EKS-EQC-00059

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00059

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	388.3	2.2E-116	165	446	282

Status

Unreviewed

Ensembl Protein

ENSECAP00000016856

UniProt Accession

F7BLS0;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK16

Gene Synonyms/Alias

CDK16;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000018820	ENSECAP00000016856	ENSECAT00000020531

Organism

Equus caballus

Functional Description

Protein Length

496

Protein Sequence
(FASTA)

MDRMKKIKRQ LSMTLRGGRG VDKTNGAPEQ IGLDESGGGG GSDLGEAPTR VAPGEPRSGR 60

GPLSSAPEIV HEDLKMGSDG ESDQASATSS DEVQSPVRVR MRNHPPRKIS TEDINKRLSL 120

PADIRLPEGY LEKLTLNSPI FDKPLSRRLR RVSLSEIGFG KLETYIKLDK LGEGTYATVY 180

KGKSKLTDNL VALKEIRLEH EEGAPCTAIR EVSLLKDLKH ANIVTLHDII HTEKSLTLVF 240

EYLDKDLKQY LDDCGNVINM HNVKLFLFQL LRGLAYCHRQ KVLHRDLKPQ NLLINERGEL 300

KLADFGLARA KSIPTKTYSN EVVTLWYRPP DILLGSTDYS TQIDMWGVGC IFYEMATGRP 360

LFPGSTVEEQ LHFIFRILGT PTEETWPGIL SNEEFKTYNY PKYRAEALLS HAPRLDSDGA 420

DLLTKLLQFE GRNRISAEDA MKHPFFLSLG ERIHKLPDTT SIFALKEIQL QKEANLRSSS 480

MPDSGRPAFR VVDTEF 496

Nucleotide Sequence
(FASTA)

ATGGATCGGA TGAAGAAGAT CAAACGGCAG CTGTCAATGA CACTCCGAGG GGGCCGAGGT 60

GTAGATAAGA CCAATGGTGC CCCTGAACAG ATAGGCCTGG ATGAGAGTGG TGGTGGTGGC 120

GGCAGTGACC TTGGAGAGGC CCCCACACGT GTCGCTCCTG GGGAACCTCG CTCTGGACGG 180

GGCCCACTCA GCTCTGCACC TGAGATTGTA CACGAGGACT TGAAGATGGG GTCTGACGGG 240

GAAAGTGACC AGGCTTCAGC CACGTCCTCG GATGAGGTGC AGTCGCCAGT GAGGGTGCGC 300

ATGCGCAACC ATCCCCCACG CAAGATCTCC ACTGAGGACA TCAACAAGCG CCTATCACTA 360

CCAGCCGACA TCCGGCTGCC CGAGGGCTAC CTTGAGAAGC TAACCCTCAA TAGCCCCATC 420

TTCGACAAGC CCCTCAGCCG CCGCCTCCGC CGTGTCAGCC TGTCTGAGAT TGGCTTTGGG 480

AAACTGGAGA CCTACATCAA GCTGGACAAG CTGGGCGAGG GTACCTATGC CACCGTCTAC 540

AAAGGCAAAA GCAAGCTCAC AGACAACCTT GTGGCACTCA AAGAGATCAG ACTGGAACAC 600

GAAGAGGGGG CACCCTGCAC CGCCATCCGG GAAGTGTCCC TACTCAAGGA CCTCAAACAT 660

GCCAACATCG TCACGCTACA CGACATTATC CACACGGAGA AGTCCCTCAC CCTTGTCTTT 720

GAGTACCTGG ACAAGGACCT GAAGCAGTAC CTGGATGACT GTGGGAACGT CATCAACATG 780

CACAACGTGA AACTGTTCCT GTTCCAGCTG CTCCGTGGCC TGGCCTACTG CCACCGGCAG 840

AAGGTGCTAC ACCGAGACCT CAAGCCCCAG AACCTGCTCA TCAATGAGAG AGGAGAGCTC 900

AAGTTGGCTG ACTTTGGCCT GGCCCGGGCC AAGTCAATTC CAACAAAGAC CTACTCCAAC 960

GAGGTGGTGA CACTGTGGTA CCGGCCCCCT GACATCCTGC TTGGGTCCAC AGACTACTCC 1020

ACCCAGATTG ACATGTGGGG TGTGGGCTGC ATCTTCTATG AGATGGCCAC GGGCCGGCCC 1080

CTCTTCCCGG GCTCCACAGT TGAGGAACAG CTGCACTTCA TCTTCCGCAT CTTGGGAACC 1140

CCAACTGAGG AGACATGGCC AGGCATCCTG TCCAACGAAG AGTTCAAGAC ATACAACTAC 1200

CCCAAGTACC GAGCCGAGGC CCTTTTGAGC CATGCACCCC GACTTGACAG CGATGGGGCT 1260

GACCTCCTCA CCAAGTTGCT GCAGTTTGAA GGTCGCAATC GGATCTCCGC AGAGGACGCC 1320

ATGAAACATC CATTCTTCCT CAGTCTAGGG GAGCGGATCC ACAAACTTCC TGACACTACT 1380

TCCATATTTG CACTAAAGGA GATCCAGCTA CAAAAGGAGG CCAACCTTCG GTCTTCGTCA 1440

ATGCCTGACT CAGGCAGGCC AGCTTTCCGT GTGGTGGACA CCGAGTTCTA A 1491

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl+k+geGty++vyk+k+k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 165   YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANI  223

         7799********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ ++k+l+Lvfe+l++dLk++l+++ +  +++++vk +l+qll+glay+H++k

Q: 224   VTLHDIIH-TEKSLTLVFEYLDKDLKQYLDDCGN-VINMHNVKLFLFQLLRGLAYCHRQK  281

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi+++g+lklaDfGlara s p+kty++evvTlwYr+P++Llg+++Yst

Q: 282   VLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYST  341

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

         ++D+W+vgci+ e++t +plf+g++  +ql+ if++lgtp+e++wp++ + +e+k +++p

Q: 342   QIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKtYNYP  401

         *******************************************************88***

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         k++++ l ++ ++l++++ dll+kll+++ ++Risa++a++h++f

Q: 402   KYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF  446

         *******************************************98

Domain Sequence
(FASTA)

YIKLDKLGEG TYATVYKGKS KLTDNLVALK EIRLEHEEGA PCTAIREVSL LKDLKHANIV 60

TLHDIIHTEK SLTLVFEYLD KDLKQYLDDC GNVINMHNVK LFLFQLLRGL AYCHRQKVLH 120

RDLKPQNLLI NERGELKLAD FGLARAKSIP TKTYSNEVVT LWYRPPDILL GSTDYSTQID 180

MWGVGCIFYE MATGRPLFPG STVEEQLHFI FRILGTPTEE TWPGILSNEE FKTYNYPKYR 240

AEALLSHAPR LDSDGADLLT KLLQFEGRNR ISAEDAMKHP FF 282

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ecb:100060831

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013