CCAAACTTGC TGCTTTGGAA 1200

CTCATTCTTC ATTTGGCTCC CAGATTAAGT GTAGAAATTC TTTTGGATCG TATTACACCG 1260

TATCTTTTGC ATTTCAGCAA TGACTCTGTC CCTAGAGTGC GGGCTGAAGC CTTGAGGACG 1320

TTGACCAAAG TTCTTGCTCT TGTCAAAGAG GTTCCTCGCA ATGATATCAA TATCTATCCG 1380

GAGTATATTC TGCCAGGCAT AGCCCACTTA GCCCAAGATG ATGCTACTAT TGTTAGACTA 1440

GCCTATGCTG AAAACATAGC TCTGTTGGCA GAAACAGCTT TGAGATTCTT GGAATTAGTA 1500

CAGTTAAAAA ATCTCAATAT GGAAAATGAT CCAAATAGTG AAGAAATAGA TGAAGTTACA 1560

CATCCCAATG GAAATTATGA CACAGAGCTC CAAGCCTTAC ATGAAATGGT CCAGCAGAAA 1620

GTTGTCACTT TGCTAAGTGA CCCTGAAAAT ATCGTGAAAC AAACCTTAAT GGAAAATGGA 1680

ATAACACGGC TGTGTGTATT CTTTGGACGT CAGAAAGCCA ATGATGTTTT ATTGTCCCAC 1740

ATGATCACTT TCCTAAATGA TAAGAATGAT TGGCATCTGC GTGGAGCCTT TTTTGATAGT 1800

ATAGTTGGTG TTGCTGCCTA TGTTGGCTGG CAGAGCTCTT CAATTCTGAA ACCCCTGCTG 1860

CAACAAGGTC TTAGTGATGC TGAGGAATTT GTTATTGTGA AAGCTCTTAA TGCCCTTACC 1920

TGTATGTGCC AGTTAGGGCT GCTACAGAAA CCCCATGTGT ACGAATTTGC CAGTGATATT 1980

GCCCCCTTTC TGTGCCATCC CAATCTCTGG ATACGCTATG GTGCTGTGGG ATTTATCACA 2040

GGGGTAGCTG ATCAAATTAG CACGGCTGAT GTCTACTGCA AACTGATGCC TTACCTTCAC 2100

CCGTATATTA CTCAACCAAT AATACAGATT GAAAGAAAAC TTGTTCTACT CAGTGTTTTA 2160

AAAGAACCAG TAAGTCGTTC TATATTTGAT TATGCTCTGA GGTCTAAAGA TATTACCAGC 2220

TTGTTCAGAC ATCTTTACAT GCGTCAGAAG AAACGAAATG GGTCTCTTCC TGACTGCCCT 2280

CCACCTGAGG ACCCTGCTAT AGCACAGCTT CTGAAGAAAT TGCTCTCACA GGGAATGACG 2340

GAAGAAGAGG AAGACAAACT TTTGGCACTG AAGGACTTCA TGATGAAATC TAACAAAGCC 2400

AAGGCCAATA TAGTGGACCA GAGCCATCTT CATGATGGTA GTCAGAAAGG TGTAATTGAC 2460

TTGGCAGCCT TAGGCATAAC CGGGAGACAA GTGGATCTTG TTAAAACCAA ACAGGAACCA 2520

GATGACAAGC GAGCTAGAAA ACATGTAAAA CAAGACTCAA ATGTAAATGA AGAATGGAAA 2580

AGCATGTTTG GGTCATTGGA ACCACCAAAC ATCCCACAGG CCCTACCTAA AGGGAGTGAC 2640

CAGGAGGTGA TTCAGACTGG GAAGCCTCCT CGTTCTGAGT CCTCTGCTGG CATTTGTGTC 2700

CCTTTGTCAA CTTCTCCGCA GATTCCAGAA GTGACAAATG TCCAAAATAG AAAACCAACA 2760

ATACAGGTTT TAAGTAGTAC AATTTTACCA TCCACCTACC AGATTCGGAT CACAACTTGT 2820

AAAACTGAAC TTCAGCAGCT CATACAACAA AAGCGGGAGC AGTGTAATGC TGAGAGGATA 2880

GCTAAGCAGA TGATGGAAAA CGCGGAGTGG GAGAGTAAAC CACCACCACC TGGATGGCGT 2940

CCTAAAGGGC TGCTTGTTGC ACATCTTCAT GAACACAAAT CTGCTGTAAA TCGAATTAGA 3000

GTCTCTGATG AACACTCACT TTTTGCAACA TGTTCAAATG ATGGCACAGT GAAAATCTGG 3060

AACAGTCAAA AGATGGAGGG GAAAACCACC ACTACCAGAT CTATTCTCAC ATATAGCCGA 3120

ATTGGAGGAC GTGTCAAAAC TCTTACATTC TGTCAGGGTT CCCACTACTT AGCCATAGCG 3180

TCTGATAATG GTGCTGTCCA GCTTCTTGGA ATCGAGGCTT CTAAGCTACC CAAGTCTCCA 3240

AAAATTCATC CTCTACAAAG CAGAACTCTA GACCAGAAGG AGGATGGTTG TGTCGTGGAT 3300

ATGCATCACT TCAACTCTGG GGCGCAGTCT GTTCTGGCCT ATGCCACTGT GAACGGCTCT 3360

CTGGTTGGCT GGGACCTCAG GTCTTCAAGC AATGCGTGGA CATTAAAGCA TGATTTGAAA 3420

TCGGGTCTCA TAACTTCTTT TGCTGTGGAC ATCCACCAGT GCTGGCTCTG CATTGGTACA 3480

AGCAGTGGTA CCATGGCTTG TTGGGACATG AGGTTCCAGT TGCCAATTTC CAGTCACTGT 3540

CATCCTTCCA GGGCTCGAAT CCGACGCCTC TCCATGCACC CTCTGTATCA GTCCTGGGTG 3600

ATTGCAGCTG TTCAGGGCAA CAATGAAGTG TCTATGTGGG ACATGGAGAC TGGTGACAGA 3660

AGATTCACTC TCTGGGCCAG CAGTGCACCA CCACTTTCTG AGTTACAGCC TTCTGCTCAC 3720

AGTGTCCATG GTATCTACTG TAGTCCTGCA GATGGAAATC CTATCTTGCT AACAGCTGGC 3780

TCAGACATGA AAATAAGGTT TTGGGACTTG GCTTACCCAG AGAGGTCCTA CATTGTTGCA 3840

GGAAGTACCA GTTCTCCATC CGTGTCCTAC TACAGGAAAA TAATTGAAGG CACCGAAGTC 3900

GTTCAGGAAA TTCAGAATAA GCAGAAGGTG GGACCAAGTG ATGACACCCC TCGGAGGGGC 3960

CCAGAGTCTT TGCCTGTGGG ACATCATGAC ATCATCACGG ATGTCGCCAC GTTCCAGACA 4020

TCACAGGGCT TCATCGTAAC TGCTTCTAGA GATGGGATTG TTAAGGTGTG GAAATGA 4077

Domain Profile

S: 1     veyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqncl  60

         +ey+k+lgstrf+kva+ak++eG++vvkvf++qdptl+l+s+kq+leelk++l++aqncl

Q: 26    FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLHSAQNCL  85

         68**********************************************************

S: 61    pfqkvlek..ekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvv  118

         pfqk++ek  ekaa+l+rqyv+dnlydr+strPfln+iek+wiafq+l+a+dq+hksgv+

Q: 86    PFQKAAEKasEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVR  145

         *******999**************************************************

S: 119   hGdiktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsa  178

         hGdiktenv+vtswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++

Q: 146   HGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDG  205

         ************************************************************

S: 179   lasdekl...rdgstelvdldsiqrlrgelkkamdifsaGcvilelftegrplfelsqll  235

         + ++++l   rd+st+lvdl+s+qr+rgelk+amdifsaGcvi+elfteg+plf+lsqll

Q: 206   GLFATELeymRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLL  265

         ******9999**************************************************

S: 236   ayrsgeflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         ayr+g+f++e+vl+kied+++r+lv+q+i++ep+kr++aed+lk+

Q: 266   AYRNGQFFPEQVLNKIEDRSIRELVTQMIHREPDKRLEAEDYLKQ  310

         *******************************************97

Domain Sequence
(FASTA)

FEYDKSLGST RFFKVARAKH REGLVVVKVF AIQDPTLPLT SYKQELEELK IRLHSAQNCL 60

PFQKAAEKAS EKAAMLFRQY VRDNLYDRIS TRPFLNNIEK RWIAFQILTA VDQAHKSGVR 120

HGDIKTENVM VTSWNWVLLT DFASFKPTYL PEDNPADFNY FFDTSRRRTC YIAPERFVDG 180

GLFATELEYM RDPSTPLVDL NSNQRTRGEL KRAMDIFSAG CVIAELFTEG VPLFDLSQLL 240

AYRNGQFFPE QVLNKIEDRS IRELVTQMIH REPDKRLEAE DYLKQ 285

Keyword

Complete proteome; Reference proteome; Repeat; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005770	; C:late endosome
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ecb:100052647

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 3.

SMARTs

SM00320

; WD40; 6.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 2.

Prints

Created Date

20-Feb-2013