EPS-EQC-00025

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-EQC-00025

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	168.5	2.6E-49	308	501	194

Status

Unreviewed

Ensembl Protein

ENSECAP00000016555

UniProt Accession

F6Z8G6;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1G

Gene Synonyms/Alias

PPM1G;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000018799	ENSECAP00000016555	ENSECAT00000020185

Organism

Equus caballus

Functional Description

Protein Length

545

Protein Sequence
(FASTA)

MGAYLSQPNT VKCSGDGVGA SRLPLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD 60

GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR 120

PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGAPH SKSGAGTGEE 180

PGSQGLNGEA GPEDPSRETS SEENGPTAKT HTGLSSNSER GTEAGQGGEP GTPTGEAGPS 240

CSSASEKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 300

AEEDEEEEEE MMVPGMEGKE EPGSDSGTTA VVALIRGKQL IVANAGDSRC VVSEAGKALD 360

MSYDHKPEDE VELARIKNAG GKVTMDGRVN GGLNLSRAIG DHFYKRNKNL PPEEQMISAL 420

PDIKVLTLTD DHEFMVIACD GIWNVMSSQE VIDFIQSKIS QRDENGELRL LSSIVEELLD 480

QCLAPDTSGD GTGCDNMTCI IICFKPRNTA ELQPESGKRK LEGVLSTEEA EENGNSDKKK 540

KAKRD 545

Nucleotide Sequence
(FASTA)

ATGGGTGCCT ACCTCTCTCA GCCCAACACG GTGAAGTGCT CCGGGGACGG GGTCGGCGCC 60

TCGCGCCTGC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGCGT CTCCATGGAG 120

GATGCTCACA ACTGTATTCC TGAGCTGGAC AGTGAGACAG CCATGTTTTC CGTCTACGAT 180

GGACATGGAG GGGAAGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCCGA TATCATCAAA 240

GATCAGAAGG CCTACAAAGA AGGCAAGCTA CAGAAGGCTT TGGAAGATGC CTTCTTGGCT 300

ATTGATGCCA AACTGACCAC TGAGGAAGTC ATTAAGGAGC TGGCACAGAT TGCAGGGCGA 360

CCCACTGAGG ATGAGGATGA AAAAGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG 420

GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAT 480

GGGCAGAACT GTCACAAGGG TGCTCCCCAC AGCAAATCTG GAGCTGGGAC AGGCGAGGAA 540

CCAGGGTCCC AGGGCCTCAA TGGGGAGGCA GGACCTGAGG ACCCATCTAG GGAAACTTCT 600

TCAGAGGAAA ATGGCCCCAC AGCTAAGACC CACACAGGCC TTTCCTCCAA CTCGGAACGT 660

GGGACTGAGG CAGGCCAAGG TGGTGAGCCT GGCACTCCCA CTGGTGAGGC TGGGCCTTCC 720

TGCTCTTCAG CCTCCGAGAA ACTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT 780

GAGGATGAGT CAGATGAGGC GGAGGAGGAA GAGGAAGACA GCGAGGAATG CAGTGAGGAA 840

GAGGATGGCT ACAGCAGTGA AGAGGCAGAG AATGAGGAAG ATGAGGATGA CACTGAGGAG 900

GCTGAAGAGG ACGAAGAAGA AGAAGAGGAG ATGATGGTGC CTGGGATGGA AGGCAAAGAG 960

GAGCCTGGCT CTGACAGTGG TACAACAGCA GTGGTGGCTC TGATACGAGG GAAGCAGTTG 1020

ATTGTAGCCA ATGCAGGAGA CTCTCGCTGT GTGGTGTCTG AGGCTGGCAA AGCTTTAGAC 1080

ATGTCCTATG ACCACAAACC AGAGGATGAA GTGGAGCTAG CACGCATCAA GAATGCTGGT 1140

GGCAAGGTCA CCATGGATGG GCGAGTCAAC GGGGGCCTCA ACCTCTCCAG AGCCATTGGA 1200

GACCACTTCT ACAAGAGAAA CAAGAACTTG CCACCTGAGG AACAGATGAT TTCAGCCCTT 1260

CCTGACATTA AGGTGCTGAC TCTCACTGAC GACCACGAAT TCATGGTCAT TGCCTGTGAT 1320

GGCATCTGGA ATGTGATGAG CAGCCAGGAA GTTATAGACT TTATTCAATC AAAGATCAGC 1380

CAGCGTGATG AAAATGGGGA GCTTCGGTTA TTGTCATCTA TCGTAGAAGA GCTGCTGGAT 1440

CAGTGCCTGG CACCTGACAC TTCTGGGGAC GGTACAGGGT GTGACAACAT GACCTGCATC 1500

ATCATTTGCT TCAAGCCCCG AAATACAGCA GAGCTTCAGC CAGAGAGTGG CAAAAGGAAA 1560

CTGGAGGGGG TGCTTTCTAC TGAGGAGGCT GAAGAAAATG GCAACAGTGA CAAGAAGAAG 1620

AAGGCCAAGC GGGACTAG 1638

Domain Profile

S: 87    deel..kvleeksldidksGstavvalikdsklyvanvGdSravLcrngkavelssdHkp  144

         +ee+    +e k++  + sG+tavvali++++l+van+GdSr+v +  gka+ +s dHkp

Q: 308   EEEMmvPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKP  367

         334412334455555666******************************************

S: 145   sredEleRieeaggsvilkdgaRvlGvLavsRalGdlylk.........pyvtpePevts  195

         + e El+Ri++agg+v+ +   Rv+G L++sRa+Gd ++k         +++++ P++ +

Q: 368   EDEVELARIKNAGGKVTMDG--RVNGGLNLSRAIGDHFYKrnknlppeeQMISALPDIKV  425

         *******************9..**************************************

S: 196   hrltsedefliLasDGlwdvvsneeavslvrdvle......kkeaeqeaakkLvklalar  249

          +lt ++ef+++a+DG+w+v+s++e+++++++ ++      + + ++++ ++L++++la

Q: 426   LTLTDDHEFMVIACDGIWNVMSSQEVIDFIQSKISqrdengELRLLSSIVEELLDQCLAP  485

         ********************************9998877666667788999999999999

S: 250   gsk......dnvsaiv  259

          ++      dn++ i+

Q: 486   DTSgdgtgcDNMTCII  501

         9987777777777766

Domain Sequence
(FASTA)

EEEMMVPGME GKEEPGSDSG TTAVVALIRG KQLIVANAGD SRCVVSEAGK ALDMSYDHKP 60

EDEVELARIK NAGGKVTMDG RVNGGLNLSR AIGDHFYKRN KNLPPEEQMI SALPDIKVLT 120

LTDDHEFMVI ACDGIWNVMS SQEVIDFIQS KISQRDENGE LRLLSSIVEE LLDQCLAPDT 180

SGDGTGCDNM TCII 194

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0007050	; P:cell cycle arrest
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

ecb:100055191

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 2.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013