EKS-EQC-00146
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00146
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR557.54.6E-168390666277
StatusUnreviewed
Ensembl ProteinENSECAP00000018830
UniProt AccessionF6U520;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR3
Gene Synonyms/Alias FGFR3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000019533ENSECAP00000018763ENSECAT00000022687
ENSECAG00000019533ENSECAP00000018658ENSECAT00000022570
ENSECAG00000019533ENSECAP00000018830ENSECAT00000022768
ENSECAG00000019533ENSECAP00000018417ENSECAT00000022299
OrganismEquus caballus
Functional Description
Protein Length724
Protein Sequence
(FASTA)
MPSDRILVGP QRLQVLNASH EDAGAYSCQQ RLTQHVLCHF SVRVTDAPSS GDDEDGEDEA 60
EDTGEITGAP YWTRPERMDK KLLAVPAANT VRFRCPAAGN PTPSISWLKN GKEFRGEHRI 120
GGIKLRHQQW SLVMESVVPS DRGNYTCVVE NKFGSIQQTY TLDVLERSPH RPILQAGLPA 180
NQTAVLGSDV EFHCKVYSDA QPHIQWLKHV EVNGSKVGPD GTPYVTVLKT AGANTTDKEL 240
EVLSLRNVTF EDAGEYTCLA GNSIGFSHHS AWLVVLPGLA APPAGEAGSV YAGVLSYGVG 300
FLLFILVVAA VTLCRLRSPP KKGLGSPTVH KVSRFPLKRQ VSLESNSSMN SNTPLVRIAR 360
LSSGEGPVLA NVSELELPAD PKWELSRARL TLGKPLGEGC FGQVVMAEAI GIDKDRAAKP 420
VTVAVKMLKD DATDKDLSDL VSEMEMMKMI GKHKNIINLL GACTQGGPLY VLVEYAAKGN 480
LREYLRARRP PGMDYSFDTC KLPEEQLTFK DLVSCAYQVA RGMEYLASQK CIHRDLAARN 540
VLVTEDNVMK IADFGLARDV HNLDYYKKTT NGRLPVKWMA PEALFDRVYT HQSDVWSFGV 600
LLWEIFTLGG SPYPGIPVEE LFKLLKEGHR MDKPANCTHD LYMIMRECWH AVPSQRPTFK 660
QLVEDLDRIL TVTSTDEYLD LSVPFEQYSP GSQDTPSSSS SGDDSVFAHD LLPPAPPSSG 720
GPRT 724
Nucleotide Sequence
(FASTA)
ATGCCATCGG ACCGCATCCT GGTGGGGCCT CAGCGGCTGC AGGTGCTAAA TGCCTCCCAT 60
GAGGACGCCG GGGCCTACAG CTGCCAGCAG CGGCTCACCC AGCATGTCCT GTGCCACTTC 120
AGCGTGCGCG TGACAGATGC TCCGTCCTCG GGAGATGACG AAGATGGGGA GGACGAGGCC 180
GAAGACACAG GTGAGATCAC AGGGGCCCCT TACTGGACGC GGCCCGAGCG GATGGACAAG 240
AAGCTGCTGG CTGTGCCAGC TGCCAACACT GTTCGCTTCC GCTGTCCGGC TGCTGGCAAC 300
CCCACTCCGT CCATCTCCTG GCTGAAGAAT GGCAAGGAGT TCCGAGGCGA GCATCGCATT 360
GGGGGCATCA AGCTGCGGCA CCAGCAGTGG AGCCTGGTCA TGGAGAGTGT GGTGCCCTCT 420
GACCGCGGCA ACTACACGTG TGTTGTGGAG AACAAGTTCG GCAGCATCCA GCAGACATAC 480
ACTCTGGACG TGCTGGAGCG CTCCCCGCAC CGGCCCATCC TGCAGGCGGG GCTGCCAGCC 540
AACCAGACGG CAGTGCTGGG CAGTGACGTG GAGTTCCACT GCAAGGTGTA CAGCGATGCG 600
CAGCCCCACA TCCAGTGGCT GAAGCACGTG GAGGTGAACG GCAGCAAAGT GGGACCCGAT 660
GGCACACCCT ACGTCACCGT GCTCAAGACG GCGGGCGCTA ACACCACCGA CAAGGAGCTA 720
GAGGTTCTGT CCTTACGCAA TGTCACCTTT GAGGACGCGG GGGAGTACAC GTGCCTGGCA 780
GGCAATTCTA TCGGGTTTTC CCATCACTCT GCGTGGCTGG TGGTGCTGCC AGGCCTCGCA 840
GCCCCACCAG CTGGTGAGGC CGGCAGCGTG TATGCAGGTG TCCTCAGCTA CGGGGTGGGC 900
TTCCTCCTCT TCATCCTGGT GGTGGCCGCC GTGACGCTCT GCCGCCTGCG CAGCCCCCCC 960
AAGAAAGGCC TGGGCTCGCC CACCGTGCAC AAGGTCTCCC GCTTCCCGCT CAAGCGACAG 1020
GTGTCCTTGG AGTCCAACTC GTCCATGAAC TCGAACACGC CCCTGGTGCG GATCGCCCGG 1080
CTGTCCTCGG GGGAGGGCCC CGTGCTGGCC AATGTCTCCG AGCTCGAGCT GCCCGCCGAC 1140
CCCAAGTGGG AGCTGTCCCG GGCCCGGCTG ACCCTGGGCA AGCCTCTCGG GGAGGGCTGC 1200
TTTGGCCAGG TGGTCATGGC AGAGGCCATT GGCATTGACA AGGACCGGGC CGCCAAGCCC 1260
GTCACCGTGG CTGTGAAGAT GCTGAAAGAC GATGCCACAG ACAAAGACCT GTCGGACCTG 1320
GTGTCCGAGA TGGAGATGAT GAAGATGATT GGCAAGCACA AGAACATCAT CAACCTGCTG 1380
GGGGCCTGCA CACAGGGCGG GCCCCTGTAC GTGCTGGTGG AGTATGCGGC CAAGGGCAAC 1440
CTGAGGGAGT ACCTGCGGGC GAGGAGGCCC CCGGGCATGG ACTACTCCTT CGACACTTGC 1500
AAGCTGCCGG AGGAGCAGCT CACCTTCAAG GACCTGGTGT CTTGCGCCTA CCAGGTGGCC 1560
CGGGGCATGG AGTACCTGGC CTCACAGAAG TGCATCCACA GGGACCTGGC GGCCCGCAAC 1620
GTGCTGGTGA CTGAGGACAA TGTGATGAAG ATCGCGGACT TTGGCCTGGC CCGAGACGTG 1680
CACAACCTTG ACTACTACAA AAAGACCACC AACGGTCGGC TGCCTGTGAA GTGGATGGCA 1740
CCCGAGGCCT TATTTGACCG AGTCTACACC CACCAGAGCG ACGTCTGGTC CTTTGGGGTC 1800
CTGCTCTGGG AGATCTTCAC ACTGGGGGGC TCGCCGTACC CTGGCATCCC AGTGGAGGAG 1860
CTCTTCAAGC TGCTGAAGGA AGGCCACCGC ATGGACAAGC CGGCCAACTG CACACACGAC 1920
CTGTACATGA TCATGCGGGA GTGCTGGCAC GCTGTGCCCT CCCAGAGGCC CACCTTCAAG 1980
CAGCTGGTGG AGGACCTGGA CCGCATTCTC ACTGTGACGT CCACCGACGA GTACCTGGAC 2040
CTGTCGGTGC CTTTCGAGCA GTACTCGCCG GGCAGCCAGG ACACCCCCAG CTCCAGCTCC 2100
TCGGGGGACG ACTCTGTGTT TGCCCACGAC CTGCTGCCCC CAGCCCCACC CAGCAGCGGG 2160
GGCCCGCGGA CATGA 2175
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aeaig+dkd+++k vtvavkmlk+datdkdl+dlvseme++k+
Q: 390   LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM  449
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyv+veyaakGnlre+lrarrp+g+++s d++k +eeqlt+
Q: 450   IGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREYLRARRPPGMDYSFDTCKLPEEQLTF  509
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh++dyykkt
Q: 510   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKT  569
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGh
Q: 570   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  629
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct++ly++mrecwha++s+rptfkqlvedl
Q: 630   RMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDL  666
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA IGIDKDRAAK PVTVAVKMLK DDATDKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQGGPL YVLVEYAAKG NLREYLRARR PPGMDYSFDT CKLPEEQLTF 120
KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNLDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTH DLYMIMRECW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00142
EKS-CAE-00120
EKS-CAF-00155
EKS-CAP-00149
EKS-DAR-00435
EKS-DRM-00072
EKS-GAM-00077
EKS-GAG-00124
EKS-GAA-00174
EKS-GOG-00150
EKS-ICT-00141
EKS-LAC-00156
EKS-LOA-00146
EKS-MEG-00114
EKS-MOD-00146
EKS-MUM-00152
EKS-MUP-00153
EKS-ORN-00181
EKS-ORA-00127
EKS-ORL-00169
EKS-OTG-00154
EKS-PAT-00138
EKS-PES-00131
EKS-PTV-00141
EKS-RAN-00146
EKS-SAH-00141
EKS-TAG-00175
EKS-TAR-00190
EKS-TEN-00186
EKS-XET-00135
EKS-XIM-00175
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0009898; C:internal side of plasma membrane
GO:0005764; C:lysosome
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0061144; P:alveolar secondary septum development
GO:0060385; P:axonogenesis involved in innervation
GO:0060349; P:bone morphogenesis
GO:0051216; P:cartilage development
GO:0022010; P:central nervous system myelination
GO:0090102; P:cochlea development
GO:0048546; P:digestive tract morphogenesis
GO:0072148; P:epithelial cell fate commitment
GO:0060113; P:inner ear receptor cell differentiation
GO:0070307; P:lens fiber cell development
GO:0002089; P:lens morphogenesis in camera-type eye
GO:0000165; P:MAPK cascade
GO:0002009; P:morphogenesis of an epithelium
GO:0043066; P:negative regulation of apoptotic process
GO:0048712; P:negative regulation of astrocyte differentiation
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0045879; P:negative regulation of smoothened signaling pathway
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0045597; P:positive regulation of cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010518; P:positive regulation of phospholipase activity
GO:0031398; P:positive regulation of protein ubiquitination
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0046777; P:protein autophosphorylation
GO:0048678; P:response to axon injury
GO:0035019; P:somatic stem cell maintenance
GO:0021762; P:substantia nigra development
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013