EKS-EQC-00161

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00161

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	477.1	1.4E-143	400	656	257

Status

Unreviewed

Ensembl Protein

ENSECAP00000017748

UniProt Accession

F7DGR6;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KA6

Gene Synonyms/Alias

RPS6KA6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000019431	ENSECAP00000017748	ENSECAT00000021543
ENSECAG00000019431	ENSECAP00000017795	ENSECAT00000021597

Organism

Equus caballus

Functional Description

Protein Length

718

Protein Sequence
(FASTA)

QVNGLKMVDE PMEEGEADSC QDEGVVKEIP ITHHVKEGYE KADPAQFDLL KVLGQGSFGK 60

VFLVRKKTGP DAGQLYAMKV LKKASLKVRD RVRTKMERDI LVEVNHPFIV KLHYAFQTEG 120

KLYLILDFLR GGDVFTRLSK EVLFTEEDVK FYLAELALAL DHLHRLGIVY RDLKPENILL 180

DEIGHIKLTD FGLSKESVDQ EKKAYSFCGT VEYMAPEVVN RRGHSQSADW WSYGVLMFEM 240

LTGTLPFQGK DRNETMNMIL KAKLGMPQFL SAEAQSLLRM LFKRNPANRL GSEGVEEIKR 300

HLFFANIDWN KLYKREVQPP FKPASGKPDD TFCFDPEYTA KTPKDSPGLP ASANAHQLFK 360

GFSFVATSIA EEYKITPITS TNVLPIIQIS GNAAQFGEVY ELKEDIGIGS YSVCKRCIHI 420

ATNMEFAVKI IDKSKRDPSE EIEILMRYGQ HPNIITLKDV YDDGRYVYLV TDLMKGGELL 480

DRILKQKCFS EREASDVLFV ITKTVDYLHC QGVVHRDLKP SNILYMDESA NADSIRICDF 540

GFAKQLRGEM DFLTPCYTAN FVAPEVLMQQ GYDAACDIWS LGVLFYTMLA GYTPFANGPN 600

DTPEEILLRI GNGKFSLSGG NWDSISDGAK DLLSHMLHMD PHQRYTTEQV LKHSWIIHRD 660

QLPNDQPNIN DTSHVIKGAV VATYSALTHK TFQPVLEPVA ASSLAQRRSM KKRTSTGL 718

Nucleotide Sequence
(FASTA)

CAGGTGAATG GTCTAAAAAT GGTTGATGAG CCAATGGAAG AGGGAGAAGC AGATTCTTGC 60

CAAGATGAAG GAGTTGTTAA AGAAATCCCT ATTACTCACC ATGTTAAGGA AGGATATGAG 120

AAAGCAGATC CTGCACAGTT TGACTTACTC AAGGTTCTTG GTCAGGGATC CTTTGGAAAG 180

GTTTTTCTTG TTAGAAAGAA GACCGGTCCT GATGCTGGGC AGCTCTATGC AATGAAGGTG 240

TTAAAAAAAG CTTCTTTAAA AGTTCGAGAC AGAGTTCGGA CAAAGATGGA GAGGGATATA 300

CTGGTGGAAG TAAATCATCC ATTTATTGTT AAATTGCACT ATGCCTTTCA GACTGAAGGG 360

AAGCTGTATT TAATATTGGA TTTTCTCAGG GGAGGAGATG TCTTCACAAG ATTATCCAAA 420

GAAGTTCTGT TTACAGAGGA AGATGTGAAA TTCTACCTCG CAGAACTGGC ACTTGCTTTG 480

GATCATCTGC ACCGATTAGG AATTGTATAT AGAGACCTGA AGCCAGAAAA CATTTTGCTT 540

GATGAAATAG GACATATCAA GTTAACAGAT TTTGGACTCA GCAAGGAATC AGTAGATCAA 600

GAAAAGAAGG CTTACTCATT TTGTGGTACA GTGGAGTATA TGGCACCTGA AGTAGTAAAT 660

AGGAGAGGTC ACTCCCAGAG TGCTGATTGG TGGTCATATG GTGTACTTAT GTTTGAAATG 720

CTTACTGGTA CTCTGCCATT TCAAGGTAAA GACAGAAATG AGACCATGAA TATGATATTA 780

AAAGCAAAAC TTGGAATGCC TCAGTTTCTT AGTGCTGAAG CACAAAGTCT TCTAAGGATG 840

TTATTCAAAA GGAATCCAGC AAATAGATTG GGTTCAGAAG GAGTTGAGGA AATCAAAAGA 900

CATCTTTTCT TTGCAAATAT TGACTGGAAT AAATTATATA AAAGAGAAGT TCAACCTCCT 960

TTCAAGCCTG CTTCTGGAAA ACCAGATGAT ACTTTTTGTT TTGATCCTGA ATATACTGCA 1020

AAAACTCCTA AAGATTCTCC TGGTTTGCCA GCCAGTGCTA ATGCTCATCA GCTCTTCAAA 1080

GGATTCAGCT TTGTTGCAAC TTCTATTGCA GAAGAATATA AAATCACTCC TATCACAAGT 1140

ACAAATGTAT TACCAATCAT TCAGATAAGT GGAAATGCTG CACAATTTGG TGAAGTATAT 1200

GAATTGAAAG AGGATATTGG TATTGGTTCC TATTCTGTTT GCAAGCGGTG TATACATATA 1260

GCTACCAACA TGGAATTTGC AGTGAAGATC ATTGACAAAA GTAAGAGAGA CCCCTCAGAA 1320

GAAATTGAAA TTTTGATGCG TTATGGACAA CACCCCAATA TTATCACTTT AAAGGATGTT 1380

TATGATGATG GTAGATATGT TTACCTTGTT ACGGACTTGA TGAAAGGAGG AGAGCTACTT 1440

GACCGTATTC TCAAGCAAAA ATGTTTCTCA GAACGGGAAG CTAGTGATGT ACTGTTTGTA 1500

ATAACTAAGA CAGTTGACTA TCTTCATTGT CAAGGAGTTG TTCATCGTGA TCTTAAACCT 1560

AGTAATATTT TATACATGGA TGAATCAGCC AATGCAGACT CCATTAGGAT CTGTGATTTT 1620

GGGTTTGCAA AACAACTTCG AGGAGAAATG GACTTCCTTA CTCCATGCTA CACTGCAAAC 1680

TTTGTAGCAC CTGAGGTTCT TATGCAACAG GGCTATGATG CTGCTTGTGA TATTTGGAGT 1740

CTGGGAGTAC TTTTTTACAC GATGTTGGCT GGCTACACTC CATTTGCTAA TGGCCCCAAT 1800

GACACTCCTG AGGAGATACT GCTGCGTATA GGCAATGGAA AGTTCTCTTT GAGTGGTGGA 1860

AACTGGGACA GTATTTCAGA TGGAGCAAAG GATTTGCTTT CCCATATGCT ACATATGGAC 1920

CCACATCAGC GGTACACTAC AGAACAAGTA TTAAAACACT CGTGGATAAT CCACAGAGAC 1980

CAGTTGCCGA ATGATCAACC AAATATAAAT GATACATCAC ATGTCATTAA GGGAGCAGTA 2040

GTTGCCACAT ATTCTGCCCT GACTCACAAG ACCTTTCAAC CAGTCCTAGA GCCTGTTGCT 2100

GCTTCAAGCT TAGCTCAGCG ACGGAGCATG AAAAAGCGAA CCTCAACTGG CCTGTAA 2157

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         ye+ked+G Gsysvckrc+h atn+efavkiidkskrd+seeieil+ry+qhpni+tlkd

Q: 400   YELKEDIGIGSYSVCKRCIHIATNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKD  459

         789*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddg+yvylv++l+kGGelldri+k+k+fsereas++l++++k+v+ylh+qGvvhrdlk

Q: 460   VYDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDVLFVITKTVDYLHCQGVVHRDLK  519

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nily+des+na+si+i+dfGfak++r e +   tpcyt+nfvapevl++qGyd+acd+

Q: 520   PSNILYMDESANADSIRICDFGFAKQLRGEMDF-LTPCYTANFVAPEVLMQQGYDAACDI  578

         ****************************99886.59************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvl+ytmlaGy+pfangp+dt+eeil +i++GkfslsG++wds+s+ akdl+s++l+

Q: 579   WSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDSISDGAKDLLSHMLH  638

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         +dp++r++ eq+lkhsw+

Q: 639   MDPHQRYTTEQVLKHSWI  656

         *****************8

Domain Sequence
(FASTA)

YELKEDIGIG SYSVCKRCIH IATNMEFAVK IIDKSKRDPS EEIEILMRYG QHPNIITLKD 60

VYDDGRYVYL VTDLMKGGEL LDRILKQKCF SEREASDVLF VITKTVDYLH CQGVVHRDLK 120

PSNILYMDES ANADSIRICD FGFAKQLRGE MDFLTPCYTA NFVAPEVLMQ QGYDAACDIW 180

SLGVLFYTML AGYTPFANGP NDTPEEILLR IGNGKFSLSG GNWDSISDGA KDLLSHMLHM 240

DPHQRYTTEQ VLKHSWI 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006978	; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013