EKS-EQC-00235

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00235

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	361.3	2.6E-108	20	271	252

Status

Unreviewed

Ensembl Protein

ENSECAP00000016544

UniProt Accession

F6Z8X4;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK2

Gene Synonyms/Alias

SIK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000018825	ENSECAP00000016544	ENSECAT00000020171

Organism

Equus caballus

Functional Description

Protein Length

927

Protein Sequence
(FASTA)

MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI IDKSQLDAVN 60

LEKIYREVQI MKMLDHPHII KLYQVMETKN MLYLVTEYAK NGEIFDYLAN HGRLNESEAR 120

RKFWQILSAV DYCHGRKIVH RDLKAENLLL DNNMNIKIAD FGFGNFFKSG ELLATWCGSP 180

PYAAPEVFEG QQYEGPQLDI WSMGVVLYVL VCGALPFDGP TLPILRQRVL EGRFRIPYFM 240

SEDCEHLIRR MLVLDPSKRL TIAQIKEHKW MLVEVPVQRP TLYPQGQENE PSIGEFNEQV 300

LRLMHSLGID QQKTIESLQN KSYNHFAAIY FLLVERLKSH RSSFPVEQRL DARQRRPSTI 360

AEQTVAKAQT VGLPVTMHSP NVRLMRSALL PQTSNVEAFP FPASGCQAEA AFMEEECVDT 420

PKVNGCLLDP VPPVLVRKGC QSLPSNMMET SIDEGLETEG EAEEDPSQAF DAFQSTRCGQ 480

RRHTLSEVTN QLVVMPGSGK IFSMSDNPSL DSVDSEYDMG SVQRDLNFLE DSPPLKDIML 540

ANQPSPRMTS PFISLRPANP AMQALSSQKR EAHNRSPVSF REGRRASDTS LTQGIVAFRQ 600

HLQNLARTKG ILELNKVQLL YEQIGSEADP NLASAAPQLQ DVASSSPQEE VSQQQKSVSA 660

LATSVRPQLS QRQGLEAQYL QHRLQKPSLL SKAQNTCQLY CKEPPRSLEQ QLQEHRLQQK 720

RLFLQKQSQL QAYFNQMQIA ESSYPQQSQQ LPLPHQETPP PSQQPPPFSL TQPLSPVLEP 780

ASEQMQYSPF LRQYQEMRLQ PLPSSPGPRA PPPLPVHLQQ QQPPPPPPPP PPPQQSGAAP 840

APLQFSYQTC ELPGAASPEP DYPTACQYPM DGAQQSGMAA PDCPRSSGPQ EAPSSYDPLA 900

LSEFPGLFDC EMLEAVDPQH SGYVLVN 927

Nucleotide Sequence
(FASTA)

ATGGTCATGG CGGATGGCCC GAGGCACTTG CAGCGCGGGC CGGTCCGGGT GGGGTTCTAC 60

GACATCGAGG GCACGCTGGG CAAGGGCAAC TTCGCCGTGG TGAAGCTGGG GCGGCACCGG 120

ATCACCAAGA CGGAGGTGGC AATAAAAATT ATAGATAAAT CTCAGCTGGA TGCAGTGAAC 180

CTTGAGAAAA TCTACCGAGA AGTACAAATA ATGAAAATGT TAGACCACCC TCACATAATC 240

AAACTTTATC AGGTAATGGA GACCAAAAAT ATGTTGTACC TTGTGACAGA ATATGCCAAA 300

AATGGAGAAA TTTTTGACTA CCTTGCTAAT CATGGCCGGT TAAACGAGTC TGAGGCCAGG 360

CGCAAATTCT GGCAAATCCT GTCAGCTGTT GATTATTGTC ATGGTCGGAA GATTGTGCAC 420

CGTGACCTCA AGGCTGAAAA TCTCCTGCTG GATAACAACA TGAATATCAA AATAGCAGAT 480

TTCGGTTTTG GAAATTTCTT TAAAAGTGGT GAACTGCTGG CAACATGGTG TGGCAGCCCC 540

CCTTATGCAG CCCCAGAAGT CTTTGAAGGG CAGCAGTATG AAGGACCACA GCTGGATATT 600

TGGAGCATGG GAGTTGTTCT TTATGTTCTT GTCTGTGGAG CTCTGCCTTT TGACGGACCA 660

ACTCTTCCGA TTTTGAGGCA AAGGGTTTTA GAAGGAAGAT TCCGGATTCC ATATTTCATG 720

TCAGAAGATT GTGAGCACCT CATTCGAAGG ATGTTGGTCC TAGACCCATC CAAACGGCTA 780

ACCATTGCTC AAATCAAGGA GCATAAATGG ATGCTCGTAG AAGTTCCTGT ACAGAGGCCT 840

ACTCTCTATC CACAAGGGCA AGAAAATGAG CCATCCATTG GGGAGTTCAA TGAGCAGGTT 900

CTGCGATTGA TGCACAGCCT TGGAATAGAT CAACAGAAAA CCATTGAGTC TCTGCAGAAC 960

AAGAGCTATA ACCATTTTGC TGCCATTTAT TTCTTGTTGG TGGAGCGCCT GAAATCACAT 1020

AGGAGCAGTT TTCCTGTGGA GCAGAGACTT GATGCCCGCC AGCGTCGGCC TAGCACCATT 1080

GCTGAACAAA CAGTTGCCAA GGCACAAACG GTGGGGCTCC CAGTGACCAT GCATTCGCCG 1140

AATGTGCGAC TGATGCGATC TGCCCTCCTC CCACAGACGT CCAATGTGGA GGCCTTCCCA 1200

TTCCCAGCCT CGGGCTGTCA GGCGGAAGCA GCCTTCATGG AAGAAGAGTG TGTCGACACT 1260

CCAAAGGTGA ATGGCTGTCT GCTGGACCCT GTGCCGCCTG TGCTGGTGAG GAAGGGGTGC 1320

CAGTCATTGC CCAGCAACAT GATGGAGACC TCCATTGATG AAGGGCTGGA GACAGAAGGA 1380

GAGGCTGAGG AGGACCCCAG CCAGGCCTTT GACGCGTTCC AGTCCACGCG CTGTGGGCAG 1440

AGACGGCACA CCCTGTCGGA AGTGACCAAC CAGCTGGTGG TAATGCCGGG GTCAGGGAAA 1500

ATTTTCTCCA TGAGTGACAA CCCCTCCCTT GACAGTGTGG ACTCTGAGTA TGATATGGGG 1560

TCTGTTCAGA GGGACCTGAA CTTCCTTGAG GACAGCCCTC CGCTTAAGGA CATCATGTTA 1620

GCCAATCAGC CATCACCCCG CATGACGTCT CCCTTCATAA GCCTGAGACC CGCCAACCCG 1680

GCCATGCAGG CTCTGAGCTC CCAGAAACGA GAGGCCCACA ACAGGTCGCC AGTGAGCTTC 1740

AGAGAGGGCC GCAGGGCGTC AGACACCTCC CTCACCCAAG GAATTGTAGC ATTTAGACAA 1800

CATCTTCAAA ATCTGGCTAG AACCAAAGGA ATCCTAGAGT TGAATAAAGT GCAGTTGCTG 1860

TATGAACAAA TAGGATCGGA GGCAGACCCT AACTTGGCCT CAGCTGCTCC TCAGCTCCAA 1920

GACGTGGCCA GCAGCTCCCC TCAGGAGGAA GTTTCTCAAC AGCAGAAAAG CGTGTCTGCT 1980

CTCGCCACCA GCGTGCGTCC TCAGCTCTCC CAGCGGCAAG GCCTGGAAGC CCAGTACCTG 2040

CAGCACAGAC TCCAGAAGCC CAGCCTTCTG TCAAAAGCCC AGAACACCTG TCAGCTTTAT 2100

TGTAAAGAAC CACCGAGGAG CCTTGAACAG CAGCTGCAGG AACACAGACT CCAACAGAAG 2160

CGACTCTTCC TCCAGAAACA GTCTCAGCTG CAGGCGTATT TTAATCAGAT GCAAATAGCG 2220

GAGAGCTCGT ACCCACAGCA GAGTCAGCAG CTGCCCCTTC CCCACCAGGA GACACCACCG 2280

CCATCACAGC AGCCACCGCC ATTCAGCCTG ACCCAGCCTC TGAGCCCCGT CCTGGAGCCT 2340

GCTTCAGAGC AAATGCAATA CAGCCCTTTC CTCCGCCAGT ACCAGGAGAT GCGGCTGCAG 2400

CCCCTGCCCT CCTCGCCTGG TCCCCGGGCT CCACCGCCGC TGCCCGTGCA CTTGCAGCAG 2460

CAGCAGCCGC CACCGCCGCC GCCGCCGCCA CCACCGCCAC AACAGTCGGG AGCTGCCCCA 2520

GCACCCTTAC AGTTCTCCTA TCAGACTTGT GAGCTGCCAG GCGCTGCCTC CCCTGAGCCA 2580

GACTATCCCA CTGCCTGTCA GTACCCCATG GATGGAGCCC AGCAGAGCGG CATGGCAGCT 2640

CCAGACTGTC CCAGGAGCTC AGGACCGCAG GAGGCCCCCT CCAGCTACGA CCCTCTAGCC 2700

CTCTCTGAGT TCCCTGGACT CTTCGATTGT GAAATGCTAG AGGCTGTGGA CCCACAGCAC 2760

AGTGGTTACG TCCTGGTAAA TTAA 2784

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++  tlG+g+f+ Vkl +h+ tk++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 20    YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI  79

         89999*******************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++lylv+eya++ge+fdy+ ++grl+e+ear+ f q++sav+Y+h ++iv

Q: 80    IKLYQVMETKNMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIV  139

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+fk+g+ll t+cGsppYaaPe+++g++Yegp++D

Q: 140   HRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLD  199

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +Ws+GvvLy+lv+g+lPfd+++l  l++++l+g+++ip+ +s+++e+L+r++Lv dp+kR

Q: 200   IWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKR  259

         ************************************************************

S: 241   atieeilkhewl  252

         +ti +i++h+w+

Q: 260   LTIAQIKEHKWM  271

         ***********8

Domain Sequence
(FASTA)

YDIEGTLGKG NFAVVKLGRH RITKTEVAIK IIDKSQLDAV NLEKIYREVQ IMKMLDHPHI 60

IKLYQVMETK NMLYLVTEYA KNGEIFDYLA NHGRLNESEA RRKFWQILSA VDYCHGRKIV 120

HRDLKAENLL LDNNMNIKIA DFGFGNFFKS GELLATWCGS PPYAAPEVFE GQQYEGPQLD 180

IWSMGVVLYV LVCGALPFDG PTLPILRQRV LEGRFRIPYF MSEDCEHLIR RMLVLDPSKR 240

LTIAQIKEHK WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008286	; P:insulin receptor signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0046777	; P:protein autophosphorylation

KEGG

ecb:100070391

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR017090	; Ser/Thr_kinase_SIK1/2.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013