EKS-EQC-00030
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00030
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak305.34.4E-91502758257
StatusUnreviewed
Ensembl ProteinENSECAP00000016316
UniProt AccessionF7B2N9;
Protein Name
Protein Synonyms/Alias
Gene NameJAK3
Gene Synonyms/Alias JAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000018212ENSECAP00000016316ENSECAT00000019899
OrganismEquus caballus
Functional Description
Protein Length1082
Protein Sequence
(FASTA)
MEPPSEETPL IAQRSCSLSS SEAGALHVLL PPRGPGPPQR LSFSFGDHSA EELCVRAAKA 60
SAILPVYHSL FALATEDLSC WFPPSHIFSV EDAGTQVLVY RLRFYFPNWF GLEKCHRFGL 120
RKDLASAILD LPVLEHLFAQ HRNDLLSGRL PVGLGLKEQG ECLSLAVLDL ARMAREQAQR 180
PEELLKTVSY KACLPPGLRD LIQGLSFVTR KRIRRTVRRA LRRVVACQAD RHSLMAWALL 240
KITAVTRCFL LQFGFLSDPQ IQPYISSPRP SKPFCDFQEI VDISIKQAPR GPSGEHRLVT 300
VTRTDNQILE AEFPGLPAAL SFVALVDGYF RLTADSRHFF CKEVAPPRLL EEVAEQCHGP 360
ITLDFAVNKL KTGGSLPGSY VLRRSPQDFD SFLLTVCVQT PLGPDYKGCL IRCDPTGTFS 420
LAGLGRPHSS LRELLAACWD GGLHVDGVAL NLTSCCTPKP KEKSNLIVVR RGCTPPTPSL 480
VQPPSRCQLS QMTFHKIPAD SLEWHENLGH GSFTKIYRGH RHEAVDGEAR ETEVLLKVMD 540
AKHKNCMESF LEAASLMSQV SYQHLVFLHG VCMAGDSIMV QEFVRLGALD TYLRKCGHLV 600
PASWKLQVIK QLAYALNYLE DKGLPHGNVS ARKVLLAREG ADGSPPFIKL SDPGVSPAVL 660
SLEMLTDRIP WVAPECLQEA HTLGLEADKW GFGATVWEVF SGVTMPISML DPAKKLQFYQ 720
ERQQLPAPKW TELALLIQQC MAYERGLRPS FRGIIRDLNS LITSDYELLS DPTPGALAPR 780
DGLWNGAQLY ACQDPTIYEE RHLKYISQLG KGNFGSVELC RYDPLGDNTG ALVAVKQLQH 840
SGPEQQRDFQ REVQILRALH SDFIVKYRGE TERPRRPDLR LVHGVTCQGR LADFLQEQQR 900
RFKPAVGLGS RWEWGGFQYL GSQRCVRDLA ARILVESETH VKIADFRLAK LLPLDKDYYV 960
VREPGQSPIF WYAPESLSDN IFSRQSDVWS FGVVLYELFT YSDKSCSPSA EFLRMMGCER 1020
DAPALCRLLE LLAEGQRLPA PPACPAEVHE LMKLCWAPSP QDRPPFSALG PQLEALWSGS 1080
RG 1082
Nucleotide Sequence
(FASTA)
ATGGAGCCAC CAAGCGAGGA GACGCCCCTG ATCGCTCAGC GCTCCTGCAG CCTCTCGTCT 60
TCAGAGGCCG GTGCTCTGCA TGTGCTGCTG CCCCCTCGGG GCCCTGGGCC CCCGCAGCGC 120
CTATCCTTCT CCTTTGGGGA CCATTCAGCT GAAGAGCTGT GTGTTCGGGC TGCTAAGGCC 180
AGTGCCATCC TGCCCGTGTA CCACTCCCTC TTTGCTCTGG CCACCGAGGA CCTGTCCTGC 240
TGGTTCCCCC CAAGCCACAT CTTCTCTGTG GAGGATGCGG GCACCCAGGT CCTTGTCTAC 300
AGACTCCGCT TTTACTTTCC CAACTGGTTT GGGCTAGAGA AGTGCCACCG CTTCGGGCTA 360
CGAAAGGACT TGGCCAGCGC CATCCTTGAC CTGCCAGTCC TGGAGCACCT CTTCGCGCAG 420
CACCGCAACG ATCTGCTGAG CGGCCGCCTC CCCGTGGGCC TTGGCCTCAA GGAACAGGGC 480
GAGTGTCTCA GCCTGGCCGT GCTGGACCTG GCCCGGATGG CCCGTGAGCA GGCGCAGCGG 540
CCTGAAGAGC TGCTGAAGAC CGTCAGCTAC AAGGCCTGCC TGCCCCCCGG CCTGCGCGAT 600
CTGATCCAGG GCCTGAGCTT CGTGACTCGG AAGCGTATCC GGAGGACCGT GCGCCGGGCC 660
CTGCGCCGCG TGGTCGCCTG CCAGGCTGAC AGGCACTCGC TCATGGCCTG GGCACTACTC 720
AAAATAACAG CAGTCACTCG ATGCTTCCTG TTACAATTCG GTTTTCTGAG TGACCCGCAA 780
ATACAACCGT ACATCTCCTC CCCTAGGCCC TCCAAGCCCT TCTGCGACTT TCAAGAAATC 840
GTGGACATCA GCATCAAGCA GGCCCCGCGC GGCCCGTCCG GGGAGCACCG TCTGGTCACC 900
GTCACCAGGA CAGACAACCA GATCCTGGAG GCCGAGTTCC CGGGGCTGCC CGCGGCCTTG 960
TCCTTCGTGG CGCTCGTGGA CGGCTACTTC CGGCTGACAG CCGACTCCCG GCACTTCTTC 1020
TGCAAGGAGG TGGCGCCCCC GCGGCTGCTC GAGGAGGTGG CCGAGCAGTG CCACGGCCCC 1080
ATCACCCTGG ATTTTGCAGT TAACAAGCTC AAGACTGGGG GCTCGCTTCC GGGCTCCTAC 1140
GTTCTCCGCC GCAGTCCCCA GGATTTTGAC AGCTTCCTCC TCACTGTCTG TGTCCAGACC 1200
CCCCTGGGCC CTGATTACAA GGGCTGCCTC ATCCGGTGCG ACCCCACGGG AACCTTCTCC 1260
CTGGCTGGCC TCGGGCGTCC CCATAGCAGT CTTCGAGAAC TCCTGGCAGC CTGCTGGGAT 1320
GGTGGCCTGC ATGTGGACGG AGTCGCGCTG AACCTCACCT CCTGCTGCAC CCCTAAACCC 1380
AAAGAAAAGT CCAATCTGAT TGTGGTCCGG AGAGGGTGCA CCCCACCCAC GCCATCCCTG 1440
GTTCAACCCC CATCCCGCTG CCAGCTGAGT CAGATGACGT TTCACAAGAT CCCGGCTGAC 1500
AGCCTGGAGT GGCACGAGAA CCTGGGTCAT GGGTCCTTCA CCAAGATTTA CCGGGGTCAT 1560
CGCCACGAGG CCGTGGACGG GGAGGCCCGG GAGACAGAGG TGCTGCTGAA AGTGATGGAT 1620
GCCAAGCACA AGAACTGCAT GGAGTCGTTC CTGGAAGCAG CGAGCTTGAT GAGCCAAGTG 1680
TCCTACCAGC ACCTCGTGTT CCTGCATGGC GTGTGCATGG CTGGAGACAG CATCATGGTG 1740
CAGGAATTTG TCCGCCTGGG GGCGCTGGAC ACATATCTGC GCAAGTGTGG CCATCTGGTG 1800
CCGGCCAGCT GGAAGCTGCA GGTGATCAAA CAGCTGGCCT ATGCCCTCAA CTATCTGGAA 1860
GACAAAGGCC TTCCCCATGG CAATGTCTCA GCCCGGAAGG TGCTCCTGGC TCGGGAGGGG 1920
GCTGACGGGA GCCCGCCTTT CATCAAGCTG AGTGACCCTG GGGTCAGCCC TGCTGTGCTA 1980
AGCCTGGAGA TGCTCACCGA CAGGATCCCC TGGGTGGCCC CTGAGTGTCT CCAGGAGGCA 2040
CACACACTTG GCTTGGAGGC TGACAAGTGG GGCTTCGGTG CCACAGTCTG GGAGGTGTTC 2100
AGCGGTGTCA CGATGCCCAT CAGCATGCTG GACCCCGCCA AGAAGCTCCA GTTTTACCAG 2160
GAACGGCAGC AGCTGCCAGC CCCCAAGTGG ACGGAGCTGG CGCTGCTGAT CCAGCAGTGC 2220
ATGGCCTACG AGCGGGGCCT CAGGCCCTCC TTCCGCGGCA TCATCCGTGA CCTGAACAGC 2280
CTCATCACCT CAGATTATGA GCTCCTCTCG GACCCCACTC CTGGTGCCCT GGCGCCCCGT 2340
GACGGGCTGT GGAATGGCGC CCAGCTCTAT GCCTGCCAGG ACCCCACCAT CTATGAGGAG 2400
AGGCACCTCA AGTACATCTC GCAGCTGGGC AAGGGCAACT TCGGCAGCGT GGAGCTGTGC 2460
CGCTATGACC CGCTGGGTGA CAACACAGGC GCCCTGGTGG CCGTGAAGCA GCTGCAGCAC 2520
AGCGGGCCAG AGCAGCAGAG GGACTTCCAG CGGGAGGTCC AGATCCTGCG AGCCCTGCAC 2580
AGCGACTTCA TCGTCAAGTA CCGCGGCGAG ACAGAGCGGC CGCGGCGCCC GGACCTTCGG 2640
CTTGTTCATG GAGTTACTTG TCAGGGGCGC CTGGCGGACT TCCTGCAGGA GCAACAGAGG 2700
AGGTTCAAGC CGGCGGTTGG CTTGGGGTCT CGGTGGGAGT GGGGTGGCTT CCAGTACCTG 2760
GGCTCCCAAC GCTGCGTGCG CGACCTGGCA GCTCGGATCC TGGTGGAGAG CGAGACGCAC 2820
GTCAAGATCG CCGACTTCCG CCTCGCCAAG TTGCTGCCGC TCGACAAAGA CTACTACGTG 2880
GTCCGCGAGC CCGGCCAGAG CCCCATTTTC TGGTACGCCC CAGAGTCGCT CTCCGACAAC 2940
ATCTTCTCGC GCCAGTCGGA CGTCTGGAGC TTCGGGGTGG TCCTGTACGA GCTCTTCACG 3000
TACAGCGACA AGAGCTGCAG CCCCTCGGCC GAGTTCCTGC GCATGATGGG CTGTGAGCGA 3060
GACGCCCCGG CCCTGTGCCG CCTCCTGGAG CTGCTGGCCG AGGGCCAGAG GCTGCCCGCG 3120
CCTCCTGCCT GCCCCGCCGA GGTTCATGAG CTCATGAAGC TGTGCTGGGC CCCCAGCCCA 3180
CAAGACCGGC CGCCGTTCAG TGCCCTGGGC CCCCAGCTGG AGGCGCTGTG GAGTGGGAGC 3240
CGGGGGTAG 3249
Domain Profile
S: 1     lkqiesLgkgtftkvfevred..aegdsteeevalkvLkesgedisrdfkreaeilsqls  58
         l+++e+Lg+g+ftk+++++++   +g+++e+ev+lkv++ ++++++++f ++a+++sq+s
Q: 502   LEWHENLGHGSFTKIYRGHRHeaVDGEARETEVLLKVMDAKHKNCMESFLEAASLMSQVS  561
         689*****************8789************************************
S: 59    hehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         ++h+v+l+gvc+a+++ ++V+e+v+ G+Ld+yLrk  + +++s++l+v kqla+a++YLe
Q: 562   YQHLVFLHGVCMAGDS-IMVQEFVRLGALDTYLRKCGHLVPASWKLQVIKQLAYALNYLE  620
         ***************9.7******************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqdeYylvreerdsripwlap  178
         dk l h++v+ar+vL++re+ +g+ppf+klsdpg++ av      l+ e+ ++ripw+ap
Q: 621   DKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAV------LSLEMLTDRIPWVAP  674
         ***************************************......***************
S: 179   eclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelleekerlpkpkcpa  238
         ecl+ea++l +++d+W+Fg+t++e+  +s  ++p+++ ++++kl++++e+++lp+pk++ 
Q: 675   ECLQEAHTLGLEADKWGFGATVWEV--FSGVTMPISMLDPAKKLQFYQERQQLPAPKWT-  731
         *************************..9*******************************.
S: 239   elaelmtnclsyepsqrpsFrailedl  265
         ela l+++c++ye   rpsFr i++dl
Q: 732   ELALLIQQCMAYERGLRPSFRGIIRDL  758
         *************************98
Domain Sequence
(FASTA)
LEWHENLGHG SFTKIYRGHR HEAVDGEARE TEVLLKVMDA KHKNCMESFL EAASLMSQVS 60
YQHLVFLHGV CMAGDSIMVQ EFVRLGALDT YLRKCGHLVP ASWKLQVIKQ LAYALNYLED 120
KGLPHGNVSA RKVLLAREGA DGSPPFIKLS DPGVSPAVLS LEMLTDRIPW VAPECLQEAH 180
TLGLEADKWG FGATVWEVFS GVTMPISMLD PAKKLQFYQE RQQLPAPKWT ELALLIQQCM 240
AYERGLRPSF RGIIRDL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00027
EKS-BOT-00033
EKS-CAF-00032
EKS-CAP-00034
EKS-FEC-00029
EKS-GOG-00029
EKS-HOS-00030
EKS-ICT-00030
EKS-LOA-00032
EKS-MAM-00030
EKS-MOD-00032
EKS-MUM-00033
EKS-MUP-00033
EKS-MYL-00033
EKS-NOL-00031
EKS-ORA-00026
EKS-OTG-00032
EKS-PAT-00027
EKS-POA-00030
EKS-PTV-00031
EKS-RAN-00034
EKS-SAH-00030
EKS-SUS-00027
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030183; P:B cell differentiation
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0035771; P:interleukin-4-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0002731; P:negative regulation of dendritic cell cytokine production
GO:0045221; P:negative regulation of FasL biosynthetic process
GO:0032693; P:negative regulation of interleukin-10 production
GO:0032695; P:negative regulation of interleukin-12 production
GO:0045626; P:negative regulation of T-helper 1 cell differentiation
GO:0070244; P:negative regulation of thymocyte apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0043029; P:T cell homeostasis
KEGG
InterPros
IPR019749; Band_41_domain.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775; Tyr_kinase_non-rcpt_Jak3.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
Prints
PR01823; JANUSKINASE.
PR01826; JANUSKINASE3.
Created Date20-Feb-2013