EKS-EQC-00270

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00270

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	453.2	3.8E-136	171	458	288

Status

Unreviewed

Ensembl Protein

ENSECAP00000017534

UniProt Accession

F7CLA3;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000019682	ENSECAP00000017534	ENSECAT00000021300

Organism

Equus caballus

Functional Description

Protein Length

469

Protein Sequence
(FASTA)

GLKCVCLLCD SSNFTCQTEG ACWASVMLTN GKEQVIKSCV SLPELNAQVF CHSSNNVTKT 60

ECCFTDFCNN ITLHLPTASP NAPKLGPLEL TIVVTVPVCL LSIAAVLTVW VCQGRQCTYR 120

KKKRQNVEEP LSECNLVNAG KTLKDLIYDV TASGSGSGLP LLVQRTIART IVLQEIVGKG 180

RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA ADNKDNGTWT 240

QLWLVSEYHE QGSLYDYLNR NIVTVAGMIK LALSIASGLA HLHMEIVGTQ GKPAIAHRDI 300

KSKNILVKKC ETCAIADLGL AVKHDSILNT IDIPQNPKVG TKRYMAPEML DDTINVNIFE 360

SFKRADIYSV GLVYWEIARR CSVGGIVEEY QLPYYDMVPS DPSIEEMRKV VCDQKFRPSI 420

PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRIKKTISQ LCVKEDCKA 469

Nucleotide Sequence
(FASTA)

GGATTGAAGT GTGTGTGTCT TTTGTGTGAC TCTTCAAACT TTACCTGCCA AACAGAAGGA 60

GCATGTTGGG CTTCAGTTAT GCTAACCAAT GGAAAGGAAC AGGTGATCAA GTCCTGTGTC 120

TCTCTCCCGG AATTAAATGC TCAAGTCTTC TGTCATAGTT CCAACAATGT TACCAAAACC 180

GAATGCTGCT TCACAGATTT TTGCAACAAC ATAACTCTGC ACCTTCCAAC AGCATCACCA 240

AATGCCCCAA AACTCGGACC CTTGGAGCTG ACCATTGTTG TTACTGTGCC AGTTTGCCTC 300

CTGTCCATAG CTGCAGTGCT GACAGTATGG GTCTGCCAAG GCCGACAGTG TACATACAGA 360

AAGAAAAAGA GACAGAATGT GGAGGAGCCC CTCTCTGAGT GCAATCTGGT AAATGCTGGA 420

AAAACTCTAA AAGATCTGAT TTACGATGTG ACCGCCTCTG GATCTGGCTC TGGTCTACCT 480

CTGTTGGTTC AAAGAACAAT TGCAAGGACG ATTGTACTTC AGGAGATCGT AGGAAAAGGG 540

AGATTTGGTG AGGTCTGGCA TGGACGATGG TGTGGGGAAG ATGTGGCTGT GAAAATATTC 600

TCTTCCAGAG ATGAAAGATC TTGGTTTCGC GAGGCGGAAA TTTACCAGAC GGTTATGCTG 660

AGACATGAAA ACATCCTTGG TTTCATTGCT GCCGACAACA AAGATAATGG AACTTGGACT 720

CAACTTTGGC TTGTCTCCGA ATATCATGAA CAGGGCTCCT TATATGACTA TTTGAATAGA 780

AACATAGTGA CAGTGGCTGG AATGATCAAA CTGGCCCTTT CGATAGCTAG TGGTCTGGCC 840

CACCTTCATA TGGAGATTGT TGGTACACAA GGTAAACCTG CTATTGCTCA TCGAGATATA 900

AAATCAAAGA ATATCTTAGT GAAAAAATGT GAAACTTGTG CCATAGCAGA CTTAGGATTG 960

GCTGTGAAGC ATGATTCAAT ACTGAACACT ATCGACATAC CTCAGAATCC TAAAGTGGGA 1020

ACCAAAAGGT ATATGGCTCC TGAAATGCTC GATGATACAA TAAATGTGAA TATCTTTGAG 1080

TCCTTCAAAC GAGCTGACAT CTATTCTGTT GGTCTGGTTT ACTGGGAAAT AGCCCGAAGG 1140

TGTTCAGTTG GAGGAATTGT TGAGGAGTAC CAGTTGCCTT ATTATGACAT GGTGCCTTCA 1200

GATCCCTCAA TAGAGGAAAT GAGGAAGGTT GTTTGTGACC AGAAGTTTCG ACCGAGTATC 1260

CCAAACCAGT GGCAAAGCTG TGAAGCACTC CGAGTCATGG GAAGAATAAT GCGCGAGTGT 1320

TGGTATGCCA ATGGGGCAGC CCGCCTAACC GCCCTCCGTA TTAAGAAGAC TATTTCTCAA 1380

CTTTGTGTCA AAGAAGACTG CAAGGCCTAA 1410

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia

Q: 171   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  230

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv+eyhe+gsL+dyL+r++++v  +++lals+asGlahLH+eivgt+

Q: 231   ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQ  290

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRD+kskNilvkk +tc+iaDlGLa+k+++  +++d+ +n +vGtkRYmaPE

Q: 291   G--KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPE  348

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         +l++++n++ fe+fkraD+Ys+gLv+WE+a+Rc+  +++veey+lp++++v+sdPs+eem

Q: 349   MLDDTINVNIFESFKRADIYSVGLVYWEIARRCSV-GGIVEEYQLPYYDMVPSDPSIEEM  407

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++k rP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++

Q: 408   RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  458

         ************************************************986

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSEYHE QGSLYDYLNR NIVTVAGMIK LALSIASGLA HLHMEIVGTQ 120

GKPAIAHRDI KSKNILVKKC ETCAIADLGL AVKHDSILNT IDIPQNPKVG TKRYMAPEML 180

DDTINVNIFE SFKRADIYSV GLVYWEIARR CSVGGIVEEY QLPYYDMVPS DPSIEEMRKV 240

VCDQKFRPSI PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRIKKTI 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0048179	; C:activin receptor complex
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030154	; P:cell differentiation
GO:0019915	; P:lipid storage
GO:0008285	; P:negative regulation of cell proliferation
GO:0046676	; P:negative regulation of insulin secretion
GO:0038092	; P:nodal signaling pathway
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002021	; P:response to dietary excess
GO:0009749	; P:response to glucose stimulus
GO:0032868	; P:response to insulin stimulus

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013