EKS-EQC-00393
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00393
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR612.52.7E-184593950358
StatusUnreviewed
Ensembl ProteinENSECAP00000016771
UniProt AccessionF7A2X2;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000018176ENSECAP00000016771ENSECAT00000020434
OrganismEquus caballus
Functional Description
Protein Length1089
Protein Sequence
(FASTA)
MGTCHRALLV LGCLLTGPSL SFCQLSLPSI LPNEDEKVVQ LNSSFSLRCF GESEVSWQYP 60
MSEEENPNVE IRNEENNSGL FVTVLEVVSA SAAHTGLYTC YYNHTQTEES EIEGRRIYIY 120
VPDPDVAFVP LGMTDYLVIV EDDDSAIIPC RTTDPETPVT LLSSDGVVLA SYDSRQGFNG 180
TFSVGPYICE ATVKGKKFRT IPFNVYALKA TSELDLEMEA LKTVYKSGET IVVTCAVFNN 240
EVVDLQWTYP GEVKGKGITM LEEIKVPSIK LVYTLSVPEA TVKDSGDYEC AARQATREVK 300
EMKKVTISVH EKGFIEIKPN FSRLEAVDLH EVKHFVVDVQ AYPPPRISWL KDNLTLIENL 360
TEITTDIEKI QEIRYRSKLK LIRAKEEDSG HYTIVVQNED DVKSYTFELL TQVPSSILDL 420
VDDHHGSTGG QTVRCTAEGT PLPDIEWMIC KDIKKCNNET SWTILANNIS NIITEVHPRD 480
RSTVEGRVTF AKVEETIAVR CLAKNLLGAE NRELKLVAPT LRSELTVAAA VLVLLVIVII 540
SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG 600
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 660
LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSRHPEK PKKELDIFGL TPADESTRSY 720
VILSFENNGD YMDMKQADTT QYVPMLERKE VSKYSDIQRS LYDRPASYKK KAMLDSEVKN 780
LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840
RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 900
VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV KCWNSEPEKR PSFYHLSEIV ENLLPGQYKK 960
SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGGLDEQ RLSADSGYII 1020
PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS 1080
SDLVEDSFL 1089
Nucleotide Sequence
(FASTA)
ATGGGGACTT GCCATCGGGC ACTCCTGGTC TTAGGCTGTC TCCTCACAGG GCCCAGCCTA 60
AGCTTCTGCC AGCTTTCATT ACCCTCCATC CTCCCAAATG AAGATGAAAA GGTTGTGCAG 120
CTGAACTCAT CCTTTTCTCT GAGATGCTTT GGGGAGAGCG AAGTGAGCTG GCAGTACCCC 180
ATGTCTGAAG AAGAGAACCC TAACGTGGAA ATCAGAAATG AGGAAAACAA CAGTGGCCTT 240
TTTGTGACGG TGCTGGAAGT GGTCAGTGCC TCAGCAGCCC ACACGGGATT GTACACTTGC 300
TATTACAACC ACACGCAGAC AGAAGAAAGC GAGATCGAAG GCAGGCGCAT TTACATCTAT 360
GTGCCAGACC CTGATGTGGC CTTCGTACCT CTAGGAATGA CAGACTATTT AGTCATCGTG 420
GAGGATGATG ATTCTGCCAT CATCCCTTGT CGCACGACTG ATCCTGAGAC TCCAGTGACC 480
TTACTCAGCA GTGACGGGGT GGTACTCGCC TCCTACGACA GCAGACAGGG CTTTAACGGA 540
ACCTTCAGCG TCGGGCCCTA CATCTGCGAG GCCACCGTCA AAGGGAAGAA GTTTCGGACC 600
ATCCCATTTA ATGTTTATGC TTTAAAAGCA ACATCAGAAC TTGATCTAGA GATGGAAGCT 660
CTTAAGACTG TGTATAAGTC GGGGGAAACG ATTGTGGTCA CCTGTGCCGT CTTTAACAAC 720
GAGGTGGTTG ACCTTCAGTG GACTTACCCT GGAGAAGTGA AAGGCAAAGG CATCACAATG 780
CTGGAGGAAA TCAAGGTCCC GTCCATCAAA TTGGTGTACA CCCTGAGCGT CCCCGAGGCC 840
ACGGTGAAAG ACAGTGGAGA TTACGAATGT GCTGCCCGCC AGGCCACCAG GGAGGTCAAA 900
GAAATGAAGA AAGTCACCAT TTCTGTCCAT GAGAAAGGCT TCATTGAAAT CAAACCCAAC 960
TTCAGCCGGC TGGAAGCCGT TGACCTGCAT GAGGTCAAAC ATTTTGTGGT GGATGTGCAG 1020
GCCTACCCGC CTCCTAGGAT ATCCTGGCTG AAGGACAACC TGACTCTGAT CGAAAATCTC 1080
ACTGAGATCA CCACTGACAT AGAAAAGATC CAGGAAATAA GGTACCGAAG CAAATTAAAG 1140
CTGATCCGTG CAAAGGAAGA AGACAGTGGT CATTATACTA TTGTAGTTCA AAATGAAGAT 1200
GATGTAAAGA GCTATACCTT TGAACTCTTA ACTCAAGTTC CCTCATCTAT TCTGGACTTG 1260
GTCGACGACC ACCATGGCTC TACCGGGGGT CAGACTGTGA GATGCACAGC TGAAGGGACC 1320
CCTCTTCCTG ACATTGAGTG GATGATTTGC AAGGATATTA AGAAATGTAA TAATGAAACT 1380
TCGTGGACGA TTTTGGCTAA CAACATCTCA AACATCATCA CGGAGGTCCA CCCCCGAGAC 1440
AGGAGTACTG TGGAGGGCCG AGTGACGTTT GCCAAAGTGG AGGAGACCAT TGCCGTTCGG 1500
TGTCTGGCTA AGAATCTCCT TGGGGCTGAG AACCGAGAGC TGAAGCTGGT GGCTCCCACT 1560
CTACGTTCTG AACTCACAGT GGCAGCTGCG GTCCTGGTGC TGTTGGTGAT TGTGATCATC 1620
TCACTTATTG TCCTGGTTGT CATTTGGAAG CAGAAACCGA GGTACGAAAT TCGTTGGAGG 1680
GTCATTGAAT CAATCAGCCC TGATGGACAT GAATATATTT ATGTGGACCC GATGCAGCTG 1740
CCTTATGACT CGAGATGGGA GTTTCCAAGA GATGGCCTCG TGCTTGGTCG TATCCTGGGA 1800
TCTGGTGCGT TTGGGAAAGT GGTCGAAGGA ACTGCTTATG GATTAAGCCG GTCCCAACCT 1860
GTCATGAAAG TAGCTGTGAA GATGCTAAAA CCCACAGCCA GATCTAGTGA AAAACAAGCT 1920
CTCATGTCGG AACTGAAGAT AATGACTCAC CTGGGGCCGC ATTTAAACAT TGTGAACTTG 1980
CTGGGAGCCT GTACCAAGTC AGGCCCAATT TACATCATCA CAGAGTACTG CTTCTATGGG 2040
GATTTGGTCA ACTATTTGCA TAAGAATAGG GACAGCTTCC TGAGCCGCCA CCCAGAGAAG 2100
CCAAAGAAAG AGCTGGACAT CTTTGGATTG ACCCCTGCTG ATGAAAGCAC ACGGAGTTAT 2160
GTTATTTTAT CTTTTGAAAA CAATGGTGAC TACATGGACA TGAAGCAAGC TGATACCACA 2220
CAGTATGTCC CCATGCTGGA GAGGAAAGAG GTTTCTAAAT ATTCGGACAT CCAGAGGTCG 2280
CTGTATGATC GCCCAGCCTC ATATAAGAAG AAAGCTATGT TAGACTCAGA AGTCAAAAAC 2340
CTCCTTTCGG ATGATAACTC AGAAGGCCTA ACTTTGCTGG ATTTGTTGAG CTTCACTTAT 2400
CAAGTTGCCC GAGGAATGGA GTTTTTGGCT TCAAAGAATT GTGTCCACCG GGACCTGGCT 2460
GCTCGCAACG TCCTCCTGGC ACAAGGGAAA ATTGTGAAGA TCTGTGACTT TGGCCTGGCC 2520
AGAGACATCA TGCATGATTC CAACTACGTG TCCAAAGGCA GCACCTTTCT CCCTGTGAAG 2580
TGGATGGCTC CTGAGAGCAT CTTCGACAAC CTCTACACCA CGCTGAGTGA CGTCTGGTCT 2640
TACGGCATTC TGCTCTGGGA GATCTTTTCT CTTGGTGGCA CACCCTACCC TGGCATGATG 2700
GTGGATTCTA CTTTCTACAA TAAGATCAAG AGTGGGTACC GGATGGCCAA GCCTGACCAT 2760
GCCACCAGTG AAGTCTATGA GATCATGGTG AAGTGCTGGA ACAGTGAGCC GGAGAAGAGG 2820
CCCTCCTTTT ACCACCTGAG TGAGATTGTG GAGAATCTGC TGCCTGGACA ATATAAAAAG 2880
AGTTATGAAA AGATTCACCT GGACTTCCTG AAGAGCGATC ATCCCGCCGT GGCACGCATG 2940
CGCGTGGACT CTGACAACGC CTACATTGGC GTCACCTACA AAAATGAGGA AGACAAGCTG 3000
AAGGACTGGG AGGGTGGCCT CGACGAGCAG AGGTTGAGTG CGGACAGTGG CTACATCATC 3060
CCTCTGCCGG ACATCGACCC TGTTCCGGAG GAGGAAGACC TGGGCAAGAG GAACAGACAC 3120
AGCTCGCAGA CCTCTGAAGA GAGTGCCATC GAGACAGGTT CCAGCAGTTC TACCTTCATT 3180
AAGAGAGAGG ATGAGACCAT TGAGGACATC GACATGATGG ACGACATTGG CATAGACTCC 3240
TCAGACCTGG TGGAGGACAG CTTCCTGTAA 3270
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 593   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  652
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sfl+++ ek   +++eld+++
Q: 653   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSRHPEK---PKKELDIFG  709
         *********************************************999...999******
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l +ad+s+rs+++ls+e++++y+d+k++                +sd+++s +d++as+k
Q: 710   LtPADESTRSYVILSFENNGDYMDMKQAdttqyvpmlerkevskYSDIQRSLYDRPASYK  769
         *9*************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kk +l++evk+ l++++se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 770   KKAMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  829
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 830   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  889
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim+kcw++epekrpsf++l+e+
Q: 890   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEI  949
         *********************************************************998
S: 344   l  344
         +
Q: 950   V  950
         6
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FLSRHPEKPK KELDIFGLTP 120
ADESTRSYVI LSFENNGDYM DMKQADTTQY VPMLERKEVS KYSDIQRSLY DRPASYKKKA 180
MLDSEVKNLL SDDNSEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYEIMVKC WNSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-DRM-00197
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0030325; P:adrenal gland development
GO:0055003; P:cardiac myofibril assembly
GO:0060326; P:cell chemotaxis
GO:0071230; P:cellular response to amino acid stimulus
GO:0007204; P:elevation of cytosolic calcium ion concentration
GO:0048701; P:embryonic cranial skeleton morphogenesis
GO:0048557; P:embryonic digestive tract morphogenesis
GO:0008210; P:estrogen metabolic process
GO:0030198; P:extracellular matrix organization
GO:0060325; P:face morphogenesis
GO:0001701; P:in utero embryonic development
GO:0033327; P:Leydig cell differentiation
GO:0030324; P:lung development
GO:0001553; P:luteinization
GO:0030539; P:male genitalia development
GO:0072277; P:metanephric glomerular capillary formation
GO:0010544; P:negative regulation of platelet activation
GO:0042475; P:odontogenesis of dentin-containing tooth
GO:0060021; P:palate development
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0070527; P:platelet aggregation
GO:0035790; P:platelet-derived growth factor receptor-alpha signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0045740; P:positive regulation of DNA replication
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0050920; P:regulation of chemotaxis
GO:2000739; P:regulation of mesenchymal stem cell differentiation
GO:0061298; P:retina vasculature development in camera-type eye
GO:0023019; P:signal transduction involved in regulation of gene expression
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
ecb:100059815;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013