EKS-EQC-00136

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00136

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	504.8	5.7E-152	148	405	258

Status

Unreviewed

Ensembl Protein

ENSECAP00000017503

UniProt Accession

F7CRF1;

Protein Name

Protein Synonyms/Alias

Gene Name

AKT3

Gene Synonyms/Alias

AKT3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000019722	ENSECAP00000017503	ENSECAT00000021259

Organism

Equus caballus

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ 60

LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS 120

PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK 180

KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE 240

RVFSEDRTRF YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA 300

ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM 360

EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDAKEIM RHSFFSGVNW QDVYDKKLVP 420

PFKPQVTSET DTRYFDEEFT AQTITITPPE KYDEDGMDCM DNERRPHFPQ FSYSASGRE 479

Nucleotide Sequence
(FASTA)

ATGAGCGATG TTACCATTGT GAAAGAAGGT TGGGTTCAGA AGAGGGGAGA ATATATAAAA 60

AACTGGAGGC CAAGATACTT CCTTTTGAAG ACAGATGGCT CGTTCATAGG GTATAAGGAG 120

AAACCTCAAG ATGTGGACCT ACCTTATCCT CTCAACAACT TCTCAGTGGC AAAATGCCAG 180

TTAATGAAAA CAGAACGACC AAAGCCAAAC ACATTTATTA TCAGATGTCT CCAGTGGACC 240

ACTGTCATAG AGAGAACCTT TCACGTAGAC ACTCCAGAAG AAAGGGAAGA ATGGACAGAA 300

GCTATCCAGG CTGTAGCAGA CAGACTTCAG AGGCAAGAAG AGGAGAGAAT GAATTGTAGT 360

CCAACTTCAC AGATAGATAA TATAGGGGAG GAAGAGATGG ATGCTTCCAC AACCCATCAT 420

AAAAGGAAGA CAATGAATGA CTTTGACTAT TTGAAACTAC TAGGTAAAGG CACTTTTGGG 480

AAAGTTATTT TGGTTCGAGA GAAGGCAAGT GGGAAATATT ATGCTATGAA GATTCTGAAG 540

AAAGAAGTTA TTATTGCAAA GGATGAAGTG GCACACACTC TAACTGAAAG CAGAGTATTA 600

AAGAACACTA GACATCCCTT TTTAACATCC TTGAAATATT CCTTCCAGAC AAAAGACCGT 660

TTGTGTTTTG TGATGGAATA TGTTAATGGG GGAGAGCTGT TTTTCCATTT GTCGAGAGAG 720

CGGGTGTTCT CTGAGGACCG CACGCGTTTC TATGGTGCAG AAATCGTCTC TGCCTTGGAC 780

TATCTGCACT CCGGGAAGAT TGTGTACCGT GATCTCAAGT TGGAGAATTT GATGCTGGAT 840

AAAGACGGGC ACATAAAAAT TACAGATTTT GGACTTTGCA AAGAAGGGAT CACAGATGCC 900

GCCACCATGA AGACGTTCTG TGGAACACCA GAATACCTGG CACCAGAGGT GTTAGAAGAT 960

AATGACTATG GCCGAGCCGT GGACTGGTGG GGCCTAGGGG TTGTCATGTA TGAAATGATG 1020

TGTGGGAGGT TGCCTTTCTA CAACCAGGAT CATGAGAAAC TTTTTGAACT AATACTAATG 1080

GAAGACATTA AATTTCCTCG AACACTCTCT TCAGATGCAA AATCATTGCT TTCAGGGCTC 1140

TTGATAAAGG ATCCAAATAA ACGCCTTGGT GGAGGACCAG ATGATGCAAA AGAAATTATG 1200

AGACACAGTT TCTTTTCTGG AGTAAACTGG CAAGATGTAT ATGATAAAAA GCTTGTACCT 1260

CCGTTTAAGC CTCAAGTAAC ATCTGAGACA GATACCAGAT ATTTTGATGA AGAATTTACG 1320

GCTCAGACTA TTACAATAAC ACCACCTGAA AAATATGACG AGGACGGCAT GGACTGCATG 1380

GACAACGAGC GGCGGCCGCA CTTCCCGCAG TTTTCCTACT CCGCAAGTGG ACGGGAATAA 1440

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvreka++k+ya+kilkkevi+akdevahtlte+rvlk+t+hpf

Q: 148   FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF  207

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l++lkysfqtk++lc+v+eyvnGGelffhls+ervfsedr+rfygaeivsaldylhs ++

Q: 208   LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI  267

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrdlklenl+ldkdGhikitdfGlcke+i+d++++ktfcGtpeylapevled+dyg+av

Q: 268   VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV  327

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dheklfelil+e++kfpr+ls++aksllsGll kdp+k

Q: 328   DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNK  387

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg+ddakei++h+ff

Q: 388   RLGGGPDDAKEIMRHSFF  405

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KASGKYYAMK ILKKEVIIAK DEVAHTLTES RVLKNTRHPF 60

LTSLKYSFQT KDRLCFVMEY VNGGELFFHL SRERVFSEDR TRFYGAEIVS ALDYLHSGKI 120

VYRDLKLENL MLDKDGHIKI TDFGLCKEGI TDAATMKTFC GTPEYLAPEV LEDNDYGRAV 180

DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEDIKFPR TLSSDAKSLL SGLLIKDPNK 240

RLGGGPDDAK EIMRHSFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000002	; P:mitochondrial genome maintenance
GO:0007165	; P:signal transduction

KEGG

ecb:100054961

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013