EKS-EQC-00155
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00155
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/RSK336.71.2E-10033301269
StatusUnreviewed
Ensembl ProteinENSECAP00000016367
UniProt AccessionF7AVS6;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000018402ENSECAP00000016367ENSECAT00000019960
OrganismEquus caballus
Functional Description
Protein Length727
Protein Sequence
(FASTA)
MGDEDEDEGC AVELRITEAN LTGHEEKVSV DNFELLKVLG TGAYGKVFLV RKAGGHDAGK 60
LYAMKVLRKA ALVQRAKTQE HTRTERSVLE LVRQAPFLVT LHYAFQTDAK LHLILDYVNG 120
GEMFTHLYQR QHFKEAEVRV YGGEIVLALE HLHKLGIIYR DLKLENVLLD SDGHIVLTDF 180
GLSKEFLTEE KERTFSFCGT IEYMAPEIIR SKSGHGKAVD WWSLGILLFE LLTGASPFTL 240
EGERNTQAEV SRRILKCSPP FPPRIGPVAQ DLLQRLLCKD PKKRLGAGPQ GAQEVKNHPF 300
FQGLDWAALA ARKIPAPFRP QIRSELDVGN FAEEFTRLEP VYSPPGSPPP GDPRIFQGYS 360
FVAPSILFDH NNAVMTDVLE ASGAGDRPGR AAVARSAMMQ DSPFFQQYEL DLCKPTVENT 420
TFHIIFDHPT RGSGLGHGPS LNGGVAWSWP RGGASLVGGA RPGSVAGWPA RRPQLHTYLV 480
LELLRGGELL EHIRKKRHFS ESEASQILRS LVSAVSFMHE EAGVVHRDLK PENILYADDT 540
PGAPVKIIDF GFARLRPQSP AGPMQTPCFT LQYAAPELLA RQGYDESCDL WSLGVILYMM 600
LSGQVPFQGA SGQGGQSQAA EIMCKIREGR FSLDGEAWQG VSEEAKELVR GLLTVDPAKR 660
LKLEGLRDSS WLQDGSARSS PPLRTPDVLE SSGPAVRSGL NATFMAFNRG KREGFFLKSV 720
EIAPLAQ 727
Nucleotide Sequence
(FASTA)
ATGGGGGACG AGGACGAGGA CGAGGGCTGC GCGGTGGAGC TGCGGATCAC GGAAGCCAAC 60
CTGACCGGGC ACGAGGAGAA GGTGAGCGTG GACAACTTCG AGCTGCTCAA GGTGCTGGGC 120
ACGGGAGCCT ACGGGAAGGT GTTCCTGGTG CGGAAGGCGG GCGGGCACGA CGCGGGGAAG 180
CTGTATGCCA TGAAGGTGCT GCGCAAGGCG GCGCTGGTGC AGCGCGCCAA GACGCAGGAG 240
CACACGCGCA CCGAGCGCTC GGTGCTGGAG CTGGTGCGCC AGGCGCCCTT CCTGGTCACG 300
CTGCACTACG CCTTCCAGAC TGATGCCAAG CTGCACCTCA TTCTGGACTA CGTGAATGGC 360
GGCGAGATGT TCACGCACCT CTACCAGCGC CAGCACTTCA AGGAGGCCGA GGTGCGCGTG 420
TACGGGGGTG AGATCGTGCT GGCCCTGGAA CACCTGCACA AGCTGGGCAT CATCTACCGA 480
GATCTGAAGC TGGAGAACGT GCTGCTGGAC TCCGACGGCC ACATCGTCCT CACGGACTTC 540
GGGCTGAGCA AGGAGTTCCT GACGGAGGAG AAAGAGCGAA CCTTCTCCTT CTGTGGCACC 600
ATCGAGTACA TGGCCCCCGA AATCATCCGC AGCAAGTCGG GGCACGGCAA GGCCGTAGAC 660
TGGTGGAGCC TTGGCATCTT GCTCTTCGAG CTGCTGACGG GGGCCTCGCC ATTCACGCTG 720
GAGGGCGAGA GGAACACGCA GGCTGAGGTG TCCCGACGGA TCCTGAAGTG CTCCCCTCCC 780
TTCCCCCCCC GGATCGGGCC CGTGGCGCAG GACCTGCTGC AGCGGCTACT TTGCAAGGAC 840
CCCAAGAAGC GTCTGGGCGC GGGGCCCCAG GGGGCACAGG AAGTCAAGAA CCACCCGTTC 900
TTCCAGGGCC TGGACTGGGC TGCTTTGGCC GCCAGGAAGA TCCCAGCCCC ATTCCGACCC 960
CAGATCCGCT CAGAGCTGGA TGTGGGCAAC TTCGCAGAGG AATTTACTAG GCTGGAGCCT 1020
GTCTACTCAC CCCCTGGCAG CCCCCCGCCT GGGGACCCTC GCATCTTCCA GGGATACTCC 1080
TTCGTGGCGC CGTCCATCCT GTTTGACCAC AACAACGCAG TGATGACCGA CGTGCTCGAA 1140
GCATCTGGCG CTGGAGACCG GCCAGGCCGG GCAGCGGTGG CCAGGAGCGC CATGATGCAG 1200
GACTCGCCCT TCTTCCAGCA GTACGAGCTG GACCTGTGTA AGCCCACGGT GGAAAATACA 1260
ACGTTTCACA TAATTTTTGA TCACCCTACC CGCGGGTCGG GGCTCGGACA CGGGCCAAGC 1320
CTGAATGGGG GTGTGGCTTG GTCGTGGCCG CGGGGCGGGG CCTCACTGGT GGGCGGGGCC 1380
CGGCCGGGGT CGGTGGCTGG TTGGCCCGCG CGCCGCCCGC AGCTGCACAC GTACCTGGTC 1440
CTGGAGCTGC TGCGGGGCGG GGAGCTGCTG GAGCACATCC GCAAGAAGCG GCACTTCAGC 1500
GAGTCCGAGG CGAGCCAGAT CCTGCGCAGC CTCGTGTCGG CCGTGAGCTT CATGCACGAG 1560
GAGGCGGGCG TGGTGCACCG CGACCTCAAG CCCGAGAACA TCCTGTACGC CGACGACACG 1620
CCCGGAGCCC CGGTGAAGAT CATCGACTTC GGGTTCGCGC GCCTGCGCCC GCAGAGCCCC 1680
GCGGGGCCCA TGCAGACGCC TTGTTTCACG CTGCAGTACG CGGCCCCCGA GCTGCTGGCC 1740
CGGCAGGGCT ACGACGAGTC CTGCGACCTC TGGAGCCTCG GCGTCATTCT GTACATGATG 1800
CTGTCGGGGC AGGTCCCCTT CCAGGGGGCC TCAGGCCAGG GCGGGCAGAG CCAGGCGGCC 1860
GAGATCATGT GCAAGATCCG CGAGGGGCGC TTCTCCCTTG ACGGGGAGGC CTGGCAGGGC 1920
GTGTCCGAGG AGGCCAAGGA GCTGGTCCGA GGGCTCCTGA CTGTGGACCC CGCCAAGCGG 1980
CTGAAGCTCG AGGGGCTGCG GGACAGCTCG TGGCTGCAGG ACGGCAGCGC GCGCTCCTCG 2040
CCCCCGCTCC GGACGCCGGA TGTGCTGGAG TCCTCGGGGC CGGCCGTGCG CTCGGGGCTC 2100
AACGCCACCT TCATGGCGTT CAACCGGGGC AAGCGCGAGG GCTTCTTCCT GAAGAGCGTG 2160
GAGATCGCTC CGCTCGCCCA A 2181
Domain Profile
S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58
         fellkvlg+Gaygkvflvrk  ++d+gklya+Kvl+ka+lv+  k++e+t++er++Le v
Q: 33    FELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQraKTQEHTRTERSVLELV  92
         89***************************************99999**************
S: 59    eh.pfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleyl  117
         ++ pf+v+lh+afq++ kl+l+l++++Gge++++l ++++f+e e++++  e+vlale+l
Q: 93    RQaPFLVTLHYAFQTDAKLHLILDYVNGGEMFTHLYQRQHFKEAEVRVYGGEIVLALEHL  152
         ************************************************************
S: 118   HskgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevl.kr  176
         H+ g++yrDLk+eN+lld++gh++ltDfgl+ke  +e++e+++sfcgT+ey+aPe++ ++
Q: 153   HKLGIIYRDLKLENVLLDSDGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIrSK  212
         *********************************************************778
S: 177   kgydeavDlwslGvllyemLtGktPftgeerketla....rilkgkfslklpaweelsee  232
         +g+ +avD+wslG+ll+e+LtG++Pft e +++t+a    rilk++  + +p    + + 
Q: 213   SGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAevsrRILKCS--PPFPPR--IGPV  268
         8****************************99988883444555555..666666..****
S: 233   akdlvkklLkkdpakRlga...taeeikehkfl  262
         a+dl+++lL kdp+kRlga   +a+e+k+h+f+
Q: 269   AQDLLQRLLCKDPKKRLGAgpqGAQEVKNHPFF  301
         ******************99999********97
Domain Sequence
(FASTA)
FELLKVLGTG AYGKVFLVRK AGGHDAGKLY AMKVLRKAAL VQRAKTQEHT RTERSVLELV 60
RQAPFLVTLH YAFQTDAKLH LILDYVNGGE MFTHLYQRQH FKEAEVRVYG GEIVLALEHL 120
HKLGIIYRDL KLENVLLDSD GHIVLTDFGL SKEFLTEEKE RTFSFCGTIE YMAPEIIRSK 180
SGHGKAVDWW SLGILLFELL TGASPFTLEG ERNTQAEVSR RILKCSPPFP PRIGPVAQDL 240
LQRLLCKDPK KRLGAGPQGA QEVKNHPFF 269
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00156
EKS-BOT-00164
EKS-CAJ-00168
EKS-CAF-00171
EKS-CAP-00163
EKS-FEC-00154
EKS-HOS-00170
EKS-ICT-00159
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MUM-00169
EKS-MUP-00168
EKS-NOL-00157
EKS-OTG-00168
EKS-PAT-00154
EKS-RAN-00161
EKS-SAH-00158
EKS-SUS-00141
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013