EKS-EQC-00275

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00275

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	408.0	2.4E-122	179	466	288

Status

Unreviewed

Ensembl Protein

ENSECAP00000017382

UniProt Accession

F7DXK7;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000019616	ENSECAP00000017382	ENSECAT00000021126

Organism

Equus caballus

Functional Description

Protein Length

501

Protein Sequence
(FASTA)

LISGGTGSGR GEAETRECIY YNANWELERT NQSGLERCEG EQDKRLHCYA SWRNSSGTIE 60

LVKKGCWLDD FNCYDRQECV ATEENPQVYF CCCEGNFCNE RFTHLPEAGG PEVTYEPPPT 120

APTLLTVLAY SLLPIGGLSL IILLAFWMYR HRKPPYGHVD IHEDPGPPPP SPLVGLKPLQ 180

LLEIKARGRF GCVWKAQLMN DFVAVKIFPL QDKQSWQSER EIFSTPGMKH ENLLQFIAAE 240

KRGSNLEVEL WLITAFHDKG SLTDYLKGNI ITWNELCHVA ETMSRGLSYL HEDVPWCRGE 300

GHKPSIAHRD FKSKNVLLKS DLTAVLADFG LAVRFEPGKP PGDTHGQVGT RRYMAPEVLE 360

GAINFQRDAF LRIDMYAMGL VLWELVSRCK AADGPVDEYM LPFEEEIGQH PSLEELQEVV 420

VHKKMRPAIK DHWLKHPGLA QLCVTIEECW DHDAEARLSA GCVEERVSLI RRSVNGTTSD 480

CLVSLVTSVT NVDLPPKESS I 501

Nucleotide Sequence
(FASTA)

CTCATTTCTG GGGGCACAGG TTCTGGGCGT GGGGAGGCTG AGACGCGGGA GTGCATCTAC 60

TACAACGCCA ACTGGGAGCT GGAGCGCACC AACCAGAGCG GCCTGGAGCG CTGCGAGGGC 120

GAGCAGGACA AGCGGCTGCA CTGCTATGCC TCCTGGCGCA ACAGCTCCGG CACCATCGAG 180

CTCGTCAAGA AGGGCTGCTG GCTGGATGAC TTCAACTGCT ATGACAGGCA GGAGTGTGTG 240

GCCACCGAGG AGAACCCCCA GGTATACTTC TGCTGCTGTG AAGGCAACTT CTGCAACGAG 300

CGCTTCACCC ACTTGCCAGA GGCTGGGGGC CCGGAAGTCA CGTACGAGCC ACCCCCGACA 360

GCCCCCACCC TGCTCACGGT GCTGGCCTAC TCGCTGCTGC CCATTGGGGG CCTCTCCCTC 420

ATCATCCTGC TGGCCTTCTG GATGTACCGG CATCGAAAAC CTCCCTATGG CCACGTGGAC 480

ATCCATGAGG ACCCTGGACC TCCACCCCCG TCCCCTCTGG TGGGCCTGAA GCCACTGCAG 540

CTGTTGGAGA TCAAGGCTCG GGGGCGCTTT GGCTGTGTTT GGAAGGCGCA GCTCATGAAT 600

GACTTTGTGG CTGTCAAGAT CTTCCCACTC CAGGACAAGC AGTCGTGGCA GAGTGAGCGG 660

GAGATCTTCA GCACGCCCGG CATGAAACAC GAGAACCTGC TGCAGTTCAT TGCCGCTGAG 720

AAGCGAGGCT CCAACCTCGA GGTGGAACTG TGGCTCATCA CAGCCTTCCA CGACAAGGGC 780

TCCCTCACGG ATTACCTCAA GGGGAACATC ATCACGTGGA ACGAACTGTG TCATGTGGCA 840

GAGACAATGT CAAGAGGTCT CTCTTACCTG CATGAGGACG TGCCCTGGTG CCGTGGTGAG 900

GGCCATAAGC CGTCTATCGC CCACAGGGAC TTTAAAAGCA AGAATGTATT GCTGAAGAGT 960

GACCTCACGG CCGTGCTGGC TGACTTTGGC CTCGCTGTTC GGTTTGAGCC AGGGAAACCC 1020

CCGGGGGACA CCCATGGGCA GGTGGGCACA CGGCGGTACA TGGCCCCTGA GGTGCTTGAG 1080

GGAGCCATCA ACTTCCAGAG AGACGCCTTC CTGCGCATTG ACATGTATGC CATGGGGCTG 1140

GTGCTGTGGG AGCTCGTGTC CCGCTGCAAG GCTGCCGATG GACCGGTGGA CGAATACATG 1200

CTACCCTTTG AGGAAGAGAT TGGCCAACAC CCGTCACTGG AGGAGCTGCA GGAGGTGGTT 1260

GTGCACAAGA AGATGCGGCC CGCCATTAAG GATCACTGGC TGAAGCACCC GGGCCTGGCC 1320

CAGCTCTGTG TGACCATTGA GGAGTGCTGG GACCATGATG CGGAGGCTCG CCTGTCTGCA 1380

GGCTGCGTGG AGGAGCGGGT GTCCCTGATC CGGAGGTCGG TCAACGGCAC TACCTCGGAC 1440

TGTCTTGTCT CCCTGGTGAC ATCCGTCACC AATGTGGACC TGCCTCCTAA AGAGTCGAGC 1500

ATCTAA 1506

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l+++ vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 179   LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIA  238

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++++el+l+t++h+kgsL+dyLk ++++++el+++a+++++Gl++LHe++++++

Q: 239   AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR  298

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +Kp+iaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 299   GeGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  356

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc+++d+ v+ey+lpfee++g++Pslee

Q: 357   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEE  415

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++evvv+kk+rP i+++w k++ l++l+ ++eecWd+d+eaRl+a +v++r

Q: 416   LQEVVVHKKMRPAIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEER  466

         ************************************************998

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDFVAVKIF PLQDKQSWQS EREIFSTPGM KHENLLQFIA 60

AEKRGSNLEV ELWLITAFHD KGSLTDYLKG NIITWNELCH VAETMSRGLS YLHEDVPWCR 120

GEGHKPSIAH RDFKSKNVLL KSDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CKAADGPVDE YMLPFEEEIG QHPSLEELQE 240

VVVHKKMRPA IKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEER 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0032147	; P:activation of protein kinase activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0060840	; P:artery development
GO:0001974	; P:blood vessel remodeling
GO:0030509	; P:BMP signaling pathway
GO:0007368	; P:determination of left/right symmetry
GO:0048617	; P:embryonic foregut morphogenesis
GO:0001702	; P:gastrulation with mouth forming second
GO:0007507	; P:heart development
GO:0030073	; P:insulin secretion
GO:0001822	; P:kidney development
GO:0030324	; P:lung development
GO:0001946	; P:lymphangiogenesis
GO:0060836	; P:lymphatic endothelial cell differentiation
GO:0007498	; P:mesoderm development
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0035265	; P:organ growth
GO:0060021	; P:palate development
GO:0031016	; P:pancreas development
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0009791	; P:post-embryonic development
GO:0009749	; P:response to glucose stimulus
GO:0061298	; P:retina vasculature development in camera-type eye
GO:0023014	; P:signal transduction by phosphorylation
GO:0048705	; P:skeletal system morphogenesis
GO:0060841	; P:venous blood vessel development

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013