EKS-EQC-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	340.3	9.5E-102	685	959	275

Status

Unreviewed

Ensembl Protein

ENSECAP00000016862

UniProt Accession

F7BLR3;

Protein Name

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000018673	ENSECAP00000016857	ENSECAT00000020532
ENSECAG00000018673	ENSECAP00000016862	ENSECAT00000020537

Organism

Equus caballus

Functional Description

Protein Length

966

Protein Sequence
(FASTA)

MAVLAISHYA MMKKMQLPEL PKDISYKRYI PETLNKSIRQ RNLLTRMRIN NVFKDFLKEF 60

NNKTICDSSV SMHDLKVKYL ATLETLTKHY GAEIFETSEL LISSENEMNR FHLNDSGNIL 120

YYEVMVTGNL GIQWRQKPNV VPVEKEKNKL KRKKLENKYK KDEEKNKIRE EWNNFSYFPE 180

ITHVVIKESV VSINKQDNKK MELKLSSHEE ALSFVSLVDG YFRLTADAHH YLCTDVAPPL 240

IVHNIQNGCH GPICTEYAIN KLRQEGGEEG MYVLRWSCTD FDNILMTVTC FEKSEVLGGQ 300

KQFKNFQIEV QKGCYSLHGS DRSFPSLGDL MSHLKKQILR TDNISFVLKR CCQPKPREIS 360

NLLVATKKAQ EWQPVYPMSQ LSFDRILKKD IVQGEHLGRG TRTHIYSGTL VDYRDDEGTP 420

EEKRIKVILK VLDPSHRDIS LASAFFEAAS MMRQVSHKHI VYLYGVCVRD VENIMVEEFV 480

EGGPLDLFMH RKSDVLTTPW KFNVAKQLAS ALSYLEDKDL VHGNVCTKNL LLAREGIDSE 540

CGPFIKLSDP GIPITVLSRQ ERLERIPWIA PECVDDSKNL SVAADKWSFG TTLWEICYNG 600

EIPLKDKTLI EKERFYESRC RPVTPSCKEL ADLMTRCMNY DPNQRPFFRA IMRDINKLEE 660

QNPDIVSERK PAAEVDPTHF EKRFLKRIRD LGEATGHFGK VELCRYDPEG DNTGEQVAVK 720

SLKPESGGNH IADLKKEIEI LRNLYHENIV KYKGICTEDG GNGIKLIMEF LPSGSLKEYL 780

PKNKNKINLK QQLKYAVQIC KGMDYLGSQQ YVHRDLAARN VLVESEHQVK IGDFGLTKAI 840

ERDKEYYTVK DDRDSPVFWY APECLIQCKF YIASDVWSFG VTLHELLTYC DSDSSPMALF 900

LKMIGPTHGQ MTVTRLVNTL KEGKRLPCPP HCPDEVYQLM RKCWEFQPSS RTTFQNLIEG 960

FEALLK 966

Nucleotide Sequence
(FASTA)

ATGGCTGTCC TGGCCATCTC ACACTATGCC ATGATGAAGA AGATGCAGTT GCCAGAGCTT 60

CCCAAGGACA TCAGCTACAA GCGATATATT CCAGAAACAT TGAATAAGTC CATCAGACAG 120

AGGAACCTTC TCACCAGGAT GCGGATAAAT AATGTTTTCA AGGATTTCCT AAAGGAATTT 180

AACAACAAGA CCATTTGTGA CAGCAGCGTG TCCATGCACG ACCTGAAGGT GAAGTACCTG 240

GCCACCTTGG AAACTTTGAC AAAACATTAT GGTGCTGAAA TATTTGAGAC TTCCGAGTTA 300

CTGATTTCAT CAGAAAATGA GATGAATCGA TTTCATCTGA ATGACAGTGG AAACATTCTC 360

TACTATGAAG TGATGGTGAC TGGAAATCTT GGAATCCAGT GGAGGCAGAA ACCAAATGTT 420

GTTCCTGTTG AAAAGGAAAA AAATAAACTG AAACGGAAAA AACTGGAAAA TAAATACAAG 480

AAGGATGAGG AGAAAAACAA AATCCGGGAA GAGTGGAACA ATTTTTCTTA CTTCCCTGAA 540

ATTACTCACG TTGTAATCAA GGAGTCTGTG GTCAGCATTA ATAAACAAGA CAACAAAAAA 600

ATGGAACTGA AGCTCTCTTC CCACGAGGAG GCCTTGTCCT TTGTGTCCCT GGTAGATGGC 660

TACTTTCGGC TCACAGCAGA CGCCCATCAT TACCTCTGCA CCGACGTGGC TCCCCCGTTG 720

ATCGTCCACA ACATACAGAA TGGCTGTCAC GGTCCAATCT GCACAGAATA TGCCATCAAT 780

AAACTGCGGC AAGAAGGAGG CGAGGAGGGG ATGTACGTGC TGCGCTGGAG CTGTACCGAC 840

TTTGACAACA TCCTCATGAC CGTCACCTGC TTTGAAAAGT CTGAGGTGCT GGGTGGCCAG 900

AAACAGTTCA AGAACTTTCA GATCGAGGTG CAGAAGGGCT GCTACAGCCT GCACGGCTCG 960

GACCGCAGCT TCCCCAGCCT CGGGGACCTC ATGAGCCACC TCAAGAAGCA GATCCTGCGC 1020

ACGGACAACA TCAGCTTTGT GCTGAAGCGC TGCTGCCAGC CTAAGCCCCG AGAAATCTCC 1080

AATCTGCTGG TGGCTACTAA GAAAGCCCAG GAGTGGCAGC CTGTCTACCC TATGAGCCAG 1140

CTGAGTTTCG ATCGGATCCT CAAGAAGGAT ATTGTGCAAG GTGAGCACCT TGGCAGAGGC 1200

ACGCGGACGC ACATCTACTC TGGGACCCTA GTGGACTACA GGGATGACGA AGGAACCCCG 1260

GAAGAGAAGC GAATAAAAGT GATCCTCAAA GTCTTGGATC CCAGCCACAG GGACATTTCT 1320

CTGGCAAGTG CCTTCTTCGA GGCAGCCAGC ATGATGAGAC AGGTCTCCCA CAAACACATC 1380

GTGTACCTCT ATGGCGTCTG TGTCCGAGAT GTGGAGAATA TCATGGTGGA AGAGTTTGTA 1440

GAGGGAGGGC CCCTGGATCT CTTCATGCAC CGGAAGAGTG ATGTCCTCAC CACACCGTGG 1500

AAGTTTAACG TCGCCAAACA GCTGGCCAGT GCCCTGAGTT ACTTGGAGGA TAAAGACTTG 1560

GTCCATGGAA ACGTGTGCAC TAAAAACCTC CTCCTGGCCC GCGAGGGCAT CGACAGTGAG 1620

TGCGGCCCGT TCATCAAGCT CAGTGACCCC GGCATCCCCA TCACTGTGCT GTCCAGGCAA 1680

GAGCGTTTAG AGCGAATCCC GTGGATTGCC CCCGAGTGTG TGGATGACTC CAAGAACCTG 1740

AGCGTGGCCG CTGACAAGTG GAGTTTTGGG ACCACGCTCT GGGAGATCTG CTACAACGGC 1800

GAGATCCCCC TGAAGGACAA GACCCTGATC GAGAAAGAGA GGTTCTATGA AAGCCGGTGC 1860

AGGCCAGTGA CACCATCTTG TAAGGAGCTG GCTGACCTGA TGACCCGCTG CATGAACTAT 1920

GACCCTAATC AGAGGCCCTT CTTCCGAGCC ATCATGAGAG ACATCAATAA GCTGGAGGAG 1980

CAGAATCCAG ACATTGTTTC AGAAAGAAAG CCAGCAGCTG AAGTGGATCC CACACATTTT 2040

GAAAAGCGGT TCTTAAAAAG GATCCGTGAC TTGGGAGAGG CAACAGGCCA CTTTGGCAAG 2100

GTCGAGCTCT GCAGGTATGA CCCTGAGGGC GACAATACTG GGGAGCAGGT GGCTGTCAAA 2160

TCCCTGAAGC CTGAGAGTGG AGGTAACCAC ATAGCTGATC TGAAGAAAGA GATCGAGATC 2220

CTAAGGAACC TCTACCATGA AAACATTGTG AAGTACAAAG GCATCTGCAC AGAAGACGGA 2280

GGAAATGGTA TTAAGCTCAT CATGGAATTT CTGCCTTCCG GAAGCCTTAA GGAATATCTT 2340

CCAAAGAATA AAAACAAAAT TAACCTCAAA CAGCAGTTAA AATACGCCGT TCAGATTTGT 2400

AAGGGCATGG ACTATCTGGG TTCTCAGCAG TACGTTCACC GCGACTTAGC AGCAAGAAAT 2460

GTCCTCGTTG AGAGTGAGCA CCAAGTGAAA ATCGGAGACT TCGGTTTAAC CAAAGCCATC 2520

GAGAGGGATA AAGAGTACTA CACGGTCAAG GATGATCGGG ACAGCCCTGT GTTCTGGTAT 2580

GCTCCAGAAT GTTTGATTCA GTGTAAATTT TACATTGCCT CTGACGTCTG GTCTTTTGGA 2640

GTGACTCTGC ACGAGCTGCT CACCTACTGC GACTCGGACT CCAGTCCCAT GGCGTTGTTC 2700

CTGAAAATGA TAGGCCCCAC TCATGGCCAG ATGACAGTGA CGAGGCTTGT GAACACACTG 2760

AAAGAGGGGA AGCGCCTGCC TTGTCCACCC CACTGTCCAG ATGAGGTTTA TCAGCTTATG 2820

AGAAAATGCT GGGAGTTCCA GCCATCTAGT CGCACCACCT TTCAGAACCT TATTGAGGGC 2880

TTTGAAGCGC TTTTAAAATA A 2901

Domain Profile

S: 1     lkqiesLgk..gtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsql  57

         lk+i++Lg+  g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l

Q: 685   LKRIRDLGEatGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNL  744

         578889986559************************************************

S: 58    shehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakame  115

         +he+ivk+kg+c+++g n  +l+me+++sGsL++yL+k+k++++l+++l++a q++k+m+

Q: 745   YHENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMD  804

         ************************************************************

S: 116   YLedkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsrip  174

         YL+++++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++

Q: 805   YLGSQQYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIERDkEYYTVKDDRDSPVF  858

         ************************......******************************

S: 175   wlapeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rkl  222

         w+apecl+++k +++asdvWsFgvtl+ellt c++++sp    l++++++       r++

Q: 859   WYAPECLIQCK-FYIASDVWSFGVTLHELLTyCDSDSSPmalfLKMIGPThgqmtvtRLV  917

         ***********.*******************************9****999*********

S: 223   elleekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         ++l+e++rlp+p+ cp+e+++lm++c++ +ps+r++F++++e

Q: 918   NTLKEGKRLPCPPhCPDEVYQLMRKCWEFQPSSRTTFQNLIE  959

         ***************************************987

Domain Sequence
(FASTA)

LKRIRDLGEA TGHFGKVELC RYDPEGDNTG EQVAVKSLKP ESGGNHIADL KKEIEILRNL 60

YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK NKINLKQQLK YAVQICKGMD 120

YLGSQQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIERDK EYYTVKDDRD SPVFWYAPEC 180

LIQCKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI GPTHGQMTVT RLVNTLKEGK 240

RLPCPPHCPD EVYQLMRKCW EFQPSSRTTF QNLIE 275

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway
GO:0007167	; P:enzyme linked receptor protein signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046677	; P:response to antibiotic

KEGG

InterPros

IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013