EKS-EQC-00310

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00310

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	328.4	3.6E-98	17	291	275

Status

Unreviewed

Ensembl Protein

ENSECAP00000017204

UniProt Accession

F7CMY7;

Protein Name

Protein Synonyms/Alias

Gene Name

OXSR1

Gene Synonyms/Alias

OXSR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000019157	ENSECAP00000017204	ENSECAT00000020926

Organism

Equus caballus

Functional Description

Protein Length

527

Protein Sequence
(FASTA)

MSEDSSALPW SINRDDYELQ EVIGSGATAV VQAAYCAPKK EKVAIKRINL EKCQTSMDEL 60

LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV LDIIKHIVAK GEHKSGVLDE 120

PTIATILREV LEGLEYLHKN GQIHRDVKAG NILLGEDGSV QIADFGVSAF LATGGDITRN 180

KVRKTFVGTP CWMAPEVMEQ VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL 240

QNDPPSLETG VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEFL 300

QEKLLQRAPT ISERAKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG KAAISQLRSP 360

RVKESLSNSE LFPATDPVGT LLQVPEQISA HLPQPAGQMP AQPTQVSLPP PAEPAKTAQA 420

LSSGAGSQET KIPISLVLRL RNSKKELNDI RFEFTPGRDT AEGVSQELIS AGLVDGRDLV 480

IVAANLQKIV EEPQSNRSVT FKLASGVEGS DIPDDGKLIG FAQLSIS 527

Nucleotide Sequence
(FASTA)

ATGTCCGAGG ACTCGAGCGC CCTGCCCTGG TCCATCAACA GGGACGATTA CGAGCTGCAG 60

GAGGTGATCG GGAGTGGAGC AACGGCTGTG GTCCAAGCAG CGTATTGTGC CCCTAAAAAG 120

GAGAAAGTGG CAATCAAACG GATAAACCTT GAGAAATGTC AAACTAGCAT GGATGAACTC 180

CTGAAAGAAA TTCAAGCCAT GAGTCAGTGC CATCATCCTA ATATTGTGTC TTACTACACG 240

TCTTTTGTGG TAAAAGATGA GCTGTGGCTA GTCATGAAGC TGCTAAGTGG AGGTTCTGTT 300

CTGGATATTA TTAAGCACAT TGTGGCAAAG GGGGAACACA AAAGTGGAGT CCTAGATGAA 360

CCTACCATTG CAACAATACT CAGAGAAGTG CTGGAAGGAT TGGAATACTT ACATAAAAAT 420

GGACAGATTC ACAGAGATGT GAAAGCTGGA AATATTCTTC TGGGAGAAGA TGGCTCAGTA 480

CAGATTGCAG ATTTTGGAGT TAGTGCTTTT TTAGCAACTG GTGGTGATAT TACCCGAAAT 540

AAAGTGAGAA AGACCTTTGT TGGAACCCCT TGCTGGATGG CACCTGAAGT TATGGAACAG 600

GTCCGAGGTT ATGATTTCAA AGCTGACATC TGGAGTTTTG GGATCACAGC GATTGAACTG 660

GCCACAGGAG CAGCTCCTTA TCATAAATAT CCGCCAATGA AGGTTTTAAT GCTGACGCTG 720

CAGAATGATC CTCCTTCTTT GGAAACTGGT GTTCAAGATA AAGAAATGCT AAAAAAATAT 780

GGAAAATCAT TTAGAAAAAT GATTTCATTG TGCCTTCAAA AGGATCCAGA AAAAAGACCA 840

ACAGCAGCAG AACTGTTAAG GCACAAATTT TTCCAAAAAG CAAAGAATAA AGAATTTCTT 900

CAAGAAAAAC TATTGCAGAG AGCTCCAACC ATTTCTGAAA GAGCTAAAAA GGTTCGGAGA 960

GTACCAGGTT CCAGTGGCCG TCTTCATAAG ACAGAGGATG GTGGCTGGGA GTGGAGTGAT 1020

GATGAATTTG ATGAAGAAAG TGAGGAAGGG AAAGCAGCAA TTTCACAACT CAGGTCTCCC 1080

CGAGTGAAGG AATCATTATC AAATTCTGAG CTCTTTCCAG CAACTGATCC CGTGGGTACT 1140

TTGCTCCAAG TTCCAGAACA GATTTCCGCT CATCTACCTC AGCCAGCTGG GCAGATGCCT 1200

GCACAACCAA CTCAAGTTTC CCTCCCACCC CCTGCAGAGC CAGCAAAAAC AGCTCAGGCT 1260

CTGTCTTCAG GAGCAGGTTC ACAAGAAACC AAGATCCCAA TCAGTCTAGT ACTAAGATTA 1320

AGGAATTCAA AAAAAGAACT AAATGATATT CGATTTGAAT TTACTCCTGG GAGAGATACA 1380

GCAGAGGGTG TGTCTCAGGA ACTCATTTCT GCTGGCCTGG TCGACGGAAG AGATTTAGTA 1440

ATAGTGGCAG CTAATTTGCA GAAAATTGTG GAAGAACCTC AGTCAAATCG ATCTGTCACT 1500

TTCAAACTGG CATCTGGTGT CGAAGGCTCA GATATTCCTG ATGACGGTAA ACTAATAGGA 1560

TTTGCCCAAC TCAGCATCAG CTAA 1584

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.ekleelqkeisvlkklkhpniv  59

         yel+e+ig+Ga++ v++a++ +++e+vaik+inlek+ ++++el kei+++++++hpniv

Q: 17    YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCqTSMDELLKEIQAMSQCHHPNIV  76

         99***********************************8899*******************

S: 60    eylesflkeeelwlvmeylagGslsdlvk......eelkselkEeqiayilrevlkaLey  113

         +y++sf++++elwlvm++l+gGs+ d++k      e+++  l+E +ia+ilrevl++Ley

Q: 77    SYYTSFVVKDELWLVMKLLSGGSVLDIIKhivakgEHKSGVLDEPTIATILREVLEGLEY  136

         *****************************9*99999999*********************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlek....trkk.rktvvgtpywmAPE  168

         lH++++iHrd+ka+niLl e+g+V+++dfgv+a l++    tr+k rkt+vgtp+wmAPE

Q: 137   LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATggdiTRNKvRKTFVGTPCWMAPE  196

         ***********************************99999988899**************

S: 169   viaqeekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklksk.....  223

         v++q  +gYd kaDiws+GItaiela+g++P+++++p+k+l+++l+n+pp+l++

Q: 197   VMEQ-VRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGvqdke  255

         ***5.9*********************************************976677778

S: 224   ..kkfskefkefvekclqknpekRpsasellkhkFl  257

           kk++k+f+++++ clqk+pekRp+a+ell+hkF+

Q: 256   mlKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF  291

         8899*******************************7

Domain Sequence
(FASTA)

YELQEVIGSG ATAVVQAAYC APKKEKVAIK RINLEKCQTS MDELLKEIQA MSQCHHPNIV 60

SYYTSFVVKD ELWLVMKLLS GGSVLDIIKH IVAKGEHKSG VLDEPTIATI LREVLEGLEY 120

LHKNGQIHRD VKAGNILLGE DGSVQIADFG VSAFLATGGD ITRNKVRKTF VGTPCWMAPE 180

VMEQVRGYDF KADIWSFGIT AIELATGAAP YHKYPPMKVL MLTLQNDPPS LETGVQDKEM 240

LKKYGKSFRK MISLCLQKDP EKRPTAAELL RHKFF 275

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006979	; P:response to oxidative stress

KEGG

ecb:100050017

;

InterPros

IPR011009	; Kinase-like_dom.
IPR024678	; Kinase_OSR1/WNK_CCT.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF12202	; OSR1_C; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013