EKS-EQC-00079
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00079
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/GSK450.13.4E-13525308284
StatusUnreviewed
Ensembl ProteinENSECAP00000017279
UniProt AccessionF7CGC0;
Protein Name
Protein Synonyms/Alias
Gene NameGSK3A
Gene Synonyms/Alias GSK3A;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000019484ENSECAP00000017279ENSECAT00000021007
OrganismEquus caballus
Functional Description
Protein Length349
Protein Sequence
(FASTA)
DSGKVTTVVA TLGQGPDRSQ EVAYTDIKVI GNGSFGVVYQ ARLAETRELV AIKKVLQDKR 60
FKNRELQIMR KLDHCNIVRL RYFFYSSGEK KDELYLNLVL EYVPETVYRV ARHFTKAKLT 120
IPIIYVKVYM YQLFRSLAYI HSQGVCHRDI KPQNLLVDPD TAVLKLCDFG SAKQLVRGEP 180
NVSYICSRYY RAPELIFGAT DYTSSIDVWS AGCVLAELLL GQPIFPGDSG VDQLVEIIKV 240
LGTPTREQIR EMNPNYTEFK FPQIKAHPWT KVFKSRTPPE AIALCSSLLE YTPSSRLSPL 300
EACAHSFFDE LRCPGTQLPN NRPLPPLFNF SPGELSIQPS LNAILIPPH 349
Nucleotide Sequence
(FASTA)
GACAGCGGGA AGGTGACCAC AGTGGTAGCC ACTCTAGGCC AAGGCCCAGA CCGCTCCCAG 60
GAGGTGGCTT ACACAGACAT CAAAGTGATT GGCAATGGCT CATTTGGGGT CGTGTACCAG 120
GCACGGCTGG CAGAGACCAG GGAACTGGTG GCCATCAAGA AGGTTCTCCA GGACAAGAGG 180
TTCAAGAACC GAGAGCTGCA GATTATGCGT AAGCTGGACC ACTGCAATAT TGTGAGGCTG 240
AGATACTTTT TCTACTCCAG TGGGGAGAAG AAAGATGAGC TTTACCTAAA TCTGGTGCTG 300
GAATATGTGC CCGAGACGGT GTACCGGGTG GCCCGTCATT TCACCAAGGC CAAGTTGACC 360
ATCCCTATCA TCTATGTCAA GGTGTACATG TACCAGCTCT TCCGGAGCTT GGCCTACATC 420
CACTCCCAAG GTGTGTGTCA CCGCGACATC AAGCCTCAGA ACCTGCTGGT GGACCCCGAC 480
ACTGCTGTCC TCAAGCTCTG CGATTTTGGC AGTGCAAAAC AGTTGGTCCG GGGGGAGCCC 540
AACGTGTCCT ACATCTGTTC TCGCTACTAC CGGGCCCCGG AGCTGATCTT CGGAGCCACT 600
GATTACACCT CATCCATCGA TGTGTGGTCA GCTGGCTGTG TACTGGCTGA GCTCCTCCTG 660
GGCCAGCCCA TCTTCCCTGG GGACAGTGGG GTAGACCAGC TGGTGGAGAT CATCAAGGTG 720
CTGGGAACAC CAACCCGGGA ACAGATCCGA GAGATGAACC CCAACTACAC GGAGTTCAAG 780
TTCCCTCAGA TTAAAGCTCA CCCCTGGACA AAGGTGTTTA AATCTCGAAC GCCGCCTGAG 840
GCCATCGCGC TCTGCTCTAG CCTGCTGGAG TACACACCGT CCTCGAGGCT CTCCCCGCTG 900
GAAGCCTGTG CCCACAGCTT CTTTGATGAA CTGCGATGTC CCGGAACCCA GCTCCCCAAC 960
AACCGCCCGC TACCCCCCCT CTTCAATTTC AGTCCTGGCG AACTCTCCAT CCAGCCATCT 1020
CTCAACGCCA TTCTCATCCC TCCTCACTGA 1050
Domain Profile
S: 2     eelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLlyf  61
         +++k+ig+GsFg+Vyqa+l+e++e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+yf
Q: 25    TDIKVIGNGSFGVVYQARLAETREL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYF  83
         789**********************.**********************************
S: 62    fsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhsl  121
         f++s ekkd++ylnlvley+Pet+++v+r+++++k ++++++vk+y+yQlfr+lay+hs+
Q: 84    FYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPIIYVKVYMYQLFRSLAYIHSQ  143
         ************************************************************
S: 122   eivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakeyt  181
         +++HrDiKPqNllvd++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++yt
Q: 144   GVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT  203
         ************************************************************
S: 182   tkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfkk  241
         ++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf++
Q: 204   SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQ  263
         ************************************************************
S: 242   ikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286
         ik+++++kv+k+++++ea++l++++l+y+p++Rls+le++ah+ff
Q: 264   IKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF  308
         ********************************************9
Domain Sequence
(FASTA)
TDIKVIGNGS FGVVYQARLA ETRELVAIKK VLQDKRFKNR ELQIMRKLDH CNIVRLRYFF 60
YSSGEKKDEL YLNLVLEYVP ETVYRVARHF TKAKLTIPII YVKVYMYQLF RSLAYIHSQG 120
VCHRDIKPQN LLVDPDTAVL KLCDFGSAKQ LVRGEPNVSY ICSRYYRAPE LIFGATDYTS 180
SIDVWSAGCV LAELLLGQPI FPGDSGVDQL VEIIKVLGTP TREQIREMNP NYTEFKFPQI 240
KAHPWTKVFK SRTPPEAIAL CSSLLEYTPS SRLSPLEACA HSFF 284
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00074
EKS-ANC-00071
EKS-BOT-00080
EKS-CAJ-00082
EKS-CAF-00081
EKS-DAR-00331
EKS-FEC-00077
EKS-GAM-00044
EKS-GAA-00099
EKS-GOG-00079
EKS-HOS-00083
EKS-LAC-00086
EKS-LOA-00076
EKS-MAM-00080
EKS-MAE-00033
EKS-MUM-00081
EKS-MUP-00081
EKS-MYL-00088
EKS-OCP-00051
EKS-ORN-00109
EKS-ORC-00076
EKS-ORL-00101
EKS-OTG-00084
EKS-PAT-00072
EKS-POA-00074
EKS-PRC-00044
EKS-PTV-00065
EKS-RAN-00077
EKS-SAH-00076
EKS-SUS-00072
EKS-TAR-00109
EKS-TEN-00106
EKS-TUT-00070
EKS-XET-00076
EKS-XIM-00104
EKS-SCP-00065
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0003214; P:cardiac left ventricle morphogenesis
GO:0016477; P:cell migration
GO:0071285; P:cellular response to lithium ion
GO:0071407; P:cellular response to organic cyclic compound
GO:0044027; P:hypermethylation of CpG island
GO:0008286; P:insulin receptor signaling pathway
GO:0061052; P:negative regulation of cell growth involved in cardiac muscle cell development
GO:0046325; P:negative regulation of glucose import
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0032007; P:negative regulation of TOR signaling cascade
GO:0051348; P:negative regulation of transferase activity
GO:0071879; P:positive regulation of adrenergic receptor signaling pathway
GO:0030819; P:positive regulation of cAMP biosynthetic process
GO:2000467; P:positive regulation of glycogen (starch) synthase activity
GO:0045823; P:positive regulation of heart contraction
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006349; P:regulation of gene expression by genetic imprinting
GO:0003073; P:regulation of systemic arterial blood pressure
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013